Research Topics
Species | FRED DOUGLASS FINKELMANSummaryCountry: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasitesFred D Finkelman
Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Immunol Rev 201:139-55. 2004....- Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cellsFred D Finkelman
Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 172:3808-13. 2004.... - Molecular mechanisms of anaphylaxis: lessons from studies with murine modelsFred D Finkelman
Division of Immunology, University of Cincinnati College of Medicine, Ohio 45267 0563, USA
J Allergy Clin Immunol 115:449-57; quiz 458. 2005..As a result, IL-4 receptor alpha chain antagonists might be particularly effective suppressors of anaphylaxis... - Suppressive effect of IL-4 on IL-13-induced genes in mouse lungFred D Finkelman
Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 174:4630-8. 2005..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma... - Anaphylaxis: lessons from mouse modelsFred D Finkelman
Department of Medicine, Cincinnati Veterans Affairs Medical Center, Ohio, USA
J Allergy Clin Immunol 120:506-15; quiz 516-7. 2007.... 
Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxisMuthuvel Arumugam
Division of Biochemistry, National Institute of Siddha, Chennai, India
BMC Immunol 12:14. 2011..v infusion were assessed. Bone marrow mast cell (BMMC)s were examined for FcεRI, c-kit, degranulation efficiency, proliferation, apoptosis and cytokine profile...- Peanut allergy and anaphylaxisFred D Finkelman
Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, United States
Curr Opin Immunol 22:783-8. 2010.... 
Key advances in mechanisms of asthma, allergy, and immunology in 2009Fred D Finkelman
Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA
J Allergy Clin Immunol 125:312-8. 2010..Critical features of these studies and their potential effect on human atopic disorders are summarized here...- Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritisRam Raj Singh
University of Cincinnati College of Medicine, Department of Internal Medicine, Veterans Affairs Medical Center and Children s Medical Center, Cincinnati, OH 45220, USA
J Immunol 170:4818-25. 2003..Thus, STAT6 and IL-4 may selectively contribute to the development of glomerulosclerosis, whereas STAT4 may play a role in autoantibody production... - IL-4 exacerbates anaphylaxisRichard T Strait
Division of Emergency Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 170:3835-42. 2003..Synergy between IL-4 and vasoactive mediators during the effector phase of allergic inflammation may both contribute to allergic immunopathology and enhance protective immunity against gastrointestinal worms... - Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gammaPatricia C Fulkerson
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45257, USA
J Immunol 173:7565-74. 2004..Collectively, we demonstrate that allergen-induced inflammation involves coordinate regulation by STAT1, STAT6, and IFN-gamma... - Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lungChristina C Lewis
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 123:795-804.e8. 2009..Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive... - Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responsesMarat Khodoun
Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Immunol 179:6429-38. 2007.... - Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrheaEric B Brandt
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 123:53-8. 2009..Intestinal anaphylaxis (manifested by acute diarrhea) is dependent on IgE and mast cells... - Expression and regulation of small proline-rich protein 2 in allergic inflammationNives Zimmermann
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 32:428-35. 2005..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology... - Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferationSuzanne C Morris
Research Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Immunol 182:1429-38. 2009..Thus, endogenously produced IL-4 is an important regulator of quantitative as well as qualitative aspects of T cell immunity... - IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathwayLi Zuo
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 185:660-9. 2010..Notably, we identified a pathway that induces EE-like changes and is IL-13-driven, eosinophil-independent, and suppressed by IL-13Ralpha2... - IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linkingRichard T Strait
Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Clin Invest 116:833-41. 2006.... - Cytokine enhancement of anaphylaxisRichard Strait
Division of Emergency Medicine, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Novartis Found Symp 257:80-91; discussion 91-100, 276-85. 2004..Inhibitors of IL4 and IL13 may ameliorate allergy by rapidly blocking the sensitizing effects of these cytokines on the effector phase of the allergic response, as well as by more slowly blocking the induction phase of this response... - Nonredundant roles for B cell-derived IL-10 in immune counter-regulationRajat Madan
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Immunol 183:2312-20. 2009.... - IL-4 induces IL-13-independent allergic airway inflammationCharles Perkins
Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
J Allergy Clin Immunol 118:410-9. 2006..The nonredundant role of IL-13 could reflect unique IL-13 activation of a signaling pathway, inhibitory effects induced by IL-4 but not IL-13, or greater production-potency of IL-13 than IL-4... - Importance of cytokines in murine allergic airway disease and human asthmaFred D Finkelman
Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Immunol 184:1663-74. 2010..Results of these analyses establish the importance of specific cytokines in MAAD and human asthma and have therapeutic implications... - Peanuts can contribute to anaphylactic shock by activating complementMarat Khodoun
Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Allergy Clin Immunol 123:342-51. 2009..Resistance to digestion and dendritic cell activation by the major peanut allergen Ara h 1 are reported to contribute to its allergenicity... - Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responsesHiroko Saito Akei
Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 118:62-9. 2006..These results draw attention to the cooperative interaction between the nasal tract and skin. CLINICAL IMPLICATIONS: The skin is a potent site for antigen sensitization in the development of experimental allergic rhinitis... - IL-4 induces in vivo production of IFN-gamma by NK and NKT cellsSuzanne C Morris
Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 176:5299-305. 2006..This explains how IL-4 can contribute to Th1 cytokine-associated immune effector functions and suggests how IL-13 can have stronger proallergic effects than IL-4... - Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatumLucy A Gildea
Division of Immunology, Cincinnati Veterans Affairs Medical Center, and University of Cincinnati College of Medicine, Ohio, USA
Infect Immun 71:3787-93. 2003..capsulatum by delaying clearance of the organism but does not prevent the generation of a Th1 response that ultimately controls infection... - Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway diseaseErin E West
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Am J Respir Cell Mol Biol 34:108-18. 2006.... - IL-4 promotes Stat6-dependent survival of autoreactive B cells in vivo without inducing autoantibody productionSuzanne C Morris
Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Immunol 169:1696-704. 2002.... - In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrheaAlison L Woo
Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267 0524, USA
J Biol Chem 277:49036-46. 2002.... - Mast cells are required for experimental oral allergen-induced diarrheaEric B Brandt
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
J Clin Invest 112:1666-77. 2003..These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent... - Foxa2 regulates alveolarization and goblet cell hyperplasiaHuajing Wan
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Development 131:953-64. 2004..FOXA2 is required for alveolarization and regulates airway epithelial cell differentiation in the postnatal lung... - Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxisHeather Osterfeld
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 125:469-476.e2. 2010..The cytokine IL-9 has been implicated in allergic reactions, including food allergy, but its contribution to parenteral versus oral antigen-induced anaphylaxis remains unclear... - Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanismKatherine R Groschwitz
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 106:22381-6. 2009..Collectively, these findings identify a mechanism by which mast cells regulate homeostatic intestinal epithelial migration and barrier function... - STAT5 is critical to maintain effector CD8+ T cell responsesPulak Tripathi
Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 185:2116-24. 2010..Finally, IL-7 and IL-15 required STAT5 to induce Bcl-2 expression and to maintain effector CD8(+) T cells. Together, these data demonstrate that IL-7 and IL-15 signaling converge on STAT5 to maintain effector CD8(+) T cell responses... - Cutting edge: mechanism of enhancement of in vivo cytokine effects by anti-cytokine monoclonal antibodiesJames D Phelan
Immunobiology Graduate Program, University of Cincinnati College of Medicine, and Division of Immunobiology, Children s Hospital Medical Research Foundation, Cincinnati, OH 45267, USA
J Immunol 180:44-8. 2008..Thus, agonist effects observed with high doses of anti-IL-2 mAb are most likely only applicable for mAbs that maintain cytokine half-life without blocking binding to receptor signaling components... - Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infectionDe Broski R Herbert
Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
J Exp Med 206:2947-57. 2009.... - IL-13R alpha 2 membrane and soluble isoforms differ in humans and miceWeiguo Chen
Division of Asthma Research, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol 183:7870-6. 2009..These observations require consideration when results of murine IL-13 studies are applied to humans... - Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogenKris A Steinbrecher
Divisions of Gastroenterology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Cancer Res 70:2634-43. 2010.... - Induction of autoantibody production is limited in nonautoimmune miceRam Raj Singh
Department of Internal Medicine, University of Cincinnati College of Medicine and Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Immunol 169:587-94. 2002..The induction of such inhibitory T cells may play a role in protecting nonautoimmune mice from developing chronic autoimmunity... - Basophils initiate IL-4 production during a memory T-dependent responseMarat V Khodoun
Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Exp Med 200:857-70. 2004.... - Prolonged culture of vaccine-primed lymphocytes results in decreased antitumor killing and change in cytokine secretionJeffrey J Sussman
Department of Surgery, Division of Surgical Oncology, University of Cincinnati, Cincinnati, Ohio, USA
Cancer Res 64:9124-30. 2004..The T-cell cytokine secretion pattern predicts decreased effector cell function and may explain the decreased antitumor effect... - Pathways of anaphylaxis in the mouseRichard T Strait
Division of Emergency Medicine, Children's Hospital Medical Center, Cincinnati, USA
J Allergy Clin Immunol 109:658-68. 2002..The presence of FcgammaRIII on human macrophages makes it possible that the IgG, FcgammaRIII, macrophage, and PAF pathway also contributes to human anaphylaxis... 
Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasisSara Wojciechowski
Division of Immunobiology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
J Exp Med 204:1665-75. 2007..Collectively, these data demonstrate a critical role for a balance between Bim and Bcl-2 in controlling homeostasis of naive and memory T cells...- Advances in asthma, allergy mechanisms, and genetics in 2006Fred D Finkelman
Division of Immunology, University of Cincinnati, Cincinnati, Ohio, USA
J Allergy Clin Immunol 120:544-50. 2007.... - Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasisDe Broski R Herbert
Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
J Immunol 184:6438-46. 2010..Thus, macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 production and maintaining the Treg/Th17 balance within the intestinal mucosa... - IL-4R alpha expression by bone marrow-derived cells is necessary and sufficient for host protection against acute schistosomiasisDe Broski R Herbert
Research Service 151, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
J Immunol 180:4948-55. 2008.... - IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasisDe Broski R Herbert
Research Service 151, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
J Immunol 181:7214-20. 2008..mansoni infection by two distinct, organ-specific mechanisms: TGF-beta and IL-10 redundantly suppress hepatic inflammation while intestinal inflammation is regulated by alternatively activated macrophages... - Untangling the complex web of IL-4- and IL-13-mediated signaling pathwaysMarsha Wills-Karp
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Sci Signal 1:pe55. 2008..A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects... - Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lungMarc E Rothenberg
Division of Allergy and Immunology, Cincinnati Children s Hospital and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Proc Natl Acad Sci U S A 103:14895-900. 2006..This process was accompanied by an increase in the number of memory T cells. Thus, our data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses...
Research Grants
- Role of Inflammatory Cytokines in the Allergic ResponseFred Finkelman; Fiscal Year: 2006..abstract_text> ..
- Role of Inflammatory Cytokines in the Allergic ResponseFred Finkelman; Fiscal Year: 2007..abstract_text> ..
- Cellular targets of IL-4 and IL-13 in worm expulsionFred Finkelman; Fiscal Year: 2007..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
- IgG Isotype Regulation of Antibody-Mediated DisordersFred Finkelman; Fiscal Year: 2007....
- Regulation of CD8+ T Cell Homeostatis by IL-4Fred Finkelman; Fiscal Year: 2009....
- Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway diseaFred Finkelman; Fiscal Year: 2009..Proposed studies with a mouse model in which airway hyperresponsiveness is induced solely by direct IL-4 and IL-13 effects on smooth muscle should help to elucidate these mechanisms and may reveal new approaches for asthma therapy. ..
- Regulation of CD8+ T Cell Homeostatis by IL-4FRED DOUGLASS FINKELMAN; Fiscal Year: 2010....
- IgG Isotype Regulation of Antibody-Mediated DisordersFRED DOUGLASS FINKELMAN; Fiscal Year: 2010....
- Inflammatory Cytokines in the Allergic ResponseFred Finkelman; Fiscal Year: 2003....
- CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMAFred Finkelman; Fiscal Year: 2003..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
- REGULATION OF IL4 PRODUCTION IN VIVOFred Finkelman; Fiscal Year: 2002..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
- IL4R AND IMMUNITY TO GI NEMATODE PARASITESFred Finkelman; Fiscal Year: 2003....
- Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway diseaFRED DOUGLASS FINKELMAN; Fiscal Year: 2010..Proposed studies with a mouse model in which airway hyperresponsiveness is induced solely by direct IL-4 and IL-13 effects on smooth muscle should help to elucidate these mechanisms and may reveal new approaches for asthma therapy. ..