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Evaluation of hexavalent chromium in sediment pore water of the Hackensack River, New Jersey, USASusan Kane Driscoll
Exponent, 1 Clock Tower Place, Suite 150, Maynard, Massachusetts 01754, USA
Environ Toxicol Chem 29:617-20. 2010..3 microg/L, while Cr(VI) was not detected (<10 microg/L). These findings are consistent with previous studies, which demonstrated limited bioavailability and toxicity of Cr in sediment at this site and others with similar conditions...
An evaluation of short-term exposures of brake mechanics to asbestos during automotive and truck brake cleaning and machining activitiesRichard O Richter
Exponent, Irvine, California 92618, USA
J Expo Sci Environ Epidemiol 19:458-74. 2009..Considering exposure duration, none of the short-term exposures were above the current OSHA excursion level...
Trace concentrations of vitamin E protect radiation crosslinked UHMWPE from oxidative degradationS M Kurtz
Exponent, Inc, 3401 Market St, Suite 300, Philadelphia, Pennsylvania 19104, USA
J Biomed Mater Res A 90:549-63. 2009..The results of this experiment therefore supported our hypotheses that trace concentrations of Vitamin E, coupled with radiation treatment-but not resin grade-influence the mechanical and oxidative degradation behavior of UHMWPE...
Building a scientific framework for studying hormonal effects on behavior and on the development of the sexually dimorphic nervous systemAbby A Li
Exponent Health Sciences, San Francisco, CA 94114, USA
Neurotoxicology 29:504-19. 2008..Understanding of the hormonal mechanisms of these behaviors, and of relevance to humans, is needed to develop biologically plausible hypotheses regarding the potential effects of hormonally active chemicals in humans...
Esfenvalerate-induced case-abandonment in the larvae of the caddisfly (Brachycentrus americanus)Katherine R Johnson
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
Environ Toxicol Chem 27:397-403. 2008..Overall, we concluded that small behavioral responses can have profound consequences for survival of species and reveal susceptible stages in life-cycles that can be overlooked by conventional approaches to ecological risk assessment...
Pesticides and prostate cancer: a review of epidemiologic studies with specific agricultural exposure informationPamela J Mink
Exponent Health Sciences Group, Exponent, Inc, Washington, DC 20036, USA
Eur J Cancer Prev 17:97-110. 2008..Existing evidence does not point to any pesticide as satisfying widely used guidelines for establishing causation: a strong, exposure-dependent and demonstrably unconfounded, unbiased association, documented in several studies...
Potential for sea otter exposure to remnants of buried oil from the Exxon Valdez oil spillPaul D Boehm
Exponent Inc, 3 Clock Tower Place, Suite 205, Maynard, Massachusetts 01754, Chemistry Department, Bowdoin College, Brunswick, Maine 04011, USA
Environ Sci Technol 41:6860-7. 2007....
Pleural plaques: a review of diagnostic issues and possible nonasbestos factorsChester C Clarke
Exponent, Inc, Bowie, MD 20715, USA
Arch Environ Occup Health 61:183-92. 2006..The authors concluded that plaques may be associated with nonasbestos exposures and certain medical conditions. Without a thorough exposure/medical history, plaque reports can be misleading...
Factors that influence the radiofrequency power output of GSM mobile phonesLinda S Erdreich
Exponent, Inc, New York, NY 10170, USA
Radiat Res 168:253-61. 2007..These results provide information applicable to improving the precision of exposure metrics for epidemiological studies of GSM mobile phones and may have broader application for other mobile phone systems and geographic locations...
Evaluation of costs for cystoid macular edema among patients after cataract surgeryJordana K Schmier
Exponent Inc, 1800 Diagonal Road, Alexandria, VA 22314, USA
Retina 27:621-8. 2007..Little is known about the costs of cystoid macular edema (CME), an important complication associated with cataract surgery. The purpose of this analysis was to estimate the cost of treatment for CME in the United States...
A phased approach for assessing combined effects from multiple stressorsCharles A Menzie
Exponent, Inc, Winchester, Massachusetts 01890, USA
Environ Health Perspect 115:807-16. 2007..The latter characteristic is considered especially important because multiple stressor problems usually involve exposures to communities or to ecologic regions with many stakeholders...
A meta-analysis of occupational trichloroethylene exposure and liver cancerDominik D Alexander
Exponent Health Sciences, 185 Hansen Ct, Suite 100, Wood Dale, IL 60191, USA
Int Arch Occup Environ Health 81:127-43. 2007..To quantitatively evaluate this association and to examine sources of heterogeneity, we conducted a meta-analysis of occupational studies of TCE exposure and liver/biliary tract cancer...
Evaluation of Medicare costs of endophthalmitis among patients after cataract surgeryJordana K Schmier
Exponent, Inc, Alexandria, Virginia 22314, USA
Ophthalmology 114:1094-9. 2007..However, little is known about the cost of treatment. The objective of this study was to estimate the direct medical cost of treatment for endophthalmitis in the United States...
Costs and outcomes of extended-release vs. immediate-release clarithromycin for lower respiratory tract infectionsMichael T Halpern
Exponent, Health Sciences Group, 1800 Diagonal Road, Suite 300, Alexandria, VA 22314, USA
COPD 2:217-23. 2005..Results indicate that clarithromycin extended-release is cost-saving compared with immediate-release for LRTI...
Have contemporary hip resurfacing designs reached maturity? A reviewKevin L Ong
Exponent Incorporated, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
J Bone Joint Surg Am 90:81-8. 2008..In addition, this review is based on an understanding of the causes of failure of revision hip resurfacing arthroplasty, which is essential to help guide research, implant design, and clinical decision-making...
Re-creation of historical chrysotile-containing joint compoundsG P Brorby
Exponent, Inc, Oakland, California 94607, USA
Inhal Toxicol 20:1043-53. 2008..g. viscosity, workability, crack resistance), indicating that these materials are sufficiently representative of the original products to support research activities...
Medicare expenditures associated with diabetes and diabetic retinopathyJordana K Schmier
Exponent, Inc, Alexandria, Virginia, USA
Retina 29:199-206. 2009..To estimate the expenditures for diabetic retinopathy in the United States by Medicare...
Processed meat and colorectal cancer: a quantitative review of prospective epidemiologic studiesDominik D Alexander
Exponent Inc Health Sciences, Wood Dale, Illinois 60191, USA
Eur J Cancer Prev 19:328-41. 2010..Therefore, the currently available epidemiologic evidence is not sufficient to support a clear and unequivocal independent positive association between processed meat consumption and CRC...
Potency factors for risk assessment at Libby, MontanaSuresh H Moolgavkar
Exponent, Inc, Bellevue, WA, USA
Risk Anal 30:1240-8. 2010..S. population for lung cancer, NMRD, and total mortality and obtained estimates that were in good agreement with those reported by Sullivan. The estimated potency factors form the basis for a quantitative risk assessment at Libby...
Accelerated aging, natural aging, and small punch testing of gamma-air sterilized polycarbonate urethane acetabular componentsS M Kurtz
Exponent, Inc, Philadelphia, Pennsylvania 19104, USA
J Biomed Mater Res B Appl Biomater 93:442-7. 2010..Overall, our findings suggest that the Bionate 80A material has greater oxidative stability than ultra-high molecular weight polyethylene following gamma irradiation in air and exposure to a severe oxidative challenge...
Benzene exposure and non-Hodgkin lymphoma: a meta-analysis of epidemiologic studiesDominik D Alexander
Center for Epidemiology, Biostatistics, and Computational Biology, Exponent Inc, Health Sciences, Wood Dale, IL 60191, USA
J Occup Environ Med 52:169-89. 2010..To conduct a meta-analysis of studies of benzene exposure and non-Hodgkin lymphoma (NHL)...
Weight-of-the-evidence review of acrylonitrile reproductive and developmental toxicity studiesBarbara H Neal
Center for Toxicology and Mechanistic Biology, Alexandria, Virginia 22314, USA
Crit Rev Toxicol 39:589-612. 2009..The inhalation reproductive toxicity study provides the most robust data for risk assessment. Based on the WoE evaluation, AN is not expected to be a developmental or reproductive toxicant in the absence of significant maternal toxicity...
Accidental falls involving medical implant re-operationKevin L Ong
Exponent, Inc, Philadelphia, PA 19104, United States
Injury 40:1088-92. 2009..0 days (median) longer and cost 108% (median) more. The greater hospital costs and hospital stay for patients needing re-operations indicate that additional medical treatment was required...
Learning cue validity through performance feedbackJason A Droll
Department of Psychology, University of California Santa Barbara, CA 93106, USA
J Vis 9:18.1-23. 2009..Comparison to an ideal observer reveals that the rate at which participants learned cue validity was suboptimal, which may have impaired performance during initial familiarization with scene statistics...
Meta-analysis of animal fat or animal protein intake and colorectal cancerDominik D Alexander
Exponent Health Sciences, Wood Dale, IL, USA
Am J Clin Nutr 89:1402-9. 2009..Objective: To clarify this potential relation, we conducted meta-analyses across a variety of subgroups, incorporating data from additional studies...
Basic principles of magnetic resonance imagingJoseph C McGowan
Drexel University, School of Biomedical Engineering, 3141 Chestnut Street, Philadelphia, PA 19104, USA
Neuroimaging Clin N Am 18:623-36, x. 2008..This article delineates the basic principles of MR imaging and illuminates specific applications...
A comparison of egg consumption with other modifiable coronary heart disease lifestyle risk factors: a relative risk apportionment studyLeila Barraj
Health Sciences Practice, Exponent, Washington, DC, USA
Risk Anal 29:401-15. 2009..Hence, focusing on decreasing egg intake as an approach to modify CHD risk would be expected to yield minimal results relative to changing other behaviors such as smoking and other dietary habits...
Relationship between fish intake, n-3 fatty acids, mercury and risk markers of CHD (National Health and Nutrition Examination Survey 1999-2002)Kimberly M Smith
Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA
Public Health Nutr 12:1261-9. 2009..The n-3 fatty acids, EPA and DHA, are naturally found only in marine sources. Dietary intakes of methylmercury from certain fish have been hypothesized to increase the risk of CHD...
The use of modelling to predict implant behaviourKevin Ong
Exponent Inc, Philadelphia, Pennsylvania 19104, USA
Med Device Technol 19:64-6. 2008..The benefits and limitations of using this technique for orthopaedic products are examined here...
US mesothelioma patterns 1973-2002: indicators of change and insights into background ratesMary Jane Teta
Exponent Inc, Health Sciences Practice, New York, New York, USA
Eur J Cancer Prev 17:525-34. 2008..The background rate for persons below age 50 is approximately one per million, independent of sex. Future data are needed to estimate this rate for older age groups...
Travoprost versus latanoprost combinations in glaucoma: economic evaluation based on visual field deficit progressionJordana K Schmier
Exponent Inc, Alexandria, VA 22314, USA
Curr Med Res Opin 22:1737-43. 2006..In addition, visual functioning is known to affect medical costs. The objective of this study was to project visual field deficit progression and subsequent costs based on clinical trial data...
Airborne crystalline silica concentrations at coal-fired power plants associated with coal fly ashJeffrey Hicks
Exponent Inc, 1970 Broadway, Oakland, CA 94612, USA
J Occup Environ Hyg 3:448-55. 2006....
Occupational magnetic field exposures of garment workers: results of personal and survey measurementsMichael A Kelsh
Exponent, Menlo Park, California, USA
Bioelectromagnetics 24:316-26. 2003..A historical exposure assessment can be conducted by linking duration of exposure with reconstructed exposure measurements but may be limited by the accuracy of work history data...
Asthma: resource use and costs for inhaled corticosteroid vs leukotriene modifier treatment--a meta-analysisMichael T Halpern
Exponent, Inc, 1800 Diagonal Road, Alexandria, VA 22314, USA
J Fam Pract 52:382-9. 2003..To compare the effects of inhaled corticosteroid treatment with leukotriene modifier treatment on medical resource use and costs for asthma patients...
Methodological aspects related to aggregate and cumulative exposures to contaminants with common mechanisms of toxicityBarbara J Petersen
Exponent formerly Novigen Sciences, Inc, 1730 Rhode Island Avenue, NW, Suite 1100, Washington, DC 20036, USA
Toxicol Lett 140:427-35. 2003..Understanding the major contributors to the estimated exposures is complicated and available tools and techniques will be demonstrated...
Oral bioaccessibility of dioxins/furans at low concentrations (50-350 ppt toxicity equivalent) in soilM V Ruby
Exponent, 4940 Pearl East Circle, Suite 300, Boulder, Colorado 80301, USA
Environ Sci Technol 36:4905-11. 2002....
A detailed analysis of the mechanisms controlling the acceleration of 2,4-DCP monooxygenation in the two-tank suspended growth processElizabeth P Dahlen
Exponent Failure Analysis Associates, Menlo Park, CA 94025, USA
Biodegradation 13:117-30. 2002..The apparently higher levels of monooxygenase in both tanks of the two-tank system also appears be a primary reason why its performance was substantially superior to that of the one-tank system in terms of 2,4-DCP removal...
Risk characterization: principles and practicePamela R D Williams
Exponent, Boulder, Colorado 80301, USA
J Toxicol Environ Health B Crit Rev 5:337-406. 2002..A brief discussion is also provided on international aspects of risk characterization. A number of examples are presented that illustrate key concepts, and citations are provided for approximately 100 of the most relevant papers...
Health effects relevant to the setting of EMF exposure limitsWilliam H Bailey
Exponent, New York, NY 10170, USA
Health Phys 83:376-86. 2002..However, a report that a 60-mT magnetic field (below the threshold for peripheral nerve stimulation) produces prolonged alterations of brain excitability and "indisposure" of subjects should be investigated in future research...
Thermomechanical behavior of virgin and highly crosslinked ultra-high molecular weight polyethylene used in total joint replacementsS M Kurtz
Exponent, Inc, Philadelphia, PA 19103, USA
Biomaterials 23:3681-97. 2002..The data collected in this study will be used to develop constitutive models based on the physics of polymer systems for predicting the thermomechanical behavior of conventional and crosslinked UHMWPE used in total joint replacements...
Constitutive modeling of ultra-high molecular weight polyethylene under large-deformation and cyclic loading conditionsJ S Bergström
Exponent, Inc, Natick, MA 01760, USA
Biomaterials 23:2329-43. 2002..In addition a new hybrid model is proposed, which incorporates many features of the previous theories. This hybrid model is shown to most effectively predict the experimentally observed mechanical behavior of UHMWPE...
Miniature specimen shear punch test for UHMWPE used in total joint replacementsS M Kurt
Exponent, Inc, Philadelphia, PA 19103, USA
Biomaterials 23:1907-19. 2002..Thus, the shear punch test represents an effective and complementary new tool in the armamentarium of miniature specimen mechanical testing methods for UHMWPE used in total joint replacement components...
Interlaboratory reproducibility of standard accelerated aging methods for oxidation of UHMWPES M Kurtz
Exponent Inc, and Drexel University, Philadelphia, PA 19103, USA
Biomaterials 22:1731-7. 2001..However, the large interinstitutional variation suggests that absolute performance standards for the oxidation index of UHMWPE after accelerated aging may not be practical at the present time...
Calcaneal loading during walking and runningV L Giddings
Mechanical Engineering Department, Stanford University, CA, USA
Med Sci Sports Exerc 32:627-34. 2000..This study of the foot uses experimentally measured kinematic and kinetic data with a numerical model to evaluate in vivo calcaneal stresses during walking and running...
The relationship between the clinical performance and large deformation mechanical behavior of retrieved UHMWPE tibial insertsS M Kurtz
Exponent Failure Analysis Associates, Philadelphia, PA 19103, USA
Biomaterials 21:283-91. 2000..Thus, the results of this study support the hypothesis that the clinical performance of UHMWPE tibial inserts is related to the large-deformation mechanical behavior measured near the articulating surface...
The economic impact of acute exacerbations of chronic bronchitis in the United States and Canada: a literature reviewMichael T Halpern
Exponent Inc, Alexandria, VA 22314, USA
J Manag Care Pharm 9:353-9. 2003..Medical resource use associated with AECB can have a substantial economic impact on the patients, health care system, and society overall...
Impact of long-term inhaled corticosteroid therapy on bone mineral density: results of a meta-analysisMichael T Halpern
Exponent, Alexandria, Virginia, USA
Ann Allergy Asthma Immunol 92:201-7; quiz 207-8, 267. 2004..The impact of long-term inhaled corticosteroid (ICS) therapy on bone mineral density (BMD) is poorly understood...
Allergic rhinitis: a potential cause of increased asthma medication use, costs, and morbidityMichael T Halpern
Exponent Inc, Alexandria, Virginia, USA
J Asthma 41:117-26. 2004..Physicians should assess asthma patients for symptoms of allergic rhinitis to improve asthma treatment...
Cost of obesity in the workplaceJordana K Schmier
Exponent Inc, Alexandria, Virginia, USA
Scand J Work Environ Health 32:5-11. 2006..Obesity is an important driver of costs in the workplace. These findings quantify the costs and can help employers consider whether to introduce workplace interventions or provide coverage for weight loss programs...
Acetabular cup geometry and bone-implant interference have more influence on initial periprosthetic joint space than joint loading and surgical cup insertionKevin L Ong
Exponent, 3401 Market St, Suite 300, Philadelphia, PA 19104, USA
J Biomech Eng 128:169-75. 2006..The equatorial diameter and eccentricity, not the patient-dependent and surgical factors, explained most of the variations in the performance measures. Perfect surface apposition was not attained with any of the cup designs...
Can accelerated aqueous aging simulate in vivo oxidation of gamma-sterilized UHMWPE?Daniel C Mazzucco
Exponent, Inc, Philadelphia, Pennsylvania 19104, USA
J Biomed Mater Res B Appl Biomater 79:79-85. 2006....
Evaluation of exposure to arsenic in residential soilJoyce S Tsuji
Exponent, Bellevue, Washington 98007, USA
Environ Health Perspect 113:1735-40. 2005..Similarly, questionnaire responses indicating soil exposure were not associated with increased urinary arsenic levels. Relatively low soil arsenic exposure likely precluded quantification of arsenic exposure above background...
Exposure reconstruction for the TCDD-exposed NIOSH cohort using a concentration- and age-dependent model of eliminationLesa L Aylward
Exponent, Inc, Alexandria, VA 22314, USA
Risk Anal 25:945-56. 2005....
Evaluation of epidemiologic and animal data associating pesticides with Parkinson's diseaseAbby A Li
Health Sciences Practice, Exponent, Inc, San Francisco, California 94114, USA
J Occup Environ Med 47:1059-87. 2005..We conclude that the animal and epidemiologic data reviewed do not provide sufficient evidence to support a causal association between pesticide exposure and PD...
Analysis of a retrieved polyethylene total disc replacement componentSteven M Kurtz
Exponent, Inc, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
Spine J 5:344-50. 2005..Although total disc replacements have been performed in Europe since the 1980s, this type of surgery is still new in the United States. The clinical performance of polyethylene in total disc replacements is still not well understood...
The biomechanical effects of kyphoplasty on treated and adjacent nontreated vertebral bodiesMarta L Villarraga
Exponent, Inc, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
J Spinal Disord Tech 18:84-91. 2005..Therefore, subsequent adjacent level fractures may be related to the underlying etiology (weakening of the bone) rather than the surgical intervention...
Estimating historical occupational exposure to airborne hexavalent chromium in a chromate production plant: 1940--1972D M Proctor
Exponent, Irvine, California, USA
J Occup Environ Hyg 1:752-67. 2004....
Static and fatigue mechanical behavior of bone cement with elevated barium sulfate content for treatment of vertebral compression fracturesS M Kurtz
Exponent, Inc, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
Biomaterials 26:3699-712. 2005....
Changing treatment patterns for coronary artery revascularization in Canada: the projected impact of drug eluting stentsMichael T Halpern
Exponent, Alexandria, VA, USA
BMC Cardiovasc Disord 4:23. 2004..To evaluate current treatment patterns for coronary artery revascularization in Canada and explore the potential impact of drug eluting stents (DES) on these treatment patterns...
Mesothelioma among brake mechanics: an expanded analysis of a case-control studyPatrick A Hessel
Exponent, Wood Dale, IL 60191, USA
Risk Anal 24:547-52. 2004..The results are consistent with the existing literature indicating that brake work does not increase the risk of mesothelioma and adds to the evidence that fiber type and size are important determinants of mesothelioma risk...
Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohortLesa L Aylward
Exponent, Inc, 1800 Diagonal Road, Suite 355, Alexandria, VA 22314, USA
J Expo Anal Environ Epidemiol 15:51-65. 2005....
Radiation and chemical crosslinking promote strain hardening behavior and molecular alignment in ultra high molecular weight polyethylene during multi-axial loading conditionsS M Kurtz
Exponent Failure Analysis Associates Inc, Philadelphia, PA 19103, USA
Biomaterials 20:1449-62. 1999..The data also illustrate the sensitivity of large deformation mechanical behavior and crystalline morphology to the method of crosslinking and resin of polyethylene...
