Tao Chen

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. doi request reprint Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Environ Mol Mutagen 51:156-63. 2010
  2. ncbi request reprint Genotoxicity of titanium dioxide nanoparticles
    Tao Chen
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA Electronic address
    J Food Drug Anal 22:95-104. 2014
  3. pmc Discovery of novel microRNAs in rat kidney using next generation sequencing and microarray validation
    Fanxue Meng
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
    PLoS ONE 7:e34394. 2012
  4. pmc Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S20. 2006
  5. doi request reprint Genotoxicity of pyrrolizidine alkaloids
    Tao Chen
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    J Appl Toxicol 30:183-96. 2010
  6. ncbi request reprint The role of MicroRNA in chemical carcinogenesis
    Tao Chen
    National Center for Toxicological Research, Jefferson, AR, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:89-124. 2010
  7. pmc Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Genomics 11:609. 2010
  8. doi request reprint Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol In Vitro 24:439-44. 2010
  9. doi request reprint The mouse lymphoma assay detects recombination, deletion, and aneuploidy
    Jianyong Wang
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Sci 109:96-105. 2009
  10. doi request reprint Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay
    Robert S Woodruff
    Division of Microbiology, Arkansas Regional Laboratory, U S Food and Drug Administration, Jefferson, AR, 72079, USA
    J Appl Toxicol 32:934-43. 2012

Collaborators

Detail Information

Publications54

  1. doi request reprint Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Environ Mol Mutagen 51:156-63. 2010
    ....
  2. ncbi request reprint Genotoxicity of titanium dioxide nanoparticles
    Tao Chen
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA Electronic address
    J Food Drug Anal 22:95-104. 2014
    ..Nearly all tests for measuring the mutagenicity of TiO(2)-NPs were negative. The current data indicate that the genotoxicity of TiO(2)-NPs is mediated mainly through the generation of oxidative stress in cells...
  3. pmc Discovery of novel microRNAs in rat kidney using next generation sequencing and microarray validation
    Fanxue Meng
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
    PLoS ONE 7:e34394. 2012
    ..In summary, 9 novel pre-miRNAs (14 novel mature miRNAs) were identified via combination of NGS, microarray and bioinformatics high-throughput technologies...
  4. pmc Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S20. 2006
    ..To evaluate whether microarray analysis can be used for distinguishing the tissue-specific carcinogenicity of AA, we examined gene expression profiles in kidney and liver of rats treated with carcinogenic doses of AA...
  5. doi request reprint Genotoxicity of pyrrolizidine alkaloids
    Tao Chen
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    J Appl Toxicol 30:183-96. 2010
    ..The signature types of mutations are G : C --> T : A transversion and tandem base substitutions. Overall, PAs are mutagenic in vivo and in vitro and their mutagenicity appears to be responsible for the carcinogenesis of PAs...
  6. ncbi request reprint The role of MicroRNA in chemical carcinogenesis
    Tao Chen
    National Center for Toxicological Research, Jefferson, AR, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:89-124. 2010
    ..Thus, the miRNA profiles and miRNAs specific to carcinogen exposure have the potential to be used as biomarkers for identifying genotoxicity and carcinogenicity of chemicals and indicating exposure of carcinogens...
  7. pmc Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Genomics 11:609. 2010
    ..However, there is little information as to if or when expression changes of miRNAs occur in normal tissues after carcinogen exposure...
  8. doi request reprint Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol In Vitro 24:439-44. 2010
    ..These results suggest that retinol is mutagenic when exposed to UVA in mouse lymphoma cells through a clastogenic mode-of-action...
  9. doi request reprint The mouse lymphoma assay detects recombination, deletion, and aneuploidy
    Jianyong Wang
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Sci 109:96-105. 2009
    ..From this analysis, it is clear that mouse lymphoma Tk mutants can result from recombination, deletion, and aneuploidy...
  10. doi request reprint Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay
    Robert S Woodruff
    Division of Microbiology, Arkansas Regional Laboratory, U S Food and Drug Administration, Jefferson, AR, 72079, USA
    J Appl Toxicol 32:934-43. 2012
    ..These results suggest that TiO2-NPs are not genotoxic under the conditions of the Ames test and Comet assay...
  11. doi request reprint Silver nanoparticle-induced mutations and oxidative stress in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Environ Mol Mutagen 53:409-19. 2012
    ..These results suggest that 5 nm Ag-NPs are mutagenic in mouse lymphoma cells due to induction of oxidative stress by the Ag-NPs...
  12. ncbi request reprint Photomutagenicity of anhydroretinol and 5,6-epoxyretinyl palmitate in mouse lymphoma cells
    Nan Mei
    Division of Genetic, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 19:1435-40. 2006
    ..These results suggest that two of RP's photodecomposition products are photomutagenic in mouse lymphoma cells, causing events that affect a large segment of the chromosome...
  13. ncbi request reprint Mutations induced by carcinogenic doses of aristolochic acid in kidney of Big Blue transgenic rats
    Ling Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, HFT 130, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Lett 165:250-6. 2006
    ..These results suggest that AA induces kidney tumors in rats though a mutagenic mechanism of action...
  14. ncbi request reprint 4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice
    Tao Chen
    Division of Genetic and Reproductive Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Int J Cancer 117:182-7. 2005
    ..Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html..
  15. doi request reprint Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys
    Zhenqiang Su
    ICF International at FDA s National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 24:1486-93. 2011
    ..However, there is clearly a need for future investigations to better understand the advantages and limitations of RNA-Seq in toxicogenomics studies and environmental health research...
  16. doi request reprint MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver
    Tao Chen
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutagenesis 27:59-66. 2012
    ....
  17. pmc Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S4. 2007
    ..Molecular analysis of the mutants indicated that there was a statistically significant difference between the mutational spectra from riddelliine-treated and control rats...
  18. ncbi request reprint Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States
    Food Chem Toxicol 46:628-36. 2008
    ....
  19. ncbi request reprint Time course of cII gene mutant manifestation in the liver, spleen, and bone marrow of N-ethyl-N-nitrosourea-treated Big Blue transgenic mice
    Jianyong Wang
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Toxicol Sci 82:124-8. 2004
    ....
  20. ncbi request reprint Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Cancer Lett 215:151-8. 2004
    ..These results suggest that the relatively high mutagenicity of riddelliine in rat liver endothelial cells may be partially responsible for the tumorigenic specificity of this agent...
  21. ncbi request reprint Effects of daidzein, genistein, and 17beta-estradiol on 7,12-dimethylbenz[a]anthracene-induced mutagenicity and uterine dysplasia in ovariectomized rats
    Anane Aidoo
    FDA Jefferson Laboratories, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Arkansas 72079, USA
    Nutr Cancer 53:82-90. 2005
    ..The absence of dysplasia in OVX rats exposed to DMBA alone also suggests, in part, a promotional mechanism via estrogen- or isoflavone-driven cell proliferation...
  22. doi request reprint Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction
    Yiying Wang
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT 120, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutagenesis 26:619-28. 2011
    ....
  23. pmc Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S16. 2006
    ..Our previous study suggested that comfrey induces liver tumors by a genotoxic mechanism and that the pyrrolizidine alkaloids in the plant are responsible for mutation induction and tumor initiation in rat liver...
  24. ncbi request reprint Mutant frequency and mutational spectra in the Tk and Hprt genes of N-ethyl-N-nitrosourea-treated mouse lymphoma cellsdagger
    Tao Chen
    Division of Genetic and Reproductive Toxicology, FDA National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 39:296-305. 2002
    ..This study provides evidence that the MLA can be used not only to detect point mutagens but also for analysis of mutational spectra...
  25. doi request reprint Metabolism, genotoxicity, and carcinogenicity of comfrey
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    J Toxicol Environ Health B Crit Rev 13:509-26. 2010
    ..Further, the two agents share common mechanisms of drug metabolism and carcinogenesis. Overall, comfrey is mutagenic in liver, and PA contained in comfrey appear to be responsible for comfrey-induced toxicity and tumor induction...
  26. doi request reprint miR-34a suppresses mutagenesis by inducing apoptosis in human lymphoblastoid TK6 cells
    Xinrong Chen
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA Electronic address
    Mutat Res 758:35-40. 2013
    ..Our study suggests miR-34a is an important negative regulator of mutagenesis and the mechanism is possibly mediated through apoptosis. ..
  27. ncbi request reprint Genotoxicity of TiO(2) anatase nanoparticles in B6C3F1 male mice evaluated using Pig-a and flow cytometric micronucleus assays
    Rakhshinda Sadiq
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Mutat Res 745:65-72. 2012
    ..These results suggest that although TiO(2)-NPs can reach the mouse bone marrow and are capable of inducing cytotoxicity, the nanoparticles are not genotoxic when assessed with in vivo micronucleus and Pig-a gene mutation tests...
  28. pmc Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S22. 2007
    ....
  29. doi request reprint Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements
    Lei Guo
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, FDA, AR 72079, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:60-87. 2010
    ..This review summarizes the current practices of microarray analysis of gene expressions in animals treated with herbal dietary supplements and discusses perspectives for the proposed strategy...
  30. ncbi request reprint Photomutagenicity of retinyl palmitate by ultraviolet a irradiation in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079, USA
    Toxicol Sci 88:142-9. 2005
    ..These results suggest that RP is photomutagenic in combination with UVA exposure in mouse lymphoma cells, with a clastogenic mode-of-action...
  31. ncbi request reprint Age-dependent sensitivity of Big Blue transgenic mice to the mutagenicity of N-ethyl-N-nitrosourea (ENU) in liver
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, HFT 130, NCTR FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 572:14-26. 2005
    ..This period correlates well with the age-dependent sensitivity to carcinogenicity in mouse liver, suggesting that mutation is an important rate-limiting factor for age-related carcinogenesis...
  32. doi request reprint MicroRNAs and their predicted target messenger RNAs are deregulated by exposure to a carcinogenic dose of comfrey in rat liver
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA
    Environ Mol Mutagen 52:469-78. 2011
    ..Our data suggest that comfrey may exert its carcinogenic effects by disturbing miRNA expression resulting in altered mRNA levels of the DEM-targeted genes that are functionally associated with carcinogenesis...
  33. ncbi request reprint Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 17:814-8. 2004
    ..These results indicate that riddelliine is a genotoxic carcinogen in rat liver and that the types of mutations induced by riddelliine are consistent with riddelliine adducts involving G:C base pairs...
  34. ncbi request reprint Photodecomposition of vitamin A and photobiological implications for the skin
    Peter P Fu
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA
    Photochem Photobiol 83:409-24. 2007
    ..Relevant clinical studies or studies in animal models are therefore needed to establish whether the pro-oxidant activity of photoexcited vitamin A is observed in vivo, and to assess the related risks...
  35. doi request reprint Genotoxicity of 2-bromo-3'-chloropropiophenone
    Fanxue Meng
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 270:158-63. 2013
    ..The results suggest that BCP is mutagenic, clastogenic, and aneugenic, and that these activities are mediated via generation of reactive metabolites...
  36. ncbi request reprint DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Mutat Res 602:83-91. 2006
    ..Although the same treatment does not produce tumors in rat liver, it does induce DNA adducts and mutations in this tissue, albeit at lower levels than in kidney...
  37. ncbi request reprint Mutagenicity of bromate: implications for cancer risk assessment
    Martha M Moore
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, HFT 120, NCTR, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Toxicology 221:190-6. 2006
    ..However, in the absence of additional information, it is reasonable, based on an extensive database, to assume that bromate induces tumors via oxidative damage that causes chromosomal breakage...
  38. ncbi request reprint Endogenous estrogen status, but not genistein supplementation, modulates 7,12-dimethylbenz[a]anthracene-induced mutation in the liver cII gene of transgenic big blue rats
    Tao Chen
    Division of Genetic and Reproductive Toxicology, Food and Drug Administration National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 45:409-18. 2005
    ..These results suggest that endogenous ovarian hormones have an inhibitory effect on liver mutagenesis by DMBA, whereas dietary genistein does not modulate spontaneous or DMBA-induced mutagenesis in either intact or ovariectomized rats...
  39. ncbi request reprint Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
    Roberta A Mittelstaedt
    Division of Genetic and Reproductive Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 561:127-38. 2004
    ..The lack of increased micronucleus frequencies and lymphocyte Hprt mutants in female mice treated with leucomalachite green suggests that its genotoxicity is targeted to the tissue at risk for tumor induction...
  40. doi request reprint Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay
    Yan Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Mutat Res 745:4-10. 2012
    ..These results demonstrate that the 5 nm AgNP are genotoxic in TK6 cells. Also, the data suggest that the in vitro micronucleus assay may be more appropriate than the Ames test for evaluating the genotoxicity of the AgNPs...
  41. ncbi request reprint 3'-azido-3'-deoxythymidine induces deletions in L5178Y mouse lymphoma cells
    Jianyong Wang
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Environ Mol Mutagen 48:248-57. 2007
    ..Our data indicate that AZT primarily induced LOH mutations in L5178Y mouse lymphoma cells and a large number of LOH mutations resulted from deletions...
  42. pmc Microarray platform consistency is revealed by biologically functional analysis of gene expression profiles
    Zhiguang Li
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U, S, Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 10:S12. 2009
    ..In this study, we investigated whether different platforms had a high consistency from the biologically functional perspective...
  43. doi request reprint Mutagenicity and DNA adduct formation by aristolochic acid in the spleen of Big Blue® rats
    L Patrice McDaniel
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, USA
    Environ Mol Mutagen 53:358-68. 2012
    ..These results indicate that AA is genotoxic in the spleen of rats exposed under conditions that result in DNA adduct formation and mutation induction in kidney and liver...
  44. doi request reprint Quality assurance and safety of herbal dietary supplements
    Peter P Fu
    National Center for Toxicological Research, Jefferson, Arkansas, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:91-119. 2009
    ..It is proposed that an organized effort with international participation on cancer risk assessment should be actively pursued so that the safety of commercial herbal plants and herbal dietary supplements can be ensured...
  45. ncbi request reprint Rat toxicogenomic study reveals analytical consistency across microarray platforms
    Lei Guo
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1162-9. 2006
    ....
  46. ncbi request reprint ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene
    Page B McKinzie
    Division of Genetic and Reproductive Toxicology, HFT 120, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutagenesis 21:391-7. 2006
    ..This data raises the possibility that N-OH-AAF may not only induce mutations by a genotoxic mechanism, but also by amplification of both de novo and pre-existing K-ras mutation...
  47. doi request reprint Expression level of miR-34a rather than P53 gene status correlates with mutability in related human lymphoblast cell lines
    Xinrong Chen
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA
    Mol Carcinog 51:674-7. 2012
    ..These results suggest that alteration of miR-34a expression is at least partially independent of P53 regulation and its expression levels are closely related to cells' mutability regardless of P53 status...
  48. doi request reprint Functional comparison of microarray data across multiple platforms using the method of percentage of overlapping functions
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR, USA
    Methods Mol Biol 802:123-39. 2012
    ..This method can also be used to compare the functional differences or similarities between experiments, projects, or laboratories...
  49. doi request reprint Sequencing analysis of mutations induced by N-ethyl-N-nitrosourea at different sampling times in mouse bone marrow
    Jianyong Wang
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA
    J Appl Toxicol 30:133-41. 2010
    ....
  50. ncbi request reprint Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Mutagenesis 17:105-9. 2002
    ..This study serves to verify that the MLA detects both point mutations and chromosomal mutations...
  51. ncbi request reprint Significance analysis of groups of genes in expression profiling studies
    James J Chen
    Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Bioinformatics 23:2104-12. 2007
    ..These two hypotheses are related but not equivalent...
  52. ncbi request reprint Mutations induced by alpha-hydroxytamoxifen in the lacI and cII genes of Big Blue transgenic rats
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 23:1751-7. 2002
    ..These results support the hypothesis that alpha-hydroxytamoxifen is a major proximate tamoxifen metabolite causing the initiation of tumors in the liver of rats treated with tamoxifen...
  53. doi request reprint Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells
    Yongbin Zhang
    National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    ACS Nano 5:7020-33. 2011
    ..These findings suggest that surface functionalization of SWCNTs decreases ROS-mediated toxicological response in vitro...
  54. doi request reprint Increased expression of miR-34a in mouse spleen one day after exposure to N-ethyl-N-nitrosourea
    David Chen
    Little Rock Central High School, Little Rock, AR 72206, USA
    J Appl Toxicol 31:496-8. 2011
    ..The result suggests that miR-34a expression responds sensitively to genotoxic insults within a short period after exposure of the mutagen, and therefore, this gene has the potential to be used as an indicator for genotoxin exposure...