Research Topics
| DAVID contact HOULESummaryAffiliation: Florida State University Country: USA Publications
Research Grants
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Detail Information
Publications
Coevolution of costly mate choice and condition-dependent display of good genesDavid Houle
Department of Biological Science, Florida State University, Tallahassee, FL 32306 1100, USA
Proc Biol Sci 269:97-104. 2002..Preference readily evolves, often causing extreme exaggeration of the display. Mate choice and trait expression can approach an equilibrium, or a limit cycle, or exaggeration can proceed forever, eventually causing extinction...
Phenomics: the next challengeDavid Houle
Department of Biological Science, Florida State University, Tallahassee, 32306 4295, USA
Nat Rev Genet 11:855-66. 2010..Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping...- Colloquium papers: Numbering the hairs on our heads: the shared challenge and promise of phenomicsDavid Houle
Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
Proc Natl Acad Sci U S A 107:1793-9. 2010..Phenotypic data can be informative about the past history of selection and unexpectedly predictive of long-term evolution. Comprehensive efforts to increase the throughput and range of phenotyping are an urgent priority... 
A dispatch from the multivariate frontierD Houle
Department of Biological Science, Florida State University, Tallahassee, FL 32306-1100, USA
J Evol Biol 20:22-3; discussion 39-44. 2007- Measurement and meaning in biologyDavid Houle
Centre for Ecological and Evolutionary Synthesis, University of Oslo, 0316 Oslo, Norway
Q Rev Biol 86:3-34. 2011..The frequency of such violations reveals the importance of raising awareness of measurement theory among biologists... - Mutation accumulation and the effect of copia insertions in Drosophila melanogasterDavid Houle
Department of Biological Science, Florida State University, Tallahassee 32306 1100, USA
Genet Res 83:7-18. 2004..3% per generation. The element number of copia was a significant predictor of fitness within generations; on average, insertions caused a 0.76% loss in fitness, although the confidence limits on this estimate are wide... 
Automated measurement of Drosophila wingsDavid Houle
Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5 Canada
BMC Evol Biol 3:25. 2003..The wings of Drosophila species are a favorable target for automated analysis because of the many interesting questions in evolution and development that can be addressed with them, and because of their simple structure...- Natural selection in a bottleDavid Houle
Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
Am Nat 161:50-67. 2003..Ultimately, laboratory systems provide the best opportunity for the study of natural selection, genetic variation, and evolutionary response in the same population... - Interpretation of the results of common principal components analysesDavid Houle
Department of Zoology, University of Toronto, ON, Canada
Evolution 56:433-40. 2002..Reordering of vectors before analysis can aid in the detection of patterns. We urge caution in the biological interpretation of CPC analysis results... - Sexual selection accelerates the elimination of a deleterious mutant in Drosophila melanogasterBrian Hollis
Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
Evolution 63:324-33. 2009..In contrast to recent experiments employing monogamy/polygamy designs, our results demonstrate a fitness benefit to sexual selection. This is consistent with the operation of good-genes female choice... - Enzyme isoforms may increase phenotypic robustnessMaurizio Tomaiuolo
Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
Evolution 62:2884-93. 2008..Thus, we show that controlling isoform proportion can be a powerful mechanism for reducing the effects of variations in the values of system parameters, increasing system robustness... - Comparing G matrices: are common principal components informative?Jason G Mezey
Department of Biological Science, Florida State University, Tallahassee, Florida 32306 1100, USA
Genetics 165:411-25. 2003..The interpretation of common PCs identified for estimates of G matrices is discussed in light of these results... - Comparing strengths of directional selection: how strong is strong?Joe Hereford
Department of Biological Science, Florida State University, Tallahassee, Florida 32306 1100, USA
Evolution 58:2133-43. 2004.... - The dimensionality of genetic variation for wing shape in Drosophila melanogasterJason G Mezey
Department of Biological Science, Florida State University, Tallahassee, Florida 32306 1100, USA
Evolution 59:1027-38. 2005..We discuss the importance of this result for resolving the relative roles of selection and drift processes versus constraints in the evolution of wing shape in Drosophila... - A supermatrix-based molecular phylogeny of the family DrosophilidaeKim van der Linde
Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
Genet Res (Camb) 92:25-38. 2010..We argue that these results support a taxonomic revision of the genus Drosophila... - Consequences of hierarchical allocation for the evolution of life-history traitsAnne C Worley
Department of Botany, University of Toronto, Toronto, Ontario M5S 3B2, Canada
Am Nat 161:153-67. 2003..Thus, allocation hierarchies can profoundly affect life-history evolution by causing traits to evolve in the opposite direction to that predicted by trade-offs... - Sensory bias as an explanation for the evolution of mate preferencesRebecca C Fuller
Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
Am Nat 166:437-46. 2005..We suggest that the importance of sensory bias as an explanation for the evolution of female preferences remains to be determined... - A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafishAmy R McCune
Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
Science 296:2398-401. 2002..These results, together with data on several Drosophila species and on Xenopus laevis, show that phylogenetically distant animals with different genome sizes and numbers of genes carry similar numbers of lethal mutations... - A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expressionScott A Rifkin
Department of Ecology and Evolutionary Biology, Yale University, PO Box 208106, New Haven, Connecticut 06520-8106, USA
Nature 438:220-3. 2005..Although spontaneous mutations have the potential to generate abundant variation in gene expression, natural variation is relatively constrained... - Naturally segregating quantitative trait loci affecting wing shape of Drosophila melanogasterJason G Mezey
Center for Population Biology and Section of Evolution and Ecology, University of California, Davis, 95616, USA
Genetics 169:2101-13. 2005..Naturally segregating variation can therefore act through known signaling pathways to produce variation in vein position... - Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogasterCathy Haag-Liautard
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
PLoS Biol 6:e204. 2008..Strand-asymmetric mutation bias, coupled with selection to maintain specific nonsynonymous bases, therefore provides an explanation for the extreme base composition of the mitochondrial genome of Drosophila... - Two classes of deleterious recessive alleles in a natural population of zebrafish, Danio rerioAmy R McCune
Department of Ecology and Evolutionary Biology, Corson Hall, Cornell University, Ithaca, NY 14853, USA
Proc Biol Sci 271:2025-33. 2004....
Research Grants
- Building, understanding and applying a dictionary of genetic effectsDAVID contact HOULE; Fiscal Year: 2010..These problems may be lessened if genomic data is combined with a comprehensive characterization of the phenotype and detailed knowledge of how genetic variation affects those phenotypes. ..