D L Fairclough
- Evaluation of quality of life in a clinical trial with nonrandom dropout: the effect of epoetin alfa in anemic cancer patientsD L Fairclough
Colorado Health Outcomes Program and Department of Preventive Medicine and Biometry, University of Colorado, Health Sciences Center, Denver, CO 80210, USA
Qual Life Res 12:1013-27. 2003..However, the between-treatment-arm comparisons were consistent across analyses, demonstrating statistically significant differences in favor of the epoetin alfa arm for four of the seven outcome measures...
- Time course and characteristics of symptom distress and quality of life at the end of lifeJean S Kutner
Division of General Internal Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
J Pain Symptom Manage 34:227-36. 2007..The persistence of significant symptom distress, particularly due to pain, argues for the need for enhanced evidence to guide care provided in the last days and weeks of life...
- Handling missing quality of life data in HIV clinical trials: what is practical?Diane L Fairclough
Preventive Medicine and Biometry, University of Colorado Health Sciences Center, Mail Stop F443, PO Box 6508, Denver, CO 80045 0508, USA
Qual Life Res 17:61-73. 2008..The goal of this investigation is to describe the use of different analytic methods under assumptions of missing completely at random (MCAR), missing at random (MAR), and missing not at random (MNAR) using HIV as an empirical example...
- Patient reported outcomes as endpoints in medical researchDiane L Fairclough
Colorado Health Outcomes Program, Department of Preventive Medicine, University of Colorado Health Sciences Center, Aurora, CO 80045 0508, USA
Stat Methods Med Res 13:115-38. 2004....
- Symptoms, depression, and quality of life in patients with heart failureDavid B Bekelman
Department of Medicine, Division of General Internal Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
J Card Fail 13:643-8. 2007..Little is known about symptoms and their burden in outpatients with chronic heart failure. Diverse symptoms may be associated with poor heart failure-related quality of life, and depression may be related to increased symptoms...
- Planning analyses of quality-of-life studies: a case example with migraine prophylaxisDiane L Fairclough
Colorado Health Outcomes Program and Department of Preventive Medicine and Biometry, University of Colorado Health Sciences Center, Denver, Colorado 80210, USA
J Biopharm Stat 14:31-51. 2004..Specifically addressed are clearly defining goals and objectives, endpoints, multiple comparisons, analysis of longitudinal data with dropout, and estimation of power...
- Comparison of several model-based methods for analysing incomplete quality of life data in cancer clinical trialsD L Fairclough
Center for Research Methodology and Biometry, AMC Cancer Research Center, Denver, CO 80214, USA
Stat Med 17:781-96. 1998..In the advanced non-small-cell lung cancer trial, with 35 per cent mortality, estimates were sensitive to the missing data assumptions and methods of analysis...
- Why are missing quality of life data a problem in clinical trials of cancer therapy?D L Fairclough
Center for Methodologic Research and Biometry, AMC Cancer Research Center, Denver, CO 80214, USA
Stat Med 17:667-77. 1998..Recommendations are presented to minimize missing data, to obtain useful documentation concerning the reasons for missing data and to perform sensitivity analyses...
- Longitudinal quality of life in advanced cancer patients: pilot study results from a VA medical cancer centerShirley S Hwang
Section of Hematology Oncology, VA New Jersey Health Care System, East Orange, NJ 07018, USA
J Pain Symptom Manage 25:225-35. 2003..The sequence of changes, and how determinants of symptom distress and QOL change over time, may help clinicians assess the prognosis of terminally ill patients and plan appropriate interventions...
- Precision of health-related quality-of-life data compared with other clinical measuresElizabeth A Hahn
Department of Preventive Medicine, Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, 1001 University Pl, Suite 100, Evanston, IL 60201, USA
Mayo Clin Proc 82:1244-54. 2007..We further discuss the necessary requirements for clinicians to adopt formal, routine HRQL assessment into their practices...
- Health-related quality of life and tolerability in treatment-experienced HIV-1-infected patients on tipranavir versus comparator regimensI Chan Huang
University of Florida, Gainesville, USA
Antivir Ther 13:15-25. 2008..This study assesses the influence of adverse events (AEs) on health-related quality of life (HRQOL) and change in HRQOL in patients treated with TPV/r versus CPI/r regimens...
- The impact of physical and psychosocial factors on work characteristics after cancerJohn F Steiner
Colorado Health Outcomes Program, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Psychooncology 17:138-47. 2008..Since changes in work are common and are associated with both physical and psychosocial symptoms, strategies are needed to reduce symptom burden and barriers to work and to improve work capacity for working-age cancer survivors...
- Trajectories of adjustment in mothers of children with newly diagnosed cancer: a natural history investigationMichael J Dolgin
Schneider Children s Medical Center, Israel
J Pediatr Psychol 32:771-82. 2007....
- Assessing the ability of topiramate to improve the daily activities of patients with migraineJan Lewis Brandes
Nashville Neuroscience Group, 300 20th Ave N, Suite 603, Nashville, TN 37203, USA
Mayo Clin Proc 81:1311-9. 2006..To assess the impact of topiramate on the daily activities of patients with migraine...
- Symptom distress and quality-of-life assessment at the end of life: the role of proxy responseJean S Kutner
Division of General Internal Medicine, University of Colorado at Denver and Health Sciences Center, Denver, 80262, USA
J Pain Symptom Manage 32:300-10. 2006....
- Longitudinal study of the relationship between chemoradiation therapy for non-small-cell lung cancer and patient symptomsXin Shelley Wang
Department of Symptom Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 24:4485-91. 2006....
- Using problem-solving skills training to reduce negative affectivity in mothers of children with newly diagnosed cancer: report of a multisite randomized trialOlle Jane Z Sahler
Golisano Children s Hospital at Strong, University of Rochester Medical Center, Rochester, NY 14642, USA
J Consult Clin Psychol 73:272-83. 2005..In general, efficacy for Spanish-speaking mothers exceeded that for English-speaking mothers. Findings also suggest young, single mothers profit most from PSST...
- Development of a cancer pain prognostic scaleShirley S Hwang
Section of Hematology Oncology, VA New Jersey Health Care System, 375 Tremont Avenue, East Orange, NJ 07018, USA
J Pain Symptom Manage 24:366-78. 2002..Higher scores correspond to a higher probability of good pain relief. The CPPS has the potential to rapidly identify patients with poor pain prognosis. It can be used as a research tool to characterize pain in cancer patients...
- Assessing the clinical significance of single items relative to summated scoresJeff A Sloan
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Mayo Clin Proc 77:479-87. 2002..The 2 types of indices are not mutually exclusive and can be used together in a single research study or in the clinical setting...
- Problem-solving skills training for mothers of children with newly diagnosed cancer: a randomized trialOlle Jane Z Sahler
Division of Hematology Oncology, Strong Children s Hospital University of Rochester Medical Center, New York 14642, USA
J Dev Behav Pediatr 23:77-86. 2002..The implications of these findings for refinement of the PSST intervention and for extension to other groups of children with serious illnesses are discussed...
- What is a clinically meaningful change on the Functional Assessment of Cancer Therapy-Lung (FACT-L) Questionnaire? Results from Eastern Cooperative Oncology Group (ECOG) Study 5592David Cella
Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Suite 100, Evanston, IL 60201, USA
J Clin Epidemiol 55:285-95. 2002....
- Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trialJean S Kutner
School of Medicine, College of Nursing, University of Colorado Denver, Denver and Aurora, Colorado, USA
Ann Intern Med 149:369-79. 2008..Small studies of variable quality suggest that massage therapy may relieve pain and other symptoms...