Krishnakumar Devadas

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Inhibition of HIV-1 replication by the combined action of anti-gp41 single chain antibody and IL-16
    Krishnakumar Devadas
    Experimental Medicine Section, Oral Immunity and Infection Branch, Building 30, Room 121, NIDCR, National Institutes of Health, 30 Convent Drive, MSC 4322, Bethesda, MD 20892 4322, USA
    Antiviral Res 59:67-70. 2003
  2. ncbi request reprint Mechanisms for macrophage-mediated HIV-1 induction
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 173:6735-44. 2004
  3. ncbi request reprint Antibodies against a multiple-peptide conjugate comprising chemically modified human immunodeficiency virus type-1 functional Tat peptides inhibit infection
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States
    Peptides 28:496-504. 2007
  4. doi request reprint Effect of sex steroid hormones on replication and transmission of major HIV subtypes
    Viswanath Ragupathy
    Laboratory of Molecular Virology, Division of Emerging Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Electronic address
    J Steroid Biochem Mol Biol 138:63-71. 2013
  5. ncbi request reprint Selective side-chain modification of cysteine and arginine residues blocks pathogenic activity of HIV-1-Tat functional peptides
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM 315, Rockville, MD 20852 1448, USA
    Peptides 27:611-21. 2006
  6. doi request reprint HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells
    Xue Wang
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States
    Cell Signal 24:1414-9. 2012
  7. doi request reprint Some mechanisms of FLIP expression in inhibition of HIV-1 replication in Jurkat cells, CD4+ T cells and PBMCs
    Jiying Tan
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
    J Cell Physiol 228:2305-13. 2013
  8. doi request reprint Lipopolysaccharide suppresses HIV-1 replication in human monocytes by protein kinase C-dependent heme oxygenase-1 induction
    Krishnakumar Devadas
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM 315, Rockville, MD 20852 1448, USA
    J Leukoc Biol 87:915-24. 2010
  9. ncbi request reprint Hemin activation ameliorates HIV-1 infection via heme oxygenase-1 induction
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 176:4252-7. 2006
  10. pmc Absence of detectable XMRV and other MLV-related viruses in healthy blood donors in the United States
    Shixing Tang
    Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 6:e27391. 2011

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Inhibition of HIV-1 replication by the combined action of anti-gp41 single chain antibody and IL-16
    Krishnakumar Devadas
    Experimental Medicine Section, Oral Immunity and Infection Branch, Building 30, Room 121, NIDCR, National Institutes of Health, 30 Convent Drive, MSC 4322, Bethesda, MD 20892 4322, USA
    Antiviral Res 59:67-70. 2003
    ..It is concluded that anti-gp41 and IL-16 act in a synergistic fashion to inhibit HIV-1 replication...
  2. ncbi request reprint Mechanisms for macrophage-mediated HIV-1 induction
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 173:6735-44. 2004
    ..These results provide a mechanism by which macrophages induce HIV-1 replication in latently infected cells...
  3. ncbi request reprint Antibodies against a multiple-peptide conjugate comprising chemically modified human immunodeficiency virus type-1 functional Tat peptides inhibit infection
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States
    Peptides 28:496-504. 2007
    ..The HIV-1-Tat-MPC, therefore, has potential for the development of a safe, effective, and economical therapeutic vaccine to reduce the progression of HIV infection...
  4. doi request reprint Effect of sex steroid hormones on replication and transmission of major HIV subtypes
    Viswanath Ragupathy
    Laboratory of Molecular Virology, Division of Emerging Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Electronic address
    J Steroid Biochem Mol Biol 138:63-71. 2013
    ..Little is known about the role of sex hormone effects on HIV Subtypes pathogenesis. The aim of our study was to determine sex hormone effects on replication and transmissibility of HIV subtypes...
  5. ncbi request reprint Selective side-chain modification of cysteine and arginine residues blocks pathogenic activity of HIV-1-Tat functional peptides
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM 315, Rockville, MD 20852 1448, USA
    Peptides 27:611-21. 2006
    ....
  6. doi request reprint HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells
    Xue Wang
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States
    Cell Signal 24:1414-9. 2012
    ..The results indicate that HIV is able to induce the autophagic signaling pathway in HIV-infected host cells, which may be required for HIV infection-mediated apoptotic cell death...
  7. doi request reprint Some mechanisms of FLIP expression in inhibition of HIV-1 replication in Jurkat cells, CD4+ T cells and PBMCs
    Jiying Tan
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
    J Cell Physiol 228:2305-13. 2013
    ..We also found that cFLIP expression downregulated Fas expression and inactivated FADD in the Fas-mediated apoptotic pathway. The inactivated FADD also inhibited HIV-1 replication...
  8. doi request reprint Lipopolysaccharide suppresses HIV-1 replication in human monocytes by protein kinase C-dependent heme oxygenase-1 induction
    Krishnakumar Devadas
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM 315, Rockville, MD 20852 1448, USA
    J Leukoc Biol 87:915-24. 2010
    ..These results demonstrate a previously undefined function of HO-1 as a host defense mechanism in LPS-mediated inhibition of HIV-1 replication...
  9. ncbi request reprint Hemin activation ameliorates HIV-1 infection via heme oxygenase-1 induction
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 176:4252-7. 2006
    ..These findings suggest an important role of hemin-induced HO-1 activity as a host defense mechanism against HIV-1 infection...
  10. pmc Absence of detectable XMRV and other MLV-related viruses in healthy blood donors in the United States
    Shixing Tang
    Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 6:e27391. 2011
    ..S. These results imply that millions of persons in the U.S. may be carrying the nucleic acid sequences of XMRV and/or MLV-related viruses, which is a serious public health and blood safety concern...
  11. pmc XMRV: usage of receptors and potential co-receptors
    Mohan Kumar Haleyur Giri Setty
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Virol J 8:423. 2011
    ..Although XMRV is thought to use XPR1 for cell entry, it infects A549 cells that do not express XPR1, suggesting usage of other receptors or co-receptors...
  12. pmc Identification of XMRV infection-associated microRNAs in four cell types in culture
    Ketha V K Mohan
    Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 7:e32853. 2012
    ..MicroRNAs (miRNA), which regulate gene expression, were so far not identified in cells infected with XMRV in culture...
  13. pmc Elevated levels of tumor necrosis factor alpha (TNF-alpha) in human immunodeficiency virus type 1-transgenic mice: prevention of death by antibody to TNF-alpha
    Swapan K De
    Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 76:11710-4. 2002
    ..We conclude that TNF-alpha contributes in a major way to HIV-1-induced pathology in transgenic mice and that both hCG and antibody to TNF-alpha prevent the development of pathology by suppressing the level of TNF-alpha...