Research Topics
| Syed F AliSummaryAffiliation: Food and Drug Administration Country: USA Publications
| Collaborators
|
Detail Information
Publications
Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunctionSyed F Ali
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72029, USA
Int J Environ Res Public Health 8:4702-13. 2011..In the current review, we will discuss various aspects of gene-environment interaction that lead to progressive dopaminergic neurodegenration, mainly focusing on our current finding based on stress-mediated parkin dysfunction...
Effects of copper nanoparticles on rat cerebral microvessel endothelial cellsWilliam J Trickler
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
Nanomedicine (Lond) 7:835-46. 2012..The purpose of the current study was to determine whether copper nanoparticles (Cu-NPs) can induce the release of proinflammatory mediators that influence the restrictive characteristics of the blood-brain barrier...
Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cellsJianyong Wang
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Neurochem Int 52:1037-43. 2008....- Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitineZbigniew K Binienda
Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Neurosci Lett 410:62-5. 2006.... - Effects of L-carnitine pretreatment in methamphetamine and 3-nitropropionic acid-induced neurotoxicityZbigniew K Binienda
Division of Neurotoxicology, HFT 132, FDA NCTR, Jefferson, AR 72079 9502, USA
Ann N Y Acad Sci 1074:74-83. 2006..The same effect observed at the transcriptional level, at least for the DA receptor D(1), may account for protection against METH toxicity... - Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeabilityWilliam J Trickler
Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research FDA, Jefferson, Arkansas, USA
Nanotoxicology 5:479-92. 2011..Together, these data suggest the responses of the cerebral microvasculature to Au-NPs have a significant relationship with the Au-NPs unique size-dependent physiochemical properties... - Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticlesJianyong Wang
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 9502, USA
Neurotoxicology 30:926-33. 2009..These data suggest that Mn and Cu nanoparticles-induced dopaminergic neurotoxicity may share some common mechanisms associated with neurodegeneration... - Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrolZbigniew K Binienda
Division of Neurotoxicology, National Center for Toxicological Research FDA, AR 72079, USA
Neurosci Lett 480:117-21. 2010..The experimental outcome of this study shows that chronic treatment with 3-NPA in rats is relevant in development of an experimental model of toxic neuropathy... - Identification of rat hippocampal mRNAs altered by the mitochondrial toxicant, 3-NPABeata D Przybyla-Zawislak
Division of Neurotoxicology, HFT 132, National Center for Toxicology Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
Ann N Y Acad Sci 1053:162-73. 2005..In conclusion, this study identified 2 new potential targets for enhancement of neuroprotection or inhibition of neurodegeneration associated with ATP depletion in the hippocampus... - Silver nanoparticle-induced mutations and oxidative stress in mouse lymphoma cellsNan Mei
Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Environ Mol Mutagen 53:409-19. 2012..These results suggest that 5 nm Ag-NPs are mutagenic in mouse lymphoma cells due to induction of oxidative stress by the Ag-NPs... - Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cellsYongbin Zhang
National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
ACS Nano 5:7020-33. 2011..These findings suggest that surface functionalization of SWCNTs decreases ROS-mediated toxicological response in vitro... - Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity studyJianyong Wang
Neurochemistry Laboratory, Division of Neurotoxicology, HFT 132, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
Neurotoxicology 28:979-87. 2007..These data also indicate that MPP+-induced toxicity shares common molecular mechanisms with the pathogenesis of PD and further pathway analyses will be conducted to explore these mechanisms... - Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on retinal dopaminergic system in miceW Ryan Hamilton
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research USFDA, Jefferson, AR 72079, USA
Neurosci Lett 515:107-10. 2012.... - Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain cultureCheng Wang
Division of Neurotoxicology, National Center for Toxicological Research US Food and Drug Administration, HFT 132 Jefferson, AR, USA
Neurotoxicology 29:613-20. 2008..These data indicate a role for nitric oxide in the enhanced degeneration induced by ketamine in vitro and also suggest that blocking neuronal nitric oxide synthase (nNOS) may help reduce the risk of ketamine in pediatrics... - On the in vivo early toxic properties of A-beta 25-35 peptide in the rat hippocampus: involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expressionElvis Cuevas
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Neurotoxicol Teratol 33:288-96. 2011..Our findings support an active role of RAGE during the early stages of Aβ₂₅₋₃₅ toxicity in the hippocampus... - Red wine but not ethanol at low doses can protect against the toxicity of methamphetamineSyed F Ali
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
Brain Res 1346:247-50. 2010..This implies the presence of other agents in red wine, which may mitigate the toxicity of methamphetamine... - L-Carnitine rescues ketamine-induced attenuated heart rate and MAPK (ERK) activity in zebrafish embryosJyotshnabala Kanungo
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
Reprod Toxicol 33:205-12. 2012..These findings demonstrate that l-carnitine counteracts ketamine's negative effects on heart rate and ERK activity in zebrafish embryos... - Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrierJohn F Bowyer
Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
Ann N Y Acad Sci 1139:127-39. 2008.... - Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51Hari Shanker Sharma
Neurochemistry Laboratory, Division of Neurotoxicology, National Centre for Toxicological Research FDA, Jefferson, AR, USA
Curr Pharm Des 13:1903-23. 2007..The possible mechanisms and functional significance of these findings are discussed... - Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cellsWilliam J Trickler
Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079, USA
Toxicol Sci 118:160-70. 2010..Further, this study suggests that Ag-NPs may interact with the cerebral microvasculature producing a proinflammatory cascade, if left unchecked; these events may further induce brain inflammation and neurotoxicity... - Cocaine induces a dose-dependent alteration in the expression of immediate early genes c-fos and SP-1 and in nuclear factor NF-kappabeta in PC12 cellsSyed Z Imam
Division of Neurotoxicology, US FDA/NCTR, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 993:362; discussion 387-93. 2003 - Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis studyBobby Gough
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 965:410-20. 2002..5 or 5 mg/kg. All dose levels of PMA significantly decreased 5-HIAA (50 to 70%). These data suggest that PMA, like MDMA and METH, is capable of producing dopaminergic and serotonergic neurotoxicity... - Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injuryHari Shanker Sharma
Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
Ann N Y Acad Sci 1139:242-58. 2008.... - Nicotine alters the expression of molecular markers of endocrine disruption in zebrafishJyotshna Kanungo
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Neurosci Lett 526:133-7. 2012..These results provide direct molecular evidence that nicotine is an endocrine disruptor in zebrafish... - Role of peroxynitrite in methamphetamine-induced dopaminergic neurodegeneration and neuroprotection by antioxidants and selective NOS inhibitorsSyed F Ali
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 1053:97-8. 2005 - Lack of hydroxyl radical generation upon central administration of methamphetamine in rat caudate nucleus: a microdialysis studyFrederico C Pereira
Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, NCTR/FDA, Jefferson, AR 72079, USA
Neurotox Res 6:149-52. 2004..p.). No significant correlation was found between changes in extracellular DA levels and *OH generation when perfusing METH locally; however, both increased after systemic METH administration... - Zinc potentiates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced dopamine depletion in caudate nucleus of mice brainSaber Hussain
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA Jefferson, AR 72079, USA
Neurosci Lett 335:25-8. 2002..In summary the data suggest that Zn treatment potentiates depletion of dopamine in MPTP treated mice... - Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cellsYongbin Zhang
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
ACS Nano 4:3181-6. 2010..Altogether these studies suggest different biological activities of the graphitic nanomaterials, with the shape playing a primary role... - Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterationsJohn F Bowyer
Division of Neurotoxicology and Biometry and Risk Assessment, National Center for Toxicological Research FDA, 72079 9502, Jefferson, AR, USA
Neurotoxicology 24:379-90. 2003..There were 80% reductions in the plasma membrane-associated 5-HT transporters 6 months after either the FEN or MDMA dosing regimen indicating that both treatments produced long-term serotonergic effects... - Methamphetamine-induced dopaminergic neurotoxicity and production of peroxynitrite are potentiated in nerve growth factor differentiated pheochromocytoma 12 cellsSyed Z Imam
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Resarch/US FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 965:204-13. 2002..The current study supports the hypothesis that METH acts at the dopaminergic nerve terminals and produces dopaminergic damage by the production of free radical peroxynitrite... - The role of caspase III inhibition in methamphetamine-induced alterations in p53 and bcl-2 expression: correlation with dopaminergic neurotoxicitySyed Z Imam
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 993:350; discussion 387-93. 2003 - The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liverBeata D Przybyla-Zawislak
Division of Neurotoxicology, FDA National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Neurosci Lett 381:354-7. 2005..In conclusion, out of the three ITFs transcripts examined here junb may activate different pathways depending on the tissue as indicated by differential responses to mitochondrial inhibition in the hippocampus and liver... - Four weeks of oral isotretinoin treatment causes few signs of general toxicity in male and female Sprague-Dawley ratsSherry A Ferguson
Division of Neurotoxicology, HFT 132, National Center for Toxicological Research FDA, 3900, NCTR Road, Jefferson, AR 72079, USA
Food Chem Toxicol 43:1289-96. 2005..Hippocampal DA concentrations were marginally increased. These data indicate mild effects resulting from oral isotretinoin treatment at doses which likely produce serum levels within the range of humans... - A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics toolsZengjun Xu
Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
BMC Bioinformatics 6:S8. 2005..MPP+ depletes dopamine content and elicits cell death in PC12 cells. However, the mechanism of MPP+-induced neurotoxicity is still unclear... - Acrylamide: a dietary carcinogen formed in vivo?Eden Tareke
Division of Personalized Nutrition and Medicine, Toxicologic Pathology Association, Inc, Jefferson, Arkansas 72079, USA
J Agric Food Chem 56:6020-3. 2008..The results of this study show that acrylamide Hb adduct levels are increased in mice treated with compounds known to induce free radicals, thus suggesting the endogenous production of acrylamide... - Evaluation of gamma-hydroxybutyric acid for genotoxicity in the mouse micronucleus assayS Balachandra Dass
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 1025:538-42. 2004..However, because increases were small and because no consistent dose-dependent increase in induced micronuclear frequency could be demonstrated, our results do not conclusively show that GHB is an in vivo genotoxicant in mammals... - Adaptation to repeated cocaine administration in ratsZbigniew K Binienda
Division of Neurotoxicology, NCTR FDA, Jefferson, Arkansas 72029, USA
Ann N Y Acad Sci 965:172-9. 2002..Further studies are necessary to establish whether regional alterations in blood flow and metabolic activity may underlie such observations...