Amy Wright

Summary

Affiliation: Florida Atlantic University
Country: USA

Publications

  1. doi request reprint The Lithistida: important sources of compounds useful in biomedical research
    Amy E Wright
    Harbor Branch Oceanographic Institute at Florida Atlantic University, Center for Marine Biomedical and Biotechnology Research, 5600 US 1 North, Fort Pierce, FL 34946, USA
    Curr Opin Biotechnol 21:801-7. 2010
  2. pmc Isolation, synthesis, and biological activity of aphrocallistin, an adenine-substituted bromotyramine metabolite from the Hexactinellida sponge Aphrocallistes beatrix
    Amy E Wright
    Center for Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University, Ft Pierce, Florida 34946, USA
    J Nat Prod 72:1178-83. 2009
  3. ncbi request reprint Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 66:1615-7. 2003
  4. ncbi request reprint Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae
    Amy E Wright
    Center for Ocean Exploration, Biomedical Marine Research Program, Harbor Branch Oceanographic Institution, Inc, 5600 US 1 North, Ft Pierce, FL 34946, USA
    J Nat Prod 70:412-6. 2007
  5. ncbi request reprint Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico
    Young Chul Park
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 69:580-4. 2006
  6. pmc Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii
    Hilaire V Kemami Wangun
    Harbor Branch Oceanographic Institute at Florida Atlantic University, Center for Marine Biomedical and Biotechnology Research, 5600 US 1 Fort Pierce, Florida 34946, USA
    J Nat Prod 73:712-5. 2010
  7. pmc Selective cytotoxic activity of the marine-derived batzelline compounds against pancreatic cancer cell lines
    Esther A Guzmán
    Center for Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University, 5600 US 1 North, Ft Pierce, FL 34946, USA
    Anticancer Drugs 20:149-55. 2009
  8. ncbi request reprint Two new cytotoxic linderazulenes from a deep-sea gorgonian of the genus Paramuricea
    N Srinivasa Reddy
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 68:248-50. 2005
  9. ncbi request reprint Lasonolides C-g, five new lasonolide compounds from the sponge Forcepia sp
    Amy E Wright
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc, 5600 US 1 North, Ft Pierce, Florida 34946, USA
    J Nat Prod 67:1351-5. 2004
  10. pmc Early effects of lasonolide a on pancreatic cancer cells
    Richard A Isbrucker
    Harbor Branch Oceanographic Institute at Florida Atlantic University, Center for Marine Biomedical and BiotechnologyResearch, Fort Pierce, Florida 34946, USA
    J Pharmacol Exp Ther 331:733-9. 2009

Collaborators

  • S P Gunasekera
  • Ying Chen
  • Alan R Duckworth
  • Richard A Isbrucker
  • Esther A Guzmán
  • Hilaire V Kemami Wangun
  • Tara P Pitts
  • Peter J McCarthy
  • John K Reed
  • Young Chul Park
  • N Srinivasa Reddy
  • Ross E Longley
  • Alexander Wood
  • Catherine Fiorilla
  • Megan K Carrier
  • Cara I Meyer
  • Jacob D Johnson
  • Jose V Lopez
  • Jennifer Cummins
  • Shirley A Pomponi

Detail Information

Publications15

  1. doi request reprint The Lithistida: important sources of compounds useful in biomedical research
    Amy E Wright
    Harbor Branch Oceanographic Institute at Florida Atlantic University, Center for Marine Biomedical and Biotechnology Research, 5600 US 1 North, Fort Pierce, FL 34946, USA
    Curr Opin Biotechnol 21:801-7. 2010
    ..Examples of compounds marketed as biological markers along with recent advances in defining the modes of action and biomedical potential of lithistid-derived compounds are presented...
  2. pmc Isolation, synthesis, and biological activity of aphrocallistin, an adenine-substituted bromotyramine metabolite from the Hexactinellida sponge Aphrocallistes beatrix
    Amy E Wright
    Center for Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University, Ft Pierce, Florida 34946, USA
    J Nat Prod 72:1178-83. 2009
    ..Aphrocallistin has been fully characterized in the NCI cancer cell line panel and has undergone in vitro ADME pharmacological profiling...
  3. ncbi request reprint Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 66:1615-7. 2003
    ..These discorhabdin analogues showed in vitro cytotoxicity against PANC-1, P-388, and A-549 cell lines. The isolation and structure elucidation of discorhabdins S, T, and U are described...
  4. ncbi request reprint Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae
    Amy E Wright
    Center for Ocean Exploration, Biomedical Marine Research Program, Harbor Branch Oceanographic Institution, Inc, 5600 US 1 North, Ft Pierce, FL 34946, USA
    J Nat Prod 70:412-6. 2007
    ..2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 microg/mL...
  5. ncbi request reprint Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico
    Young Chul Park
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 69:580-4. 2006
    ..The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies...
  6. pmc Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii
    Hilaire V Kemami Wangun
    Harbor Branch Oceanographic Institute at Florida Atlantic University, Center for Marine Biomedical and Biotechnology Research, 5600 US 1 Fort Pierce, Florida 34946, USA
    J Nat Prod 73:712-5. 2010
    ....
  7. pmc Selective cytotoxic activity of the marine-derived batzelline compounds against pancreatic cancer cell lines
    Esther A Guzmán
    Center for Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University, 5600 US 1 North, Ft Pierce, FL 34946, USA
    Anticancer Drugs 20:149-55. 2009
    ....
  8. ncbi request reprint Two new cytotoxic linderazulenes from a deep-sea gorgonian of the genus Paramuricea
    N Srinivasa Reddy
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 68:248-50. 2005
    ..8, 2.7, and 15.6 microg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC(50) of 18.7 microg/mL...
  9. ncbi request reprint Lasonolides C-g, five new lasonolide compounds from the sponge Forcepia sp
    Amy E Wright
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc, 5600 US 1 North, Ft Pierce, Florida 34946, USA
    J Nat Prod 67:1351-5. 2004
    ..38, 4.89, 0.57, and 15.6 microM, respectively. Compound 3 inhibits the in vitro proliferation of the NCI-ADR-RES cell line with an IC50 of 1.12 microM...
  10. pmc Early effects of lasonolide a on pancreatic cancer cells
    Richard A Isbrucker
    Harbor Branch Oceanographic Institute at Florida Atlantic University, Center for Marine Biomedical and BiotechnologyResearch, Fort Pierce, Florida 34946, USA
    J Pharmacol Exp Ther 331:733-9. 2009
    ..Our results indicate that lasonolide A activates multiple signal transduction pathways and suggest that the origin is upstream of PKC...
  11. ncbi request reprint Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 67:749-56. 2004
    ..The preparation, purification, structure elucidation, and biological activity of these new analogues are described...
  12. ncbi request reprint Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 67:110-1. 2004
    ..was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described...
  13. ncbi request reprint New bioactive peroxides from marine sponges of the family plakiniidae
    Ying Chen
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc, 5600 US 1 North, Ft Pierce, Florida 34946, USA
    J Nat Prod 65:1509-12. 2002
    ..albicans with MICs of 5, 1.6, and 1.6 microg/mL respectively, for 1, 3, and 4. Compound 1 also showed in vitro inhibition of the fungal pathogen A. fumigatus with an IC(90) value of 5.6 microg/mL...
  14. ncbi request reprint In vitro culture of the tropical sponge Axinella corrugata (Demospongiae): effect of food cell concentration on growth, clearance rate, and biosynthesis of stevensine
    Alan R Duckworth
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc, 5600 US 1 North, Fort Pierce, FL 34946, USA
    Mar Biotechnol (NY) 5:519-27. 2003
    ..The good growth and increased production of the target metabolite stevensine for A. corrugata explants fed a 3NC diet suggests that in vitro culture is a viable method of supplying some sponge metabolites...
  15. ncbi request reprint Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin
    Richard A Isbrucker
    Harbor Branch Oceanographic Institution, Inc, Division of Biomedical Marine Research, 5600 US 1 North, Fort Pierce, FL 34946, USA
    Biochem Pharmacol 66:75-82. 2003
    ..Together, these results indicate that dictyostatin-1 is a potent inducer of tubulin polymerization and retains activity in cells expressing the P-glycoprotein efflux pump...

Research Grants6

  1. ANTITUMOR AGENTS EFFECTIVE AGAINST PANCREATIC CANCER
    Amy Wright; Fiscal Year: 2005
    ..abstract_text> ..
  2. Discovery of Novel Antitumor Agents Effective Against Pancreatic Cancer
    Amy E Wright; Fiscal Year: 2010
    ..The compounds discovered under this project may be used as drugs themselves, modified to provide drugs with improved pharmacological properties or be used as biochemical tools to further understand pancreatic cancer. ..