B F Coles

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Quantitative analysis of interindividual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype
    B F Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Cancer Res 60:573-9. 2000
  2. ncbi request reprint Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu, and pi expression in gastrointestinal tract mucosa of normal individuals
    Brian F Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Arch Biochem Biophys 403:270-6. 2002
  3. ncbi request reprint Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression
    B F Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    Pharmacogenetics 11:663-9. 2001
  4. ncbi request reprint The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk
    B Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research HFT 100, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 482:3-10. 2001
  5. ncbi request reprint Expression of hGSTP1 alleles in human lung and catalytic activity of the native protein variants towards 1-chloro-2,4-dinitrobenzene, 4-vinylpyridine and (+)-anti benzo[a]pyrene-7,8-diol-9,10-oxide
    B Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Cancer Lett 156:167-75. 2000
  6. ncbi request reprint Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs?
    Brian F Coles
    National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
    Biofactors 17:115-30. 2003
  7. ncbi request reprint Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile105Val polymorphism
    C Sweeney
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Cancer Res 60:5621-4. 2000
  8. ncbi request reprint Purification and characterization of a glutathione S-transferase from the fungus Cunninghamella elegans
    C J Cha
    Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    FEMS Microbiol Lett 203:257-61. 2001
  9. ncbi request reprint Expression of cytochromes P450 and glutathione S-transferases in human prostate, and the potential for activation of heterocyclic amine carcinogens via acetyl-coA-, PAPS- and ATP-dependent pathways
    Oscar A Di Paolo
    Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
    Int J Cancer 117:8-13. 2005
  10. ncbi request reprint Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities
    Wolfgang W Huber
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Environ Mol Mutagen 44:265-76. 2004

Detail Information

Publications15

  1. ncbi request reprint Quantitative analysis of interindividual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype
    B F Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Cancer Res 60:573-9. 2000
    ..Interindividual variation of GST expression is, therefore, a factor that should be taken account of in epidemiological studies...
  2. ncbi request reprint Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu, and pi expression in gastrointestinal tract mucosa of normal individuals
    Brian F Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Arch Biochem Biophys 403:270-6. 2002
    ..This may be a factor in the greater susceptibility of stomach and colon to cancers compared to duodenum/small intestine...
  3. ncbi request reprint Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression
    B F Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    Pharmacogenetics 11:663-9. 2001
    ....
  4. ncbi request reprint The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk
    B Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research HFT 100, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 482:3-10. 2001
    ....
  5. ncbi request reprint Expression of hGSTP1 alleles in human lung and catalytic activity of the native protein variants towards 1-chloro-2,4-dinitrobenzene, 4-vinylpyridine and (+)-anti benzo[a]pyrene-7,8-diol-9,10-oxide
    B Coles
    Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Cancer Lett 156:167-75. 2000
    ..Neither the expression of the hGSTP1 alleles nor the catalytic properties of the protein variants appears to provide a simple mechanistic rationale for the observed over-representation of the hGSTP1*B and/or 1*C alleles in lung cancer...
  6. ncbi request reprint Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs?
    Brian F Coles
    National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
    Biofactors 17:115-30. 2003
    ..Mechanistic models for chemical aspects of colorectal cancer and chemotherapy for breast cancer demonstrate some of the ways by which such interactions can be studied and the potential for future studies...
  7. ncbi request reprint Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile105Val polymorphism
    C Sweeney
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Cancer Res 60:5621-4. 2000
    ..8 (95% confidence interval, 0.5-1.3) for Ile/Val and 0.3 (95% confidence interval, 0.1-1.0) for Val/Val (P for trend = 0.04). Inherited metabolic variability may influence treatment outcomes...
  8. ncbi request reprint Purification and characterization of a glutathione S-transferase from the fungus Cunninghamella elegans
    C J Cha
    Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    FEMS Microbiol Lett 203:257-61. 2001
    ..The N-terminal amino acid sequence of the purified enzyme showed no significant homology with other known GSTs...
  9. ncbi request reprint Expression of cytochromes P450 and glutathione S-transferases in human prostate, and the potential for activation of heterocyclic amine carcinogens via acetyl-coA-, PAPS- and ATP-dependent pathways
    Oscar A Di Paolo
    Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
    Int J Cancer 117:8-13. 2005
    ..However, there were no significant correlations between expression/activities and DNA adducts formed in vitro or in vivo, DNA adducts in vivo possibly reflecting carcinogen exposure...
  10. ncbi request reprint Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities
    Wolfgang W Huber
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Environ Mol Mutagen 44:265-76. 2004
    ..In summary, the unique potential of K/C to convert rapid acetylators to a slow acetylator phenotype, accompanied by GST induction, might contribute to chemoprevention against cancers associated with heterocyclic amines...
  11. ncbi request reprint Lack of association between Caucasian lung cancer risk and O6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism
    Mihi Yang
    Department of Preventive Medicine, Cancer Research Institute, College of Medicine, Seoul National University, Chongno go, South Korea
    Lung Cancer 44:281-6. 2004
    ..Because this "deletion" was observed in all sequenced samples (N = 20), the previously reported human (Caucasian) MGMT gene sequence should be revised to exclude this 10bp segment...
  12. ncbi request reprint Association between a glutathione S-transferase A1 promoter polymorphism and survival after breast cancer treatment
    Carol Sweeney
    Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA
    Int J Cancer 103:810-4. 2003
    ..Further studies should consider the possible association between the novel GSTA1*B variant and outcomes of cancer therapy...
  13. ncbi request reprint Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer
    Carol Sweeney
    Division of Molecular Epidemiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicology 181:83-7. 2002
    ..001). GSTA1 genotype and CYP2A6 phenotype should be evaluated as markers of susceptibility to dietary carcinogens in future studies...
  14. ncbi request reprint Effects of the ADH3, CYP2E1, and GSTP1 genetic polymorphisms on their expressions in Caucasian lung tissue
    Mihi Yang
    Department of Preventive Medicine, Cancer Research Institute, College of Medicine, Seoul National University, 28 Yongon Dong, Chongno Gu, 110 799, Seoul, Republic of Korea
    Lung Cancer 38:15-21. 2002
    ..In conclusion, subjects with the ADH3*1 allele showed higher ADH activity and acetaldehyde-DNA adducts in lung than other subjects; thus, the ADH3*1 allele could be considered a risk factor for lung cancer...
  15. ncbi request reprint Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease
    Brian F Coles
    Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Methods Enzymol 401:9-42. 2005
    ..Methods for identification and quantitation of human alpha class GST protein, mRNA, and genotype are reviewed, and the potential for GST-alpha in plasma to be used as a marker for hepatic expression and induction is discussed...