Ayman H Fanous

Summary

Country: USA

Publications

  1. doi request reprint Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population
    Ayman H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC, USA
    Am J Med Genet B Neuropsychiatr Genet 159:383-91. 2012
  2. pmc Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families
    Ayman H Fanous
    Washington VA Medical Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 150:411-7. 2009
  3. ncbi request reprint Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density families
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC, USA
    Biol Psychiatry 64:121-7. 2008
  4. ncbi request reprint A longitudinal study of personality and major depression in a population-based sample of male twins
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Psychol Med 37:1163-72. 2007
  5. ncbi request reprint A genome-wide scan for modifier loci in schizophrenia
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 144:589-95. 2007
  6. ncbi request reprint Association between the 5q31.1 gene neurogenin1 and schizophrenia
    Ayman H Fanous
    Washington VA Medical Center, Washington, District of Columbia, USA
    Am J Med Genet B Neuropsychiatr Genet 144:207-14. 2007
  7. ncbi request reprint Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia
    Ayman H Fanous
    Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
    Am J Psychiatry 162:1824-32. 2005
  8. ncbi request reprint Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework
    A H Fanous
    Washington VA Medical Center, Georgetown University Medical Center Schizophrenia Research Program, Washington DC 20008, USA
    Mol Psychiatry 10:6-13. 2005
  9. ncbi request reprint The genetic relationship of personality to major depression and schizophrenia
    Ayman H Fanous
    Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
    Neurotox Res 6:43-50. 2004
  10. ncbi request reprint Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature
    Ayman H Fanous
    Washington VA Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Curr Psychiatry Rep 10:164-70. 2008

Detail Information

Publications28

  1. doi request reprint Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population
    Ayman H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC, USA
    Am J Med Genet B Neuropsychiatr Genet 159:383-91. 2012
    ..These results suggest that high-density marker maps may provide greater power and precision in linkage studies than lower density maps. They also further support the hypothesis that SZ and BP share at least some risk alleles...
  2. pmc Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families
    Ayman H Fanous
    Washington VA Medical Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 150:411-7. 2009
    ..Because of multiple testing, these results do not provide support for HTR2A as a susceptibility gene for psychotic illness, or for suicidal ideation within psychotic illness...
  3. ncbi request reprint Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density families
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC, USA
    Biol Psychiatry 64:121-7. 2008
    ..Genetic heterogeneity may decrease the signal-to-noise ratio in linkage and association studies. Therefore, linkage studies of clinically homogeneous classes of psychotic illness may result in greater power to detect at least some loci...
  4. ncbi request reprint A longitudinal study of personality and major depression in a population-based sample of male twins
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Psychol Med 37:1163-72. 2007
    ..The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other...
  5. ncbi request reprint A genome-wide scan for modifier loci in schizophrenia
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 144:589-95. 2007
    ..06. We conclude that genes located near 9q33.1 and 14q24.2 may modify the clinical course and severity of schizophrenia. A gene in 6q may affect several clinical features of illness...
  6. ncbi request reprint Association between the 5q31.1 gene neurogenin1 and schizophrenia
    Ayman H Fanous
    Washington VA Medical Center, Washington, District of Columbia, USA
    Am J Med Genet B Neuropsychiatr Genet 144:207-14. 2007
    ..This gene should be tested in additional and larger samples...
  7. ncbi request reprint Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia
    Ayman H Fanous
    Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
    Am J Psychiatry 162:1824-32. 2005
    ....
  8. ncbi request reprint Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework
    A H Fanous
    Washington VA Medical Center, Georgetown University Medical Center Schizophrenia Research Program, Washington DC 20008, USA
    Mol Psychiatry 10:6-13. 2005
    ..We describe five classes of genes and their predictions of the outcomes of family, twin, and several types of linkage studies. We go on to explore how these predictions can in turn be used to aid in the design of linkage studies...
  9. ncbi request reprint The genetic relationship of personality to major depression and schizophrenia
    Ayman H Fanous
    Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
    Neurotox Res 6:43-50. 2004
    ..Furthermore, although several putative susceptibility genes for schizophrenia have been reported and replicated, only one--catechol-O-methyltransferase (COMT)--has been tested in schizotypy...
  10. ncbi request reprint Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature
    Ayman H Fanous
    Washington VA Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Curr Psychiatry Rep 10:164-70. 2008
    ..Future directions include using whole-genome association studies to search for genetic modifiers of schizophrenia...
  11. pmc The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample
    Brien Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Schizophr Res 115:245-53. 2009
    ..DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples...
  12. pmc Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features
    Sarah E Bergen
    Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, Virginia 23219, USA
    Schizophr Res 109:94-7. 2009
    ..031) and QPDTPHASE (chi-square=12.54, p=.028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square=15.51, p=.030), but not QTDT (chi-square=2.07, p=.560)...
  13. pmc Comprehensive gene-based association study of a chromosome 20 linked region implicates novel risk loci for depressive symptoms in psychotic illness
    T Bernard Bigdeli
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e21440. 2011
    ..Prior genomewide scans of schizophrenia support evidence of linkage to regions of chromosome 20. However, association analyses have yet to provide support for any etiologically relevant variants...
  14. pmc No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010
    ..Several possibilities, such as differing risk haplotypes, may explain this finding...
  15. pmc Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder
    Kia J Jackson
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23219, USA
    Psychiatr Genet 23:20-8. 2013
    ..To investigate this hypothesis, we examined the association of the 15q25 gene cluster, the most significant candidate region to date implicated in ND and smoking behavior, with schizophrenia and bipolar disorder...
  16. ncbi request reprint Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia
    Jingchun Chen
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Suite 390, 800 E Leigh Street, Richmond, VA 23298, USA
    Schizophr Res 131:43-51. 2011
    ..Given the results that 2 non-synonymous markers in PTPN21 are associated with schizophrenia, further investigation of this locus is warranted...
  17. pmc Apoptotic engulfment pathway and schizophrenia
    Xiangning Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    PLoS ONE 4:e6875. 2009
    ..In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease...
  18. pmc Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms
    Ayman H Fanous
    Mental Health Service Line, Washington, DC, USA
    Am J Psychiatry 169:1309-17. 2012
    ..The authors present the first genome-wide association study (GWAS) of dimensional symptom scores among individuals with schizophrenia...
  19. pmc Concordance between chart review and structured interview assessments of schizophrenic symptoms
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Compr Psychiatry 53:275-9. 2012
    ..We examined agreement between symptom ratings derived from direct patient interviews and from review of casenotes...
  20. pmc Detection of susceptibility genes as modifiers due to subgroup differences in complex disease
    Sarah E Bergen
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Eur J Hum Genet 18:960-4. 2010
    ..This may explain some of the inconsistent association results for many candidate gene studies of complex diseases...
  21. doi request reprint Association study of 83 candidate genes for bipolar disorder in chromosome 6q selected using an evidence-based prioritization algorithm
    T Bernard Bigdeli
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia
    Am J Med Genet B Neuropsychiatr Genet 162:898-906. 2013
    ..Prior genome-scans of bipolar disorder have revealed chromosome 6q22 as a promising candidate region. However, linkage disequilibrium (LD) mapping studies have yet to identify replicated susceptibility loci...
  22. ncbi request reprint Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy
    A H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC 20422, USA
    Mol Psychiatry 12:958-65. 2007
    ..Power may therefore be increased in molecular genetic studies of schizophrenia if they incorporate measures of schizotypy in non-psychotic relatives...
  23. pmc Genomewide association study of movement-related adverse antipsychotic effects
    Karolina Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Psychiatry 67:279-82. 2010
    ..Understanding individual differences in the development of extrapyramidal side effects (EPS) as a response to antipsychotic therapy is essential to individualize treatment...
  24. ncbi request reprint Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study
    Ayman H Fanous
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004
    ..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia...
  25. pmc Association study of SNAP25 and schizophrenia in Irish family and case-control samples
    A H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 153:663-74. 2010
    ..Although we failed to replicate this in an independent sample, this gene should be further tested in other samples...
  26. ncbi request reprint Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137
    Albert H Kim
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, USA
    Schizophr Res 141:60-4. 2012
    ..2011) as hsa-miR-137 targets. Here, using in silico, cellular and luciferase based approaches we also provide evidence that another well replicated candidate schizophrenia gene, ZNF804A, is also target for hsa-miR-137...
  27. pmc DIST: direct imputation of summary statistics for unmeasured SNPs
    Donghyung Lee
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Bioinformatics 29:2925-7. 2013
    ..Even when subject-level genotypes are available, due to the substantial computational cost of the typical genotype imputation, there is a need for faster imputation methods...
  28. pmc Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
    B Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 15:29-37. 2010
    ..This study replicates the original reported association of ZNF804A with schizophrenia and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for schizophrenia...