David Brunell

Summary

Affiliation: Florida Atlantic University
Country: USA

Publications

  1. pmc A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A
    David Brunell
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida, USA
    Assay Drug Dev Technol 8:615-20. 2010
  2. ncbi request reprint Selenocompounds can serve as oxidoreductants with the methionine sulfoxide reductase enzymes
    Daphna Sagher
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida 33431, USA
    J Biol Chem 281:31184-7. 2006
  3. pmc Studies on the metabolism and biological activity of the epimers of sulindac
    David Brunell
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, John D MacArthur Campus, Jupiter, FL 33458, USA
    Drug Metab Dispos 39:1014-21. 2011
  4. pmc Thionein can serve as a reducing agent for the methionine sulfoxide reductases
    Daphna Sagher
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, FL 33431, USA
    Proc Natl Acad Sci U S A 103:8656-61. 2006

Collaborators

Detail Information

Publications4

  1. pmc A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A
    David Brunell
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida, USA
    Assay Drug Dev Technol 8:615-20. 2010
    ..A specific activator of MsrA could have important therapeutic value for diseases that involve oxidative damage, especially age-related diseases, whereas a specific inhibitor of MsrA would have value for a variety of research studies...
  2. ncbi request reprint Selenocompounds can serve as oxidoreductants with the methionine sulfoxide reductase enzymes
    Daphna Sagher
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida 33431, USA
    J Biol Chem 281:31184-7. 2006
    ..In the present study, we provide evidence that some selenium compounds are potent reducing agents for both hMsrB2 and hMsrB3...
  3. pmc Studies on the metabolism and biological activity of the epimers of sulindac
    David Brunell
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, John D MacArthur Campus, Jupiter, FL 33458, USA
    Drug Metab Dispos 39:1014-21. 2011
    ..Both epimers can protect normal lung cells against oxidative damage and enhance the killing of lung cancer cells exposed to oxidative stress...
  4. pmc Thionein can serve as a reducing agent for the methionine sulfoxide reductases
    Daphna Sagher
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, FL 33431, USA
    Proc Natl Acad Sci U S A 103:8656-61. 2006
    ..The results indicate that thionein (T), which is formed when the zinc is removed from Zn-MT, can function as a reducing system for the Msr proteins because of its high content of cysteine residues and that Trx can reduce oxidized T...