Research Topics
| M J BrennanSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Detail Information
Publications
Tuberculosis vaccine development: research, regulatory and clinical strategiesMichael J Brennan
Center for Biologics Evaluation and Research, Laboratory of Mycobacterial Diseases and Cellular Immunology, Food and Drug Administration, Bldg 29 Rm 503 HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
Expert Opin Biol Ther 4:1493-504. 2004....- The tuberculosis vaccine challengeMichael J Brennan
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29 Rm 503 HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
Tuberculosis (Edinb) 85:7-12. 2005..This presents a major challenge to pre-clinical testing and clinical evaluation as well as eventual uptake of the new TB vaccines into areas of the world that are most at risk for tuberculosis... - The PE multigene family: a 'molecular mantra' for mycobacteriaMichael J Brennan
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29 Room 502, 29 Lincoln Drive, Bethesda, MD 20892, USA
Trends Microbiol 10:246-9. 2002.... - Global Forum on TB Vaccine Research and Development. World Health Organization, June 7-8 2001, GenevaM J Brennan
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Tuberculosis (Edinb) 81:365-8. 2001.... 
Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cellsM J Brennan
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Infect Immun 69:7326-33. 2001..Together these results suggest that certain PE_PGRS proteins may be found at the surface of mycobacteria and influence both cell surface interactions among mycobacteria as well as the interactions of mycobacteria with macrophages...- Moving new vaccines for tuberculosis through the regulatory processM J Brennan
Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA
Clin Infect Dis 30:S247-9. 2000.... - Propelling novel vaccines directed against tuberculosis through the regulatory processM J Brennan
Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852 1448, USA
Tuber Lung Dis 79:145-51. 1999..It is hoped that the comments provided here will help accelerate the development of new effective vaccines for the prevention and treatment of tuberculosis... - Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosisG Delogu
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Infect Immun 69:5606-11. 2001..These results suggest that the PE vaccine can elicit an effective cellular immune response and that immune recognition of the PE antigen is influenced by the Gly-Ala-rich PGRS domain... 
A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteinsPrachi P Singh
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20910, USA
Microbiology 154:3469-79. 2008..tuberculosis...- The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosisMarcela Parra
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29, Rm. 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA
Infect Immun 72:6799-805. 2004..tuberculosis are critical for generating effective host immune responses. The vaccine studies described here demonstrate that HBHA is a promising new vaccine candidate for tuberculosis... - A PE protein expressed by Mycobacterium avium is an effective T-cell immunogenMarcela Parra
Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA
Infect Immun 74:786-9. 2006..Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes... - Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivoVeerabadran Dheenadhayalan
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Bacteriol 188:3721-5. 2006..tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis... - Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survivalVeerabadran Dheenadhayalan
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29, Room 503, HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
Microbes Infect 8:262-72. 2006.... - Peptide nucleic acid probe detection of mutations in Mycobacterium tuberculosis genes associated with drug resistanceL E Bockstahler
US Food and Drug Administration, Rockville, MD 20857, USA
Biotechniques 32:508-10, 512, 514. 2002..Using the M. tuberculosis cloned genes and PCR-PNA-ELISA format developed here, M. tuberculosis sequences containing point mutations associated with drug resistance can be identified in less than 24 h... 
Development of new tuberculosis vaccines: a global perspective on regulatory issuesMichael J Brennan
Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America
PLoS Med 4:e252. 2007- Tuberculosis vaccine research: the impact of immunologyLewellys F Barker
Aeras Global TB Vaccine Foundation, Rockville, MD 20850, USA
Curr Opin Immunol 21:331-8. 2009.... - Cloning and sequencing of the structural gene for the porin protein of Bordetella pertussisZ M Li
Division of Bacterial Products, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892
Mol Microbiol 5:1649-56. 1991..DNA hybridization studies indicated that both virulent and avirulent strains of B. pertussis contain only one copy of this gene and that Bordetella bronchiseptica and Bordetella parapertussis contain a similar gene... - New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical developmentArun T Kamath
Department of Pathology and Immunology, Center for Vaccinology and Neonatal Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland
Vaccine 23:3753-61. 2005..The proposed criteria suggested in this consensus document may facilitate the movement of the most promising vaccine candidates to the clinic and towards control of tuberculosis... - PE_PGRS proteins are differentially expressed by Mycobacterium tuberculosis in host tissuesGiovanni Delogu
Institute of Microbiology, Catholic University of Sacred Heart, L go A Gemelli, 8, 00168 Rome, Italy
Microbes Infect 8:2061-7. 2006..The results of this study indicate that M. tuberculosis can differentially regulate expression of PE_PGRS genes and that genes such as rv0746 and rv1651c are significantly induced while M. tuberculosis persists in host cells and tissues... - Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutininStephane Temmerman
Laboratory of Immunology, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik, 808, B 1070 Brussels, Belgium
Nat Med 10:935-41. 2004..Thus, post-translational modifications of proteins may be crucial for their ability to induce protective T cell-mediated immunity against infectious diseases such as tuberculosis... - Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structureGiovanni Delogu
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
Mol Microbiol 52:725-33. 2004..Regulated expression of PE genes could have implications for the survival and pathogenesis of mycobacteria within the human host and in other environmental niches... - Evidence-based oral transmucosal fentanyl citrate (OTFC) dosing guidelinesGerald M Aronoff
Carolina Pain Associates, Presbyterian Orthopedic Hospital, Charlotte, NC 28207, USA
Pain Med 6:305-14. 2005..To review the evidence for dosing and efficacy of oral transmucosal fentanyl citrate in the management of pain and produce dosing guidelines... - Expression and purification of recombinant methylated HBHA in Mycobacterium smegmatisGiovanni Delogu
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43 B, 07100 Sassari
FEMS Microbiol Lett 239:33-9. 2004..The use of fast-growing strains of M. smegmatis to obtain significant amounts of purified HBHA protein within a short timeframe, should be an effective strategy for the evaluation of a new HBHA-based vaccine candidate for tuberculosis...