Siobhán C Cowley

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Immunity to francisella
    Siobhán C Cowley
    Center for Biologics Evaluation and Research, U S Food and Drug Administration Bethesda, MD, USA
    Front Microbiol 2:26. 2011
  2. ncbi request reprint Differential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growth
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 179:7709-19. 2007
  3. doi request reprint The membrane form of tumor necrosis factor is sufficient to mediate partial innate immunity to Francisella tularensis live vaccine strain
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US Food and Drug Administration, Rockville, MD 20852, USA
    J Infect Dis 198:284-92. 2008
  4. doi request reprint Lung CD4-CD8- double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain
    Siobhán C Cowley
    Division of Bacterial, Parasitic and Allergenic Products, Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 184:5791-801. 2010
  5. pmc CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Exp Med 202:309-19. 2005
  6. pmc Multiple T cell subsets control Francisella tularensis LVS intracellular growth without stimulation through macrophage interferon gamma receptors
    Siobhán C Cowley
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    J Exp Med 198:379-89. 2003
  7. doi request reprint Survival of secondary lethal systemic Francisella LVS challenge depends largely on interferon gamma
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER FDA, HFM 431, Rockville, MD 20852, USA
    Microbes Infect 12:28-36. 2010
  8. ncbi request reprint CD4+ T cells mediate IFN-gamma-independent control of Mycobacterium tuberculosis infection both in vitro and in vivo
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 171:4689-99. 2003
  9. ncbi request reprint Innate and adaptive immunity to Francisella
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER U S FDA, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1105:284-324. 2007
  10. ncbi request reprint Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain
    Karen L Elkins
    Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
    Microbes Infect 5:135-42. 2003

Collaborators

Detail Information

Publications14

  1. pmc Immunity to francisella
    Siobhán C Cowley
    Center for Biologics Evaluation and Research, U S Food and Drug Administration Bethesda, MD, USA
    Front Microbiol 2:26. 2011
    ..Overall, recent data profile a pathogen that is adept at subverting host immune responses, but susceptible to many elements of the immune system's antimicrobial arsenal...
  2. ncbi request reprint Differential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growth
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 179:7709-19. 2007
    ....
  3. doi request reprint The membrane form of tumor necrosis factor is sufficient to mediate partial innate immunity to Francisella tularensis live vaccine strain
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US Food and Drug Administration, Rockville, MD 20852, USA
    J Infect Dis 198:284-92. 2008
    ..Thus, memTNF partially functions to regulate chemokine expression, cell recruitment, and nitric oxide production during primary LVS infection and protects against the induction of apoptosis observed in TNF KO mice...
  4. doi request reprint Lung CD4-CD8- double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain
    Siobhán C Cowley
    Division of Bacterial, Parasitic and Allergenic Products, Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 184:5791-801. 2010
    ....
  5. pmc CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Exp Med 202:309-19. 2005
    ..tb. or F. tularensis LVS, and then acquire a memory cell phenotype. Thus, CD4(-)CD8(-) T cells have a role in the control of intracellular infection and may contribute to successful vaccination...
  6. pmc Multiple T cell subsets control Francisella tularensis LVS intracellular growth without stimulation through macrophage interferon gamma receptors
    Siobhán C Cowley
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    J Exp Med 198:379-89. 2003
    ....
  7. doi request reprint Survival of secondary lethal systemic Francisella LVS challenge depends largely on interferon gamma
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER FDA, HFM 431, Rockville, MD 20852, USA
    Microbes Infect 12:28-36. 2010
    ..Thus successful priming of protective LVS-immune T cells, as well as complete expression of protection against Francisella during secondary challenge, depends heavily on IFN-gamma...
  8. ncbi request reprint CD4+ T cells mediate IFN-gamma-independent control of Mycobacterium tuberculosis infection both in vitro and in vivo
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 171:4689-99. 2003
    ..These findings demonstrate that CD4(+) T cells possess IFN-gamma-independent mechanisms that can limit the growth of an intracellular pathogen and are dominant in secondary responses to M. tuberculosis...
  9. ncbi request reprint Innate and adaptive immunity to Francisella
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER U S FDA, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1105:284-324. 2007
    ..Thus a number of known proinflammatory and Th-1 T cell related components of the immune system combat this virulent bacterium; no doubt others remain to be discovered...
  10. ncbi request reprint Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain
    Karen L Elkins
    Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
    Microbes Infect 5:135-42. 2003
    ..Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens...
  11. ncbi request reprint Francisella: a little bug hits the big time
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, CBER FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
    Expert Rev Vaccines 2:735-8. 2003
  12. pmc In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70
    Karen L Elkins
    Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, CBER FDA, Rockville, Maryland 20852, USA
    Infect Immun 70:1936-48. 2002
    ..Instead, an additional mechanism dependent on the IL-12 p40 protein, either alone or in another complex such as the newly discovered heterodimer IL-23, appears to be responsible for actual clearance of this intracellular bacterium...
  13. doi request reprint Measurement of macrophage-mediated killing of intracellular bacteria, including Francisella and mycobacteria
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER U S FDA, Rockville, Maryland, USA
    Curr Protoc Immunol . 2011
    ....
  14. pmc MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection
    Anda Meierovics
    Division of Bacterial, Parasitic, and Allergenic Products, Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 110:E3119-28. 2013
    ..tularensis LVS growth. This study provides in vivo evidence demonstrating that MAIT cells are an important T-cell subset with activities that influence the innate and adaptive phases of mucosal immunity. ..