Hengli Tang

Summary

Affiliation: Florida State University
Country: USA

Publications

  1. pmc A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach
    Feng Yang
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS Pathog 6:e1001118. 2010
  2. pmc Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation
    Xianfang Wu
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS Pathog 8:e1002617. 2012
  3. pmc Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation
    Rachael Kenworthy
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Nucleic Acids Res 37:6587-99. 2009
  4. doi request reprint Cellular and molecular biology of HCV infection and hepatitis
    Hengli Tang
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Clin Sci (Lond) 117:49-65. 2009
  5. pmc Cyclophilin inhibitors as a novel HCV therapy
    Hengli Tang
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA E Mail Tel 1 850 645 2402
    Viruses 2:1621-34. 2010
  6. doi request reprint Selection and characterization of drug-resistant HCV replicons in vitro with a flow cytometry-based assay
    Jason M Robotham
    Department of Biological Science, Florida State University, Tallahassee, FL, USA
    Methods Mol Biol 510:227-42. 2009
  7. pmc Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro
    Feng Yang
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4370, USA
    J Virol 82:5269-78. 2008
  8. pmc Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex
    Zhe Liu
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    J Virol 83:6554-65. 2009
  9. pmc A conserved tandem cyclophilin-binding site in hepatitis C virus nonstructural protein 5A regulates Alisporivir susceptibility
    Henry Grise
    Department of Biological Science, Florida State University, Tallahassee, Florida, USA
    J Virol 86:4811-22. 2012
  10. pmc Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A
    Zhe Liu
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Hepatology 50:25-33. 2009

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach
    Feng Yang
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS Pathog 6:e1001118. 2010
    ..This study describes a new genetic approach to identifying viral targets of cellular cofactors and identifies a major regulator of HCV's susceptibility to CsA and its derivatives that are currently in clinical trials...
  2. pmc Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation
    Xianfang Wu
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS Pathog 8:e1002617. 2012
    ....
  3. pmc Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation
    Rachael Kenworthy
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Nucleic Acids Res 37:6587-99. 2009
    ..We also demonstrated that retinoic-acid-inducible gene I, and not melanoma differentiation associated gene 5 or toll-like receptor 3, is the cytoplasmic sensor for intracellularly expressed shRNAs that trigger IFN activation...
  4. doi request reprint Cellular and molecular biology of HCV infection and hepatitis
    Hengli Tang
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Clin Sci (Lond) 117:49-65. 2009
    ..In the present review, the molecular and cellular aspects of the HCV life cycle and the role of viral proteins in pathological liver conditions caused by HCV infection are described...
  5. pmc Cyclophilin inhibitors as a novel HCV therapy
    Hengli Tang
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA E Mail Tel 1 850 645 2402
    Viruses 2:1621-34. 2010
    ....
  6. doi request reprint Selection and characterization of drug-resistant HCV replicons in vitro with a flow cytometry-based assay
    Jason M Robotham
    Department of Biological Science, Florida State University, Tallahassee, FL, USA
    Methods Mol Biol 510:227-42. 2009
    ....
  7. pmc Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro
    Feng Yang
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4370, USA
    J Virol 82:5269-78. 2008
    ..These findings reveal the molecular mechanism of CsA resistance and identify CyPA as a critical cellular cofactor for HCV replication and infection...
  8. pmc Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex
    Zhe Liu
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    J Virol 83:6554-65. 2009
    ..Our results provide a mechanism of action for the cyclosporine-mediated inhibition of HCV and identify a critical role of CyPA's PPIase activity in the proper assembly and function of the HCV RC...
  9. pmc A conserved tandem cyclophilin-binding site in hepatitis C virus nonstructural protein 5A regulates Alisporivir susceptibility
    Henry Grise
    Department of Biological Science, Florida State University, Tallahassee, Florida, USA
    J Virol 86:4811-22. 2012
    ..Together, these data provide a high-resolution mapping of proline residues important for CyPA binding and identify critical amino acids modulating HCV susceptibility to the clinical CPI Alisporivir...
  10. pmc Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A
    Zhe Liu
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Hepatology 50:25-33. 2009
    ....
  11. pmc Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro
    John M Robida
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    J Virol 81:5829-40. 2007
    ..Our results demonstrate that CsA exerts selective pressure on the HCV genome, leading to the emergence of resistance-conferring mutations in the viral genome despite acting upon a cellular protein...
  12. pmc Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors
    Anita Nag
    Department of Biological Science, Florida State University, Tallahassee, Florida, USA
    J Virol 86:12616-24. 2012
    ..The host-directed nature and the ability to interfere with more than one step in the HCV life cycle may result in a higher genetic barrier to resistance for this class of HCV inhibitors...
  13. pmc Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression
    Heather B Nelson
    Bio Unit I, Chieftan Way, Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    J Virol 80:1181-90. 2006
    ..These results suggest that cell growth arrest is not sufficient for HCV replicon inhibition and reveal a mechanism for HCV RNA inhibition by cell confluence...
  14. pmc Cyclophilins as modulators of viral replication
    Stephen D Frausto
    Department of Biological Science, The Florida State University, Tallahassee, FL 32306, USA
    Viruses 5:1684-701. 2013
    ..In this review, we will summarize the evidence of cyclophilins as key mediators of viral infection and prospective drug targets. ..
  15. ncbi request reprint Molecular determinants of nucleolar translocation of RNA helicase A
    Zhe Liu
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    Exp Cell Res 313:3743-54. 2007
    ..RNA interference studies revealed that RHA is essential for survival of cultured hepatoma cells and the ATPase activity appears to be important for this critical role...
  16. doi request reprint Combining ligand design with photoligation to provide compact, colloidally stable, and easy to conjugate quantum dots
    Naiqian Zhan
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306, USA
    ACS Appl Mater Interfaces 5:2861-9. 2013
    ..The ability to carry out conjugation in acidic as well as basic conditions opens up the possibility to use such self-assembled QD-protein conjugates in various biological applications...
  17. pmc Simultaneous reduction and digestion of proteins with disulfide bonds for hydrogen/deuterium exchange monitored by mass spectrometry
    Hui Min Zhang
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    Anal Chem 82:1450-4. 2010
    ..This method yields dramatically increased sequence coverage and localization of solvent-exposed segments for mass-analyzed solution-phase H/D exchange of proteins containing disulfide bonds...
  18. pmc Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach
    Shani Waninger
    Department of Biological Sciences, Biology Unit 1, Florida State University, Tallahassee, FL 32306 4370, USA
    J Virol 78:12829-37. 2004
    ..Identification of the gene targets of these and other selected ribozymes may reveal novel therapeutic targets for combating HIV infection...

Research Grants2

  1. Cyclosporine, Cyclophilins and HCV Replication
    Hengli Tang; Fiscal Year: 2010
    ..The proposed research will illustrate the molecular basis of drug resistance for a new drug candidate and may also identify a novel aspect of virus-host cell interaction than can serve as target for a new class of drugs. ..