Rakesh Kumar Singh

Summary

Affiliation: Florida State University
Country: USA

Publications

  1. pmc Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae
    Rakesh Kumar Singh
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA
    PLoS ONE 7:e36295. 2012
  2. pmc Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis
    Rakesh Kumar Singh
    Department of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306 4300, USA
    Nat Cell Biol 11:925-33. 2009
  3. pmc Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway
    Dun Liang
    Department of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306 4300, USA
    Nucleic Acids Res 40:9604-20. 2012
  4. pmc Histone tyrosine phosphorylation comes of age
    Rakesh Kumar Singh
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA
    Epigenetics 6:153-60. 2011
  5. pmc Excess histone levels mediate cytotoxicity via multiple mechanisms
    Rakesh Kumar Singh
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA
    Cell Cycle 9:4236-44. 2010
  6. ncbi request reprint Generation and management of excess histones during the cell cycle
    Rakesh Kumar Singh
    Florida State University College of Medicine, Department of Biomedical Sciences, 1115 West Call Street, Tallahassee, FL 32306 4300, USA
    Front Biosci (Landmark Ed) 14:3145-58. 2009

Collaborators

  • Dun Liang
  • Marie Helene Miquel Kabbaj
  • Akash Gunjan
  • Sarah Lyn Burkhart

Detail Information

Publications6

  1. pmc Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae
    Rakesh Kumar Singh
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA
    PLoS ONE 7:e36295. 2012
    ..Overall, our results highlight the importance of posttranslational histone regulatory mechanisms that employ multiple E3 ubiquitin ligases to ensure excess histone degradation and thus contribute to the maintenance of genomic stability...
  2. pmc Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis
    Rakesh Kumar Singh
    Department of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306 4300, USA
    Nat Cell Biol 11:925-33. 2009
    ..Regulated histone proteolysis has major implications for the maintenance of epigenetic marks on chromatin, genomic stability and the packaging of sperm DNA...
  3. pmc Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway
    Dun Liang
    Department of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306 4300, USA
    Nucleic Acids Res 40:9604-20. 2012
    ..Our findings may have important implications for DNA repair, genomic stability, carcinogenesis and aging in human cells that have dozens of histone genes...
  4. pmc Histone tyrosine phosphorylation comes of age
    Rakesh Kumar Singh
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA
    Epigenetics 6:153-60. 2011
    ..These pioneering studies provide the initial conceptual framework for further analyses of the diverse roles of tyrosine phosphorylation on different histones, with far reaching implications for human health and disease...
  5. pmc Excess histone levels mediate cytotoxicity via multiple mechanisms
    Rakesh Kumar Singh
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA
    Cell Cycle 9:4236-44. 2010
    ....
  6. ncbi request reprint Generation and management of excess histones during the cell cycle
    Rakesh Kumar Singh
    Florida State University College of Medicine, Department of Biomedical Sciences, 1115 West Call Street, Tallahassee, FL 32306 4300, USA
    Front Biosci (Landmark Ed) 14:3145-58. 2009
    ..Proper regulation of histone levels has major implications for the maintenance of epigenetic marks on chromatin, genomic stability and the packaging of sperm DNA...