Wu Min Deng

Summary

Affiliation: Florida State University
Country: USA

Publications

  1. Sun J, Smith L, Armento A, Deng W. Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling. J Cell Biol. 2008;182:885-96 pubmed publisher
  2. Xie G, Chen H, Jia D, Shu Z, Palmer W, Huang Y, et al. The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues. Cancer Res. 2017;77:862-873 pubmed publisher
    ..i>Cancer Res; 77(4); 862-73. ©2017 AACR. ..
  3. Tamori Y, Deng W. Compensatory cellular hypertrophy: the other strategy for tissue homeostasis. Trends Cell Biol. 2014;24:230-7 pubmed publisher
    ..Here we highlight these findings and discuss the underlying mechanisms of CCH, which is likely an evolutionarily conserved strategy for homeostatic tissue growth in metazoans. ..
  4. Lo P, Huang Y, Corcoran D, Jiao R, Deng W. Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation. J Cell Sci. 2019;132: pubmed publisher
    ..In conclusion, our studies suggest CAF1 plays a dual role to sustain cell proliferation by positively or negatively regulating Drosophila Notch signaling in a tissue-context-dependent manner. ..
  5. Palmer W, Deng W. Ligand-Independent Mechanisms of Notch Activity. Trends Cell Biol. 2015;25:697-707 pubmed publisher
    ..In this review, we summarize genes implicated in ligand-independent Notch activity and remark on the mechanisms by which this process could occur. ..
  6. Shu Z, Row S, Deng W. Endoreplication: The Good, the Bad, and the Ugly. Trends Cell Biol. 2018;28:465-474 pubmed publisher
    ..In this Review, we discuss mechanisms of endoreplication and polyploidization, their essential and positive roles in normal development and tissue homeostasis, and the relationship between polyploidy and cancer. ..
  7. Yang S, Deng W. Serrate/Notch Signaling Regulates the Size of the Progenitor Cell Pool in Drosophila Imaginal Rings. Genetics. 2018;209:829-843 pubmed publisher
  8. Huang Y, Moreno H, Row S, Jia D, Deng W. Germline silencing of UASt depends on the piRNA pathway. J Genet Genomics. 2018;: pubmed publisher
    ..Taken together, our studies reveal a crucial role of the piRNA pathway, potentially via the suppression of the hsp70 promoter, in germline UASt silencing in Drosophila ovaries. ..
  9. Jia D, Bryant J, Jevitt A, Calvin G, Deng W. The Ecdysone and Notch Pathways Synergistically Regulate Cut at the Dorsal-Ventral Boundary in Drosophila Wing Discs. J Genet Genomics. 2016;43:179-86 pubmed publisher
    ..Additionally, we show br promotes Delta, a Notch ligand, near the DV boundary to suppress aberrant high Notch activity, indicating further interaction between the two pathways for DV patterning of the wing disc. ..

More Information

Publications14

  1. Shu Z, Deng W. Differential Regulation of Cyclin E by Yorkie-Scalloped Signaling in Organ Development. G3 (Bethesda). 2017;7:1049-1060 pubmed publisher
  2. Yatsenko A, Kucherenko M, Pantoja M, Fischer K, Madeoy J, Deng W, et al. The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function. BMC Dev Biol. 2009;9:18 pubmed publisher
  3. Tamori Y, Deng W. Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis. Trends Cancer. 2017;3:259-268 pubmed publisher
  4. Jia D, Tamori Y, Pyrowolakis G, Deng W. Regulation of broad by the Notch pathway affects timing of follicle cell development. Dev Biol. 2014;392:52-61 pubmed publisher
    ..Our findings suggest an important role of br in the timing of follicle cell development, and its transcriptional regulation by the Notch pathway. ..
  5. Lo P, Huang Y, Poulton J, Leake N, Palmer W, Vera D, et al. RNA helicase Belle/DDX3 regulates transgene expression in Drosophila. Dev Biol. 2016;412:57-70 pubmed publisher