V G Desai

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Changes in expression level of genes as a function of time of day in the liver of rats
    Varsha G Desai
    Center for Functional Genomics, National Center for Toxicological Research, US FDA, Jefferson, AR, USA
    Mutat Res 549:115-29. 2004
  2. ncbi request reprint Activity profile of glutathione-dependent enzymes and respiratory chain complexes in rats supplemented with antioxidants and treated with carcinogens
    V G Desai
    Department of Health and Human Services, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Arch Biochem Biophys 394:255-64. 2001
  3. ncbi request reprint Influence of dietary antioxidants on the mutagenicity of 7,12-dimethylbenz[a]anthracene and bleomycin in female rats
    M Khaidakov
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA Jefferson Laboratories, Jefferson, AR 72079, USA
    Mutat Res 480:163-70. 2001
  4. ncbi request reprint Attenuation of bleomycin-induced Hprt mutant frequency in female and male rats by calorie restriction
    A Aidoo
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mutat Res 430:155-63. 1999
  5. ncbi request reprint Hypothermia enhances bcl-2 expression and protects against oxidative stress-induced cell death in Chinese hamster ovary cells
    W Slikker
    Division of Neurotoxicology, National Center for Toxicological Research/US FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
    Free Radic Biol Med 31:405-11. 2001
  6. ncbi request reprint Analysis of variance components in gene expression data
    James J Chen
    Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Bioinformatics 20:1436-46. 2004
  7. doi request reprint Effect of p53 genotype on gene expression profiles in murine liver
    Suzanne M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States
    Mutat Res 640:54-73. 2008
  8. ncbi request reprint Mutagenicity of food-derived carcinogens and the effect of antioxidant vitamins
    Beverly A Montgomery
    Division of Genetic and Reproductive Toxicology, Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Nutr Cancer 43:103-10. 2002
  9. ncbi request reprint Transcriptional profiling for understanding the basis of mitochondrial involvement in disease and toxicity using the mitochondria-specific MitoChip
    Varsha G Desai
    Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, HFT 130, Jefferson, AR 72079, USA
    Mutat Res 616:210-2. 2007
  10. pmc Elimination of laboratory ozone leads to a dramatic improvement in the reproducibility of microarray gene expression measurements
    William S Branham
    Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    BMC Biotechnol 7:8. 2007

Detail Information

Publications13

  1. ncbi request reprint Changes in expression level of genes as a function of time of day in the liver of rats
    Varsha G Desai
    Center for Functional Genomics, National Center for Toxicological Research, US FDA, Jefferson, AR, USA
    Mutat Res 549:115-29. 2004
    ....
  2. ncbi request reprint Activity profile of glutathione-dependent enzymes and respiratory chain complexes in rats supplemented with antioxidants and treated with carcinogens
    V G Desai
    Department of Health and Human Services, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Arch Biochem Biophys 394:255-64. 2001
    ..Furthermore, in addition to being an enhancer of the catalytic function of glutathione peroxidase, selenium may directly play a role as an antioxidant...
  3. ncbi request reprint Influence of dietary antioxidants on the mutagenicity of 7,12-dimethylbenz[a]anthracene and bleomycin in female rats
    M Khaidakov
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA Jefferson Laboratories, Jefferson, AR 72079, USA
    Mutat Res 480:163-70. 2001
    ..Pending molecular analysis of mitochondrial DNA mutations will also indicate whether there is a shift in the mutational spectra produced by the carcinogens in the presence of antioxidants...
  4. ncbi request reprint Attenuation of bleomycin-induced Hprt mutant frequency in female and male rats by calorie restriction
    A Aidoo
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mutat Res 430:155-63. 1999
    ..The results indicate that calorie intake of 60% reduced the mutagenic response of BLM, a compound known to induce oxidative DNA damage, and suggest a possible decrease in ROS as a function of calorie restriction...
  5. ncbi request reprint Hypothermia enhances bcl-2 expression and protects against oxidative stress-induced cell death in Chinese hamster ovary cells
    W Slikker
    Division of Neurotoxicology, National Center for Toxicological Research/US FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
    Free Radic Biol Med 31:405-11. 2001
    ....
  6. ncbi request reprint Analysis of variance components in gene expression data
    James J Chen
    Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Bioinformatics 20:1436-46. 2004
    ..Finally, we describe the use of variance-component estimates to determine optimal numbers of animals, arrays per animal and sections per array in planning microarray experiments...
  7. doi request reprint Effect of p53 genotype on gene expression profiles in murine liver
    Suzanne M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States
    Mutat Res 640:54-73. 2008
    ..This may indicate that alternate pathways are brought into play in the unperturbed liver when loss or reduction in p53 levels occurs...
  8. ncbi request reprint Mutagenicity of food-derived carcinogens and the effect of antioxidant vitamins
    Beverly A Montgomery
    Division of Genetic and Reproductive Toxicology, Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Nutr Cancer 43:103-10. 2002
    ....
  9. ncbi request reprint Transcriptional profiling for understanding the basis of mitochondrial involvement in disease and toxicity using the mitochondria-specific MitoChip
    Varsha G Desai
    Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, HFT 130, Jefferson, AR 72079, USA
    Mutat Res 616:210-2. 2007
    ....
  10. pmc Elimination of laboratory ozone leads to a dramatic improvement in the reproducibility of microarray gene expression measurements
    William S Branham
    Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    BMC Biotechnol 7:8. 2007
    ..Cyanine 3 (Cy3) is much less affected by atmospheric ozone. Degradation of the Cy5 signal relative to the Cy3 signal in 2-color microarrays will adversely reduce the Cy5/Cy3 ratio resulting in unreliable microarray data...
  11. ncbi request reprint Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR
    Varsha G Desai
    Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Mitochondrion 7:322-9. 2007
    ..The real-time PCR data confirmed the observations by microarray analysis suggesting that the MitoChip may be an important tool for examining mitochondrial involvement in diseases and drug-induced toxicities...
  12. doi request reprint Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
    Varsha G Desai
    Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mitochondrion 8:181-95. 2008
    ..These results suggest that NRTI-related effect on expression level of genes associated with mitochondrial functions was much greater in response to AZT/3TC combination treatment than AZT alone...
  13. pmc Testing for treatment effects on gene ontology
    Taewon Lee
    Department of Information and Mathematics, Korea University, Jochiwon, Chungnam 339 700, Korea
    BMC Bioinformatics 9:S20. 2008
    ..For such applications to real data of limited statistical power, and also in computer simulations, we demonstrate that our method gives reasonable test results...