Research Topics
Genomes and GenesSpecies | JAMES FADOOLSummaryAffiliation: Florida State University Country: USA Publications
Research Grants
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Detail Information
Publications
Genetics of photoreceptor degeneration and regeneration in zebrafishSusan E Brockerhoff
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Cell Mol Life Sci 68:651-9. 2011..A model outlining the sequence of gene expression starting from the dedifferentiation of Müller glia to the formation of rod and cone precursors is presented...- Zebrafish: a model system for the study of eye geneticsJames M Fadool
Department of Biological Science, Graduate Program in Neuroscience, Florida State University, Tallahassee, FL 32312, USA
Prog Retin Eye Res 27:89-110. 2008.... 
Development of a rod photoreceptor mosaic revealed in transgenic zebrafishJames M Fadool
Department of Biological Science, The Florida State University, Tallahassee, FL 32306 4340, USA
Dev Biol 258:277-90. 2003..With the growing interest in neuronal stem cells, revisiting this model of neurogenesis provides an avenue to uncover mechanisms underlying the precise integration of new neuronal elements into a preexisting neural network...- Rod genesis in the teleost retina as a model of neural stem cellsJames M Fadool
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4340, USA
Exp Neurol 184:14-9. 2003 - Studying rod photoreceptor development in zebrafishA C Morris
Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
Physiol Behav 86:306-13. 2005..Finally, we present some alternative strategies to target the rod developmental pathway in zebrafish... - Genetic and environmental variation in the visual properties of bluefin killifish, Lucania goodeiR C Fuller
Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
J Evol Biol 18:516-23. 2005..Lighting conditions affected expression of all opsins except SWS2A and mimicked the pattern found among populations. These results highlight the fact that sensory systems are both plastic and yet readily evolvable traits... - Population variation in opsin expression in the bluefin killifish, Lucania goodei: a real-time PCR studyR C Fuller
Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 190:147-54. 2004..Understanding this system requires quantitative genetic studies. Real-time PCR is an effective tool for studies requiring inferences of visual physiology in large numbers of individuals... - Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafishAna C deCarvalho
Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4340, USA
Dev Dyn 229:869-76. 2004..The expression of brn-3b in the mechanosensory lateral line of fish suggests a conserved function of a class IV POU domain transcription factor in sensory system development... - Photoreceptor structure and development: analyses using GFP transgenesBrian D Perkins
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Methods Cell Biol 76:315-31. 2004 - Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamilyJudith D Ochrietor
Whitney Laboratory of the University of Florida, St Augustine, Florida 32080, USA
Invest Ophthalmol Vis Sci 44:4086-96. 2003..Previous reports indicate the presence of multiple 5A11/Basigin polypeptides within the retina. Therefore, in an effort to determine the function of 5A11/Basigin, the molecular diversity of its expression was evaluated... - Cone survival despite rod degeneration in XOPS-mCFP transgenic zebrafishAnn C Morris
Biomedical Research Facility, Department of Biological Science and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306, USA
Invest Ophthalmol Vis Sci 46:4762-71. 2005..In animal models of retinitis pigmentosa, rod photoreceptor degeneration eventually leads to loss of cone photoreceptors. The purpose of this study was to characterize a transgenic model of rod degeneration in zebrafish... - Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retinaAnn C Morris
Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
Dev Neurobiol 68:605-19. 2008..These two genetic models therefore offer new opportunities for investigating the molecular mechanisms of selective degeneration and regeneration of rods and cones... - Rod progenitor cells in the mature zebrafish retinaAnn C Morris
Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
Adv Exp Med Biol 613:361-8. 2008..This in turn may help to refine future approaches in higher vertebrates aimed at enhancing retinal progenitor cell activity for therapeutic purposes... - A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafishGeorge Stearns
Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Neurosci 27:13866-74. 2007..Our zebrafish mutant serves as a model for developing therapeutic treatments for photoreceptor degeneration in humans... - Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiationRonald G Gregg
Department of Biochemistry and Molecular Biology, University of Louisville, 319 Abraham Flexner Way, KY 40202, USA
Proc Natl Acad Sci U S A 100:6535-40. 2003..Lastly, through investigations of mutants in other chromatin remodeling subunits, we provide genetic evidence for gene and tissue specificity of the Brahma chromatin remodeling complex... - Expressed sequence tag analysis of zebrafish eye tissues for NEIBankThomas S Vihtelic
Center for Zebrafish Research, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Mol Vis 11:1083-100. 2005..To characterize gene expression patterns in various tissues of the zebrafish (Danio rerio) eye and identify zebrafish orthologs of human genes by expressed sequence tag (EST) analysis for NEIBank... - A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafishAmy R McCune
Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
Science 296:2398-401. 2002..These results, together with data on several Drosophila species and on Xenopus laevis, show that phylogenetically distant animals with different genome sizes and numbers of genes carry similar numbers of lethal mutations...
Research Grants
- Developing Models of Retinal and Eye DefectsJAMES FADOOL; Fiscal Year: 2007..Descriptions and images of the mutant phenotypes will be available at the PI's website and the Zebrafish Information Network and distribution will be handled through the Zebrafish International Resource Center. ..
- TRANSGENIC ANAYLSIS OF RETINAL DEVELOPMENTJAMES FADOOL; Fiscal Year: 2003..This feature of the enhancer trap is particularly significant because it should enable a fine-grained analysis of subtle abnormalities in retina that would otherwise escape detection. ..
- Developing Models of Retinal and Eye DefectsJames M Fadool; Fiscal Year: 2010..Descriptions and images of the mutant phenotypes will be available at the PI's website and the Zebrafish Information Network and distribution will be handled through the Zebrafish International Resource Center. ..