Konstantin Chumakov

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Universal oligonucleotide microarray for sub-typing of Influenza A virus
    Vladimir A Ryabinin
    Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
    PLoS ONE 6:e17529. 2011
  2. pmc New generation of inactivated poliovirus vaccines for universal immunization after eradication of poliomyelitis
    Konstantin Chumakov
    Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20852, USA
    Clin Infect Dis 47:1587-92. 2008
  3. doi request reprint MAPREC assay for quantitation of mutants in a recombinant flavivirus vaccine strain using near-infrared fluorescent dyes
    Bella Bidzhieva
    Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Virol Methods 175:14-9. 2011
  4. doi request reprint Quantitative one-step RT-PCR assay for rapid and sensitive identification and titration of polioviruses in clinical specimens
    Majid Laassri
    Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852 1448, USA
    J Virol Methods 189:7-14. 2013
  5. ncbi request reprint Vaccination against polio should not be stopped
    Konstantin Chumakov
    Konstantin Chumakov is at the Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852, USA
    Nat Rev Microbiol 5:952-8. 2007
  6. pmc Massively parallel sequencing for monitoring genetic consistency and quality control of live viral vaccines
    Alexander Neverov
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 107:20063-8. 2010
  7. pmc Microarray hybridization for assessment of the genetic stability of chimeric West Nile/dengue 4 virus
    Majid Laassri
    Laboratory of Method Development, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20852 1448, USA
    J Med Virol 83:910-20. 2011
  8. pmc Chimpanzee-human monoclonal antibodies for treatment of chronic poliovirus excretors and emergency postexposure prophylaxis
    Zhaochun Chen
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    J Virol 85:4354-62. 2011
  9. doi request reprint Repertoire of antibodies against type 1 poliovirus in human sera
    Gennady Rezapkin
    FDA Center for Biologics Evaluation and Research, Rockville, MD 20852, USA
    J Virol Methods 169:322-31. 2010
  10. doi request reprint Microarray-based assay for the detection of genetic variations of structural genes of West Nile virus
    Andriyan Grinev
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Rockville, MD 20852, USA
    J Virol Methods 154:27-40. 2008

Collaborators

Detail Information

Publications23

  1. pmc Universal oligonucleotide microarray for sub-typing of Influenza A virus
    Vladimir A Ryabinin
    Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
    PLoS ONE 6:e17529. 2011
    ..Out of 40 samples tested, 36 unambiguously identified HA and NA subtypes of Influenza A virus...
  2. pmc New generation of inactivated poliovirus vaccines for universal immunization after eradication of poliomyelitis
    Konstantin Chumakov
    Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20852, USA
    Clin Infect Dis 47:1587-92. 2008
    ..Here, we discuss the desired properties of a vaccine and methods to create a new polio vaccine...
  3. doi request reprint MAPREC assay for quantitation of mutants in a recombinant flavivirus vaccine strain using near-infrared fluorescent dyes
    Bella Bidzhieva
    Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Virol Methods 175:14-9. 2011
    ..The modified MAPREC assay could be used as an alternative to the radioisotope-based standard protocol for quality control of live viral vaccines...
  4. doi request reprint Quantitative one-step RT-PCR assay for rapid and sensitive identification and titration of polioviruses in clinical specimens
    Majid Laassri
    Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852 1448, USA
    J Virol Methods 189:7-14. 2013
    ..The multiplex assay that quantifies all three serotypes of poliovirus was found to be highly specific, sensitive, and takes only one day to complete...
  5. ncbi request reprint Vaccination against polio should not be stopped
    Konstantin Chumakov
    Konstantin Chumakov is at the Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852, USA
    Nat Rev Microbiol 5:952-8. 2007
    ..It is crucially important that high levels of population immunity are maintained against polio in the foreseeable future...
  6. pmc Massively parallel sequencing for monitoring genetic consistency and quality control of live viral vaccines
    Alexander Neverov
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 107:20063-8. 2010
    ..This approach may represent the ultimate tool for monitoring genetic consistency of live viral vaccines...
  7. pmc Microarray hybridization for assessment of the genetic stability of chimeric West Nile/dengue 4 virus
    Majid Laassri
    Laboratory of Method Development, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20852 1448, USA
    J Med Virol 83:910-20. 2011
    ..The approach described in this article could be useful for monitoring the molecular consistency and quality control of vaccine strains...
  8. pmc Chimpanzee-human monoclonal antibodies for treatment of chronic poliovirus excretors and emergency postexposure prophylaxis
    Zhaochun Chen
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    J Virol 85:4354-62. 2011
    ..The MAbs described here could be tested in clinical trials to determine whether they might be useful for treatment of immunocompromised chronic virus excretors and for emergency protection of contacts of a paralytic poliomyelitis case...
  9. doi request reprint Repertoire of antibodies against type 1 poliovirus in human sera
    Gennady Rezapkin
    FDA Center for Biologics Evaluation and Research, Rockville, MD 20852, USA
    J Virol Methods 169:322-31. 2010
    ..The new method may be useful for analyzing results of clinical trials and to compare immunity induced by different poliovirus vaccines...
  10. doi request reprint Microarray-based assay for the detection of genetic variations of structural genes of West Nile virus
    Andriyan Grinev
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Rockville, MD 20852, USA
    J Virol Methods 154:27-40. 2008
    ....
  11. ncbi request reprint Sequence diversity of Jeryl Lynn strain of mumps virus: quantitative mutant analysis for vaccine quality control
    Georgios Amexis
    Center for Biologics Evaluation and Research, FDA Rockville, Maryland 20852, USA
    Virology 300:171-9. 2002
    ..Based on the findings presented here, it is proposed that the substrain composition of Jeryl Lynn vaccine can be monitored as a part of its quality control to ensure consistency of the vaccine...
  12. ncbi request reprint Microarray assay for evaluation of the genetic stability of modified vaccinia virus Ankara B5R gene
    Majid Laassri
    Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, Maryland 20852, USA
    J Med Virol 79:791-802. 2007
    ..Potentially, the proposed method could be used as an identity test and could be extended for the entire viral genome and used to monitor consistency of vaccine production...
  13. ncbi request reprint Recovery of strains of the polyomavirus SV40 from rhesus monkey kidney cells dating from the 1950s to the early 1960s
    Keith Peden
    Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Virology 370:63-76. 2008
    ..These results, and those of others, suggest that a limited number of SV40 strains might exist in rhesus macaques in the United States, and thus determining the origin of the SV40 sequences detected in human tumors might be difficult...
  14. ncbi request reprint Detection and discrimination of orthopoxviruses using microarrays of immobilized oligonucleotides
    Majid Laassri
    Laboratory of Method Development, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852, USA
    J Virol Methods 112:67-78. 2003
    ..The oligonucleotide microarray hybridization technique identified reliably and correctly all samples. This new procedure takes only 3 h, and it can be used for parallel testing of multiple samples...
  15. pmc Genomic analysis of vaccine-derived poliovirus strains in stool specimens by combination of full-length PCR and oligonucleotide microarray hybridization
    Majid Laassri
    Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852, USA
    J Clin Microbiol 43:2886-94. 2005
    ..The amplified full-length viral cDNA can be archived and used to recover live virus for further virological studies...
  16. ncbi request reprint Analysis of reversions in the 5'-untranslated region of attenuated poliovirus after sequential administration of inactivated and oral poliovirus vaccines
    Majid Laassri
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA
    J Infect Dis 193:1344-9. 2006
    ..Polioviruses of Sabin types 2 and 3 reverted more easily than those of type 1. Prior vaccination with IPV did not increase the proportion of revertants after OPV administration...
  17. pmc Microarray analysis of evolution of RNA viruses: evidence of circulation of virulent highly divergent vaccine-derived polioviruses
    Elena Cherkasova
    Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 100:9398-403. 2003
    ..The proposed methods for fine genotyping of heterogeneous viral populations can also have utility for a variety of other applications in studies of genetic changes in viruses, bacteria, and genes of higher organisms...
  18. ncbi request reprint Effect of different vaccination schedules on excretion of oral poliovirus vaccine strains
    Majid Laassri
    Center for Biologics Evaluation and Research, Food and Drug Administration, Baltimore, Maryland, USA
    J Infect Dis 192:2092-8. 2005
    ..This suggests that IPV-vaccinated communities are partially protected from the spread of poliovirus. Further enhancement of IPV potency may lead to even higher levels of mucosal immunity...
  19. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
    ..The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed...
  20. ncbi request reprint Improved ELISA test for determination of potency of Inactivated Poliovirus Vaccine (IPV)
    Gennady Rezapkin
    Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852, USA
    Biologicals 33:17-27. 2005
    ..An in-house Reference Reagent was formulated and calibrated against the International Reference for IPV...
  21. ncbi request reprint Analysis of antigenic profiles of inactivated poliovirus vaccine and vaccine-derived polioviruses by block-ELISA method
    Gennady Rezapkin
    Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852, USA
    Biologicals 33:29-39. 2005
    ....
  22. ncbi request reprint Medical applications of microarray technologies: a regulatory science perspective
    Emanuel F Petricoin
    Division of Therapeutic Products, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA
    Nat Genet 32:474-9. 2002
    ....
  23. pmc Immunogenicity of inactivated polio vaccine with concurrent antiviral V-073 administration in mice
    Diana Kouiavskaia
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA
    Clin Vaccine Immunol 18:1387-90. 2011
    ..A strategy involving coadministration of antiviral V-073 and IPV can be considered for the management of poliovirus incidents...