Roberto De Pascalis

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Diverse myeloid and lymphoid cell subpopulations produce gamma interferon during early innate immune responses to Francisella tularensis live vaccine strain
    Roberto De Pascalis
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US FDA, 1401 Rockville Pike, HFM 431, Rockville, Maryland 20852, USA
    Infect Immun 76:4311-21. 2008
  2. doi request reprint NK cells activated in vivo by bacterial DNA control the intracellular growth of Francisella tularensis LVS
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
    Microbes Infect 11:49-56. 2009
  3. pmc T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria
    Carmen M Collazo
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, Maryland 20852, USA
    Infect Immun 77:2010-21. 2009
  4. pmc Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS
    Roberto De Pascalis
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, Maryland, United States of America
    PLoS Pathog 8:e1002494. 2012
  5. ncbi request reprint Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody
    Roberto De Pascalis
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3076-84. 2002
  6. ncbi request reprint SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity
    Noreen R Gonzales
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Room 8B09, 10 Center Drive, Building 10, Bethesda, MD 20892 1750, USA
    Mol Immunol 41:863-72. 2004
  7. ncbi request reprint Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    M E Christine Lutsiak
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 10, Rm 8B09, Bethesda, MD 20892, USA
    Blood 105:2862-8. 2005

Collaborators

Detail Information

Publications7

  1. pmc Diverse myeloid and lymphoid cell subpopulations produce gamma interferon during early innate immune responses to Francisella tularensis live vaccine strain
    Roberto De Pascalis
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US FDA, 1401 Rockville Pike, HFM 431, Rockville, Maryland 20852, USA
    Infect Immun 76:4311-21. 2008
    ....
  2. doi request reprint NK cells activated in vivo by bacterial DNA control the intracellular growth of Francisella tularensis LVS
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
    Microbes Infect 11:49-56. 2009
    ..Thus, NK cells contribute to DNA-mediated protection by production of cytokines including IFN-gamma and TNF-alpha, resulting in nitric oxide production and control of intracellular Francisella replication...
  3. pmc T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria
    Carmen M Collazo
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, Maryland 20852, USA
    Infect Immun 77:2010-21. 2009
    ..Thus, our results indicate functional similarities between immune T cells residing in spleens, livers, and lungs of LVS-immune mice...
  4. pmc Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS
    Roberto De Pascalis
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, Maryland, United States of America
    PLoS Pathog 8:e1002494. 2012
    ..The overall approach may be applicable to intracellular pathogens in general...
  5. ncbi request reprint Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody
    Roberto De Pascalis
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3076-84. 2002
    ..The final variant of the HuCOL-1, which retains its Ag-binding reactivity and shows significantly lower serum reactivity than that of the parental Ab, can serve as a prototype for the development of a potentially useful clinical reagent...
  6. ncbi request reprint SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity
    Noreen R Gonzales
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Room 8B09, 10 Center Drive, Building 10, Bethesda, MD 20892 1750, USA
    Mol Immunol 41:863-72. 2004
    ....
  7. ncbi request reprint Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    M E Christine Lutsiak
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 10, Rm 8B09, Bethesda, MD 20892, USA
    Blood 105:2862-8. 2005
    ..The relevance of the loss of suppressor functionality and the changes in gene expression are further discussed...