Abdu I Alayash

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives
    Abdu I Alayash
    Center for Biologics Evaluation and Research, Food and Drug Administration, Laboratory of Biochemistry and Vascular Biology, Division of Hematology, National Institutes of Health Campus, Bethesda, MD 20892, USA
    Expert Opin Biol Ther 7:665-75. 2007
  2. doi request reprint Setbacks in blood substitutes research and development: a biochemical perspective
    Abdu I Alayash
    Division of Hematology, Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration PHS, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Clin Lab Med 30:381-9. 2010
  3. pmc Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration
    Chad E N Reiter
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, U S Food and Drug Administration FDA, Bethesda, MD 20892, United States
    FEBS Open Bio 2:113-8. 2012
  4. doi request reprint Blood substitutes: why haven't we been more successful?
    Abdu I Alayash
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA Electronic address
    Trends Biotechnol 32:177-85. 2014
  5. doi request reprint Haptoglobin: old protein with new functions
    Abdu I Alayash
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA
    Clin Chim Acta 412:493-8. 2011
  6. doi request reprint Haptoglobin: the hemoglobin detoxifier in plasma
    Abdu I Alayash
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Electronic address
    Trends Biotechnol 31:2-3. 2013
  7. doi request reprint Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification
    Paul W Buehler
    Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, Washington, DC, USA
    Blood 113:2578-86. 2009
  8. doi request reprint Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94
    Jin Hyen Baek
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1809:262-8. 2011
  9. pmc Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 8:e59841. 2013
  10. ncbi request reprint Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Pharmacol Exp Ther 323:49-60. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives
    Abdu I Alayash
    Center for Biologics Evaluation and Research, Food and Drug Administration, Laboratory of Biochemistry and Vascular Biology, Division of Hematology, National Institutes of Health Campus, Bethesda, MD 20892, USA
    Expert Opin Biol Ther 7:665-75. 2007
    ..Here the authors provide an overview of their research experiences, novel insights into the molecular basis of toxicities of these products and some lessons learned...
  2. doi request reprint Setbacks in blood substitutes research and development: a biochemical perspective
    Abdu I Alayash
    Division of Hematology, Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration PHS, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Clin Lab Med 30:381-9. 2010
    ..It is hoped that this will aid in the development of a safe and effective second generation of HBOCs...
  3. pmc Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration
    Chad E N Reiter
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, U S Food and Drug Administration FDA, Bethesda, MD 20892, United States
    FEBS Open Bio 2:113-8. 2012
    ..Together, CO reduced ET-1, and, at low doses, had no effect on endothelial mitochondria oxygen consumption. CO ligation to Hb may be developed further as non-vasoactive oxygen therapeutic without compromising mitochondrial function...
  4. doi request reprint Blood substitutes: why haven't we been more successful?
    Abdu I Alayash
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA Electronic address
    Trends Biotechnol 32:177-85. 2014
    ..Moreover, recent mechanistic and animal studies support a role for globin and heme scavengers in controlling oxidative toxicity associated with Hb infusion. ..
  5. doi request reprint Haptoglobin: old protein with new functions
    Abdu I Alayash
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA
    Clin Chim Acta 412:493-8. 2011
    ..It may prove necessary to explore these protective clearing mechanisms to counter the toxicity associated with free Hb when used as oxygen therapeutics in hemolytic anemias and in RBC storage lesions...
  6. doi request reprint Haptoglobin: the hemoglobin detoxifier in plasma
    Abdu I Alayash
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Electronic address
    Trends Biotechnol 31:2-3. 2013
    ..Potential therapeutic benefits of using Hp for inactivation and clearance of free Hb under a number of clinical settings are considered...
  7. doi request reprint Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification
    Paul W Buehler
    Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, Washington, DC, USA
    Blood 113:2578-86. 2009
    ..In addition, our data provide in vivo evidence that unbound Hb is oxidatively modified within extravascular compartments consistent with our in vitro findings...
  8. doi request reprint Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94
    Jin Hyen Baek
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1809:262-8. 2011
    ..In conclusion, we have identified the inhibition of iron-binding pocket of PHD as an underlying mechanism of HIF induction in vivo and in vitro by a bidentate hydroxypyridinone...
  9. pmc Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 8:e59841. 2013
    ..This may ultimately provide a safe oxidative inactivation and clearance pathway for chemically modified Hbs in circulation...
  10. ncbi request reprint Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Pharmacol Exp Ther 323:49-60. 2007
    ..The present findings suggest the importance of plasma AA in maintaining the stability of acellular Hb susceptible to oxidation, and they may be relevant to humans, which display a similar plasma/tissue antioxidant status to guinea pig...
  11. doi request reprint Effects of cross-linking and zero-link polymerization on oxygen transport and redox chemistry of bovine hemoglobin
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology LBVB, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, MD 20892, USA
    Biochim Biophys Acta 1794:1234-42. 2009
    ....
  12. doi request reprint Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions
    Bindu Abraham
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland 20892, United States
    Biochemistry 50:9752-66. 2011
    ....
  13. ncbi request reprint Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Anal Chem 77:3466-78. 2005
    ..Structural modification imparted by glutaraldehyde resulted in nearly identical functional characteristics of PolyHbBv and its fractions with regard to oxygen equilibrium, ligand binding, and autoxidative kinetics...
  14. ncbi request reprint Oxygen sensing in the circulation: "cross talk" between red blood cells and the vasculature
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, MD 20892, USA
    Antioxid Redox Signal 6:1000-10. 2004
    ..We believe that there are important and yet unexplored mechanisms by which RBCs can directly or indirectly communicate via redox intermediates with extravascular sites as part of the global O(2) sensing mechanism...
  15. ncbi request reprint Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 282:4894-907. 2007
    ....
  16. ncbi request reprint Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1672:164-73. 2004
    ..However, the reduction in the allosteric function of this protein and the lack of apparent quaternary T-->R transition may hinder its physiological role as an oxygen transporter...
  17. doi request reprint Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin
    Todd L Mollan
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA
    Free Radic Biol Med 69:265-77. 2014
    ....
  18. doi request reprint Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney
    Dominador J Manalo
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 416:421-6. 2011
    ..These data demonstrate EGCG's therapeutic potential in modulating hepcidin expression in diseases associated with altered iron metabolism...
  19. ncbi request reprint O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification
    Robert A Boykins
    Laboratory of Biophysics, Division of Bacterial, Parasitic and Allergenic Products, Bethesda, Maryland 20892, USA
    Proteins 59:840-55. 2005
    ..Structural data presented here when taken together with the oxidative instability of O-R-PolyHbA0 may provide some basis for the reported toxicity of this oxygen carrier...
  20. ncbi request reprint Effects of cell-free hemoglobin on hypoxia-inducible factor (HIF-1alpha) and heme oxygenase (HO-1) expressions in endothelial cells subjected to hypoxia
    Li Hong Yeh
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Antioxid Redox Signal 6:944-53. 2004
    ..DBBF-Hb modulates key cell-signaling pathways by competing with peroxides required for the deactivation of HIF-1alpha, which may modulate important physiological mediators...
  21. pmc Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu))
    Todd L Mollan
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Protein Sci 21:1444-55. 2012
    ..These kinetic data help explain the high O₂ affinity characteristics of Hb Brigham and provide further evidence for the importance of the contribution of Pro100 to intersubunit contacts and stabilization of the T quaternary structure...
  22. doi request reprint Heme binding to human alpha-1 proteinase inhibitor
    Elena Karnaukhova
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1820:2020-9. 2012
    ..While heme binding by hemopexin, albumin and α(1)-microglobulin has been extensively studied, the role of other plasma proteins remains largely unknown...
  23. pmc Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Biochem J 384:367-75. 2004
    ..Although the physiological ramifications of locking HbA(0) in the T conformation with the O-raffinose are still unknown, valuable insights into haemoglobin function are provided by these studies of O-R-polyHbA(0)...
  24. doi request reprint Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats
    Dominador J Manalo
    LBVB Laboratory of Biochemistry and Vascular Biology, Division of Hematology, CBER Center for Biologics Evaluation and Research, FDA Food and Drug Administration, NIH National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 414:461-9. 2008
    ....
  25. doi request reprint Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, U S Food and Drug Administration FDA, Rockville, Maryland, USA
    Antioxid Redox Signal 10:1449-62. 2008
    ..Based on these results, a rational and systematic approach to HBOC design may be used to optimize interaction with endogenous Hb clearance and detoxification pathways...
  26. pmc α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide
    Todd L Mollan
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20852, USA
    J Biol Chem 288:4288-98. 2013
    ..Hexacoordination in the AHSP·met-α complex markedly decreases the rate of the initial H(2)O(2) reaction with iron and thus provides α-subunits protection against damaging oxidative reactions...
  27. ncbi request reprint A role for the myoglobin redox cycle in the induction of endothelial cell apoptosis
    FELICE D'AGNILLO
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Free Radic Biol Med 33:1153-64. 2002
    ..These results suggest a role for the Mb redox cycle in the induction of endothelial cell apoptosis, which may be relevant in the pathophysiology of diseases characterized by the release of Mb from damaged muscle...
  28. ncbi request reprint Oxygen therapeutics: can we tame haemoglobin?
    Abdu I Alayash
    Laboratory of Biochemistry, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Drug Discov 3:152-9. 2004
    ..Current protective strategies designed to produce safe Hb-based products are focused on controlling or suppressing the 'radical' nature of Hb while retaining its oxygen-carrying function...
  29. doi request reprint Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health Campus, Bethesda, MD 20892, USA
    Free Radic Biol Med 45:659-66. 2008
    ..A balance between pro and antioxidant properties of EGCG should be taken into account if EGCG is used in combination therapy with redox active acellular Hbs...
  30. ncbi request reprint Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Bethesda, Maryland, USA
    Transfusion 44:1516-30. 2004
    ....
  31. doi request reprint All hemoglobin-based oxygen carriers are not created equally
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology LBVB, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Maryland 20892, USA
    Biochim Biophys Acta 1784:1378-81. 2008
    ....
  32. ncbi request reprint Chemical characterization of diaspirin cross-linked hemoglobin polymerized with poly(ethylene glycol)
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Anal Chem 78:4634-41. 2006
    ..e., 64 kDa) has a direct influence on HBOC-mediated vasoactivity and that other protective strategies should be considered to control blood pressure imbalances...
  33. ncbi request reprint Redox biology of blood revisited: the role of red blood cells in maintaining circulatory reductive capacity
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Antioxid Redox Signal 7:1755-60. 2005
    ..In the current short review, we have revisited the topic of redox biology of blood and focused on yet another emerging area of research, which deals with the reductive power of blood and the physiological Redox Signal...
  34. doi request reprint Blood aging, safety, and transfusion: capturing the "radical" menace
    Paul W Buehler
    Division of Hematology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland 20892, USA
    Antioxid Redox Signal 14:1713-28. 2011
    ..Furthermore, some of the same naturally occurring protective mechanisms can potentially be employed to oxidatively inactivate this redox active protein and control its damaging side reactions when released outside of the RBC...
  35. pmc Redox reactions of hemoglobin: mechanisms of toxicity and control
    Todd L Mollan
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
    Antioxid Redox Signal 18:2251-3. 2013
    ..Our goal has been to update this critically important research area, because we believe that it will ultimately impact the practice of transfusion medicine in a number of important ways. Antioxid. Redox Signal. 18, 2251-2253...
  36. ncbi request reprint Stopped-flow fluorescence method for the detection of heme degradation products in solutions of chemically modified hemoglobins and peroxide
    Yiping Jia
    Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Anal Biochem 308:186-8. 2002
  37. ncbi request reprint Differential effects of sodium selenite in reducing tissue damage caused by three hemoglobin-based oxygen carriers
    Ann L Baldwin
    Department of Physiology, College of Medicine, University of Arizona, Tucson, Arizona 85724 5051, USA
    J Appl Physiol (1985) 96:893-903. 2004
    ....
  38. ncbi request reprint Sodium selenite reduces hemoglobin-induced venular leakage in the rat mesentery
    Ann L Baldwin
    Department of Physiology, College of Medicine, University of Arizona, Tucson 85724 5051, USA
    Am J Physiol Heart Circ Physiol 284:H81-91. 2003
    ..In vitro, Na(2)SeO(3) reduced the oxidation rate of DBBF-Hb while in the presence of oxidants. These results suggest that Na(2)SeO(3) reduces DBBF-Hb-induced microvascular leakage partly by retarding the oxidation of its heme iron...
  39. ncbi request reprint Comparison of effects of two hemoglobin-based O(2) carriers on intestinal integrity and microvascular leakage
    Ann L Baldwin
    Department of Physiology, College of Medicine, University of Arizona, Tucson 85724 5051, USA
    Am J Physiol Heart Circ Physiol 283:H1292-301. 2002
    ..These results indicate that intravascular PolyHbBv produces significantly less disruption of the intestinal exchange barrier than does DBBF-Hb, probably because the heme is not so easily oxidized...
  40. ncbi request reprint Site-specific cross-linking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Biochemistry 41:7407-15. 2002
    ..These findings establish the importance of these secondary oxidative reactions over autoxidation in evaluating the toxicity of HBOCs...
  41. ncbi request reprint Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins
    Celia Bonaventura
    Nicholas School of the Environment and Earth Sciences, Duke University Marine Laboratory, Beaufort, North Carolina 28516, USA
    IUBMB Life 59:498-505. 2007
    ..These redox reactions can drive formation of SNO-Hb and other reactive species and are of significance for the use of cell-free Hbs in vivo...
  42. ncbi request reprint CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin
    Dominik J Schaer
    Medical Clinic B Research Unit, University Hospital, CH 8091 Zurich, Switzerland
    Blood 107:373-80. 2006
    ..These results identify CD163 as a scavenger receptor for native Hb and small-molecular-weight Hb-based blood substitutes after Hp depletion...
  43. pmc Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo
    Jacqueline Dunne
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Biochem J 399:513-24. 2006
    ..g. haemolytic anaemias, subarachnoid haemorrhage, rhabdomyolysis...
  44. ncbi request reprint The heme pocket geometry of Lucina pectinata hemoglobin II restricts nitric oxide and peroxide entry: model of ligand control for the design of a stable oxygen carrier
    Walleska De Jesus-Bonilla
    Department of Chemistry, University of Puerto Rico, Mayaguez Campus, P O Box 9019, Mayagüez 00681 9019, Puerto Rico
    Biochemistry 46:10451-60. 2007
    ..Engineering of second-generation Hb-based oxygen therapeutics that are resistant to NO/H2O2-driven oxidation may ultimately require further optimization of the heme pocket architecture to limit heme exposure to solvent...
  45. ncbi request reprint Hemodilution with stroma-free [correction of stoma-free] hemoglobin at physiologically maintained viscosity delays the onset of vasoconstriction
    Géraldine Rochon
    Department of Hematology and Physiology, School of Pharmacy, University Henri Poincaré Nancy, France
    Hypertension 43:1110-5. 2004
    ....
  46. ncbi request reprint Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor
    Dominik J Schaer
    Medical Clinic B Research Unit, University of Zurich, Switzerland
    Antioxid Redox Signal 9:991-9. 2007
    ..Here, an overview and novel insights into the role of CD163 in Hb redox inactivation and clearance are provided...
  47. ncbi request reprint Redox biology of blood
    Abdu I Alayash
    Antioxid Redox Signal 6:941-3. 2004