FRED DOUGLASS FINKELMAN

Summary

Country: USA

Publications

  1. ncbi Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Immunol Rev 201:139-55. 2004
  2. ncbi Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cells
    Fred D Finkelman
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 172:3808-13. 2004
  3. ncbi Molecular mechanisms of anaphylaxis: lessons from studies with murine models
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Ohio 45267 0563, USA
    J Allergy Clin Immunol 115:449-57; quiz 458. 2005
  4. ncbi Suppressive effect of IL-4 on IL-13-induced genes in mouse lung
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 174:4630-8. 2005
  5. ncbi Anaphylaxis: lessons from mouse models
    Fred D Finkelman
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Ohio, USA
    J Allergy Clin Immunol 120:506-15; quiz 516-7. 2007
  6. pmc Basophils initiate IL-4 production during a memory T-dependent response
    Marat V Khodoun
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Exp Med 200:857-70. 2004
  7. pmc Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection
    De Broski R Herbert
    Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Exp Med 206:2947-57. 2009
  8. pmc Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
    Charles Perkins
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Exp Med 208:853-67. 2011
  9. pmc MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice
    Richard T Strait
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 208:2525-44. 2011
  10. pmc Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis
    Muthuvel Arumugam
    Division of Biochemistry, National Institute of Siddha, Chennai, India
    BMC Immunol 12:14. 2011

Research Grants

  1. Role of Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2006
  2. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
  3. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2003
  4. Regulation of CD8+ T Cell Homeostatis by IL-4
    Fred Finkelman; Fiscal Year: 2009
  5. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2004
  6. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2005
  7. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2006
  8. IgG Isotype Regulation of Antibody-Mediated Disorders
    Fred Finkelman; Fiscal Year: 2009
  9. Regulation of CD8+ T Cell Homeostatis by IL-4
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
  10. IgG Isotype Regulation of Antibody-Mediated Disorders
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications51

  1. ncbi Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Immunol Rev 201:139-55. 2004
    ....
  2. ncbi Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cells
    Fred D Finkelman
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 172:3808-13. 2004
    ....
  3. ncbi Molecular mechanisms of anaphylaxis: lessons from studies with murine models
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Ohio 45267 0563, USA
    J Allergy Clin Immunol 115:449-57; quiz 458. 2005
    ..As a result, IL-4 receptor alpha chain antagonists might be particularly effective suppressors of anaphylaxis...
  4. ncbi Suppressive effect of IL-4 on IL-13-induced genes in mouse lung
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 174:4630-8. 2005
    ..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma...
  5. ncbi Anaphylaxis: lessons from mouse models
    Fred D Finkelman
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Ohio, USA
    J Allergy Clin Immunol 120:506-15; quiz 516-7. 2007
    ....
  6. pmc Basophils initiate IL-4 production during a memory T-dependent response
    Marat V Khodoun
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Exp Med 200:857-70. 2004
    ....
  7. pmc Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection
    De Broski R Herbert
    Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Exp Med 206:2947-57. 2009
    ....
  8. pmc Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
    Charles Perkins
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Exp Med 208:853-67. 2011
    ..These observations demonstrate that IL-4Rα promotes AHR through multiple mechanisms and provide a model for testing smooth muscle-directed asthma therapeutics...
  9. pmc MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice
    Richard T Strait
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 208:2525-44. 2011
    ..These observations have important implications for the prevention and treatment of TRALI...
  10. pmc Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis
    Muthuvel Arumugam
    Division of Biochemistry, National Institute of Siddha, Chennai, India
    BMC Immunol 12:14. 2011
    ..v infusion were assessed. Bone marrow mast cell (BMMC)s were examined for FcεRI, c-kit, degranulation efficiency, proliferation, apoptosis and cytokine profile...
  11. pmc Peanut allergy and anaphylaxis
    Fred D Finkelman
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, United States
    Curr Opin Immunol 22:783-8. 2010
    ....
  12. doi Key advances in mechanisms of asthma, allergy, and immunology in 2009
    Fred D Finkelman
    Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 125:312-8. 2010
    ..Critical features of these studies and their potential effect on human atopic disorders are summarized here...
  13. pmc Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung
    Christina C Lewis
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:795-804.e8. 2009
    ..Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive...
  14. ncbi Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45257, USA
    J Immunol 173:7565-74. 2004
    ..Collectively, we demonstrate that allergen-induced inflammation involves coordinate regulation by STAT1, STAT6, and IFN-gamma...
  15. ncbi IL-4 exacerbates anaphylaxis
    Richard T Strait
    Division of Emergency Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 170:3835-42. 2003
    ..Synergy between IL-4 and vasoactive mediators during the effector phase of allergic inflammation may both contribute to allergic immunopathology and enhance protective immunity against gastrointestinal worms...
  16. pmc Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis
    Ram Raj Singh
    University of Cincinnati College of Medicine, Department of Internal Medicine, Veterans Affairs Medical Center and Children s Medical Center, Cincinnati, OH 45220, USA
    J Immunol 170:4818-25. 2003
    ..Thus, STAT6 and IL-4 may selectively contribute to the development of glomerulosclerosis, whereas STAT4 may play a role in autoantibody production...
  17. ncbi Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses
    Marat Khodoun
    Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 179:6429-38. 2007
    ....
  18. pmc Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:53-8. 2009
    ..Intestinal anaphylaxis (manifested by acute diarrhea) is dependent on IgE and mast cells...
  19. ncbi Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
    ..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology...
  20. pmc Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation
    Suzanne C Morris
    Research Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 182:1429-38. 2009
    ..Thus, endogenously produced IL-4 is an important regulator of quantitative as well as qualitative aspects of T cell immunity...
  21. ncbi IL-4 induces IL-13-independent allergic airway inflammation
    Charles Perkins
    Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Allergy Clin Immunol 118:410-9. 2006
    ..The nonredundant role of IL-13 could reflect unique IL-13 activation of a signaling pathway, inhibitory effects induced by IL-4 but not IL-13, or greater production-potency of IL-13 than IL-4...
  22. ncbi Cytokine enhancement of anaphylaxis
    Richard Strait
    Division of Emergency Medicine, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Novartis Found Symp 257:80-91; discussion 91-100, 276-85. 2004
    ..Inhibitors of IL4 and IL13 may ameliorate allergy by rapidly blocking the sensitizing effects of these cytokines on the effector phase of the allergic response, as well as by more slowly blocking the induction phase of this response...
  23. pmc Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
    Rajat Madan
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Immunol 183:2312-20. 2009
    ....
  24. pmc IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway
    Li Zuo
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 185:660-9. 2010
    ..Notably, we identified a pathway that induces EE-like changes and is IL-13-driven, eosinophil-independent, and suppressed by IL-13Ralpha2...
  25. pmc IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking
    Richard T Strait
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 116:833-41. 2006
    ....
  26. pmc Peanuts can contribute to anaphylactic shock by activating complement
    Marat Khodoun
    Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 123:342-51. 2009
    ..Resistance to digestion and dendritic cell activation by the major peanut allergen Ara h 1 are reported to contribute to its allergenicity...
  27. pmc Importance of cytokines in murine allergic airway disease and human asthma
    Fred D Finkelman
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 184:1663-74. 2010
    ..Results of these analyses establish the importance of specific cytokines in MAAD and human asthma and have therapeutic implications...
  28. pmc Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum
    Lucy A Gildea
    Division of Immunology, Cincinnati Veterans Affairs Medical Center, and University of Cincinnati College of Medicine, Ohio, USA
    Infect Immun 71:3787-93. 2003
    ..capsulatum by delaying clearance of the organism but does not prevent the generation of a Th1 response that ultimately controls infection...
  29. ncbi IL-4 induces in vivo production of IFN-gamma by NK and NKT cells
    Suzanne C Morris
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 176:5299-305. 2006
    ..This explains how IL-4 can contribute to Th1 cytokine-associated immune effector functions and suggests how IL-13 can have stronger proallergic effects than IL-4...
  30. ncbi Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses
    Hiroko Saito Akei
    Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:62-9. 2006
    ..The skin is often the first organ that manifests allergic disease and may provide an early entry point for antigen sensitization...
  31. ncbi Foxa2 regulates alveolarization and goblet cell hyperplasia
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 131:953-64. 2004
    ..FOXA2 is required for alveolarization and regulates airway epithelial cell differentiation in the postnatal lung...
  32. pmc Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway disease
    Erin E West
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Respir Cell Mol Biol 34:108-18. 2006
    ....
  33. pmc Mast cells are required for experimental oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 112:1666-77. 2003
    ..These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent...
  34. ncbi In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea
    Alison L Woo
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267 0524, USA
    J Biol Chem 277:49036-46. 2002
    ....
  35. ncbi IL-4 promotes Stat6-dependent survival of autoreactive B cells in vivo without inducing autoantibody production
    Suzanne C Morris
    Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 169:1696-704. 2002
    ....
  36. pmc STAT5 is critical to maintain effector CD8+ T cell responses
    Pulak Tripathi
    Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 185:2116-24. 2010
    ..Finally, IL-7 and IL-15 required STAT5 to induce Bcl-2 expression and to maintain effector CD8(+) T cells. Together, these data demonstrate that IL-7 and IL-15 signaling converge on STAT5 to maintain effector CD8(+) T cell responses...
  37. pmc Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism
    Katherine R Groschwitz
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:22381-6. 2009
    ..Collectively, these findings identify a mechanism by which mast cells regulate homeostatic intestinal epithelial migration and barrier function...
  38. doi Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis
    Heather Osterfeld
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 125:469-476.e2. 2010
    ..The cytokine IL-9 has been implicated in allergic reactions, including food allergy, but its contribution to parenteral versus oral antigen-induced anaphylaxis remains unclear...
  39. ncbi Cutting edge: mechanism of enhancement of in vivo cytokine effects by anti-cytokine monoclonal antibodies
    James D Phelan
    Immunobiology Graduate Program, University of Cincinnati College of Medicine, and Division of Immunobiology, Children s Hospital Medical Research Foundation, Cincinnati, OH 45267, USA
    J Immunol 180:44-8. 2008
    ..Thus, agonist effects observed with high doses of anti-IL-2 mAb are most likely only applicable for mAbs that maintain cytokine half-life without blocking binding to receptor signaling components...
  40. ncbi Prolonged culture of vaccine-primed lymphocytes results in decreased antitumor killing and change in cytokine secretion
    Jeffrey J Sussman
    Department of Surgery, Division of Surgical Oncology, University of Cincinnati, Cincinnati, Ohio, USA
    Cancer Res 64:9124-30. 2004
    ..The T-cell cytokine secretion pattern predicts decreased effector cell function and may explain the decreased antitumor effect...
  41. ncbi Induction of autoantibody production is limited in nonautoimmune mice
    Ram Raj Singh
    Department of Internal Medicine, University of Cincinnati College of Medicine and Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 169:587-94. 2002
    ..The induction of such inhibitory T cells may play a role in protecting nonautoimmune mice from developing chronic autoimmunity...
  42. pmc IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice
    Weiguo Chen
    Division of Asthma Research, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 183:7870-6. 2009
    ..These observations require consideration when results of murine IL-13 studies are applied to humans...
  43. ncbi Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen
    Kris A Steinbrecher
    Divisions of Gastroenterology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cancer Res 70:2634-43. 2010
    ....
  44. ncbi Pathways of anaphylaxis in the mouse
    Richard T Strait
    Division of Emergency Medicine, Children s Hospital Medical Center, Cincinnati, USA
    J Allergy Clin Immunol 109:658-68. 2002
    ....
  45. doi Untangling the complex web of IL-4- and IL-13-mediated signaling pathways
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Sci Signal 1:pe55. 2008
    ..A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects...
  46. pmc Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis
    Sara Wojciechowski
    Division of Immunobiology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Exp Med 204:1665-75. 2007
    ..Collectively, these data demonstrate a critical role for a balance between Bim and Bcl-2 in controlling homeostasis of naive and memory T cells...
  47. ncbi Advances in asthma, allergy mechanisms, and genetics in 2006
    Fred D Finkelman
    Division of Immunology, University of Cincinnati, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 120:544-50. 2007
    ....
  48. pmc IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis
    De Broski R Herbert
    Research Service 151, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Immunol 181:7214-20. 2008
    ..mansoni infection by two distinct, organ-specific mechanisms: TGF-beta and IL-10 redundantly suppress hepatic inflammation while intestinal inflammation is regulated by alternatively activated macrophages...
  49. pmc IL-4R alpha expression by bone marrow-derived cells is necessary and sufficient for host protection against acute schistosomiasis
    De Broski R Herbert
    Research Service 151, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Immunol 180:4948-55. 2008
    ....
  50. pmc Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis
    De Broski R Herbert
    Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Immunol 184:6438-46. 2010
    ..Thus, macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 production and maintaining the Treg/Th17 balance within the intestinal mucosa...
  51. pmc Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung
    Marc E Rothenberg
    Division of Allergy and Immunology, Cincinnati Children s Hospital and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 103:14895-900. 2006
    ..This process was accompanied by an increase in the number of memory T cells. Thus, our data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses...

Research Grants39

  1. Role of Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2006
    ..abstract_text> ..
  2. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ..Proposed studies with a mouse model in which airway hyperresponsiveness is induced solely by direct IL-4 and IL-13 effects on smooth muscle should help to elucidate these mechanisms and may reveal new approaches for asthma therapy. ..
  3. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2003
    ....
  4. Regulation of CD8+ T Cell Homeostatis by IL-4
    Fred Finkelman; Fiscal Year: 2009
    ....
  5. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2004
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  6. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2005
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  7. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2006
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  8. IgG Isotype Regulation of Antibody-Mediated Disorders
    Fred Finkelman; Fiscal Year: 2009
    ....
  9. Regulation of CD8+ T Cell Homeostatis by IL-4
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ....
  10. IgG Isotype Regulation of Antibody-Mediated Disorders
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ....
  11. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2003
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  12. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2000
    ..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
  13. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2001
    ..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
  14. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2001
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  15. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2000
    ....
  16. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 1999
    ..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
  17. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2000
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  18. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 1999
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  19. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 1999
    ....
  20. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2002
    ....
  21. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    Fred Finkelman; Fiscal Year: 2009
    ..Proposed studies with a mouse model in which airway hyperresponsiveness is induced solely by direct IL-4 and IL-13 effects on smooth muscle should help to elucidate these mechanisms and may reveal new approaches for asthma therapy. ..
  22. IgG Isotype Regulation of Antibody-Mediated Disorders
    Fred Finkelman; Fiscal Year: 2007
    ....
  23. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2007
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  24. Role of Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2007
    ..abstract_text> ..
  25. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  26. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2002
    ..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
  27. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2003
    ..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
  28. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2001
    ....
  29. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2005
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  30. Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2003
    ....