Joe Leigh Simpson

Summary

Affiliation: Florida International University
Country: USA

Publications

  1. doi request reprint Genetics of female infertility due to anomalies of the ovary and mullerian ducts
    Joe Leigh Simpson
    Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, AHC2 693, Miami, FL, 33199, USA
    Methods Mol Biol 1154:39-73. 2014
  2. doi request reprint Preimplantation genetic diagnosis at 20 years
    Joe Leigh Simpson
    Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
    Prenat Diagn 30:682-95. 2010
  3. doi request reprint Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part II--vitamin D, vitamin A, iron, zinc, iodine, essential fatty acids
    Joe Leigh Simpson
    Florida International University, College of Medicine, Miami, FL 33199, USA
    J Matern Fetal Neonatal Med 24:1-24. 2011
  4. doi request reprint Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part I--Folate, Vitamin B12, Vitamin B6
    Joe Leigh Simpson
    College of Medicine, Florida International University, Miami, FL 33199, USA
    J Matern Fetal Neonatal Med 23:1323-43. 2010
  5. doi request reprint Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genes
    Joe Leigh Simpson
    Florida International University, College of Medicine, Miami, FL 33199, USA
    Ann N Y Acad Sci 1135:146-54. 2008
  6. doi request reprint Florida International University: development and accreditation of Miami's Public College of Medicine
    John A Rock
    Florida International University College of Medicine, 11200 SW Eighth Street, HLS II 693, Miami, FL 33199, USA
    Acad Med 84:1454-8. 2009
  7. doi request reprint What next for preimplantation genetic screening? Randomized clinical trial in assessing PGS: necessary but not sufficient
    Joe Leigh Simpson
    College of Medicine, Florida International University, Building HLS II, Room 672, Miami, FL 33315, USA
    Hum Reprod 23:2179-81. 2008
  8. pmc Transcription factor FIGLA is mutated in patients with premature ovarian failure
    Han Zhao
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 82:1342-8. 2008
  9. ncbi request reprint Oocyte-specific G-protein-coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report)
    Ertug Kovanci
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    Fertil Steril 90:1269-71. 2008
  10. pmc NOBOX homeobox mutation causes premature ovarian failure
    Yingying Qin
    Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan, China
    Am J Hum Genet 81:576-81. 2007

Collaborators

Detail Information

Publications16

  1. doi request reprint Genetics of female infertility due to anomalies of the ovary and mullerian ducts
    Joe Leigh Simpson
    Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, AHC2 693, Miami, FL, 33199, USA
    Methods Mol Biol 1154:39-73. 2014
    ..Among uterine anomalies, incomplete mullerian fusion is most common. Increased recurrence risks for first-degree relatives confirm a role for genetic factors; interrogation of candidate genes is under way. ..
  2. doi request reprint Preimplantation genetic diagnosis at 20 years
    Joe Leigh Simpson
    Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
    Prenat Diagn 30:682-95. 2010
    ....
  3. doi request reprint Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part II--vitamin D, vitamin A, iron, zinc, iodine, essential fatty acids
    Joe Leigh Simpson
    Florida International University, College of Medicine, Miami, FL 33199, USA
    J Matern Fetal Neonatal Med 24:1-24. 2011
    ..To assure adequate iodine, food is fortified worldwide with iodated salt. If urinary iodine levels are low, supplementation is needed. Essential fatty acids requirements can be met by one to two portions of fish per week...
  4. doi request reprint Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part I--Folate, Vitamin B12, Vitamin B6
    Joe Leigh Simpson
    College of Medicine, Florida International University, Miami, FL 33199, USA
    J Matern Fetal Neonatal Med 23:1323-43. 2010
    ..Vitamin B6 is required for many reactions, primarily in amino acid metabolism. Meat, fish and poultry are good dietary sources. Supplementation beyond routine prenatal vitamins is not recommended...
  5. doi request reprint Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genes
    Joe Leigh Simpson
    Florida International University, College of Medicine, Miami, FL 33199, USA
    Ann N Y Acad Sci 1135:146-54. 2008
    ..Analysis of other genes is necessary, including many likely to show novel mechanisms of action...
  6. doi request reprint Florida International University: development and accreditation of Miami's Public College of Medicine
    John A Rock
    Florida International University College of Medicine, 11200 SW Eighth Street, HLS II 693, Miami, FL 33199, USA
    Acad Med 84:1454-8. 2009
    ..Preliminary approval of FIU COM was conferred in February 2008, with the first cohort of 40 students matriculating in August 2009...
  7. doi request reprint What next for preimplantation genetic screening? Randomized clinical trial in assessing PGS: necessary but not sufficient
    Joe Leigh Simpson
    College of Medicine, Florida International University, Building HLS II, Room 672, Miami, FL 33315, USA
    Hum Reprod 23:2179-81. 2008
    ..Lacking either of the latter two, even an elegantly designed RCT is not necessarily valid...
  8. pmc Transcription factor FIGLA is mutated in patients with premature ovarian failure
    Han Zhao
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 82:1342-8. 2008
    ..140 delN mutation disrupted FIGLA binding to the TCF3 helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA...
  9. ncbi request reprint Oocyte-specific G-protein-coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report)
    Ertug Kovanci
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    Fertil Steril 90:1269-71. 2008
    ..None of the 82 POF samples showed perturbations of significance. We conclude that perturbations in GPR3 are not a common explanation for POF in this population...
  10. pmc NOBOX homeobox mutation causes premature ovarian failure
    Yingying Qin
    Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan, China
    Am J Hum Genet 81:576-81. 2007
    ..Arg355His, disrupted NOBOX homeodomain binding to NOBOX DNA-binding element (NBE) and had a dominant negative effect on the binding of wild-type NOBOX to DNA. Our findings demonstrate that NOBOX mutations can cause POF...
  11. pmc Analysis of LHX8 mutation in premature ovarian failure
    Yingying Qin
    Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan, China
    Fertil Steril 89:1012-4. 2008
    ..1787A>G) of the LHX8 gene. These polymorphisms also were found in controls (n = 94), at frequencies that were not statistically different from those in POF women. Mutations in the LHX8 exons are uncommon in Caucasian women with POF...
  12. pmc Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure
    Han Zhao
    Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China
    Fertil Steril 88:1474-6. 2007
    ..Thr238Ala) and was not present in any of 96 controls. Substitution of the hydrophobic amino acid residue alanine for hydrophilic threonine may disrupt growth differentiation factor 9 function...
  13. pmc Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure
    Yingying Qin
    Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China
    Fertil Steril 88:1465-7. 2007
    ..No additional single-nucleotide polymorphisms or mutations were found in exons encoding for NANOS3. Our findings suggest that mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure...
  14. ncbi request reprint Growth differentiating factor-9 mutations may be associated with premature ovarian failure
    Ertug Kovanci
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Fertil Steril 87:143-6. 2007
    ..To determine whether perturbations of the growth differentiating factor-9 (GDF9) gene are associated with premature ovarian failure (POF)...
  15. ncbi request reprint The FMR1 premutation and reproduction
    Michael D Wittenberger
    Intramural Research Program, Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Fertil Steril 87:456-65. 2007
    ..It is now recognized that this was incorrect, specifically with respect to female reproduction...
  16. ncbi request reprint Heritability and molecular genetic studies of endometriosis
    Joe Leigh Simpson
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 955:239-51; discussion 293-5, 396-406. 2002
    ..It shall also illustrate our approach to testing the hypothesis that endometriosis bears similarity to neoplasia and, hence, is a multistep phenomenon of clonal origin...