Irina Agoulnik

Summary

Affiliation: Herbert Wertheim College of Medicine
Location: Miami, USA

Publications

  1. pmc Sequence of general transcription factor TFIIB and relationships to other initiation factors
    S Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 88:9553-7. 1991
  2. pmc Androgen receptor footprint on the way to prostate cancer progression
    Myles C Hodgson
    Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
    World J Urol 30:279-85. 2012
  3. pmc Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
    Myles C Hodgson
    Florida International University, Miami, Florida 33199, USA
    Cancer Res 71:572-82. 2011
  4. pmc Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 22:2420-32. 2008
  5. doi Androgen receptor coactivators and prostate cancer
    Irina U Agoulnik
    Dept of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Adv Exp Med Biol 617:245-55. 2008
  6. ncbi Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 66:10594-602. 2006
  7. ncbi Androgen receptor action in hormone-dependent and recurrent prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 99:362-72. 2006
  8. ncbi Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7959-67. 2005
  9. ncbi Androgen receptor signaling and vitamin D receptor action in prostate cancer cells
    Shalini Murthy
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030, USA
    Prostate 64:362-72. 2005
  10. ncbi A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 89:6340-7. 2004

Collaborators

Detail Information

Publications14

  1. pmc Sequence of general transcription factor TFIIB and relationships to other initiation factors
    S Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 88:9553-7. 1991
    ..These findings argue for a common origin of TFIIB, TFIID, and other general transcription factors and for the evolutionary segregation of complementary functions...
  2. pmc Androgen receptor footprint on the way to prostate cancer progression
    Myles C Hodgson
    Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
    World J Urol 30:279-85. 2012
    ..may drive the development of castration-resistant disease and therefore the question remains: Does effective inhibition of AR activity mark the end of the road for PCa or only a sharp turn toward a different type of malignancy?..
  3. pmc Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
    Myles C Hodgson
    Florida International University, Miami, Florida 33199, USA
    Cancer Res 71:572-82. 2011
    ..Our findings reinforce the concept that patients undergoing androgen ablation may benefit from Akt-targeting therapies...
  4. pmc Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 22:2420-32. 2008
    ..Thus, treatments that reduce p42/p44 MAPK activity in prostate cancer have the potential to reduce AR activity through a reduction in expression levels as well as by target gene-selective inhibition of AR function...
  5. doi Androgen receptor coactivators and prostate cancer
    Irina U Agoulnik
    Dept of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Adv Exp Med Biol 617:245-55. 2008
  6. ncbi Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 66:10594-602. 2006
    ..The elevated expression of TIF2 at low hormone levels likely aids in inducing AR activity under these conditions; treatment with Casodex has the potential to counteract this induction...
  7. ncbi Androgen receptor action in hormone-dependent and recurrent prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 99:362-72. 2006
    ..These pathways are, therefore, potential therapeutic targets...
  8. ncbi Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7959-67. 2005
    ....
  9. ncbi Androgen receptor signaling and vitamin D receptor action in prostate cancer cells
    Shalini Murthy
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030, USA
    Prostate 64:362-72. 2005
    ..Because androgen ablation therapy is used for metastatic prostate cancer, we sought to better characterize this androgen dependence...
  10. ncbi A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 89:6340-7. 2004
    ..This is of special interest, because only a few genetic markers are available for the majority of women diagnosed with sporadic ovarian cancer...
  11. ncbi Repressors of androgen and progesterone receptor action
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:31136-48. 2003
    ..We found that although DAX-1 is expressed in normal human prostate, its expression is strongly reduced in benign prostatic hyperplasia suggesting that DAX-1 plays a role in limiting AR activity in prostate...
  12. ncbi A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity
    Alaina J James
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Endocrinol 16:2692-705. 2002
    ..Consistent with this conclusion, our structural model predicts that A748T disrupts crucial contact points with ligand, thereby altering the conformation of the ligand-binding domain...
  13. ncbi A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse
    C E Bishop
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 26:490-4. 2000
    ..Our data are consistent with Sox9 being a direct downstream target of Sry and provide genetic evidence to support a general repressor model of sex determination in mammals...
  14. pmc Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice
    Myles C Hodgson
    Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America
    PLoS ONE 8:e60455. 2013
    ..Erbb3 mRNA levels were significantly elevated in tumors in comparison to normal mammary glands. Thus the loss of AR in mouse mammary epithelium accelerates malignant transformation rather than the rate of tumorigenesis...