JAMES FADOOL

Summary

Affiliation: Florida State University
Country: USA

Publications

  1. pmc Genetics of photoreceptor degeneration and regeneration in zebrafish
    Susan E Brockerhoff
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell Mol Life Sci 68:651-9. 2011
  2. pmc Zebrafish: a model system for the study of eye genetics
    James M Fadool
    Department of Biological Science, Graduate Program in Neuroscience, Florida State University, Tallahassee, FL 32312, USA
    Prog Retin Eye Res 27:89-110. 2008
  3. ncbi request reprint Development of a rod photoreceptor mosaic revealed in transgenic zebrafish
    James M Fadool
    Department of Biological Science, The Florida State University, Tallahassee, FL 32306 4340, USA
    Dev Biol 258:277-90. 2003
  4. ncbi request reprint Rod genesis in the teleost retina as a model of neural stem cells
    James M Fadool
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    Exp Neurol 184:14-9. 2003
  5. pmc Studying rod photoreceptor development in zebrafish
    A C Morris
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    Physiol Behav 86:306-13. 2005
  6. ncbi request reprint Genetic and environmental variation in the visual properties of bluefin killifish, Lucania goodei
    R C Fuller
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    J Evol Biol 18:516-23. 2005
  7. ncbi request reprint Population variation in opsin expression in the bluefin killifish, Lucania goodei: a real-time PCR study
    R C Fuller
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 190:147-54. 2004
  8. ncbi request reprint Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish
    Ana C deCarvalho
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4340, USA
    Dev Dyn 229:869-76. 2004
  9. ncbi request reprint Photoreceptor structure and development: analyses using GFP transgenes
    Brian D Perkins
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Methods Cell Biol 76:315-31. 2004
  10. ncbi request reprint Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily
    Judith D Ochrietor
    Whitney Laboratory of the University of Florida, St Augustine, Florida 32080, USA
    Invest Ophthalmol Vis Sci 44:4086-96. 2003

Research Grants

  1. Developing Models of Retinal and Eye Defects
    JAMES FADOOL; Fiscal Year: 2007
  2. TRANSGENIC ANAYLSIS OF RETINAL DEVELOPMENT
    JAMES FADOOL; Fiscal Year: 2003
  3. Developing Models of Retinal and Eye Defects
    James M Fadool; Fiscal Year: 2010

Detail Information

Publications17

  1. pmc Genetics of photoreceptor degeneration and regeneration in zebrafish
    Susan E Brockerhoff
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell Mol Life Sci 68:651-9. 2011
    ..A model outlining the sequence of gene expression starting from the dedifferentiation of Müller glia to the formation of rod and cone precursors is presented...
  2. pmc Zebrafish: a model system for the study of eye genetics
    James M Fadool
    Department of Biological Science, Graduate Program in Neuroscience, Florida State University, Tallahassee, FL 32312, USA
    Prog Retin Eye Res 27:89-110. 2008
    ....
  3. ncbi request reprint Development of a rod photoreceptor mosaic revealed in transgenic zebrafish
    James M Fadool
    Department of Biological Science, The Florida State University, Tallahassee, FL 32306 4340, USA
    Dev Biol 258:277-90. 2003
    ..With the growing interest in neuronal stem cells, revisiting this model of neurogenesis provides an avenue to uncover mechanisms underlying the precise integration of new neuronal elements into a preexisting neural network...
  4. ncbi request reprint Rod genesis in the teleost retina as a model of neural stem cells
    James M Fadool
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    Exp Neurol 184:14-9. 2003
  5. pmc Studying rod photoreceptor development in zebrafish
    A C Morris
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    Physiol Behav 86:306-13. 2005
    ..Finally, we present some alternative strategies to target the rod developmental pathway in zebrafish...
  6. ncbi request reprint Genetic and environmental variation in the visual properties of bluefin killifish, Lucania goodei
    R C Fuller
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    J Evol Biol 18:516-23. 2005
    ..Lighting conditions affected expression of all opsins except SWS2A and mimicked the pattern found among populations. These results highlight the fact that sensory systems are both plastic and yet readily evolvable traits...
  7. ncbi request reprint Population variation in opsin expression in the bluefin killifish, Lucania goodei: a real-time PCR study
    R C Fuller
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 190:147-54. 2004
    ..Understanding this system requires quantitative genetic studies. Real-time PCR is an effective tool for studies requiring inferences of visual physiology in large numbers of individuals...
  8. ncbi request reprint Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish
    Ana C deCarvalho
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4340, USA
    Dev Dyn 229:869-76. 2004
    ..The expression of brn-3b in the mechanosensory lateral line of fish suggests a conserved function of a class IV POU domain transcription factor in sensory system development...
  9. ncbi request reprint Photoreceptor structure and development: analyses using GFP transgenes
    Brian D Perkins
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Methods Cell Biol 76:315-31. 2004
  10. ncbi request reprint Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily
    Judith D Ochrietor
    Whitney Laboratory of the University of Florida, St Augustine, Florida 32080, USA
    Invest Ophthalmol Vis Sci 44:4086-96. 2003
    ..Previous reports indicate the presence of multiple 5A11/Basigin polypeptides within the retina. Therefore, in an effort to determine the function of 5A11/Basigin, the molecular diversity of its expression was evaluated...
  11. pmc Cone survival despite rod degeneration in XOPS-mCFP transgenic zebrafish
    Ann C Morris
    Biomedical Research Facility, Department of Biological Science and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306, USA
    Invest Ophthalmol Vis Sci 46:4762-71. 2005
    ..In animal models of retinitis pigmentosa, rod photoreceptor degeneration eventually leads to loss of cone photoreceptors. The purpose of this study was to characterize a transgenic model of rod degeneration in zebrafish...
  12. pmc Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina
    Ann C Morris
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Dev Neurobiol 68:605-19. 2008
    ..These two genetic models therefore offer new opportunities for investigating the molecular mechanisms of selective degeneration and regeneration of rods and cones...
  13. pmc Rod progenitor cells in the mature zebrafish retina
    Ann C Morris
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Adv Exp Med Biol 613:361-8. 2008
    ..This in turn may help to refine future approaches in higher vertebrates aimed at enhancing retinal progenitor cell activity for therapeutic purposes...
  14. ncbi request reprint A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish
    George Stearns
    Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 27:13866-74. 2007
    ..Our zebrafish mutant serves as a model for developing therapeutic treatments for photoreceptor degeneration in humans...
  15. pmc Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation
    Ronald G Gregg
    Department of Biochemistry and Molecular Biology, University of Louisville, 319 Abraham Flexner Way, KY 40202, USA
    Proc Natl Acad Sci U S A 100:6535-40. 2003
    ..Lastly, through investigations of mutants in other chromatin remodeling subunits, we provide genetic evidence for gene and tissue specificity of the Brahma chromatin remodeling complex...
  16. ncbi request reprint Expressed sequence tag analysis of zebrafish eye tissues for NEIBank
    Thomas S Vihtelic
    Center for Zebrafish Research, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Mol Vis 11:1083-100. 2005
    ..To characterize gene expression patterns in various tissues of the zebrafish (Danio rerio) eye and identify zebrafish orthologs of human genes by expressed sequence tag (EST) analysis for NEIBank...
  17. ncbi request reprint A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafish
    Amy R McCune
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
    Science 296:2398-401. 2002
    ..These results, together with data on several Drosophila species and on Xenopus laevis, show that phylogenetically distant animals with different genome sizes and numbers of genes carry similar numbers of lethal mutations...

Research Grants10

  1. Developing Models of Retinal and Eye Defects
    JAMES FADOOL; Fiscal Year: 2007
    ..Descriptions and images of the mutant phenotypes will be available at the PI's website and the Zebrafish Information Network and distribution will be handled through the Zebrafish International Resource Center. ..
  2. TRANSGENIC ANAYLSIS OF RETINAL DEVELOPMENT
    JAMES FADOOL; Fiscal Year: 2003
    ..This feature of the enhancer trap is particularly significant because it should enable a fine-grained analysis of subtle abnormalities in retina that would otherwise escape detection. ..
  3. Developing Models of Retinal and Eye Defects
    James M Fadool; Fiscal Year: 2010
    ..Descriptions and images of the mutant phenotypes will be available at the PI's website and the Zebrafish Information Network and distribution will be handled through the Zebrafish International Resource Center. ..