Harry E Prince

Summary

Affiliation: Focus Diagnostics
Country: USA

Publications

  1. pmc Comparison of the Babesia duncani (WA1) IgG detection rates among clinical sera submitted to a reference laboratory for WA1 IgG testing and blood donor specimens from diverse geographic areas of the United States
    Harry E Prince
    Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630, USA
    Clin Vaccine Immunol 17:1729-33. 2010
  2. pmc Impact of the Yosemite hantavirus outbreak on hantavirus antibody testing at a national reference laboratory
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA, USA
    Clin Vaccine Immunol 20:1213-6. 2013
  3. doi request reprint Reactivity of human IgM binding murine monoclonal 6B6C1 (IgG2a) with other murine monoclonal IgG antibodies
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA 90630, USA
    J Clin Lab Anal 27:27-30. 2013
  4. pmc Age-related differences in patterns of increased Bordetella pertussis antibodies
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, California, USA
    Clin Vaccine Immunol 19:545-50. 2012
  5. pmc Persistence of West Nile virus-specific antibodies in viremic blood donors
    Harry E Prince
    Focus Diagnostics, Cypress, California, USA
    Clin Vaccine Immunol 14:1228-30. 2007
  6. ncbi request reprint Identification of interferon-beta antibodies in a reference laboratory setting: findings for 1144 consecutive sera
    Harry E Prince
    Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630, USA
    J Neuroimmunol 190:165-9. 2007
  7. doi request reprint Persistence of antibodies to West Nile virus nonstructural protein 5
    Harry E Prince
    Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630, USA
    J Clin Virol 43:102-6. 2008
  8. pmc Development of a more efficient algorithm for identifying false-positive reactivity results in a dengue virus immunoglobulin M screening assay
    Harry E Prince
    Focus Diagnostics Inc, Cypress, California 90630, USA
    Clin Vaccine Immunol 15:1304-6. 2008
  9. pmc Frequency of missed cases of probable acute West Nile virus (WNV) infection when testing for WNV RNA alone or WNV immunoglobulin M alone
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA 90630, USA
    Clin Vaccine Immunol 16:587-8. 2009
  10. doi request reprint Performance characteristics of the Euroimmun enzyme-linked immunosorbent assay kits for Brucella IgG and IgM
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA 90630, USA
    Diagn Microbiol Infect Dis 65:99-102. 2009

Detail Information

Publications35

  1. pmc Comparison of the Babesia duncani (WA1) IgG detection rates among clinical sera submitted to a reference laboratory for WA1 IgG testing and blood donor specimens from diverse geographic areas of the United States
    Harry E Prince
    Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630, USA
    Clin Vaccine Immunol 17:1729-33. 2010
    ..Rather, the findings suggest that infection with WA1 or a related organism is more common than indicated by the literature and is not limited to Pacific coast states...
  2. pmc Impact of the Yosemite hantavirus outbreak on hantavirus antibody testing at a national reference laboratory
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA, USA
    Clin Vaccine Immunol 20:1213-6. 2013
    ..We identified a modified algorithm requiring analysis of fewer specimens for SNV-specific antibodies without loss of sensitivity. ..
  3. doi request reprint Reactivity of human IgM binding murine monoclonal 6B6C1 (IgG2a) with other murine monoclonal IgG antibodies
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA 90630, USA
    J Clin Lab Anal 27:27-30. 2013
    ..To better understand this interaction, we assessed the reactivity of captured IgM from these sera with other HRP-labeled MAbs...
  4. pmc Age-related differences in patterns of increased Bordetella pertussis antibodies
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, California, USA
    Clin Vaccine Immunol 19:545-50. 2012
    ..pertussis infections actually have other infections that induce FHA-reactive antibodies. Similarly, the 2010 rise in the frequency of increased FHA antibodies only in some age groups suggests an increase in non-B. pertussis infections...
  5. pmc Persistence of West Nile virus-specific antibodies in viremic blood donors
    Harry E Prince
    Focus Diagnostics, Cypress, California, USA
    Clin Vaccine Immunol 14:1228-30. 2007
    ..At 1-year of follow-up, 17% of the donors (n = 23) were positive for WNV IgM, 57% were positive for WNV IgA, and 100% were positive for WNV IgG...
  6. ncbi request reprint Identification of interferon-beta antibodies in a reference laboratory setting: findings for 1144 consecutive sera
    Harry E Prince
    Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630, USA
    J Neuroimmunol 190:165-9. 2007
    ..We further identified a predictive relationship between positive BAbs levels and NAbs activity in patients treated with IFNbeta-1a products, but not those treated with IFNbeta-1b...
  7. doi request reprint Persistence of antibodies to West Nile virus nonstructural protein 5
    Harry E Prince
    Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630, USA
    J Clin Virol 43:102-6. 2008
    ..Published findings for a single patient suggest that the presence of antibody against WNV nonstructural protein 5 (NS5) indicates recent infection...
  8. pmc Development of a more efficient algorithm for identifying false-positive reactivity results in a dengue virus immunoglobulin M screening assay
    Harry E Prince
    Focus Diagnostics Inc, Cypress, California 90630, USA
    Clin Vaccine Immunol 15:1304-6. 2008
    ..No false positives were found among 427 sera with screen ELISA indices of >6.00; thus, retesting this specimen subset by BS ELISA is unnecessary...
  9. pmc Frequency of missed cases of probable acute West Nile virus (WNV) infection when testing for WNV RNA alone or WNV immunoglobulin M alone
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA 90630, USA
    Clin Vaccine Immunol 16:587-8. 2009
    ..05). WNV infections may be missed if only RNA or IgM testing is requested, with a higher frequency of missed cases if only RNA testing is requested...
  10. doi request reprint Performance characteristics of the Euroimmun enzyme-linked immunosorbent assay kits for Brucella IgG and IgM
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA 90630, USA
    Diagn Microbiol Infect Dis 65:99-102. 2009
    ..These findings demonstrate the acceptable performance of the Euroimmun ELISAs for Brucella antibodies...
  11. pmc Dengue virus immunoglobulin M detection in a reference laboratory setting during the 2010 dengue virus outbreak on Caribbean islands
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, California 90630, USA
    Clin Vaccine Immunol 18:1104-7. 2011
    ....
  12. pmc Utility of IgM/IgG ratio and IgG avidity for distinguishing primary and secondary dengue virus infections using sera collected more than 30 days after disease onset
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, California 90630, USA
    Clin Vaccine Immunol 18:1951-6. 2011
    ....
  13. pmc Estimation of dengue virus IgM persistence using regression analysis
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA 90630, USA
    Clin Vaccine Immunol 18:2183-5. 2011
    ..This difference reflected significantly higher first-sample IgM indices in primary infections than in secondary infections rather than differences in IgM decay rates...
  14. pmc Primary and probable secondary dengue virus (DV) infection rates in relation to age among DV IgM-positive patients residing in the United States mainland versus the Caribbean islands
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, California, USA
    Clin Vaccine Immunol 19:105-8. 2012
    ..Among patients 21 to 60 years old, the primary infection rate was markedly higher in U.S. residents...
  15. ncbi request reprint Utilization of hantavirus antibody results generated over a five-year period to develop an improved serologic algorithm for detecting acute Sin Nombre hantavirus infection
    Harry E Prince
    Focus Diagnostics Inc, Cypress, California, USA
    J Clin Lab Anal 21:7-13. 2007
    ..These findings were used to design a modified algorithm that identified all 37 patients with acute HPS, but reduced the number of specimens that required SNV antibody testing by 42%...
  16. pmc Utilization of follow-up specimens from viremic blood donors to assess the value of west nile virus immunoglobulin G avidity as an indicator of recent infection
    Harry E Prince
    Focus Diagnostics, Cypress, CA 90630, USA
    Clin Diagn Lab Immunol 12:1123-6. 2005
    ..Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection...
  17. pmc Development and persistence of West Nile virus-specific immunoglobulin M (IgM), IgA, and IgG in viremic blood donors
    Harry E Prince
    Focus Diagnostics, Cypress, CA 90630, USA
    J Clin Microbiol 43:4316-20. 2005
    ..Thus, unlike some other flavivirus infections, WNV infection is not characterized by a relatively rapid disappearance of virus-specific IgA...
  18. ncbi request reprint Biomarkers for diagnosing and monitoring autoimmune diseases
    Harry E Prince
    Focus Diagnostics, Inc, Cypress, CA 90630, USA
    Biomarkers 10:S44-9. 2005
    ..Thus, from a practical standpoint, the most useful autoimmune biomarkers will be those measurable in serum or plasma...
  19. pmc Evaluation of the INOVA diagnostics enzyme-linked immunosorbent assay kits for measuring serum immunoglobulin G (IgG) and IgA to deamidated gliadin peptides
    Harry E Prince
    Focus Diagnostics, Cypress, California 90630, USA
    Clin Vaccine Immunol 13:150-1. 2006
    ..DGP antibody results showed 97% concordance with EMA and TGA results. Of 56 sera negative for EMA and TGA but positive for conventional gliadin antibodies, 54 (96%) were negative for DGP antibodies...
  20. pmc Evaluation of a tetraplex microsphere assay for Bordetella pertussis antibodies
    Harry E Prince
    Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630, USA
    Clin Vaccine Immunol 13:266-70. 2006
    ..These findings show that antibodies to B. pertussis antigens can be measured easily and accurately using a tetraplex microsphere system...
  21. pmc Performance of immunoglobulin G (IgG) and IgM enzyme-linked immunosorbent assays using a West Nile virus recombinant antigen (preM/E) for detection of West Nile virus- and other flavivirus-specific antibodies
    Wayne R Hogrefe
    Focus Technologies, Cypress, California 90630, USA
    J Clin Microbiol 42:4641-8. 2004
    ..The use of a background subtraction method for the IgM ELISA eliminated all 15 false-positive results, giving a specificity of 100% for the Focus IgM ELISA...
  22. doi request reprint Evaluation of a multiplex bead-based screening assay for detection of binding antibodies to interferon-beta
    Mary Lape Nixon
    Focus Diagnostics, Cypress, CA 90630, USA
    J Neuroimmunol 210:104-7. 2009
    ..Our data indicate that the MAID assay is an accurate and cost-effective alternative to ELISA for detecting BAbs to IFNbeta...
  23. pmc Evaluation of a West Nile virus immunoglobulin A capture enzyme-linked immunosorbent assay
    Harry E Prince
    Focus Technologies, 5785 Corporate Ave, Cypress, CA 90630, USA
    Clin Diagn Lab Immunol 12:231-3. 2005
    ..WNV IgA is thus highly prevalent among WNV-infected patients and typically appears after WNV IgM but before WNV IgG...
  24. doi request reprint Evaluation of enzyme-linked immunosorbent assays for detecting circulating antibodies to Candida albicans
    Harry E Prince
    Focus Diagnostics, Inc Cypress, California, USA
    J Clin Lab Anal 22:234-8. 2008
    ..These findings demonstrate the acceptable performance of assay systems employing Candida Detect ELISA reagents...
  25. pmc Validation of an in-house assay for cytomegalovirus immunoglobulin G (CMV IgG) avidity and relationship of avidity to CMV IgM levels
    Harry E Prince
    Focus Technologies, Cypress, California 90630, USA
    Clin Diagn Lab Immunol 9:824-7. 2002
    ....
  26. ncbi request reprint West Nile virus immunoglobulin A (WNV IgA) detection in cerebrospinal fluid in relation to WNV IgG and IgM reactivity
    Mary Lapé Nixon
    Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA, United States
    J Clin Virol 37:174-8. 2006
    ..CSF IgA characterizes other flavivirus infections, but WNV IgA in CSF has not been evaluated. WNV IgM in CSF correlates with IgM in serum but the presence of WNV IgA in CSF compared to serum is unknown...
  27. pmc Utility of the focus technologies west nile virus immunoglobulin M capture enzyme-linked immunosorbent assay for testing cerebrospinal fluid
    Harry E Prince
    Focus Technologies, Cypress, California 90630, USA
    J Clin Microbiol 42:12-5. 2004
    ..These findings show that the Focus Technologies WNV IgM capture ELISA, when utilized as recommended, offers accurate qualitative detection of WNV IgM in CSF specimens...
  28. pmc Detection of West Nile virus (WNV)-specific immunoglobulin M in a reference laboratory setting during the 2002 WNV season in the United States
    Harry E Prince
    Focus Technologies, Cypress, California 90630, USA
    Clin Diagn Lab Immunol 10:764-8. 2003
    ....
  29. pmc Performance characteristics of an in-house assay system used to detect West Nile Virus (WNV)-specific immunoglobulin M during the 2001 WNV season in the United States
    Harry E Prince
    Focus Technologies, Cypress, California, 90630, USA
    Clin Diagn Lab Immunol 10:177-9. 2003
    ..These findings demonstrate that an in-house ELISA system for WNV-specific IgM effectively identifies patients with WNV infection...
  30. pmc Comparison of complement fixation and hemagglutination inhibition assays for detecting antibody responses following influenza virus vaccination
    Harry E Prince
    Focus Technologies, Cypress, California 90630, USA
    Clin Diagn Lab Immunol 10:481-2. 2003
    ..These findings indicate that due to low sensitivity, CF assays should not be used to assess the antibody response to influenza virus vaccination...
  31. pmc Performance characteristics of the PolyTiter Immunofluorescent Titration system for determination of antinuclear antibody endpoint dilution
    Karen A Flessland
    Alidex, Inc, Redmond, Washington 98052, USA
    Clin Diagn Lab Immunol 9:329-32. 2002
    ..Pattern identification with the PolyTiter was similar to that with serial dilution. The PolyTiter system demonstrates acceptable performance for routine ANA-IFA testing in the clinical laboratory...
  32. doi request reprint Virus and antibody dynamics in acute west nile virus infection
    Michael P Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Infect Dis 198:984-93. 2008
    ..The dynamics of the early stages of West Nile virus (WNV) infection can be assessed by follow-up studies of viremic blood donors...
  33. doi request reprint Interferon and interferon-induced chemokine expression is associated with control of acute viremia in West Nile virus-infected blood donors
    Leslie H Tobler
    University of California, San Francisco, CA 94118, USA
    J Infect Dis 198:979-83. 2008
    ..These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication...
  34. pmc West Nile virus infections projected from blood donor screening data, United States, 2003
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Emerg Infect Dis 12:395-402. 2006
    ..In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population...
  35. ncbi request reprint Further comparisons of assays for detecting MAG IgM autoantibodies
    Troy D Jaskowski
    Associated Regional and University Pathologists ARUP, Institute for Clinical and Experimental Pathology, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    J Neuroimmunol 187:175-8. 2007
    ..Patients having low titers by EIA, but negative by WB may have other autoimmune neuropathies without demyelination...