R Fass

Summary

Country: USA

Publications

  1. ncbi Gastroesophageal reflux disease revisited
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System 1 111G 1, University of Arizona Health Sciences Center, Tucson, AZ, USA
    Gastroenterol Clin North Am 31:S1-10. 2002
  2. doi Maintenance of heartburn relief after step-down from twice-daily proton pump inhibitor to once-daily dexlansoprazole modified release
    Ronnie Fass
    Section of Gastroenterology, Southern Arizona VA Healthcare System, Tucson, Arizona 85723, USA
    Clin Gastroenterol Hepatol 10:247-53. 2012
  3. ncbi The pathophysiological mechanisms of GERD in the obese patient
    Ronnie Fass
    Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona School of Medicine, 3601 S 6th Avenue, Tucson, AZ 85723 0001, USA
    Dig Dis Sci 53:2300-6. 2008
  4. ncbi Functional heartburn: misdiagnosed gastroesophageal reflux or a distinct entity?
    Ronnie Fass
    Neuro Enteric Clinical Research Group at Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
    Nat Clin Pract Gastroenterol Hepatol 2:120-1. 2005
  5. ncbi Predictors of heartburn during sleep in a large prospective cohort study
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
    Chest 127:1658-66. 2005
  6. pmc Functional heartburn: the stimulus, the pain, and the brain
    R Fass
    Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723, USA
    Gut 51:885-92. 2002
  7. ncbi Review article: supra-oesophageal manifestations of gastro-oesophageal reflux disease and the role of night-time gastro-oesophageal reflux
    R Fass
    Section of Gastroenterology, Southern Arizona VA Healthcare System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 20:26-38. 2004
  8. ncbi Distinct phenotypic presentations of gastroesophageal reflux disease: a new view of the natural history
    Ronnie Fass
    Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Ariz, USA
    Dig Dis 22:100-7. 2004
  9. ncbi Sensory testing of the esophagus
    Ronnie Fass
    Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona 85723, USA
    J Clin Gastroenterol 38:628-41. 2004
  10. ncbi Treatment of gastroesophageal reflux disease
    Ronnie Fass
    Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson 85723, USA
    Clin Cornerstone 5:18-29; discussion 30-1. 2003

Detail Information

Publications116 found, 100 shown here

  1. ncbi Gastroesophageal reflux disease revisited
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System 1 111G 1, University of Arizona Health Sciences Center, Tucson, AZ, USA
    Gastroenterol Clin North Am 31:S1-10. 2002
    ..This new paradigm will shift our focus to mechanisms leading to symptom generation in each group and foster specific therapeutic modalities that benefit each individual group of patients...
  2. doi Maintenance of heartburn relief after step-down from twice-daily proton pump inhibitor to once-daily dexlansoprazole modified release
    Ronnie Fass
    Section of Gastroenterology, Southern Arizona VA Healthcare System, Tucson, Arizona 85723, USA
    Clin Gastroenterol Hepatol 10:247-53. 2012
    ..We investigated whether step-down to once-daily dexlansoprazole controls heartburn in patients with GERD who were receiving twice-daily PPI therapy...
  3. ncbi The pathophysiological mechanisms of GERD in the obese patient
    Ronnie Fass
    Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona School of Medicine, 3601 S 6th Avenue, Tucson, AZ 85723 0001, USA
    Dig Dis Sci 53:2300-6. 2008
    ..Whilst the current efforts are to focus on one major underlying mechanism, it is highly likely that multiple factors contribute to the increased prevalence of GERD in the obese patient...
  4. ncbi Functional heartburn: misdiagnosed gastroesophageal reflux or a distinct entity?
    Ronnie Fass
    Neuro Enteric Clinical Research Group at Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
    Nat Clin Pract Gastroenterol Hepatol 2:120-1. 2005
  5. ncbi Predictors of heartburn during sleep in a large prospective cohort study
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
    Chest 127:1658-66. 2005
    ..The aim of this study was to determine the clinical predictors of heartburn during sleep in a large prospective cohort study...
  6. pmc Functional heartburn: the stimulus, the pain, and the brain
    R Fass
    Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723, USA
    Gut 51:885-92. 2002
    ..Current and future treatment strategies for functional heartburn patients who have failed standard dose proton pump inhibitors (PPIs) include increased PPI dose in some, as well as addition of pain modulators in others...
  7. ncbi Review article: supra-oesophageal manifestations of gastro-oesophageal reflux disease and the role of night-time gastro-oesophageal reflux
    R Fass
    Section of Gastroenterology, Southern Arizona VA Healthcare System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 20:26-38. 2004
    ..In this article we review the relationship between supra-oesophageal symptoms and GERD and, where possible, highlight the evidence supporting the role of night-time reflux as a contributing factor to these symptoms...
  8. ncbi Distinct phenotypic presentations of gastroesophageal reflux disease: a new view of the natural history
    Ronnie Fass
    Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Ariz, USA
    Dig Dis 22:100-7. 2004
    ..Additionally, it supports the usage of on-demand or intermittent antireflux treatment in clinical practice and provides better understanding of one of the most important clinical dilemmas - proton pump inhibitor failure...
  9. ncbi Sensory testing of the esophagus
    Ronnie Fass
    Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona 85723, USA
    J Clin Gastroenterol 38:628-41. 2004
    ..This is primarily due to lack of recognition of factors that can modulate esophageal sensation...
  10. ncbi Treatment of gastroesophageal reflux disease
    Ronnie Fass
    Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson 85723, USA
    Clin Cornerstone 5:18-29; discussion 30-1. 2003
    ..In addition, the recent introduction of various endoscopic techniques offers GERD patients a long-term solution with less morbidity and lower cost than antireflux surgery...
  11. doi The effect of dexlansoprazole MR on nocturnal heartburn and GERD-related sleep disturbances in patients with symptomatic GERD
    Ronnie Fass
    Southern Arizona VA Health Care System, Section of Gastroenterology 111G 1, Tucson, Arizona 85723, USA
    Am J Gastroenterol 106:421-31. 2011
    ..This study evaluated the efficacy of dexlansoprazole MR 30 mg in relieving nocturnal heartburn and GERD-related sleep disturbances, improving work productivity, and decreasing nocturnal symptom severity in patients with symptomatic GERD...
  12. ncbi Clinical and economic assessment of the omeprazole test in patients with symptoms suggestive of gastroesophageal reflux disease
    R Fass
    Department of Medicine, Tucson Veterans Affairs Medical Center and Arizona Health Sciences Center, 85723, USA
    Arch Intern Med 159:2161-8. 1999
    ..To evaluate the diagnostic accuracy of a trial of a high-dose proton pump inhibitor (the omeprazole test) in detecting gastroesophageal reflux disease (GERD) in patients with heartburn symptoms...
  13. ncbi Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trial
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723 0001, USA
    Clin Gastroenterol Hepatol 4:50-6. 2006
    ....
  14. ncbi Extension of squamous epithelium into the proximal stomach: a newly recognized mucosal abnormality
    R Fass
    Arizona Health Sciences Center, Department of Internal Medicine, Tucson, USA
    Endoscopy 32:27-32. 2000
    ..We report the documentation, over a period of 9 months, of squamous epithelium extending beyond the esophagogastric junction and into the proximal stomach in 16 patients who underwent upper endoscopy...
  15. ncbi Empirical trials in treatment of gastroesophageal reflux disease
    R Fass
    Department of Medicine, Section of Gastroenterology, Southern Arizona V A Halth Care System and University of Arizona Health Sciences Center, Tucson, AZ 85273, USA
    Dig Dis 18:20-6. 2000
    ..Thus the PPI empirical trial should be considered as the initial diagnostic step in patients with the disease spectrum of GERD...
  16. ncbi Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    J Clin Gastroenterol 41:131-7. 2007
    ..Additionally, NERD patients demonstrate a longer lag-time for symptom resolution and lack of difference in symptom response rate between half to full dose proton pump inhibitor as compared with patients with erosive esophagitis...
  17. ncbi Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastro-oesophageal reflux
    R Fass
    Section of Gastroenterology, Department of Medicine, Tucson VA Medical Center and Arizona Health Sciences Center, 85723, USA
    Age Ageing 29:125-30. 2000
    ..elderly patients appear to have a more aggressive form of gastro-oesophageal reflux disease than younger patients. Reduced pain perception with age is a possible underlying mechanism...
  18. ncbi Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-oesophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy-a prospective, randomized, multi-ce
    R Fass
    Section of Gastroenterology, Department of Medicine, Tucson VA Medical Center, Tucson, Arizona, USA
    Aliment Pharmacol Ther 14:1595-603. 2000
    ..Most of the comparative studies have assessed the effect of the two proton pump inhibitors (PPIs) on gastric acid secretion or gastric pH. Few studies have compared clinical end-points such as oesophageal healing and symptom control...
  19. pmc Correlation of oesophageal acid exposure with Barrett's oesophagus length
    R Fass
    Section of Gastroenterology, Department of Medicine and Health Services Research Center, Southern Arizona VA Health Care, 3601 S 6th Avenue 111G1, Tucson, AZ 85723, USA
    Gut 48:310-3. 2001
    ..Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient...
  20. ncbi Non-cardiac chest pain: an update
    R Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, AZ 85723 0001, USA
    Neurogastroenterol Motil 18:408-17. 2006
    ..The main therapeutic interventions in GORD-related NCCP patients are potent antireflux modalities and pain modulators in those with non-GORD-related NCCP...
  21. ncbi Introduction: the evolving role of 24-h oesophageal pH monitoring
    R Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    Aliment Pharmacol Ther 23:1-2. 2006
  22. ncbi Symptom assessment tools for gastroesophageal reflux disease (GERD) treatment
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
    J Clin Gastroenterol 41:437-44. 2007
    ..Thus far, 14 instruments have been developed to assess GERD symptoms and potentially can be used to evaluate treatment response during a therapeutic trial in GERD patients. However, comparison of the different evaluative tools is needed...
  23. ncbi Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease--where next?
    R Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona, School of Medicine, Tucson, AZ, USA
    Aliment Pharmacol Ther 22:79-94. 2005
    ..Treatment relies primarily on escalating dosing of proton-pump inhibitors. However, new insights into the pathophysiology of proton-pump inhibitor failure are likely to provide alternative therapeutic options...
  24. doi The effect of antireflux treatment on patients with gastroesophageal reflux disease undergoing a mental arithmetic stressor
    C H Poh
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    Neurogastroenterol Motil 23:e489-96. 2011
    ..The aim of the study was to determine if antireflux treatment can still alter stimulus response functions to acid in patients undergoing acute stress as compared with placebo...
  25. doi Increased oesophageal acid exposure at the beginning of the recumbent period is primarily a recumbent-awake phenomenon
    L Allen
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
    Aliment Pharmacol Ther 32:787-94. 2010
    ..A significant increase in oesophageal acid exposure during early recumbent period has been demonstrated...
  26. ncbi The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups
    M Shapiro
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    Aliment Pharmacol Ther 23:321-9. 2006
    ..Studies have demonstrated that patients with Barrett's oesophagus have the highest oesophageal acid exposure profile, followed by erosive oesophagitis and non-erosive reflux disease patients, but the exact extent of overlap remains unknown...
  27. ncbi Feasibility and tolerability of transnasal/per-oral placement of the wireless pH capsule vs. traditional 24-h oesophageal pH monitoring--a randomized trial
    W M Wong
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 21:155-63. 2005
    ..The wireless pH is a new technique to monitor oesophageal acid exposure...
  28. ncbi Correlation of gastroesophageal reflux disease symptoms characteristics with long-segment Barrett's esophagus
    R Dickman
    The Neuro Enteric Clinical Research Group, Tucson, AZ, USA
    Dis Esophagus 19:360-5. 2006
    ..Reports of severe or very severe dysphagia were more common in long-segment Barrett's esophagus patients. Only longer duration of chest pain was correlated with longer lengths of Barrett's esophagus...
  29. ncbi The omeprazole test is as sensitive as 24-h oesophageal pH monitoring in diagnosing gastro-oesophageal reflux disease in symptomatic patients with erosive oesophagitis
    R Fass
    Section of Gastroenterology, Tucson VA Medical Center and Arizona Health Sciences Center, 85723
    Aliment Pharmacol Ther 14:389-96. 2000
    ..However, comparative studies of the diagnostic accuracy and reliability of both strategies have not been performed...
  30. ncbi Preferential repair by squamous epithelium of thermal induced injury to the proximal stomach in patients undergoing ablation of Barrett's esophagus
    R Fass
    Department of Medicine, Sections of Gastroenterology and Oncology/Hematology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723, USA
    Gastrointest Endosc 53:711-6. 2001
    ..Recognition of this lesion is essential because it may lead to confusion as to the location of the esophagogastric junction in subsequent endoscopic evaluations...
  31. doi Clinical trial: the effect of Johrei on symptoms of patients with functional chest pain
    A Gasiorowska
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ, USA
    Aliment Pharmacol Ther 29:126-34. 2009
    ..Patients with functional chest pain (FCP) represent a therapeutic challenge for practising physicians...
  32. ncbi The effect of a therapeutic trial of high-dose rabeprazole on symptom response of patients with non-cardiac chest pain: a randomized, double-blind, placebo-controlled, crossover trial
    R Dickman
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 22:547-55. 2005
    ..Therapeutic trials with high-dose lansoprazole and omeprazole have been shown to be sensitive clinical tools for diagnosing patients with gastro-oesophageal reflux disease-related non-cardiac chest pain...
  33. doi Riser's reflux--an eye-opening experience
    C H Poh
    Department of Medicine, Southern Arizona VA Health Care System, University Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    Neurogastroenterol Motil 22:387-94. 2010
    ..The aim of the study was to compare the prevalence and frequency of acid reflux events prior to and immediately after awakening from sleep in the morning between GORD patients and normal subjects...
  34. doi Step-by-step management of refractory gastresophageal reflux disease
    T Hershcovici
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, AZ 87523, USA
    Dis Esophagus 26:27-36. 2013
    ..In those with functional heartburn, pain modulators are the cornerstone of therapy...
  35. doi Systematic review: the treatment of noncardiac chest pain
    T Hershcovici
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
    Aliment Pharmacol Ther 35:5-14. 2012
    ..This is in part due to the heterogeneous nature of this disorder. Several conditions are associated with NCCP including gastro-oesophageal reflux disease (GERD), oesophageal dysmotility, oesophageal hypersensitivity as well as others...
  36. doi Systematic review: the relationship between interstitial lung diseases and gastro-oesophageal reflux disease
    T Hershcovici
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, USA
    Aliment Pharmacol Ther 34:1295-305. 2011
    ..There may be an association between lung and oesophageal involvement in systemic sclerosis and mixed connective tissue disease, but a causal relationship cannot be established...
  37. doi The effect of esomeprazole 20 mg twice daily on acoustic and perception parameters of the voice in laryngopharyngeal reflux
    R Fass
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    Neurogastroenterol Motil 22:134-41, e44-5. 2010
    ..We compared the effect of esomeprazole 20 mg twice daily (b.i.d.) vs placebo on voice and acoustic-related measures in patients with LPR...
  38. ncbi Nonerosive reflux disease--current concepts and dilemmas
    R Fass
    Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, USA
    Am J Gastroenterol 96:303-14. 2001
    ..Treatment with acid inhibitory agents is effective, and proton pump inhibitors are the most effective form of therapy...
  39. ncbi The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain--a randomized, double-blind, placebo-controlled, crossover trial
    J Bautista
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S 6th Avenue, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 19:1123-30. 2004
    ..Empirical trial with high-dose omeprazole has been shown to be a sensitive tool for diagnosing patients with gastro-oesophageal reflux disease-related non-cardiac chest pain...
  40. ncbi Non-erosive reflux disease (NERD)--acid reflux and symptom patterns
    S D Martinez
    Department of Medicine, Section of Gastroenterology and Hematology Oncology, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 17:537-45. 2003
    ..Recent reports suggest that patients with non-erosive reflux disease (NERD) treated with anti-reflux medications show lower symptom improvement rates than patients with erosive oesophagitis treated with the same medications...
  41. pmc Duodenal fat intensifies the perception of heartburn
    J H Meyer
    Department of Medicine, Division of Gastroenterology, West Los Angeles Healthcare Center, VA Greater Los Angeles Healthcare System, UCLA School of Medicine, Los Angeles, CA, USA
    Gut 49:624-8. 2001
    ..01) shorter, and intensity and severity of heartburn significantly (p<0.05) greater, during duodenal perfusion with fat. CONCLUSION: We conclude that duodenal fat intensifies the perception of heartburn...
  42. ncbi Short segment Barrett's esophagus: relationship of age with extent of intestinal metaplasia
    P Benipal
    Department of Medicine, Southern Arizona Veterans Affairs Health Care System and University of Arizona Health Science Center, Tucson 85723, USA
    Am J Gastroenterol 96:3084-8. 2001
    ..Finding that SSBE length does not change across the various age groups and during a 64-month mean follow-up, suggests that SSBE does not progress over time...
  43. ncbi Comparisons of the distribution of oesophageal acid exposure throughout the sleep period among the different gastro-oesophageal reflux disease groups
    R Dickman
    The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ, USA
    Aliment Pharmacol Ther 26:41-8. 2007
    ..Nocturnal gastro-oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra-oesophageal complications...
  44. ncbi Assessment of 24-h oesophageal pH monitoring should be divided to awake and asleep rather than upright and supine time periods
    R Dickman
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, GI Section, Tucson, AZ 85723 0001, USA
    Neurogastroenterol Motil 19:709-15. 2007
    ..3 +/- 6.9, 1.86 +/- 2.7 and 0.01 +/- 0.05, P < 0.0001, respectively). The principal characteristics of the acid-reflux events in the supine-awake period are closer to the upright period than to the supine-asleep period...
  45. doi Management of heartburn not responding to proton pump inhibitors
    R Fass
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
    Gut 58:295-309. 2009
    ..Failure of such a therapeutic strategy may result in the addition of a transient lower oesophageal sphincter reducer or pain modulator. Anti-reflux surgery may be suitable for a subset of carefully studied patients...
  46. ncbi Assessment of dietary nutrients that influence perception of intra-oesophageal acid reflux events in patients with gastro-oesophageal reflux disease
    M Shapiro
    Department of Medicine, Section of Gastroenterology, The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, AZ 85723 0001, USA
    Aliment Pharmacol Ther 25:93-101. 2007
    ..Gastro-oesophageal reflux disease symptoms are most commonly reported postprandially, suggesting that some diet components are likely to induce symptoms more than others...
  47. doi Night-time intra-oesophageal bile and acid: a comparison between gastro-oesophageal reflux disease patients who failed and those who were treated successfully with a proton pump inhibitor
    T Hershcovici
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, 3601 South Sixth Avenue 1 111 GI, Tucson, AZ 85723 0001, USA
    Aliment Pharmacol Ther 33:837-44. 2011
    ..Little is known about the contribution of bile and acid reflux to night-time symptoms generation in patients who failed PPI treatment...
  48. ncbi Noncardiac chest pain
    Ram Dickman
    Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723, USA
    Clin Gastroenterol Hepatol 4:558-63. 2006
  49. ncbi Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acid
    Michael Shapiro
    The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723 0001, USA
    Am J Gastroenterol 101:1084-91. 2006
    ..Thus far, there is paucity of information about their physiological and clinical characteristics that may separate them from the other NERD patients...
  50. doi Reassessment of the principal characteristics of gastroesophageal reflux during the recumbent period using integrated actigraphy-acquired information
    Choo Hean Poh
    Department of Medicine, Section of Gastroenterology, Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona, Tucson, Arizona 85723 0001, USA
    Am J Gastroenterol 105:1024-31. 2010
    ....
  51. ncbi Assessment of oesophageal motor function in patients with dysphagia or chest pain - the Clinical Outcomes Research Initiative experience
    R Dekel
    Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    Aliment Pharmacol Ther 18:1083-9. 2003
    ..Available prospectively acquired data on the distribution of oesophageal motor abnormalities in patients being evaluated for non-cardiac chest pain and/or dysphagia are relatively scarce...
  52. ncbi Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburn
    R Dickman
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ, USA
    Aliment Pharmacol Ther 26:1333-44. 2007
    ..Aims To determine the efficacy of adding acupuncture vs. doubling the proton pump inhibitor dose in gastro-oesophageal reflux disease patients who failed symptomatically on proton pump inhibitors once daily...
  53. ncbi Barrett's oesophagus: optimal strategies for prevention and treatment
    Ronnie Fass
    Department of Internal Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723, USA
    Drugs 63:555-64. 2003
    ..Future developments in understanding the biology of Barrett's oesophagus and in therapeutic interventions will provide an opportunity for more effective screening, surveillance and prevention of neoplastic progression...
  54. ncbi Clinical predictors of Barrett's esophagus length
    Ram Dickman
    The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
    Gastrointest Endosc 62:675-81. 2005
    ..The aim of this multicenter study was to determine which clinical factors are highly correlated with the length of BE...
  55. ncbi Prevalence of upper gastrointestinal tract findings in patients with noncardiac chest pain versus those with gastroesophageal reflux disease (GERD)-related symptoms: results from a national endoscopic database
    Ram Dickman
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
    Am J Gastroenterol 102:1173-9. 2007
    ..Available data on the prevalence of esophageal and upper gut findings in patients with noncardiac chest pain (NCCP) are scarce and limited to one center's experience...
  56. ncbi The value of ambulatory 24 hr esophageal pH monitoring in clinical practice in patients who were referred with persistent gastroesophageal reflux disease (GERD)-related symptoms while on standard dose anti-reflux medications
    Jimmy M Bautista
    Department of Medicine, The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, University of Arizona College of Medicine, Tucson, Arizona 85723 0001, USA
    Dig Dis Sci 50:1909-15. 2005
    ..05). Most patients who continued to be symptomatic on proton pump inhibitor once daily demonstrated a normal pH test and overall lack of increased chemoreceptor sensitivity to acid...
  57. doi Noncardiac chest pain: diagnostic evaluation
    R Fass
    Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
    Dis Esophagus 25:89-101. 2012
    ..A variety of diagnostic tests are available to the practicing clinician to identify the origin of pain, including ambulatory pH testing, esophageal motility, upper endoscopy, provocative testing and even therapeutic trials...
  58. doi Systematic review: the effects of carbonated beverages on gastro-oesophageal reflux disease
    T Johnson
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, AZ, USA
    Aliment Pharmacol Ther 31:607-14. 2010
    ..Cessation of carbonated beverage consumption is commonly recommended as part of lifestyle modifications for patients with GERD...
  59. ncbi Pharmacokinetic comparison of orally-disintegrating metoclopramide with conventional metoclopramide tablet formulation in healthy volunteers
    R Fass
    University of Arizona Health Science Center, Tucson, AZ, USA
    Aliment Pharmacol Ther 30:301-6. 2009
    ..Because of this, a metoclopramide orally-disintegrating tablet (ODT) has been developed...
  60. doi Clinical trial: maintenance intermittent therapy with rabeprazole 20 mg in patients with symptomatic gastro-oesophageal reflux disease - a double-blind, placebo-controlled, randomized study
    R Fass
    Department of Medicine, Southern Arizona Health Care System and University of Arizona School of Medicine, Tucson, AZ, USA
    Aliment Pharmacol Ther 31:950-60. 2010
    ..Optimal long-term management of symptomatic gastro-oesophageal reflux disease (sGERD) patients has not been established...
  61. ncbi Esophageal acid exposure at pH < or = 2 is more common in Barrett's esophagus patients and is associated with oxidative stress
    K Dvorak
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
    Dis Esophagus 19:366-72. 2006
    ..In vitro studies using brief pH 2 exposure are biologically relevant to the clinical situation. Our studies indicate that such exposure induces oxidative stress. This stress may cause DNA damage, mutations and progression to cancer...
  62. doi Effect of gastroesophageal reflux disease on sleep
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona School of Medicine, Tucson, Arizona 85723 0001, USA
    J Gastroenterol Hepatol 25:S41-4. 2010
    ..Future studies are needed to further explore the relationship between GERD and sleep and the potential of novel therapeutic options to interrupt the vicious cycle between GERD and sleep...
  63. ncbi Proton-pump inhibitor therapy in patients with gastro-oesophageal reflux disease: putative mechanisms of failure
    Ronnie Fass
    Section of Gastroenterology, The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
    Drugs 67:1521-30. 2007
    ..Because of the importance of PPI failure as a target for future drug development, further understanding of the most relevant underlying mechanisms is needed...
  64. doi Review: treatment of gastroesophageal reflux disease in the elderly
    Choo Hean Poh
    The Neuroenteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
    Am J Med 123:496-501. 2010
    ..Overall, proton pump inhibitors seem to be safe for both short- and long-term therapy in elderly patients with GERD. Antireflux surgery may be safe and effective in a subset of elderly patients with GERD...
  65. ncbi Functional heartburn, nonerosive reflux disease, and reflux esophagitis are all distinct conditions--a debate: pro
    Tomas Navarro-Rodriguez
    Ronnie Fass, MD GI Section 1 111G 1, The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, 3601 South 6th Avenue, Tucson, AZ 85723 0001, USA
    Curr Treat Options Gastroenterol 10:294-304. 2007
    ..The other GERD patients remained within their respective phenotypic presentations of GERD...
  66. doi The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA
    Gastroenterology 134:696-705. 2008
    ..We sought to determine the effect of an acute laboratory stressor on perceptual and emotional responses to intraesophageal acid perfusion in healthy controls and patients with GERD...
  67. doi Noncardiac chest pain
    Ronnie Fass
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723 0001, USA
    J Clin Gastroenterol 42:636-46. 2008
    ..NCCP patients with or without spastic esophageal motor disorders are responsive to pain modulators. The value of botulinum toxin injection, endoscopic treatment for GERD, and antireflux surgery in alleviating NCCP symptoms is limited...
  68. ncbi Refractory GERD: what is it?
    Ronnie Fass
    University of Arizona, Southern Arizona VA Health Care System, GI Section 1 111 GI, 3601 South 6th Avenue, Tucson, AZ 85723 0001, USA
    Curr Gastroenterol Rep 10:252-7. 2008
    ..Pill-induced esophagitis, Zollinger-Ellison syndrome, achalasia, and other disorders are rarely responsible for PPI failure and usually are not confused with GERD...
  69. ncbi Proton pump inhibitor failure--what are the therapeutic options?
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona, Tucson, Arizona 85723 0001, USA
    Am J Gastroenterol 104:S33-8. 2009
    ..Treatment of PPI failure due to delayed gastric emptying should be focused on improving gastric motor activity. Psychological management may supplement any medical or surgical approach toward PPI failure...
  70. doi Evaluation and diagnosis of noncardiac chest pain
    Ronnie Fass
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA
    Dis Mon 54:627-41. 2008
  71. ncbi The relationship between gastroesophageal reflux disease and sleep
    Ronnie Fass
    Southern Arizona VA Health Care System, GI Section 1 111 GI, Tucson, AZ 85723, USA
    Curr Gastroenterol Rep 11:202-8. 2009
    ..Future studies are needed to further explore the relationship between GERD and sleep and the potential of novel therapeutic options to interrupt the vicious cycle between them...
  72. doi Persistent heartburn in a patient on proton-pump inhibitor
    Ronnie Fass
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
    Clin Gastroenterol Hepatol 6:393-400. 2008
  73. ncbi A predictive model for length of Barrett's esophagus with hiatal hernia length and duration of esophageal acid exposure
    Donald E Wakelin
    Department of Medicine, Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Tucson 85723 0001, USA
    Gastrointest Endosc 58:350-5. 2003
    ....
  74. ncbi Clinical consequences of silent gastroesophageal reflux disease
    Ronnie Fass
    Southern Arizona VA Health Care System, GI Section 1 11G 1, Tucson, 85723 0001, USA
    Curr Gastroenterol Rep 8:195-201. 2006
    ..Recent studies have suggested that sleep disturbances and poor quality of sleep could be the needed clues to identify individuals with silent GERD...
  75. ncbi The effect of life stress on symptoms of heartburn
    Bruce D Naliboff
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, Los Angeles, CA, USA
    Psychosom Med 66:426-34. 2004
    ..The present longitudinal study tests the general hypothesis that life stressors can exacerbate symptoms in patients with chronic heartburn...
  76. ncbi Is there a relationship between obstructive sleep apnea and gastroesophageal reflux disease?
    Chad A Morse
    Neuro Enteric Clinical Research Group, Department of Medicine, Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
    Clin Gastroenterol Hepatol 2:761-8. 2004
    ..The aim of the study is to further explore the relationship between OSA and GERD in a large group of patients with OSA...
  77. ncbi Extraesophageal and atypical manifestations of GERD
    Wai Man Wong
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona Veterans Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723, USA
    J Gastroenterol Hepatol 19:S33-43. 2004
    ..Properly designed therapeutic studies are still lacking as well as the exact role of antireflux surgery in this patient population...
  78. ncbi The lower esophageal sphincter
    T Hershcovici
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Tucson, AZ 85723 0001 USA
    Neurogastroenterol Motil 23:819-30. 2011
    ..Pharmacologic and non-pharmacologic manipulation of receptors involved in the control of TLESR has recently emerged as a potential target for GERD therapy...
  79. doi Review article: gastro-oesophageal reflux disease and psychological comorbidity
    I Mizyed
    Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    Aliment Pharmacol Ther 29:351-8. 2009
    ..A growing number of studies have shown the impact of psychological comorbidities on gastro-oesophageal reflux disease (GERD) patients' symptom reports and healthcare-seeking behaviour...
  80. doi Clinical trial: the effects of the proton pump inhibitor dexlansoprazole MR on daytime and nighttime heartburn in patients with non-erosive reflux disease
    R Fass
    Section of Gastroenterology, University of Arizona Health Science Center and Southern Arizona VA Health Care System, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 29:1261-72. 2009
    ..The proportion of patients who respond to proton pump inhibitor (PPI) therapy is about 20% lower in those with non-erosive reflux disease (NERD) than in those with erosive oesophagitis...
  81. ncbi Impact of esophageal acid exposure on the endoscopic reversal of Barrett's esophagus
    Richard E Sampliner
    Department of Internal Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723, USA
    Am J Gastroenterol 97:270-2. 2002
    ..This assumption is examined by evaluating the esophageal pH in a group of patients undergoing reversal therapy with fixed high-dose proton pump inhibitor therapy and endoscopic multipolar electrocoagulation (MPEC)...
  82. doi Comparison of the different characteristics of sensed reflux events among different heartburn groups
    Ron Schey
    Section of Gastroenterology, Department of Medicine, The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care, Tucson, AZ, USA
    J Clin Gastroenterol 43:699-704. 2009
    ..Our aim was to compare the different esophageal acid reflux characteristics of an SARE among the different heartburn groups...
  83. doi Upper GI tract findings in patients with heartburn in whom proton pump inhibitor treatment failed versus those not receiving antireflux treatment
    Choo Hean Poh
    Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
    Gastrointest Endosc 71:28-34. 2010
    ..Failure of proton pump inhibitor (PPI) treatment in patients with heartburn is very common. Because endoscopy is easily accessible, it is commonly used as the first evaluative tool in these patients...
  84. ncbi The relationship between the esophageal tissue content of neurotensin and the presence or absence of esophageal inflammation
    Roy Dekel
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Science Center, Tucson, Arizona 85723, USA
    Dig Dis Sci 49:42-7. 2004
    ..We suggest that the lower tissue content detected in patients with erosive esophagitis may represent a local protective mechanism against gastroesophageal reflux...
  85. ncbi Attitudes and referral patterns of primary care physicians when evaluating subjects with noncardiac chest pain--a national survey
    Wai Man Wong
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, Arizona 85723, USA
    Dig Dis Sci 50:656-61. 2005
    ..6%) clinics. We conclude that most PCP's diagnose and treat NCCP patients without referring them to a gastroenterologist. However, diagnostic and treatment strategies may not follow the current understanding and knowledge of the disorder...
  86. ncbi The pathophysiology of non-cardiac chest pain
    Daniel Van Handel
    The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    J Gastroenterol Hepatol 20:S6-13. 2005
    ..Further understanding of the underlying mechanisms for pain in patients with NCCP will likely improve our current therapeutic approach...
  87. ncbi Comparison of esophageal acid exposure distribution along the esophagus among the different gastroesophageal reflux disease (GERD) groups
    Ram Dickman
    The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
    Am J Gastroenterol 101:2463-9. 2006
    ..Patients with nonerosive reflux disease (NERD) have the lowest esophageal acid exposure profile compared with the other gastroesophageal reflux disease (GERD) groups...
  88. ncbi Update on symptomatic GERD
    Ronnie Fass
    University of Arizona, Tucson, Arisona, USA
    Rev Gastroenterol Mex 69:36-7. 2004
  89. ncbi Non-erosive reflux disease (NERD) and erosive esophagitis--a spectrum of disease or special entities?
    R Fass
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
    Z Gastroenterol 45:1156-63. 2007
    ..The other GERD patients remained within their respective phenotypic presentation of GERD...
  90. ncbi Progression or regression of Barrett's esophagus--is it all in the eye of the beholder?
    Roy Dekel
    Section of Gastroenterology, Department of Medicine, Southern Arizona Veterans Affairs Health Care System, 3601 S 6th Avenue, Tucson, AZ 85723, USA
    Am J Gastroenterol 98:2612-5. 2003
    ..The relationship between Barrett's mucosa length and the absolute change in Barrett's length measurements on a follow-up endoscopy was also evaluated...
  91. ncbi Relationship between rate of change in acid exposure along the esophagus and length of Barrett's epithelium
    Eugene F Tharalson
    Department of Medicine, Southern Arizona Veterans Affairs Health Care System, Tucson 85723, USA
    Am J Gastroenterol 97:851-6. 2002
    ..The aim of this study was to determine whether there is a relationship between the rate of the change in acid exposure along the esophagus and the length of Barrett's esophagus...
  92. ncbi Evaluation of symptom index in identifying gastroesophageal reflux disease-related noncardiac chest pain
    Roy Dekel
    Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Science Center, 3601 S 6th Avenue, Tucson, AZ 85723, USA
    J Clin Gastroenterol 38:24-9. 2004
    ..Because no study has evaluated the value of the symptom index in NCCP patients, data to support this claim have yet to be elucidated...
  93. doi Management of gastroesophageal reflux disease that does not respond well to proton pump inhibitors
    Tiberiu Hershcovici
    Southern Arizona VA Healthcare System and University of Arizona, Tucson, Arizona 85723 0001, USA
    Curr Opin Gastroenterol 26:367-78. 2010
    ..We reviewed newly accumulated information about the management of PPI failure that has been published over the past 2 years...
  94. ncbi The role of proton pump inhibitors in gastro-oesophageal reflux disease
    Roy Dekel
    Section of Gastroenterology, Department of Medicine, Southern Arizona Veterans Affairs Health Care System and University of Arizona Health Science Center, Tucson, Arizona 85723, USA
    Drugs 64:277-95. 2004
    ..However, PPIs have changed the face of GORD in the new millennium as the focus in gastroenterology practice has shifted to primarily treating patients who fail PPI therapy...
  95. ncbi Gastroesophageal reflux disease--should we adopt a new conceptual framework?
    Ronnie Fass
    Department of Medicine, Southern Arizona VA Health Care System, and Arizona Health Sciences Center, Tucson 85723, USA
    Am J Gastroenterol 97:1901-9. 2002
    ....
  96. doi Comparison of the degree of duodenogastroesophageal reflux and acid reflux between patients who failed to respond and those who were successfully treated with a proton pump inhibitor once daily
    Anita Gasiorowska
    Department of Medicine, Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
    Am J Gastroenterol 104:2005-13. 2009
    ....
  97. ncbi The proton pump inhibitor (PPI) test in GERD: does it still have a role?
    Anita Gasiorowska
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, AZ
    J Clin Gastroenterol 42:867-74. 2008
    ..Although the results were conflicting, the PPI test remains a popular tool for determining the presence of GERD. Attempts to challenge the PPI test without offering attractive alternatives are unlikely to alter clinical practice...
  98. ncbi Sleep deprivation is hyperalgesic in patients with gastroesophageal reflux disease
    Ron Schey
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona
    Gastroenterology 133:1787-95. 2007
    ..Sleep deprivation has been associated with reports of increased GERD severity. Our aim was to determine whether sleep deprivation enhances perception of intraesophageal acid in patients with GERD vs healthy controls...
  99. doi Power spectral analysis of the sleep electroencephalogram in heartburn patients with or without gastroesophageal reflux disease: a feasibility study
    Rohit Budhiraja
    Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Tucson, AZ, USA
    J Clin Gastroenterol 44:91-6. 2010
    ..Determine the feasibility of using power spectrum of the sleep electroencephalogram (EEG) as a more sensitive tool than sleep architecture to evaluate the relationship between gastroesophageal reflux disease (GERD) and sleep...
  100. ncbi Usage of supplemental alternative medicine by community-based patients with gastroesophageal reflux disease (GERD)
    Craig W Hayden
    Southem Arizona VA Health Care System and University of Arizona Health Sciences Center, Department of Medicine, Tucson 85723, USA
    Dig Dis Sci 47:1-8. 2002
    ..Being female and having acid regurgitation daily were positively associated with alternative medicine usage for GERD...
  101. ncbi Gastroesophageal reflux disease and irritable bowel syndrome: a common overlap syndrome
    Ram Dickman
    Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, GI Section, Tucson, AZ 85723 0001, USA
    Curr Gastroenterol Rep 8:261-5. 2006
    ....