Affiliation: Florida State University
Feresin R, Huang J, Klarich D, Zhao Y, Pourafshar S, Arjmandi B, et al
. Blackberry, raspberry and black raspberry polyphenol extracts attenuate angiotensin II-induced senescence in vascular smooth muscle cells. Food Funct. 2016;7:4175-4187 pubmed
..Our findings indicate that Ang II-induced senescence is attenuated by BL polyphenols through a Nox1-dependent mechanism and by RB and BRB polyphenols in a Nox1-independent manner, likely by increasing the cellular antioxidant capacity. ..
Serino A, Salazar G. Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease. Nutrients. 2018;11: pubmed publisher
..We also discuss the therapeutic potential of polyphenols in reducing the effects of the SASP and the incidence of CVD. ..
Salazar G. NADPH Oxidases and Mitochondria in Vascular Senescence. Int J Mol Sci. 2018;19: pubmed publisher
Salazar G, Huang J, Feresin R, Zhao Y, Griendling K. Zinc regulates Nox1 expression through a NF-?B and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells. Free Radic Biol Med. 2017;108:225-235 pubmed publisher
Feresin R, Pourafshar S, Huang J, Zhao Y, Arjmandi B, Salazar G. Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro. J Vis Exp. 2017;: pubmed publisher
..The crude extract was further purified and fractionated using chloroform and ethyl acetate, respectively. The effects of both crude and purified extracts were tested on Vascular Smooth Muscle Cells (VSMCs) in culture. ..