A S Heiman

Summary

Affiliation: Florida A and M University
Country: USA

Publications

  1. ncbi request reprint Cytokines potentiate human eosinophil superoxide generation in the presence of N(omega)-nitro-L-arginine methyl ester
    A S Heiman
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Int J Immunopharmacol 22:171-81. 2000
  2. ncbi request reprint New steroidal anti-inflammatory antedrugs: methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and methyl 21-acetyloxy-3,20-dioxo-11 beta, 17 alpha-dihydroxy-9 alpha-fluoro-1,4-pregnadiene-16 alpha-carboxyl
    A S Heiman
    Center for Anti Inflammatory Research, Florida A and M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee 32307, USA
    Steroids 62:491-9. 1997
  3. ncbi request reprint Novel fluorinated antiinflammatory steroid with reduced side effects: methyl 9 alpha-fluoroprednisolone-16-carboxylate
    H M McLean
    Center for Anti Inflammatory Research, College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307
    J Pharm Sci 83:476-80. 1994
  4. ncbi request reprint Inhibition of CCL11, CCL24, and CCL26-induced degranulation in HL-60 eosinophilic cells by specific inhibitors of MEK1/MEK2, p38 MAP kinase, and PI 3-kinase
    A P Badewa
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, Florida 32307, USA
    Immunopharmacol Immunotoxicol 25:145-57. 2003
  5. ncbi request reprint Novel steroid spiro enones: condensation of prednisolone derivatives with diethyl oxalate
    Z You
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307, USA
    Steroids 65:109-15. 2000
  6. ncbi request reprint Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation
    B O Abonyo
    Florida A and M Univ, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, 32307, USA
    Am J Physiol Lung Cell Mol Physiol 289:L478-88. 2005
  7. ncbi request reprint The in vitro effects of Pb acetate on NO production by C6 glial cells
    M M Garber
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Toxicol In Vitro 16:499-508. 2002
  8. ncbi request reprint Regulatory effects of eotaxin, eotaxin-2, and eotaxin-3 on eosinophil degranulation and superoxide anion generation
    A P Badewa
    Florida A and M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, Florida 32307, USA
    Exp Biol Med (Maywood) 227:645-51. 2002
  9. ncbi request reprint New steroidal anti-inflammatory antedrugs: methyl 21-desoxy-21-chloro-11beta,17alpha-dihydroxy-3,20-dioxo-1, 4-pregnadiene-16alpha-carboxylate, methyl 21-desoxy-21-chloro-11beta-hydroxy-3,20-dioxo-1, 4-pregnadiene-16alpha-carboxylate, and their 9alpha-flu
    D Ko
    Center for Anti Inflammatory Research, Florida A and M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, FL, USA
    Steroids 65:210-8. 2000

Collaborators

  • A P Badewa
  • B O Abonyo
  • H J Lee
  • M M Garber
  • M Chen
  • Z You
  • D Ko
  • M S Alexander
  • C E Hudson
  • H M McLean
  • M A Khalil

Detail Information

Publications9

  1. ncbi request reprint Cytokines potentiate human eosinophil superoxide generation in the presence of N(omega)-nitro-L-arginine methyl ester
    A S Heiman
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Int J Immunopharmacol 22:171-81. 2000
    ..These results further suggest that at an inflammatory site or during an allergic response, EOS may concomitantly synthesize NO and generate superoxide anion, fractions of which may rapidly react to form the potent oxidant peroxynitrite...
  2. ncbi request reprint New steroidal anti-inflammatory antedrugs: methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and methyl 21-acetyloxy-3,20-dioxo-11 beta, 17 alpha-dihydroxy-9 alpha-fluoro-1,4-pregnadiene-16 alpha-carboxyl
    A S Heiman
    Center for Anti Inflammatory Research, Florida A and M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee 32307, USA
    Steroids 62:491-9. 1997
    ..These new antedrugs may be useful as anti-inflammatory steroids for local applications...
  3. ncbi request reprint Novel fluorinated antiinflammatory steroid with reduced side effects: methyl 9 alpha-fluoroprednisolone-16-carboxylate
    H M McLean
    Center for Anti Inflammatory Research, College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307
    J Pharm Sci 83:476-80. 1994
    ..This lack of adverse systemic effects is ostensibly due to the presence of the metabolically labile 16-carboxylate ester moiety...
  4. ncbi request reprint Inhibition of CCL11, CCL24, and CCL26-induced degranulation in HL-60 eosinophilic cells by specific inhibitors of MEK1/MEK2, p38 MAP kinase, and PI 3-kinase
    A P Badewa
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, Florida 32307, USA
    Immunopharmacol Immunotoxicol 25:145-57. 2003
    ..Thus, these signaling molecules may provide the biochemical basis for mechanism-based therapy of allergic inflammatory diseases...
  5. ncbi request reprint Novel steroid spiro enones: condensation of prednisolone derivatives with diethyl oxalate
    Z You
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307, USA
    Steroids 65:109-15. 2000
    ..Molecular modeling studies confirm that the spiro enones adopt a rigid planar geometry with the ester group in the plane...
  6. ncbi request reprint Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation
    B O Abonyo
    Florida A and M Univ, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, 32307, USA
    Am J Physiol Lung Cell Mol Physiol 289:L478-88. 2005
    ..This CCL26-CCR3 ligand-receptor system may be an attractive target for development of therapeutics that limits progress of inflammation in airway disease...
  7. ncbi request reprint The in vitro effects of Pb acetate on NO production by C6 glial cells
    M M Garber
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Toxicol In Vitro 16:499-508. 2002
    ....
  8. ncbi request reprint Regulatory effects of eotaxin, eotaxin-2, and eotaxin-3 on eosinophil degranulation and superoxide anion generation
    A P Badewa
    Florida A and M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, Florida 32307, USA
    Exp Biol Med (Maywood) 227:645-51. 2002
    ..Collectively, the present studies have advanced knowledge of the eotaxin family of chemokines to include eosinophil priming and modulation of eosinophil activation and secretion effector functions...
  9. ncbi request reprint New steroidal anti-inflammatory antedrugs: methyl 21-desoxy-21-chloro-11beta,17alpha-dihydroxy-3,20-dioxo-1, 4-pregnadiene-16alpha-carboxylate, methyl 21-desoxy-21-chloro-11beta-hydroxy-3,20-dioxo-1, 4-pregnadiene-16alpha-carboxylate, and their 9alpha-flu
    D Ko
    Center for Anti Inflammatory Research, Florida A and M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, FL, USA
    Steroids 65:210-8. 2000
    ....