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Species | Joe Leigh SimpsonSummaryAffiliation: Florida International University Country: USA Publications
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Publications
Preimplantation genetic diagnosis at 20 yearsJoe Leigh Simpson
Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
Prenat Diagn 30:682-95. 2010....- Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part II--vitamin D, vitamin A, iron, zinc, iodine, essential fatty acidsJoe Leigh Simpson
Florida International University, College of Medicine, Miami, FL 33199, USA
J Matern Fetal Neonatal Med 24:1-24. 2011..To assure adequate iodine, food is fortified worldwide with iodated salt. If urinary iodine levels are low, supplementation is needed. Essential fatty acids requirements can be met by one to two portions of fish per week... - Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part I--Folate, Vitamin B12, Vitamin B6Joe Leigh Simpson
College of Medicine, Florida International University, Miami, FL 33199, USA
J Matern Fetal Neonatal Med 23:1323-43. 2010..Vitamin B6 is required for many reactions, primarily in amino acid metabolism. Meat, fish and poultry are good dietary sources. Supplementation beyond routine prenatal vitamins is not recommended... - Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genesJoe Leigh Simpson
Florida International University, College of Medicine, Miami, FL 33199, USA
Ann N Y Acad Sci 1135:146-54. 2008..Analysis of other genes is necessary, including many likely to show novel mechanisms of action... - Florida International University: development and accreditation of Miami's Public College of MedicineJohn A Rock
Florida International University College of Medicine, 11200 SW Eighth Street, HLS II 693, Miami, FL 33199, USA
Acad Med 84:1454-8. 2009..Preliminary approval of FIU COM was conferred in February 2008, with the first cohort of 40 students matriculating in August 2009... - What next for preimplantation genetic screening? Randomized clinical trial in assessing PGS: necessary but not sufficientJoe Leigh Simpson
College of Medicine, Florida International University, Building HLS II, Room 672, Miami, FL 33315, USA
Hum Reprod 23:2179-81. 2008..Lacking either of the latter two, even an elegantly designed RCT is not necessarily valid... 
Transcription factor FIGLA is mutated in patients with premature ovarian failureHan Zhao
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
Am J Hum Genet 82:1342-8. 2008..140 delN mutation disrupted FIGLA binding to the TCF3 helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA...
Oocyte-specific G-protein-coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report)Ertug Kovanci
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
Fertil Steril 90:1269-71. 2008..None of the 82 POF samples showed perturbations of significance. We conclude that perturbations in GPR3 are not a common explanation for POF in this population...- NOBOX homeobox mutation causes premature ovarian failureYingying Qin
Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan, China
Am J Hum Genet 81:576-81. 2007..Arg355His, disrupted NOBOX homeodomain binding to NOBOX DNA-binding element (NBE) and had a dominant negative effect on the binding of wild-type NOBOX to DNA. Our findings demonstrate that NOBOX mutations can cause POF... - Analysis of LHX8 mutation in premature ovarian failureYingying Qin
Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan, China
Fertil Steril 89:1012-4. 2008..1787A>G) of the LHX8 gene. These polymorphisms also were found in controls (n = 94), at frequencies that were not statistically different from those in POF women. Mutations in the LHX8 exons are uncommon in Caucasian women with POF... - Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failureHan Zhao
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China
Fertil Steril 88:1474-6. 2007..Thr238Ala) and was not present in any of 96 controls. Substitution of the hydrophobic amino acid residue alanine for hydrophilic threonine may disrupt growth differentiation factor 9 function... - Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failureYingying Qin
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China
Fertil Steril 88:1465-7. 2007..No additional single-nucleotide polymorphisms or mutations were found in exons encoding for NANOS3. Our findings suggest that mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure... - Growth differentiating factor-9 mutations may be associated with premature ovarian failureErtug Kovanci
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
Fertil Steril 87:143-6. 2007..To determine whether perturbations of the growth differentiating factor-9 (GDF9) gene are associated with premature ovarian failure (POF)... - The FMR1 premutation and reproductionMichael D Wittenberger
Intramural Research Program, Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
Fertil Steril 87:456-65. 2007..It is now recognized that this was incorrect, specifically with respect to female reproduction... - Heritability and molecular genetic studies of endometriosisJoe Leigh Simpson
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
Ann N Y Acad Sci 955:239-51; discussion 293-5, 396-406. 2002..It shall also illustrate our approach to testing the hypothesis that endometriosis bears similarity to neoplasia and, hence, is a multistep phenomenon of clonal origin...