Research Topics
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Publications
Maintenance of heartburn relief after step-down from twice-daily proton pump inhibitor to once-daily dexlansoprazole modified releaseRonnie Fass
Section of Gastroenterology, Southern Arizona VA Healthcare System, Tucson, Arizona 85723, USA
Clin Gastroenterol Hepatol 10:247-53. 2012..We investigated whether step-down to once-daily dexlansoprazole controls heartburn in patients with GERD who were receiving twice-daily PPI therapy...
Clinical and economic assessment of the omeprazole test in patients with symptoms suggestive of gastroesophageal reflux diseaseR Fass
Department of Medicine, Tucson Veterans Affairs Medical Center and Arizona Health Sciences Center, 85723, USA
Arch Intern Med 159:2161-8. 1999..To evaluate the diagnostic accuracy of a trial of a high-dose proton pump inhibitor (the omeprazole test) in detecting gastroesophageal reflux disease (GERD) in patients with heartburn symptoms...
Gastroesophageal reflux disease revisitedRonnie Fass
Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System 1 111G 1, University of Arizona Health Sciences Center, Tucson, AZ, USA
Gastroenterol Clin North Am 31:S1-10. 2002..This new paradigm will shift our focus to mechanisms leading to symptom generation in each group and foster specific therapeutic modalities that benefit each individual group of patients...
Functional heartburn: misdiagnosed gastroesophageal reflux or a distinct entity?Ronnie Fass
Neuro Enteric Clinical Research Group at Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
Nat Clin Pract Gastroenterol Hepatol 2:120-1. 2005
Sensory testing of the esophagusRonnie Fass
Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona 85723, USA
J Clin Gastroenterol 38:628-41. 2004..This is primarily due to lack of recognition of factors that can modulate esophageal sensation...
Symptom assessment tools for gastroesophageal reflux disease (GERD) treatmentRonnie Fass
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
J Clin Gastroenterol 41:437-44. 2007..Thus far, 14 instruments have been developed to assess GERD symptoms and potentially can be used to evaluate treatment response during a therapeutic trial in GERD patients. However, comparison of the different evaluative tools is needed...
Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease--where next?R Fass
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona, School of Medicine, Tucson, AZ, USA
Aliment Pharmacol Ther 22:79-94. 2005..Treatment relies primarily on escalating dosing of proton-pump inhibitors. However, new insights into the pathophysiology of proton-pump inhibitor failure are likely to provide alternative therapeutic options...
The effect of dexlansoprazole MR on nocturnal heartburn and GERD-related sleep disturbances in patients with symptomatic GERDRonnie Fass
Southern Arizona VA Health Care System, Section of Gastroenterology 111G 1, Tucson, Arizona 85723, USA
Am J Gastroenterol 106:421-31. 2011..This study evaluated the efficacy of dexlansoprazole MR 30 mg in relieving nocturnal heartburn and GERD-related sleep disturbances, improving work productivity, and decreasing nocturnal symptom severity in patients with symptomatic GERD...
Predictors of heartburn during sleep in a large prospective cohort studyRonnie Fass
Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
Chest 127:1658-66. 2005..The aim of this study was to determine the clinical predictors of heartburn during sleep in a large prospective cohort study...
Non-cardiac chest pain: an updateR Fass
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, AZ 85723 0001, USA
Neurogastroenterol Motil 18:408-17. 2006..The main therapeutic interventions in GORD-related NCCP patients are potent antireflux modalities and pain modulators in those with non-GORD-related NCCP...
Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristicsRonnie Fass
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
J Clin Gastroenterol 41:131-7. 2007..Additionally, NERD patients demonstrate a longer lag-time for symptom resolution and lack of difference in symptom response rate between half to full dose proton pump inhibitor as compared with patients with erosive esophagitis...
Review article: supra-oesophageal manifestations of gastro-oesophageal reflux disease and the role of night-time gastro-oesophageal refluxR Fass
Section of Gastroenterology, Southern Arizona VA Healthcare System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
Aliment Pharmacol Ther 20:26-38. 2004..In this article we review the relationship between supra-oesophageal symptoms and GERD and, where possible, highlight the evidence supporting the role of night-time reflux as a contributing factor to these symptoms...
Treatment of gastroesophageal reflux diseaseRonnie Fass
Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson 85723, USA
Clin Cornerstone 5:18-29; discussion 30-1. 2003..In addition, the recent introduction of various endoscopic techniques offers GERD patients a long-term solution with less morbidity and lower cost than antireflux surgery...
Distinct phenotypic presentations of gastroesophageal reflux disease: a new view of the natural historyRonnie Fass
Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Ariz, USA
Dig Dis 22:100-7. 2004..Additionally, it supports the usage of on-demand or intermittent antireflux treatment in clinical practice and provides better understanding of one of the most important clinical dilemmas - proton pump inhibitor failure...
Functional heartburn: the stimulus, the pain, and the brainR Fass
Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723, USA
Gut 51:885-92. 2002..Current and future treatment strategies for functional heartburn patients who have failed standard dose proton pump inhibitors (PPIs) include increased PPI dose in some, as well as addition of pain modulators in others...
Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trialRonnie Fass
The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723 0001, USA
Clin Gastroenterol Hepatol 4:50-6. 2006....
Introduction: the evolving role of 24-h oesophageal pH monitoringR Fass
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA
Aliment Pharmacol Ther 23:1-2. 2006
Correlation of oesophageal acid exposure with Barrett's oesophagus lengthR Fass
Section of Gastroenterology, Department of Medicine and Health Services Research Center, Southern Arizona VA Health Care, 3601 S 6th Avenue 111G1, Tucson, AZ 85723, USA
Gut 48:310-3. 2001..Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient...
Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-oesophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy-a prospective, randomized, multi-ceR Fass
Section of Gastroenterology, Department of Medicine, Tucson VA Medical Center, Tucson, Arizona, USA
Aliment Pharmacol Ther 14:1595-603. 2000..Most of the comparative studies have assessed the effect of the two proton pump inhibitors (PPIs) on gastric acid secretion or gastric pH. Few studies have compared clinical end-points such as oesophageal healing and symptom control...
Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastro-oesophageal refluxR Fass
Section of Gastroenterology, Department of Medicine, Tucson VA Medical Center and Arizona Health Sciences Center, 85723, USA
Age Ageing 29:125-30. 2000..elderly patients appear to have a more aggressive form of gastro-oesophageal reflux disease than younger patients. Reduced pain perception with age is a possible underlying mechanism...
Empirical trials in treatment of gastroesophageal reflux diseaseR Fass
Department of Medicine, Section of Gastroenterology, Southern Arizona V A Halth Care System and University of Arizona Health Sciences Center, Tucson, AZ 85273, USA
Dig Dis 18:20-6. 2000..Thus the PPI empirical trial should be considered as the initial diagnostic step in patients with the disease spectrum of GERD...
Extension of squamous epithelium into the proximal stomach: a newly recognized mucosal abnormalityR Fass
Arizona Health Sciences Center, Department of Internal Medicine, Tucson, USA
Endoscopy 32:27-32. 2000..We report the documentation, over a period of 9 months, of squamous epithelium extending beyond the esophagogastric junction and into the proximal stomach in 16 patients who underwent upper endoscopy...
The pathophysiological mechanisms of GERD in the obese patientRonnie Fass
Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona School of Medicine, 3601 S 6th Avenue, Tucson, AZ 85723 0001, USA
Dig Dis Sci 53:2300-6. 2008..Whilst the current efforts are to focus on one major underlying mechanism, it is highly likely that multiple factors contribute to the increased prevalence of GERD in the obese patient...
The effect of antireflux treatment on patients with gastroesophageal reflux disease undergoing a mental arithmetic stressorC H Poh
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
Neurogastroenterol Motil 23:e489-96. 2011..The aim of the study was to determine if antireflux treatment can still alter stimulus response functions to acid in patients undergoing acute stress as compared with placebo...
Increased oesophageal acid exposure at the beginning of the recumbent period is primarily a recumbent-awake phenomenonL Allen
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
Aliment Pharmacol Ther 32:787-94. 2010..A significant increase in oesophageal acid exposure during early recumbent period has been demonstrated...
The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groupsM Shapiro
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA
Aliment Pharmacol Ther 23:321-9. 2006....
The omeprazole test is as sensitive as 24-h oesophageal pH monitoring in diagnosing gastro-oesophageal reflux disease in symptomatic patients with erosive oesophagitisR Fass
Section of Gastroenterology, Tucson VA Medical Center and Arizona Health Sciences Center, 85723
Aliment Pharmacol Ther 14:389-96. 2000..However, comparative studies of the diagnostic accuracy and reliability of both strategies have not been performed...
Correlation of gastroesophageal reflux disease symptoms characteristics with long-segment Barrett's esophagusR Dickman
The Neuro-Enteric Clinical Research Group, Tucson, AZ, USA
Dis Esophagus 19:360-5. 2006..Reports of severe or very severe dysphagia were more common in long-segment Barrett's esophagus patients. Only longer duration of chest pain was correlated with longer lengths of Barrett's esophagus...
Feasibility and tolerability of transnasal/per-oral placement of the wireless pH capsule vs. traditional 24-h oesophageal pH monitoring--a randomized trialW-M Wong
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
Aliment Pharmacol Ther 21:155-63. 2005..001, P = 0.003, P = 0.025, respectively), and had overall satisfaction with the test (P = 0.023). CONCLUSIONS: Transnasal/per-oral placement of the wireless pH capsule is significantly better tolerated then the traditional pH probe...
Clinical trial: the effect of Johrei on symptoms of patients with functional chest painA Gasiorowska
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ, USA
Aliment Pharmacol Ther 29:126-34. 2009..Patients with functional chest pain (FCP) represent a therapeutic challenge for practising physicians...
Preferential repair by squamous epithelium of thermal induced injury to the proximal stomach in patients undergoing ablation of Barrett's esophagusR Fass
Department of Medicine, Sections of Gastroenterology and Oncology/Hematology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723, USA
Gastrointest Endosc 53:711-6. 2001..Recognition of this lesion is essential because it may lead to confusion as to the location of the esophagogastric junction in subsequent endoscopic evaluations...
The effect of a therapeutic trial of high-dose rabeprazole on symptom response of patients with non-cardiac chest pain: a randomized, double-blind, placebo-controlled, crossover trialR Dickman
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723, USA
Aliment Pharmacol Ther 22:547-55. 2005..CONCLUSIONS: A rabeprazole therapeutic trial is highly sensitive and specific for diagnosing gastro-oesophageal reflux disease-related non-cardiac chest pain patients...
Riser's reflux--an eye-opening experienceC H Poh
Department of Medicine, Southern Arizona VA Health Care System, University Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
Neurogastroenterol Motil 22:387-94. 2010..The aim of the study was to compare the prevalence and frequency of acid reflux events prior to and immediately after awakening from sleep in the morning between GORD patients and normal subjects...
Systematic review: the treatment of noncardiac chest painT Hershcovici
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
Aliment Pharmacol Ther 35:5-14. 2012..This is in part due to the heterogeneous nature of this disorder. Several conditions are associated with NCCP including gastro-oesophageal reflux disease (GERD), oesophageal dysmotility, oesophageal hypersensitivity as well as others...
Systematic review: the relationship between interstitial lung diseases and gastro-oesophageal reflux diseaseT Hershcovici
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, USA
Aliment Pharmacol Ther 34:1295-305. 2011..There may be an association between lung and oesophageal involvement in systemic sclerosis and mixed connective tissue disease, but a causal relationship cannot be established...
The effect of esomeprazole 20 mg twice daily on acoustic and perception parameters of the voice in laryngopharyngeal refluxR Fass
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
Neurogastroenterol Motil 22:134-41, e44-5. 2010..We compared the effect of esomeprazole 20 mg twice daily (b.i.d.) vs placebo on voice and acoustic-related measures in patients with LPR...
Non-erosive reflux disease (NERD)--acid reflux and symptom patternsS D Martinez
Department of Medicine, Section of Gastroenterology and Hematology/Oncology, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, AZ 85723, USA
Aliment Pharmacol Ther 17:537-45. 2003..CONCLUSIONS: Patients with NERD commonly demonstrate a negative pH test. Acid reflux characteristics and symptom patterns suggest a heterogeneous group of patients...
The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain--a randomized, double-blind, placebo-controlled, crossover trialJ Bautista
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S. 6th Avenue, Tucson, AZ 85723, USA
Aliment Pharmacol Ther 19:1123-30. 2004..The trial enables diagnosing most of the responders within the first 2 days and thus a shorter duration of therapy may be considered in a subset of non-cardiac chest pain patients...
Nonerosive reflux disease--current concepts and dilemmasR Fass
Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, USA
Am J Gastroenterol 96:303-14. 2001..Treatment with acid inhibitory agents is effective, and proton pump inhibitors are the most effective form of therapy...
Duodenal fat intensifies the perception of heartburnJ H Meyer
Department of Medicine, Division of Gastroenterology, West Los Angeles Healthcare Center, VA Greater Los Angeles Healthcare System, UCLA School of Medicine, Los Angeles, CA, USA
Gut 49:624-8. 2001..01) shorter, and intensity and severity of heartburn significantly (p<0.05) greater, during duodenal perfusion with fat. CONCLUSION: We conclude that duodenal fat intensifies the perception of heartburn...
Comparisons of the distribution of oesophageal acid exposure throughout the sleep period among the different gastro-oesophageal reflux disease groupsR Dickman
The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ, USA
Aliment Pharmacol Ther 26:41-8. 2007..Nocturnal gastro-oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra-oesophageal complications...
Management of heartburn not responding to proton pump inhibitorsR Fass
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
Gut 58:295-309. 2009..Failure of such a therapeutic strategy may result in the addition of a transient lower oesophageal sphincter reducer or pain modulator. Anti-reflux surgery may be suitable for a subset of carefully studied patients...
Assessment of dietary nutrients that influence perception of intra-oesophageal acid reflux events in patients with gastro-oesophageal reflux diseaseM Shapiro
Department of Medicine, Section of Gastroenterology, The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, AZ 85723 0001, USA
Aliment Pharmacol Ther 25:93-101. 2007..Gastro-oesophageal reflux disease symptoms are most commonly reported postprandially, suggesting that some diet components are likely to induce symptoms more than others...
Assessment of 24-h oesophageal pH monitoring should be divided to awake and asleep rather than upright and supine time periodsR Dickman
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, GI Section, Tucson, AZ 85723 0001, USA
Neurogastroenterol Motil 19:709-15. 2007..3 +/- 6.9, 1.86 +/- 2.7 and 0.01 +/- 0.05, P < 0.0001, respectively). The principal characteristics of the acid-reflux events in the supine-awake period are closer to the upright period than to the supine-asleep period...
Short segment Barrett's esophagus: relationship of age with extent of intestinal metaplasiaP Benipal
Department of Medicine, Southern Arizona Veterans Affairs Health Care System and University of Arizona Health Science Center, Tucson 85723, USA
Am J Gastroenterol 96:3084-8. 2001..Finding that SSBE length does not change across the various age groups and during a 64-month mean follow-up, suggests that SSBE does not progress over time...
Night-time intra-oesophageal bile and acid: a comparison between gastro-oesophageal reflux disease patients who failed and those who were treated successfully with a proton pump inhibitorT Hershcovici
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, 3601 South Sixth Avenue 1 111 GI, Tucson, AZ 85723 0001, USA
Aliment Pharmacol Ther 33:837-44. 2011..Little is known about the contribution of bile and acid reflux to night-time symptoms generation in patients who failed PPI treatment...
Noncardiac chest painRam Dickman
Neuro-Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723, USA
Clin Gastroenterol Hepatol 4:558-63. 2006
Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acidMichael Shapiro
The Neuro-Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723-0001, USA
Am J Gastroenterol 101:1084-91. 2006..This suggests that while FH patients harbor clinical traits of a functional bowel disorder, hypersensitivity to acid is not a general phenomenon...
Reassessment of the principal characteristics of gastroesophageal reflux during the recumbent period using integrated actigraphy-acquired informationChoo Hean Poh
Department of Medicine, Section of Gastroenterology, Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona, Tucson, Arizona 85723 0001, USA
Am J Gastroenterol 105:1024-31. 2010....
Assessment of oesophageal motor function in patients with dysphagia or chest pain - the Clinical Outcomes Research Initiative experienceR Dekel
Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA
Aliment Pharmacol Ther 18:1083-9. 2003....
Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburnR Dickman
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ, USA
Aliment Pharmacol Ther 26:1333-44. 2007..Aims To determine the efficacy of adding acupuncture vs. doubling the proton pump inhibitor dose in gastro-oesophageal reflux disease patients who failed symptomatically on proton pump inhibitors once daily...
The value of ambulatory 24 hr esophageal pH monitoring in clinical practice in patients who were referred with persistent gastroesophageal reflux disease (GERD)-related symptoms while on standard dose anti-reflux medicationsJimmy M Bautista
Department of Medicine, The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, University of Arizona College of Medicine, Tucson, Arizona 85723-0001, USA
Dig Dis Sci 50:1909-15. 2005..05). Most patients who continued to be symptomatic on proton pump inhibitor once daily demonstrated a normal pH test and overall lack of increased chemoreceptor sensitivity to acid...
Clinical predictors of Barrett's esophagus lengthRam Dickman
The Neuro-Enteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723-0001, USA
Gastrointest Endosc 62:675-81. 2005..05) were correlated with a shorter segment of BE. CONCLUSIONS: PPIs were correlated with shorter lengths of BE. In contrast, a longer hiatal hernia, any dysplasia, nonsmoking, or use of H2-RAs were correlated with a longer BE segment...
Prevalence of upper gastrointestinal tract findings in patients with noncardiac chest pain versus those with gastroesophageal reflux disease (GERD)-related symptoms: results from a national endoscopic databaseRam Dickman
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
Am J Gastroenterol 102:1173-9. 2007..Available data on the prevalence of esophageal and upper gut findings in patients with noncardiac chest pain (NCCP) are scarce and limited to one center's experience...
Barrett's oesophagus: optimal strategies for prevention and treatmentRonnie Fass
Department of Internal Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723, USA
Drugs 63:555-64. 2003..Future developments in understanding the biology of Barrett's oesophagus and in therapeutic interventions will provide an opportunity for more effective screening, surveillance and prevention of neoplastic progression...
Esophageal acid exposure at pH < or = 2 is more common in Barrett's esophagus patients and is associated with oxidative stressK Dvorak
Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
Dis Esophagus 19:366-72. 2006..In vitro studies using brief pH 2 exposure are biologically relevant to the clinical situation. Our studies indicate that such exposure induces oxidative stress. This stress may cause DNA damage, mutations and progression to cancer...
Systematic review: the effects of carbonated beverages on gastro-oesophageal reflux diseaseT Johnson
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, AZ, USA
Aliment Pharmacol Ther 31:607-14. 2010..Cessation of carbonated beverage consumption is commonly recommended as part of lifestyle modifications for patients with GERD...
Clinical trial: maintenance intermittent therapy with rabeprazole 20 mg in patients with symptomatic gastro-oesophageal reflux disease - a double-blind, placebo-controlled, randomized studyR Fass
Department of Medicine, Southern Arizona Health Care System and University of Arizona School of Medicine, Tucson, AZ, USA
Aliment Pharmacol Ther 31:950-60. 2010..Optimal long-term management of symptomatic gastro-oesophageal reflux disease (sGERD) patients has not been established...
Pharmacokinetic comparison of orally-disintegrating metoclopramide with conventional metoclopramide tablet formulation in healthy volunteersR Fass
University of Arizona Health Science Center, Tucson, AZ, USA
Aliment Pharmacol Ther 30:301-6. 2009..Because of this, a metoclopramide orally-disintegrating tablet (ODT) has been developed...
A predictive model for length of Barrett's esophagus with hiatal hernia length and duration of esophageal acid exposureDonald E Wakelin
Department of Medicine, Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Tucson 85723-0001, USA
Gastrointest Endosc 58:350-5. 2003..A predictive model for Barrett's length by using hiatal hernia length and duration of esophageal acid exposure was developed. This suggested that these two pathophysiologic factors are good predictors of the length of Barrett's mucosa...
Persistent heartburn in a patient on proton-pump inhibitorRonnie Fass
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona 85723-0001, USA
Clin Gastroenterol Hepatol 6:393-400. 2008
Proton-pump inhibitor therapy in patients with gastro-oesophageal reflux disease: putative mechanisms of failureRonnie Fass
Section of Gastroenterology, The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
Drugs 67:1521-30. 2007..Because of the importance of PPI failure as a target for future drug development, further understanding of the most relevant underlying mechanisms is needed...
The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux diseaseRonnie Fass
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA
Gastroenterology 134:696-705. 2008..We sought to determine the effect of an acute laboratory stressor on perceptual and emotional responses to intraesophageal acid perfusion in healthy controls and patients with GERD...
Review: treatment of gastroesophageal reflux disease in the elderlyChoo Hean Poh
The Neuroenteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
Am J Med 123:496-501. 2010..Overall, proton pump inhibitors seem to be safe for both short- and long-term therapy in elderly patients with GERD. Antireflux surgery may be safe and effective in a subset of elderly patients with GERD...
Noncardiac chest painRonnie Fass
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
J Clin Gastroenterol 42:636-46. 2008..NCCP patients with or without spastic esophageal motor disorders are responsive to pain modulators. The value of botulinum toxin injection, endoscopic treatment for GERD, and antireflux surgery in alleviating NCCP symptoms is limited...
Effect of gastroesophageal reflux disease on sleepRonnie Fass
Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona School of Medicine, Tucson, Arizona 85723 0001, USA
J Gastroenterol Hepatol 25:S41-4. 2010..Future studies are needed to further explore the relationship between GERD and sleep and the potential of novel therapeutic options to interrupt the vicious cycle between GERD and sleep...
Refractory GERD: what is it?Ronnie Fass
University of Arizona, Southern Arizona VA Health Care System, GI Section 1 111 GI, 3601 South 6th Avenue, Tucson, AZ 85723 0001, USA
Curr Gastroenterol Rep 10:252-7. 2008..Pill-induced esophagitis, Zollinger-Ellison syndrome, achalasia, and other disorders are rarely responsible for PPI failure and usually are not confused with GERD...
The effect of life stress on symptoms of heartburnBruce D Naliboff
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, Los Angeles, CA, USA
Psychosom Med 66:426-34. 2004..The present longitudinal study tests the general hypothesis that life stressors can exacerbate symptoms in patients with chronic heartburn...
Evaluation and diagnosis of noncardiac chest painRonnie Fass
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA
Dis Mon 54:627-41. 2008
Extraesophageal and atypical manifestations of GERDWai-Man Wong
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona Veterans Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723, USA
J Gastroenterol Hepatol 19:S33-43. 2004..Properly designed therapeutic studies are still lacking as well as the exact role of antireflux surgery in this patient population...
Is there a relationship between obstructive sleep apnea and gastroesophageal reflux disease?Chad A Morse
Neuro Enteric Clinical Research Group, Department of Medicine, Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
Clin Gastroenterol Hepatol 2:761-8. 2004..The aim of the study is to further explore the relationship between OSA and GERD in a large group of patients with OSA...
The relationship between gastroesophageal reflux disease and sleepRonnie Fass
Southern Arizona VA Health Care System, GI Section 1 111 GI, Tucson, AZ 85723, USA
Curr Gastroenterol Rep 11:202-8. 2009..Future studies are needed to further explore the relationship between GERD and sleep and the potential of novel therapeutic options to interrupt the vicious cycle between them...
Proton pump inhibitor failure--what are the therapeutic options?Ronnie Fass
The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona, Tucson, Arizona 85723 0001, USA
Am J Gastroenterol 104:S33-8. 2009..Treatment of PPI failure due to delayed gastric emptying should be focused on improving gastric motor activity. Psychological management may supplement any medical or surgical approach toward PPI failure...
Clinical consequences of silent gastroesophageal reflux diseaseRonnie Fass
Southern Arizona VA Health Care System, GI Section 1 11G 1, Tucson, 85723 0001, USA
Curr Gastroenterol Rep 8:195-201. 2006..Recent studies have suggested that sleep disturbances and poor quality of sleep could be the needed clues to identify individuals with silent GERD...
Functional heartburn, nonerosive reflux disease, and reflux esophagitis are all distinct conditions--a debate: proTomas Navarro-Rodriguez
Ronnie Fass, MD GI Section 1 111G 1, The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, 3601 South 6th Avenue, Tucson, AZ 85723 0001, USA
Curr Treat Options Gastroenterol 10:294-304. 2007..The other GERD patients remained within their respective phenotypic presentations of GERD...
The lower esophageal sphincterT Hershcovici
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Tucson, AZ 85723 0001 USA
Neurogastroenterol Motil 23:819-30. 2011..Pharmacologic and non-pharmacologic manipulation of receptors involved in the control of TLESR has recently emerged as a potential target for GERD therapy...
Clinical trial: the effects of the proton pump inhibitor dexlansoprazole MR on daytime and nighttime heartburn in patients with non-erosive reflux diseaseR Fass
Section of Gastroenterology, University of Arizona Health Science Center and Southern Arizona VA Health Care System, Tucson, AZ 85723, USA
Aliment Pharmacol Ther 29:1261-72. 2009..The proportion of patients who respond to proton pump inhibitor (PPI) therapy is about 20% lower in those with non-erosive reflux disease (NERD) than in those with erosive oesophagitis...
Review article: gastro-oesophageal reflux disease and psychological comorbidityI Mizyed
Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
Aliment Pharmacol Ther 29:351-8. 2009..A growing number of studies have shown the impact of psychological comorbidities on gastro-oesophageal reflux disease (GERD) patients' symptom reports and healthcare-seeking behaviour...
Upper GI tract findings in patients with heartburn in whom proton pump inhibitor treatment failed versus those not receiving antireflux treatmentChoo Hean Poh
Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
Gastrointest Endosc 71:28-34. 2010..Failure of proton pump inhibitor (PPI) treatment in patients with heartburn is very common. Because endoscopy is easily accessible, it is commonly used as the first evaluative tool in these patients...
Update on symptomatic GERDRonnie Fass
University of Arizona, Tucson, Arisona, USA
Rev Gastroenterol Mex 69:36-7. 2004
Comparison of the different characteristics of sensed reflux events among different heartburn groupsRon Schey
Section of Gastroenterology, Department of Medicine, The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care, Tucson, AZ, USA
J Clin Gastroenterol 43:699-704. 2009..Our aim was to compare the different esophageal acid reflux characteristics of an SARE among the different heartburn groups...
The pathophysiology of non-cardiac chest painDaniel Van Handel
The Neuro-Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA
J Gastroenterol Hepatol 20:S6-13. 2005..Further understanding of the underlying mechanisms for pain in patients with NCCP will likely improve our current therapeutic approach...
Comparison of esophageal acid exposure distribution along the esophagus among the different gastroesophageal reflux disease (GERD) groupsRam Dickman
The Neuro-Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona 85723-0001, USA
Am J Gastroenterol 101:2463-9. 2006..Unlike erosive esophagitis and BE, NERD patients demonstrate a more homogenous acid distribution along the esophagus...
The relationship between the esophageal tissue content of neurotensin and the presence or absence of esophageal inflammationRoy Dekel
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Science Center, Tucson, Arizona 85723, USA
Dig Dis Sci 49:42-7. 2004..We suggest that the lower tissue content detected in patients with erosive esophagitis may represent a local protective mechanism against gastroesophageal reflux...
Attitudes and referral patterns of primary care physicians when evaluating subjects with noncardiac chest pain--a national surveyWai-Man Wong
The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, Arizona 85723, USA
Dig Dis Sci 50:656-61. 2005..6%) clinics. We conclude that most PCP's diagnose and treat NCCP patients without referring them to a gastroenterologist. However, diagnostic and treatment strategies may not follow the current understanding and knowledge of the disorder...
Impact of esophageal acid exposure on the endoscopic reversal of Barrett's esophagusRichard E Sampliner
Department of Internal Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723, USA
Am J Gastroenterol 97:270-2. 2002..Also, patients can fail reversal even with normal esophageal acid exposure. The necessary reduction of esophageal acid exposure for reversal therapy has yet to be defined...
Non-erosive reflux disease (NERD) and erosive esophagitis--a spectrum of disease or special entities?R Fass
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
Z Gastroenterol 45:1156-63. 2007..The other GERD patients remained within their respective phenotypic presentation of GERD...
Comparison of the degree of duodenogastroesophageal reflux and acid reflux between patients who failed to respond and those who were successfully treated with a proton pump inhibitor once dailyAnita Gasiorowska
Department of Medicine, Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
Am J Gastroenterol 104:2005-13. 2009....
Gastroesophageal reflux disease--should we adopt a new conceptual framework?Ronnie Fass
Department of Medicine, Southern Arizona VA Health Care System, and Arizona Health Sciences Center, Tucson 85723, USA
Am J Gastroenterol 97:1901-9. 2002....
Management of gastroesophageal reflux disease that does not respond well to proton pump inhibitorsTiberiu Hershcovici
Southern Arizona VA Healthcare System and University of Arizona, Tucson, Arizona 85723 0001, USA
Curr Opin Gastroenterol 26:367-78. 2010..We reviewed newly accumulated information about the management of PPI failure that has been published over the past 2 years...
Sleep deprivation is hyperalgesic in patients with gastroesophageal reflux diseaseRon Schey
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona
Gastroenterology 133:1787-95. 2007..Sleep deprivation has been associated with reports of increased GERD severity. Our aim was to determine whether sleep deprivation enhances perception of intraesophageal acid in patients with GERD vs healthy controls...
The role of proton pump inhibitors in gastro-oesophageal reflux diseaseRoy Dekel
Section of Gastroenterology, Department of Medicine, Southern Arizona Veterans Affairs Health Care System and University of Arizona Health Science Center, Tucson, Arizona 85723, USA
Drugs 64:277-95. 2004..However, PPIs have changed the face of GORD in the new millennium as the focus in gastroenterology practice has shifted to primarily treating patients who fail PPI therapy...
Progression or regression of Barrett's esophagus--is it all in the eye of the beholder?Roy Dekel
Section of Gastroenterology, Department of Medicine, Southern Arizona Veterans Affairs Health Care System, 3601 S 6th Avenue, Tucson, AZ 85723, USA
Am J Gastroenterol 98:2612-5. 2003..The relationship between Barrett's mucosa length and the absolute change in Barrett's length measurements on a follow-up endoscopy was also evaluated...
The proton pump inhibitor (PPI) test in GERD: does it still have a role?Anita Gasiorowska
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, AZ
J Clin Gastroenterol 42:867-74. 2008..Although the results were conflicting, the PPI test remains a popular tool for determining the presence of GERD. Attempts to challenge the PPI test without offering attractive alternatives are unlikely to alter clinical practice...
Evaluation of symptom index in identifying gastroesophageal reflux disease-related noncardiac chest painRoy Dekel
Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Science Center, 3601 S. 6th Avenue, Tucson, AZ 85723, USA
J Clin Gastroenterol 38:24-9. 2004..CONCLUSION: Positive SI is relatively uncommon in NCCP patients, regardless if GERD is present or absent. Hence, symptom index provides very little improvement in diagnosing GERD-related NCCP...
Relationship between rate of change in acid exposure along the esophagus and length of Barrett's epitheliumEugene F Tharalson
Department of Medicine, Southern Arizona Veterans Affairs Health Care System, Tucson 85723, USA
Am J Gastroenterol 97:851-6. 2002..Thus, as the rate at which recorded acid exposure values increases from the proximal to distal esophagus, the length of Barrett's esophagus significantly increases (for percent total time and upright position)...
Step-by-step management of refractory gastresophageal reflux diseaseT Hershcovici
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System University of Arizona Health Sciences Center, Tucson, Arizona, USA
Dis Esophagus 26:27-36. 2013..In those with functional heartburn, pain modulators are the cornerstone of therapy...
Noncardiac chest pain: diagnostic evaluationR Fass
Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
Dis Esophagus 25:89-101. 2012..A variety of diagnostic tests are available to the practicing clinician to identify the origin of pain, including ambulatory pH testing, esophageal motility, upper endoscopy, provocative testing and even therapeutic trials...
Power spectral analysis of the sleep electroencephalogram in heartburn patients with or without gastroesophageal reflux disease: a feasibility studyRohit Budhiraja
Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Tucson, AZ, USA
J Clin Gastroenterol 44:91-6. 2010..Determine the feasibility of using power spectrum of the sleep electroencephalogram (EEG) as a more sensitive tool than sleep architecture to evaluate the relationship between gastroesophageal reflux disease (GERD) and sleep...
Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stressBritta Dickhaus
University of California, Department of Medicine, Los Angeles (UCLA)/CNS: Center for Neurovisceral Sciences and Women's Health, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Gastroenterol 98:135-43. 2003..CONCLUSION: These findings confirm the hypothesis of altered stress-induced modulation of visceral perception in IBS patients...
Gastroesophageal reflux disease and irritable bowel syndrome: a common overlap syndromeRam Dickman
Neuro-Enteric Clinical Research Group, Southern Arizona VA Health Care System, GI Section, Tucson, AZ 85723-0001, USA
Curr Gastroenterol Rep 8:261-5. 2006....
