MARC EDWARD FREEMAN

Summary

Affiliation: Florida State University
Country: USA

Publications

  1. ncbi request reprint Prolactin: structure, function, and regulation of secretion
    M E Freeman
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4340, USA
    Physiol Rev 80:1523-631. 2000
  2. pmc A-type K(+) current can act as a trigger for bursting in the absence of a slow variable
    Natalia Toporikova
    Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA
    Neural Comput 20:436-51. 2008
  3. ncbi request reprint Knockdown of clock genes in the suprachiasmatic nucleus blocks prolactin surges and alters FRA expression in the locus coeruleus of female rats
    Maristela O Poletini
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306 4340, USA
    Am J Physiol Endocrinol Metab 293:E1325-34. 2007
  4. pmc Oxytocin action at the lactotroph is required for prolactin surges in cervically stimulated ovariectomized rats
    De nise T McKee
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
    Endocrinology 148:4649-57. 2007
  5. pmc Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents
    Joel Tabak
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    J Comput Neurosci 22:211-22. 2007
  6. ncbi request reprint Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins
    Richard Bertram
    Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA
    Sci STKE 2006:er2. 2006
  7. pmc A mathematical model for the mating-induced prolactin rhythm of female rats
    Richard Bertram
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Am J Physiol Endocrinol Metab 290:E573-82. 2006
  8. pmc Prolactin secretory rhythm of mated rats induced by a single injection of oxytocin
    Marcel Egli
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Am J Physiol Endocrinol Metab 290:E566-72. 2006
  9. ncbi request reprint Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins
    Richard Bertram
    Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA
    Sci STKE 2006:pe4. 2006
  10. pmc Anatomical and functional characterization of clock gene expression in neuroendocrine dopaminergic neurons
    Michael T Sellix
    Department of Biological Science, Florida State Univ, Tallahassee, Florida, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1309-23. 2006

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Prolactin: structure, function, and regulation of secretion
    M E Freeman
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4340, USA
    Physiol Rev 80:1523-631. 2000
    ..It is the purpose of this review to provide a comprehensive survey of our current understanding of prolactin's function and its regulation and to expose some of the controversies still existing...
  2. pmc A-type K(+) current can act as a trigger for bursting in the absence of a slow variable
    Natalia Toporikova
    Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA
    Neural Comput 20:436-51. 2008
    ..To our knowledge, this is the first example of a physiologically based, single-compartmental model of bursting with no slow subsystem...
  3. ncbi request reprint Knockdown of clock genes in the suprachiasmatic nucleus blocks prolactin surges and alters FRA expression in the locus coeruleus of female rats
    Maristela O Poletini
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306 4340, USA
    Am J Physiol Endocrinol Metab 293:E1325-34. 2007
    ..SCN neurons therefore determine PRL secretory surges, possibly by modulating LC circadian neuronal activity...
  4. pmc Oxytocin action at the lactotroph is required for prolactin surges in cervically stimulated ovariectomized rats
    De nise T McKee
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
    Endocrinology 148:4649-57. 2007
    ....
  5. pmc Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents
    Joel Tabak
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    J Comput Neurosci 22:211-22. 2007
    ..Thus, the stimulatory effects of DA could be mediated by a fast K+ conductance which converts tonically spiking cells to bursters. In addition, the study illustrates that..
  6. ncbi request reprint Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins
    Richard Bertram
    Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA
    Sci STKE 2006:er2. 2006
    ..The initial effect is stimulatory, followed later by inhibition that persists long after the agonist has been removed. Recent research has uncovered several G protein pathways that mediate these effects...
  7. pmc A mathematical model for the mating-induced prolactin rhythm of female rats
    Richard Bertram
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Am J Physiol Endocrinol Metab 290:E573-82. 2006
    ..Finally, we consider potential targets for a rhythm-terminating factor and make predictions that may be used to determine which mechanism is operational in terminating the OT- or mating-induced PRL rhythm...
  8. pmc Prolactin secretory rhythm of mated rats induced by a single injection of oxytocin
    Marcel Egli
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Am J Physiol Endocrinol Metab 290:E566-72. 2006
    ..Mathematical modeling was used to illustrate the proposed network function. The experimental results further suggest an additional feedback mechanism in which certain hypothalamic OTergic neurons are influenced by PRL...
  9. ncbi request reprint Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins
    Richard Bertram
    Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA
    Sci STKE 2006:pe4. 2006
    ..The initial effect is stimulatory, followed later by inhibition that persists long after the agonist has been removed. Recent research has uncovered several G protein pathways that mediate these effects...
  10. pmc Anatomical and functional characterization of clock gene expression in neuroendocrine dopaminergic neurons
    Michael T Sellix
    Department of Biological Science, Florida State Univ, Tallahassee, Florida, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1309-23. 2006
    ..These data suggest that clock gene expression, particularly PER1 and PER2, within NDNs may act to modulate diurnal rhythms of DA release from NDNs in the OVX rat...
  11. ncbi request reprint Ovarian steroid hormones modulate circadian rhythms of neuroendocrine dopaminergic neuronal activity
    Michael T Sellix
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
    Brain Res 1005:164-81. 2004
    ..Therefore, ovarian steroids differentially adjust the timing and magnitude of NDN activity to facilitate coupling of DA release and PRL secretion...
  12. pmc Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin
    Marcel Egli
    Department of Biological Sciecne, Florida State University, Tallahassee, Florida 32306 4340, USA
    Endocrinology 145:3386-94. 2004
    ..This hypothesis is illustrated with a mathematical model...
  13. ncbi request reprint Newly proliferated cells in the adult male amygdala are affected by gonadal steroid hormones
    Christie D Fowler
    Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, Florida 32306, USA
    J Neurobiol 57:257-69. 2003
    ....
  14. ncbi request reprint Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycle
    Bela Kanyicska
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    Endocrine 20:53-8. 2003
    ..We propose that intensification of the endogenous endothelin- mediated negative feedback at estrus may play a role in restraining PRL secretion following the estradiol- induced proestrous PRL surge...
  15. ncbi request reprint Circadian rhythms of neuroendocrine dopaminergic neuronal activity in ovariectomized rats
    Michael T Sellix
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, Fla 32306 4340, USA
    Neuroendocrinology 77:59-70. 2003
    ....
  16. ncbi request reprint Antagonism of vasoactive intestinal peptide mRNA in the suprachiasmatic nucleus disrupts the rhythm of FRAs expression in neuroendocrine dopaminergic neurons
    Lynnette M Gerhold
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee 32306, USA
    J Comp Neurol 450:135-43. 2002
    ..These data suggest that VIP fibers from the SCN may relay time-of-day information to neuroendocrine dopaminergic neurons to inhibit their activity and, thus, initiate prolactin release in the evening...
  17. pmc Vasoactive intestinal polypeptide modulates the estradiol-induced prolactin surge by entraining oxytocin neuronal activity
    Jessica E Kennett
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Brain Res 1196:65-73. 2008
    ..Thus, the SCN influences the precise timing of the E(2)-induced PRL surge via VIP projections to oxytocinergic neurons of the PVN and PeVN...
  18. ncbi request reprint Species differences in anxiety-related responses in male prairie and meadow voles: the effects of social isolation
    Jennifer R Stowe
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
    Physiol Behav 86:369-78. 2005
    ..Together, these data indicate a neural circuit involved in mediating anxiety-associated behavior in voles, and that the functioning of this circuit is influenced by social environment differently between social and non-social species...

Research Grants31

  1. SECRETION OF PROLACTIN--REGULATION BY ENDOTHELIN
    MARC FREEMAN; Fiscal Year: 2004
    ..abstract_text> ..
  2. REGULATION OF PROLACTIN SECRETION AT THE LACTOTROPH
    MARC FREEMAN; Fiscal Year: 2003
    ..Results of these studies lead to a better understanding of the control of PRL secretion and hence treatment of states of infertility associated with hyperprolactinemia. ..
  3. REGULATION OF PROLACTIN SECRETION AT THE LACTOTROPH
    MARC FREEMAN; Fiscal Year: 2009
    ..Then, using antisense technology, their disruption will show function of the expressing neurons. The health relatedness of this project is to suggest new ways of treating diseases related to hyperprolactinemia and breast cancer. ..
  4. REGULATION OF PROLACTIN SECRETION AT THE LACTOTROPH
    JOEL TABAK SZNAJDER; Fiscal Year: 2010
    ..Moreover, prolactin has been implicated in disorders related to more than 300 of its other biological actions. Results from these studies may serve as an approach to treating these disorders. ..
  5. REGULATION OF PROLACTIN SECRETION AT THE LACTOTROPH
    MARC EDWARD FREEMAN; Fiscal Year: 2010
    ..Then, using antisense technology, their disruption will show function of the expressing neurons. The health relatedness of this project is to suggest new ways of treating diseases related to hyperprolactinemia and breast cancer. ..
  6. REGULATION OF PROLACTIN SECRETION AT THE LACTOTROPH
    MARC FREEMAN; Fiscal Year: 1993
    ..In addition, these studies may suggest strategies through which clinicians might wish to control prolactin secretion...
  7. REGULATION OF PROLACTIN SECRETION AT THE LACTOTROPH
    MARC FREEMAN; Fiscal Year: 1999
    ..Thorough knowledge of the control of PRL secretion will allow other approaches to its manipulation in disease states. ..
  8. REGULATION OF PROLACTIN SECRETION AT THE LACTOTROPH
    JOEL TABAK SZNAJDER; Fiscal Year: 2010
    ..Moreover, prolactin has been implicated in disorders related to more than 300 of its other biological actions. Results from these studies may serve as an approach to treating these disorders. ..