Yuan Liu

Summary

Affiliation: Florida International University
Country: USA

Publications

  1. pmc Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1
    Meng Xu
    Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
    Nucleic Acids Res 41:1684-97. 2013
  2. pmc Instability of CTG repeats is governed by the position of a DNA base lesion through base excision repair
    Yanhao Lai
    Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, USA
    PLoS ONE 8:e56960. 2013
  3. pmc DNA base excision repair: a mechanism of trinucleotide repeat expansion
    Yuan Liu
    Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA
    Trends Biochem Sci 37:162-72. 2012
  4. pmc Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion
    Meng Xu
    Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA, Department of Environmental Health, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P R China and Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Nucleic Acids Res 42:3675-91. 2014
  5. pmc Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia
    Yanhao Lai
    Department of Environmental Health, Sichuan University West China School of Public Health, Chengdu, Sichuan, P R China Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America
    PLoS ONE 9:e93464. 2014

Collaborators

  • Yanbin Zhang
  • Yanhao Lai
  • Meng Xu
  • Zunzhen Zhang
  • Justin Torner
  • Irina U Agoulnik
  • Shyama Ramjagsingh
  • Karla Lorente
  • Jonathan Melo
  • Jill M Beaver
  • Jonathan Gabison

Detail Information

Publications5

  1. pmc Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1
    Meng Xu
    Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
    Nucleic Acids Res 41:1684-97. 2013
    ..Our results provide new insight into the role of BER in modulating genome stability that is associated with human diseases...
  2. pmc Instability of CTG repeats is governed by the position of a DNA base lesion through base excision repair
    Yanhao Lai
    Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, USA
    PLoS ONE 8:e56960. 2013
    ..Our study indicates that the position of a DNA base lesion governs whether TNR is expanded or deleted through BER...
  3. pmc DNA base excision repair: a mechanism of trinucleotide repeat expansion
    Yuan Liu
    Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA
    Trends Biochem Sci 37:162-72. 2012
    ....
  4. pmc Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion
    Meng Xu
    Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA, Department of Environmental Health, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P R China and Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Nucleic Acids Res 42:3675-91. 2014
    ..This further resulted in prevention and attenuation of repeat expansion. Our results demonstrate that TNR expansion can be prevented via BER in hairpin loops that is coupled with the removal of TNR hairpins. ..
  5. pmc Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia
    Yanhao Lai
    Department of Environmental Health, Sichuan University West China School of Public Health, Chengdu, Sichuan, P R China Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America
    PLoS ONE 9:e93464. 2014
    ..This further suggests the potential of developing chemotherapeutic alkylating agents to shorten expanded GAA repeats for treatment of FRDA. ..