J M Overton

Summary

Affiliation: Florida State University
Country: USA

Publications

  1. doi request reprint Phenotyping small animals as models for the human metabolic syndrome: thermoneutrality matters
    J M Overton
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306 4340, USA
    Int J Obes (Lond) 34:S53-8. 2010
  2. ncbi request reprint Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats
    J M Overton
    Departments of Nutrition, Food and Exercise Sciences and Program in Neuroscience, 236 Biomedical Research Facility, Florida State University, Tallahassee, FL 32306 4340, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1007-15. 2001
  3. pmc Electrophysiological and behavioral phenotype of insulin receptor defective mice
    P Das
    Department of Biological Science, Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
    Physiol Behav 86:287-96. 2005
  4. pmc Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice
    K Tucker
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Int J Obes (Lond) 32:1222-32. 2008
  5. ncbi request reprint Cardiovascular and metabolic responses to fasting and thermoneutrality in Ay mice
    T D Williams
    Department of Nutrition, Food, and Exercise Sciences, Florida State University, 236 Biomedical Research Facility, Tallahassee, FL 32306 4340, USA
    Physiol Behav 78:615-23. 2003
  6. ncbi request reprint Long-Evans and Sprague-Dawley rats exhibit divergent responses to refeeding after caloric restriction
    S A Evans
    Department of Nutrition, Food and Exercise Sciences and Program in Neuroscience, 236 Biomedical Research Facility, Florida State University, Tallahassee, FL 32306 4340, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1468-76. 2005
  7. ncbi request reprint Adaptive thermogenesis is intact in B6 and A/J mice studied at thermoneutrality
    L R DeRuisseau
    Department of Nutrition, Food, and Exercise Sciences, Florida State University, Tallahassee, FL 32306 4340, USA
    Metabolism 53:1417-23. 2004
  8. ncbi request reprint Homeostatic responses to caloric restriction: influence of background metabolic rate
    S A Evans
    Department of Biomedical Sciences, Florida State University, Tallahassee, 32306 4340, USA
    J Appl Physiol 99:1336-42. 2005
  9. ncbi request reprint Central leptin infusion attenuates the cardiovascular and metabolic effects of fasting in rats
    J M Overton
    Departments of Nutrition, Food, and Exercise Sciences, The Program in Neuroscience, Florida State University, Tallahassee, USA
    Hypertension 37:663-9. 2001
  10. doi request reprint Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
    S J Swoap
    Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
    Am J Physiol Heart Circ Physiol 294:H1581-8. 2008

Collaborators

Detail Information

Publications19

  1. doi request reprint Phenotyping small animals as models for the human metabolic syndrome: thermoneutrality matters
    J M Overton
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306 4340, USA
    Int J Obes (Lond) 34:S53-8. 2010
    ..This paper will review these observations, which must be understood in the context of phenotyping small mammals to enhance our understanding of the biology of human disease...
  2. ncbi request reprint Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats
    J M Overton
    Departments of Nutrition, Food and Exercise Sciences and Program in Neuroscience, 236 Biomedical Research Facility, Florida State University, Tallahassee, FL 32306 4340, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1007-15. 2001
    ....
  3. pmc Electrophysiological and behavioral phenotype of insulin receptor defective mice
    P Das
    Department of Biological Science, Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
    Physiol Behav 86:287-96. 2005
    ....
  4. pmc Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice
    K Tucker
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Int J Obes (Lond) 32:1222-32. 2008
    ..In this study, we investigate whether or not gene-targeted deletion of Kv1.3 (Shaker family member) can abrogate weight gain in a genetic model of obesity, the melanocortin-4 receptor-null mouse (MC4R-null)...
  5. ncbi request reprint Cardiovascular and metabolic responses to fasting and thermoneutrality in Ay mice
    T D Williams
    Department of Nutrition, Food, and Exercise Sciences, Florida State University, 236 Biomedical Research Facility, Tallahassee, FL 32306 4340, USA
    Physiol Behav 78:615-23. 2003
    ..We conclude that inhibition of melanocortin signaling is not requisite for, but participates in, the metabolic and cardiovascular responses to negative energy balance...
  6. ncbi request reprint Long-Evans and Sprague-Dawley rats exhibit divergent responses to refeeding after caloric restriction
    S A Evans
    Department of Nutrition, Food and Exercise Sciences and Program in Neuroscience, 236 Biomedical Research Facility, Florida State University, Tallahassee, FL 32306 4340, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1468-76. 2005
    ..We conclude that during recovery from CR, homeostatic stimulation of appetite or suppression of energy expenditure may occur selectively to restore body weight...
  7. ncbi request reprint Adaptive thermogenesis is intact in B6 and A/J mice studied at thermoneutrality
    L R DeRuisseau
    Department of Nutrition, Food, and Exercise Sciences, Florida State University, Tallahassee, FL 32306 4340, USA
    Metabolism 53:1417-23. 2004
    ..Furthermore, the results suggest that differences in control of caloric intake, rather than capacity for adaptive thermogenesis, may contribute to the relative susceptibility to obesity in A/J and B6 mice...
  8. ncbi request reprint Homeostatic responses to caloric restriction: influence of background metabolic rate
    S A Evans
    Department of Biomedical Sciences, Florida State University, Tallahassee, 32306 4340, USA
    J Appl Physiol 99:1336-42. 2005
    ....
  9. ncbi request reprint Central leptin infusion attenuates the cardiovascular and metabolic effects of fasting in rats
    J M Overton
    Departments of Nutrition, Food, and Exercise Sciences, The Program in Neuroscience, Florida State University, Tallahassee, USA
    Hypertension 37:663-9. 2001
    ..The results are consistent with the hypothesis that reductions in central leptin signaling contribute to the integrated cardiovascular and metabolic responses to acute caloric deprivation...
  10. doi request reprint Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
    S J Swoap
    Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
    Am J Physiol Heart Circ Physiol 294:H1581-8. 2008
    ..These experiments conclusively demonstrate that in the absence of cold stress, regulation of vagal tone and modulation of intrinsic rate are important determinants of HR control in the mouse...
  11. ncbi request reprint Diet-induced obesity and cardiovascular regulation in C57BL/6J mice
    T D Williams
    Department of Nutrition, Food and Exercise Sciences, The Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4340, USA
    Clin Exp Pharmacol Physiol 30:769-78. 2003
    ..We argue that mouse physiology studies should be performed in thermoneutral conditions...
  12. doi request reprint Combined amylin-leptin treatment lowers blood pressure and adiposity in lean and obese rats
    R Seth
    Department of Biomedical Sciences and Program in Neuroscience, College of Medicine, Florida State University, Tallahassee, FL 32306, USA
    Int J Obes (Lond) 35:1183-92. 2011
    ..Objective: To examine the cardiovascular effects of combined amylin (AMN) and leptin (LEP) treatment in lean and obese rats...
  13. pmc Diet-induced obesity resistance of Kv1.3-/- mice is olfactory bulb dependent
    K Tucker
    Program in Neuroscience, The Florida State University, Tallahassee, FL, USA
    J Neuroendocrinol 24:1087-95. 2012
    ..Thus, these findings add to a growing body of evidence suggesting that the olfactory system can modulate the pathways involved in the regulation of energy balance...
  14. ncbi request reprint Behavioral and physiologic responses to caloric restriction in mice
    J M Overton
    Department of Nutrition, Program in Neuroscience, 236 Biomedical Research Facility, Florida State University, Tallahassee, FL 32306 4340, USA
    Physiol Behav 81:749-54. 2004
    ..We suggest that researchers using mice to investigate energy homeostasis and cardiovascular physiology carefully consider the influence of T(a) on physiology and behavior...
  15. pmc Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics
    D A Fadool
    Department of Biological Science, Programs in Neuroscience and Molecular Biophysics, The Florida State University, Tallahassee, FL 32306, USA
    Neuron 41:389-404. 2004
    ..3 plays a far more reaching role in signal transduction, development, and olfactory coding than that of the classically defined role of a potassium channel-to shape excitability by influencing membrane potential...
  16. ncbi request reprint The effect of food deprivation and experimental diabetes on orexin and NPY mRNA levels
    I Swart
    Program in Neuroscience, The Florida State University, Tallahassee, FL 32306, USA
    Peptides 22:2175-9. 2001
    ..NPY mRNA levels were increased by either treatment. These results suggest that increased orexin gene expression is not a consistent correlate of negative energy balance challenges...
  17. ncbi request reprint Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice
    I Swart
    Program in Neuroscience, The Florida State University, Tallahassee, Florida 32306 4340, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1020-6. 2002
    ..These results suggest that gradual postabsorptive events subsequent to refeeding are required for the restoration of peptide mRNA to baseline levels after food deprivation in mice...
  18. ncbi request reprint Cardiovascular responses to caloric restriction and thermoneutrality in C57BL/6J mice
    T D Williams
    Department of Nutrition, Food, and Exercise Sciences, Florida State University, Tallahassee, Florida 32306 4340, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1459-67. 2002
    ..The results reveal that mice exhibit robust cardiovascular responses to both acute and chronic negative energy balance. Furthermore, we conclude that T(a) is a very important consideration when assessing cardiovascular function in mice...
  19. ncbi request reprint Effects of chronic exercise on blood pressure in Dahl salt-sensitive rats
    J M Overton
    Department of Nutrition, Food, and Movement Sciences, Florida State University, Tallahassee 32306 4075, USA
    Am J Hypertens 11:73-80. 1998
    ..The findings suggest that overall resting sympathetic neural activity or cardiac beta-adrenergic responsiveness to sympathetic activity is reduced in this model of hypertension by daily wheel running exercise...