Henry J Lee

Summary

Affiliation: Florida A and M University
Country: USA

Publications

  1. ncbi request reprint A novel approach to the discovery of non-systemic anti-inflammatory steroids; antedrug
    H J Lee
    Center for Anti Inflammatory Research, College of Pharmacy, Florida A and M University, Tallahassee 32307, USA
    Arch Pharm Res 22:279-87. 1999
  2. ncbi request reprint Novel steroid spiro enones: condensation of prednisolone derivatives with diethyl oxalate
    Z You
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307, USA
    Steroids 65:109-15. 2000
  3. ncbi request reprint Prodrug and antedrug: two diametrical approaches in designing safer drugs
    Henry J Lee
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307, USA
    Arch Pharm Res 25:111-36. 2002
  4. ncbi request reprint In vitro anti-inflammatory activities of new steroidal antedrugs: [16alpha,17alpha-d] Isoxazoline and [16alpha,17alpha-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9alpha-fluoroprednisolone
    Kwan K Park
    Center for Anti Inflammatory Research, College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, FL 32307, USA
    Steroids 71:183-8. 2006
  5. ncbi request reprint New steroidal antiinflammatory antedrugs: Methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and its 21-O-acyl derivatives
    Dong Hoon Ko
    Center for Anti Inflammatory Research, Florida A and M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, Florida 32307, USA
    Steroids 67:211-9. 2002
  6. ncbi request reprint New steroidal anti-inflammatory antedrugs: 21-thioalkylether derivatives of methyl 16-prednisolone carboxylates
    M Omar
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Med Chem 3:572-5. 2007
  7. ncbi request reprint Antedrugs: an approach to safer drugs
    M Omar F Khan
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Curr Med Chem 12:2227-39. 2005

Collaborators

Detail Information

Publications7

  1. ncbi request reprint A novel approach to the discovery of non-systemic anti-inflammatory steroids; antedrug
    H J Lee
    Center for Anti Inflammatory Research, College of Pharmacy, Florida A and M University, Tallahassee 32307, USA
    Arch Pharm Res 22:279-87. 1999
    ..Taken together, the antedrug concept appears to be a fundamentally sound strategy for the separation of local anti-inflammatory activity from systemic adverse effects...
  2. ncbi request reprint Novel steroid spiro enones: condensation of prednisolone derivatives with diethyl oxalate
    Z You
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307, USA
    Steroids 65:109-15. 2000
    ..Molecular modeling studies confirm that the spiro enones adopt a rigid planar geometry with the ester group in the plane...
  3. ncbi request reprint Prodrug and antedrug: two diametrical approaches in designing safer drugs
    Henry J Lee
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307, USA
    Arch Pharm Res 25:111-36. 2002
    ..As for antedrugs, emphasis in research has been based upon the design and synthesis of systemically inactive molecule by incorporating a metabolically labile functional group into an active molecule...
  4. ncbi request reprint In vitro anti-inflammatory activities of new steroidal antedrugs: [16alpha,17alpha-d] Isoxazoline and [16alpha,17alpha-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9alpha-fluoroprednisolone
    Kwan K Park
    Center for Anti Inflammatory Research, College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, FL 32307, USA
    Steroids 71:183-8. 2006
    ..1 and 4.2 min, respectively. The half-lives of FP-ISO-21OH and 11beta,21-dihydroxy-9alpha-fluoro-3,20-dioxo-1,4-pregnadieno [16alpha,17alpha-d]-3'-hydroxyiminoformyl isoxazoline (FP-OXIM-21OH) were 92.2 and 110.2 min, respectively...
  5. ncbi request reprint New steroidal antiinflammatory antedrugs: Methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and its 21-O-acyl derivatives
    Dong Hoon Ko
    Center for Anti Inflammatory Research, Florida A and M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, Florida 32307, USA
    Steroids 67:211-9. 2002
    ....
  6. ncbi request reprint New steroidal anti-inflammatory antedrugs: 21-thioalkylether derivatives of methyl 16-prednisolone carboxylates
    M Omar
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Med Chem 3:572-5. 2007
    ....
  7. ncbi request reprint Antedrugs: an approach to safer drugs
    M Omar F Khan
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Curr Med Chem 12:2227-39. 2005
    ....