DAVID contact HOULE

Summary

Affiliation: Florida State University
Country: USA

Publications

  1. doi request reprint Properties of spontaneous mutational variance and covariance for wing size and shape in Drosophila melanogaster
    David Houle
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Evolution 67:1116-30. 2013
  2. ncbi request reprint Measurement and meaning in biology
    David Houle
    Centre for Ecological and Evolutionary Synthesis, University of Oslo, 0316 Oslo, Norway
    Q Rev Biol 86:3-34. 2011
  3. doi request reprint Phenomics: the next challenge
    David Houle
    Department of Biological Science, Florida State University, Tallahassee, 32306 4295, USA
    Nat Rev Genet 11:855-66. 2010
  4. pmc Colloquium papers: Numbering the hairs on our heads: the shared challenge and promise of phenomics
    David Houle
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Proc Natl Acad Sci U S A 107:1793-9. 2010
  5. ncbi request reprint A dispatch from the multivariate frontier
    D Houle
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 1100, USA
    J Evol Biol 20:22-3; discussion 39-44. 2007
  6. pmc Coevolution of costly mate choice and condition-dependent display of good genes
    David Houle
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 1100, USA
    Proc Biol Sci 269:97-104. 2002
  7. ncbi request reprint Mutation accumulation and the effect of copia insertions in Drosophila melanogaster
    David Houle
    Department of Biological Science, Florida State University, Tallahassee 32306 1100, USA
    Genet Res 83:7-18. 2004
  8. pmc Automated measurement of Drosophila wings
    David Houle
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5 Canada
    BMC Evol Biol 3:25. 2003
  9. ncbi request reprint Interpretation of the results of common principal components analyses
    David Houle
    Department of Zoology, University of Toronto, ON, Canada
    Evolution 56:433-40. 2002
  10. ncbi request reprint Natural selection in a bottle
    David Houle
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Am Nat 161:50-67. 2003

Research Grants

Detail Information

Publications23

  1. doi request reprint Properties of spontaneous mutational variance and covariance for wing size and shape in Drosophila melanogaster
    David Houle
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Evolution 67:1116-30. 2013
    ..Genotypic differences are likely to be involved, as the two genotypes have different molecular mutation rates and properties...
  2. ncbi request reprint Measurement and meaning in biology
    David Houle
    Centre for Ecological and Evolutionary Synthesis, University of Oslo, 0316 Oslo, Norway
    Q Rev Biol 86:3-34. 2011
    ..The frequency of such violations reveals the importance of raising awareness of measurement theory among biologists...
  3. doi request reprint Phenomics: the next challenge
    David Houle
    Department of Biological Science, Florida State University, Tallahassee, 32306 4295, USA
    Nat Rev Genet 11:855-66. 2010
    ..Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping...
  4. pmc Colloquium papers: Numbering the hairs on our heads: the shared challenge and promise of phenomics
    David Houle
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Proc Natl Acad Sci U S A 107:1793-9. 2010
    ..Phenotypic data can be informative about the past history of selection and unexpectedly predictive of long-term evolution. Comprehensive efforts to increase the throughput and range of phenotyping are an urgent priority...
  5. ncbi request reprint A dispatch from the multivariate frontier
    D Houle
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 1100, USA
    J Evol Biol 20:22-3; discussion 39-44. 2007
  6. pmc Coevolution of costly mate choice and condition-dependent display of good genes
    David Houle
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 1100, USA
    Proc Biol Sci 269:97-104. 2002
    ..Preference readily evolves, often causing extreme exaggeration of the display. Mate choice and trait expression can approach an equilibrium, or a limit cycle, or exaggeration can proceed forever, eventually causing extinction...
  7. ncbi request reprint Mutation accumulation and the effect of copia insertions in Drosophila melanogaster
    David Houle
    Department of Biological Science, Florida State University, Tallahassee 32306 1100, USA
    Genet Res 83:7-18. 2004
    ..3% per generation. The element number of copia was a significant predictor of fitness within generations; on average, insertions caused a 0.76% loss in fitness, although the confidence limits on this estimate are wide...
  8. pmc Automated measurement of Drosophila wings
    David Houle
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5 Canada
    BMC Evol Biol 3:25. 2003
    ..The wings of Drosophila species are a favorable target for automated analysis because of the many interesting questions in evolution and development that can be addressed with them, and because of their simple structure...
  9. ncbi request reprint Interpretation of the results of common principal components analyses
    David Houle
    Department of Zoology, University of Toronto, ON, Canada
    Evolution 56:433-40. 2002
    ..Reordering of vectors before analysis can aid in the detection of patterns. We urge caution in the biological interpretation of CPC analysis results...
  10. ncbi request reprint Natural selection in a bottle
    David Houle
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Am Nat 161:50-67. 2003
    ..Ultimately, laboratory systems provide the best opportunity for the study of natural selection, genetic variation, and evolutionary response in the same population...
  11. ncbi request reprint Comparing strengths of directional selection: how strong is strong?
    Joe Hereford
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 1100, USA
    Evolution 58:2133-43. 2004
    ....
  12. pmc Comparing G matrices: are common principal components informative?
    Jason G Mezey
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 1100, USA
    Genetics 165:411-25. 2003
    ..The interpretation of common PCs identified for estimates of G matrices is discussed in light of these results...
  13. doi request reprint Sexual selection accelerates the elimination of a deleterious mutant in Drosophila melanogaster
    Brian Hollis
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Evolution 63:324-33. 2009
    ..In contrast to recent experiments employing monogamy/polygamy designs, our results demonstrate a fitness benefit to sexual selection. This is consistent with the operation of good-genes female choice...
  14. pmc Enzyme isoforms may increase phenotypic robustness
    Maurizio Tomaiuolo
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Evolution 62:2884-93. 2008
    ..Thus, we show that controlling isoform proportion can be a powerful mechanism for reducing the effects of variations in the values of system parameters, increasing system robustness...
  15. ncbi request reprint The dimensionality of genetic variation for wing shape in Drosophila melanogaster
    Jason G Mezey
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 1100, USA
    Evolution 59:1027-38. 2005
    ..We discuss the importance of this result for resolving the relative roles of selection and drift processes versus constraints in the evolution of wing shape in Drosophila...
  16. ncbi request reprint Consequences of hierarchical allocation for the evolution of life-history traits
    Anne C Worley
    Department of Botany, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Am Nat 161:153-67. 2003
    ..Thus, allocation hierarchies can profoundly affect life-history evolution by causing traits to evolve in the opposite direction to that predicted by trade-offs...
  17. doi request reprint A supermatrix-based molecular phylogeny of the family Drosophilidae
    Kim van der Linde
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Genet Res (Camb) 92:25-38. 2010
    ..We argue that these results support a taxonomic revision of the genus Drosophila...
  18. ncbi request reprint Sensory bias as an explanation for the evolution of mate preferences
    Rebecca C Fuller
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Am Nat 166:437-46. 2005
    ..We suggest that the importance of sensory bias as an explanation for the evolution of female preferences remains to be determined...
  19. ncbi request reprint A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression
    Scott A Rifkin
    Department of Ecology and Evolutionary Biology, Yale University, PO Box 208106, New Haven, Connecticut 06520 8106, USA
    Nature 438:220-3. 2005
    ..Although spontaneous mutations have the potential to generate abundant variation in gene expression, natural variation is relatively constrained...
  20. pmc Naturally segregating quantitative trait loci affecting wing shape of Drosophila melanogaster
    Jason G Mezey
    Center for Population Biology and Section of Evolution and Ecology, University of California, Davis, 95616, USA
    Genetics 169:2101-13. 2005
    ..Naturally segregating variation can therefore act through known signaling pathways to produce variation in vein position...
  21. ncbi request reprint A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafish
    Amy R McCune
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
    Science 296:2398-401. 2002
    ..These results, together with data on several Drosophila species and on Xenopus laevis, show that phylogenetically distant animals with different genome sizes and numbers of genes carry similar numbers of lethal mutations...
  22. pmc Two classes of deleterious recessive alleles in a natural population of zebrafish, Danio rerio
    Amy R McCune
    Department of Ecology and Evolutionary Biology, Corson Hall, Cornell University, Ithaca, NY 14853, USA
    Proc Biol Sci 271:2025-33. 2004
    ....
  23. pmc Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogaster
    Cathy Haag-Liautard
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 6:e204. 2008
    ..Strand-asymmetric mutation bias, coupled with selection to maintain specific nonsynonymous bases, therefore provides an explanation for the extreme base composition of the mitochondrial genome of Drosophila...

Research Grants1

  1. Building, understanding and applying a dictionary of genetic effects
    DAVID contact HOULE; Fiscal Year: 2010
    ..These problems may be lessened if genomic data is combined with a comprehensive characterization of the phenotype and detailed knowledge of how genetic variation affects those phenotypes. ..