Randall Brand

Summary

Affiliation: Evanston Northwestern Healthcare
Country: USA

Publications

  1. ncbi request reprint Genotype/phenotype of familial pancreatic cancer
    Randall E Brand
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, and Section of Gastroenterology, Evanston Northwestern Healthcare, 2100 Pfingsten Road, Glenview, IL 60026, USA
    Endocrinol Metab Clin North Am 35:405-15, xi. 2006
  2. ncbi request reprint The specificity of amylin for the diagnosis of pancreatic adenocarcinoma
    Randall E Brand
    Department of Internal Medicine, Evanston Northwestern Healthcare, Glenview, IL 60025, USA
    Int J Gastrointest Cancer 31:123-8. 2002
  3. pmc Advances in counselling and surveillance of patients at risk for pancreatic cancer
    Randall E Brand
    Evanston Northwestern Healthcare, Evanston, Illinois, USA
    Gut 56:1460-9. 2007
  4. ncbi request reprint Risk factors for pancreatic adenocarcinoma: are we ready for screening and surveillance?
    Randall Brand
    Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Evanston Northwestern Healthcare, Glenview, IL 60026, USA
    Curr Gastroenterol Rep 7:122-7. 2005
  5. pmc Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?
    Venkata Muddana
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Pancreas 39:1215-9. 2010
  6. pmc Inherited pancreatic cancer syndromes
    Sheila Solomon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer J 18:485-91. 2012
  7. doi request reprint Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis
    Thomas Liggett
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois
    Cancer 116:1674-80. 2010
  8. pmc Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosa
    Vladimir Turzhitsky
    Biomedical Engineering Department, Northwestern University, Evanston, IL, USA
    Dis Markers 25:313-21. 2008
  9. pmc Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012
    Michael R Rickels
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 15213, USA
    Pancreatology 13:336-42. 2013
  10. ncbi request reprint BRCA1 and pancreatic cancer: pedigree findings and their causal relationships
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 158:119-25. 2005

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Genotype/phenotype of familial pancreatic cancer
    Randall E Brand
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, and Section of Gastroenterology, Evanston Northwestern Healthcare, 2100 Pfingsten Road, Glenview, IL 60026, USA
    Endocrinol Metab Clin North Am 35:405-15, xi. 2006
    ..The aim of this article is to review the challenges in identifying pancreatic cancer-prone families and how environmental factors interact with genetic factors in these families...
  2. ncbi request reprint The specificity of amylin for the diagnosis of pancreatic adenocarcinoma
    Randall E Brand
    Department of Internal Medicine, Evanston Northwestern Healthcare, Glenview, IL 60025, USA
    Int J Gastrointest Cancer 31:123-8. 2002
    ....
  3. pmc Advances in counselling and surveillance of patients at risk for pancreatic cancer
    Randall E Brand
    Evanston Northwestern Healthcare, Evanston, Illinois, USA
    Gut 56:1460-9. 2007
  4. ncbi request reprint Risk factors for pancreatic adenocarcinoma: are we ready for screening and surveillance?
    Randall Brand
    Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Evanston Northwestern Healthcare, Glenview, IL 60026, USA
    Curr Gastroenterol Rep 7:122-7. 2005
    ..It is recommended that surveillance be performed on these high-risk individuals in a research setting to allow for the development of a successful detection strategy...
  5. pmc Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?
    Venkata Muddana
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Pancreas 39:1215-9. 2010
    ..We also tested the hypothesis that PDGF-[beta] polymorphisms in combination with environmental risk factors such as alcohol and smoking are associated with CP...
  6. pmc Inherited pancreatic cancer syndromes
    Sheila Solomon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer J 18:485-91. 2012
    ..Because the best methods for surveillance have not been established, the recommendation to refer at-risk patients to centers with ongoing research programs in pancreatic cancer surveillance is supported...
  7. doi request reprint Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis
    Thomas Liggett
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois
    Cancer 116:1674-80. 2010
    ..In this article, the authors describe a methylation profile of cell-free plasma DNA that distinguished CP from PanCa with >90% accuracy...
  8. pmc Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosa
    Vladimir Turzhitsky
    Biomedical Engineering Department, Northwestern University, Evanston, IL, USA
    Dis Markers 25:313-21. 2008
    ....
  9. pmc Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012
    Michael R Rickels
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 15213, USA
    Pancreatology 13:336-42. 2013
    ..Diabetes and glucose intolerance are common complications of chronic pancreatitis, yet clinical guidance on their detection, classification, and management is lacking...
  10. ncbi request reprint BRCA1 and pancreatic cancer: pedigree findings and their causal relationships
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 158:119-25. 2005
    ....
  11. ncbi request reprint Hereditary factors in pancreatic cancer
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha NE 68178, USA
    J Hepatobiliary Pancreat Surg 9:12-31. 2002
    ..If changes in these putative biomarkers are observed, endoscopic retrograde cholangiopancreatography (ERCP) would be the next diagnostic step. We conclude with a discussion of ethical concerns about this research...
  12. ncbi request reprint Familial pancreatic carcinoma in Jews
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68131, USA
    Fam Cancer 3:233-40. 2004
    ..Attention should also be given to the search for mutations predisposing to PC in Jews so that opportunities to learn more about the disease's pathogenesis, as well as screening and control, may take place...
  13. ncbi request reprint Identification of high-risk pancreatic cancer-prone families
    Randall E Brand
    Northwestern University Feinberg School of Medicine, Division of Gastroenterology, Evanston Northwestern Healthcare, 2100 Pfingston Road, B230, Glenview, IL 60025, USA
    Gastroenterol Clin North Am 33:907-18. 2004
    ..Ultimately, this knowledge could be applied to the more common sporadic form of pancreatic cancer, where diagnosis is almost always late, and prognosis remains quite grim...
  14. ncbi request reprint Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Cancer 94:84-96. 2002
    ....
  15. ncbi request reprint Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking
    Rhonda M Brand
    Division of Emergency Medicine, Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, Evanston, IL 60201, USA
    World J Gastroenterol 12:4485-91. 2006
    ..To investigate whether a fuzzy logic model could predict colorectal cancer (CRC) risk engendered by smoking in hereditary non-polyposis colorectal cancer (HNPCC) patients...
  16. ncbi request reprint ErbB2 oncogene antibodies differentiate between the normal and diseased pancreas, and between chronic pancreatitis and pancreatic cancer
    Jens Standop
    UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA
    Oncol Rep 12:1309-15. 2004
    ..The utilized ErbB2 antibodies discriminate between the normal pancreas, chronic pancreatitis and pancreatic cancer. Hence, these antibodies seem to present an additional useful aid in the surgical pathology of pancreatic diseases...
  17. ncbi request reprint Decreasing malathion application time for lice treatment reduces transdermal absorption
    Rhonda M Brand
    Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, 1001 University Place, Evanston, IL 60201, USA
    Int J Pharm 301:48-53. 2005
    ..Our concern of over exposing children to malathion has led us to examine whether significantly more malathion will penetrate transdermally when applied for the recommended 8 h than for a shorter but apparently equally effective period...
  18. ncbi request reprint Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screening
    Anna L Zisman
    Department of Internal Medicine, Evanston Northwestern Healthcare, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
    Arch Intern Med 166:629-34. 2006
    ..Although hereditary predisposition is commonly used, the effect of exogenous risk factors has remained largely unexplored. To address this, we analyzed the age at presentation and location of CRC in relation to alcohol and tobacco use...
  19. ncbi request reprint ErbB2 growth factor receptor, a marker for neuroendocrine cells?
    Jens Standop
    UNMC Eppley Institute, University of Nebraska Medical Center, Omaha, NE, USA
    Pancreatology 5:44-58. 2005
    ..To validate our findings and to understand the reasons for the reported differences in the frequency of ErbB2 overexpression in pancreatic cancer, the following studies were performed...
  20. ncbi request reprint ErbB2 oncogene expression supports the acute pancreatitis-chronic pancreatitis sequence
    Jens Standop
    Eppley Institute, University of Nebraska Medical Center, Omaha, 68198 6805, USA
    Virchows Arch 441:385-91. 2002
    ..In conclusion, the similarities in the immunoreactivity of anti-ErbB2 antibodies in recurrent acute pancreatitis and chronic pancreatitis support the hypothesis that acute pancreatitis can be a forerunner of chronic pancreatitis...
  21. ncbi request reprint Inflammatory bowel disease in Ashkenazi Jews: implications for familial colorectal cancer
    Henry T Lynch
    Department of Preventive Medicine, Creighton University Medical School, 2500 California Plaza, Omaha, NE 68178, USA
    Fam Cancer 3:229-32. 2004
    ..Additional biopsies should be taken of any flat lesions, masses, or strictures. Prophylactic colectomy may then be indicated when severe dysplasia is confirmed by knowledgeable pathologists...
  22. ncbi request reprint A prospective study of gastric emptying and its relationship to the development of nausea, vomiting, and anorexia after autologous stem cell transplantation
    John K DiBaise
    Section of Gastroenterology, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Gastroenterol 100:1571-7. 2005
    ..We sought to define the prevalence of gastric emptying abnormalities and their relationship to the development of nausea, vomiting, and anorexia in patients undergoing HDT and autologous SCT...
  23. pmc Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Gastroenterology 135:1069-78. 2008
    ..To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo...
  24. pmc Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical study
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 2650 Ridge Avenue, G208, Evanston, Illinois 60201, USA
    Dis Colon Rectum 51:1381-6. 2008
    ..In this study, we assessed the translatability of spectral slope analysis to human colorectal cancer screening...
  25. ncbi request reprint Genetic predisposition to pancreatic cancer: a brief review
    Julia B Greer
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 102:2564-9. 2007
  26. ncbi request reprint Optical markers in duodenal mucosa predict the presence of pancreatic cancer
    Yang Liu
    Biomedical Engineering Department, Northwestern University, Illinois, USA
    Clin Cancer Res 13:4392-9. 2007
    ..We propose a novel approach to predict pancreatic cancer through the assessment of the adjacent periampullary duodenal mucosa without any interrogation of the pancreatic duct or imaging of the pancreas...
  27. ncbi request reprint Phase I trial of fixed dose rate infusion gemcitabine with gefitinib in patients with pancreatic carcinoma
    Benedito A Carneiro
    Department of Medicine, Kellogg Cancer Care Center, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Cancer Invest 25:366-71. 2007
    ..To determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of gemcitabine using a fixed dose rate infusion (FDRI) in combination with gefitinib in patients (pts) with pancreatic adenocarcinoma (PCa)...
  28. ncbi request reprint Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Pancreas 31:301-16. 2005
    ..The molecular mechanisms associated with antitumoral properties and the clinical benefits of gemcitabine alone or in combination with other cytotoxic agents for the treatment of pancreatic cancer are discussed...
  29. ncbi request reprint MUC4-expressing pancreatic adenocarcinomas show elevated levels of both T1 and T2 cytokines: potential pathobiologic implications
    Mahefatiana Andrianifahanana
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    Am J Gastroenterol 101:2319-29. 2006
    ..In the present study, we established the pathobiological association of various cytokines and MUC4 in pancreatic tumor tissues and tumor cell lines...
  30. ncbi request reprint Value of preoperative upper endoscopy in patients undergoing laparoscopic gastric bypass
    Tallal M Zeni
    Minimally Invasive Surgery Center, Department of Surgery, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Obes Surg 16:142-6. 2006
    ..Preoperative evaluation of patients undergoing laparoscopic Roux-en-Y gastric bypass (LRYGBP) has included esophagogastroduodenoscopy (EGD) with little data to substantiate its use...
  31. ncbi request reprint The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitis
    David A Sass
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pancreatology 6:297-300. 2006
    ..Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP...
  32. ncbi request reprint Multiplexed analysis of glycan variation on native proteins captured by antibody microarrays
    Songming Chen
    Van Andel Research Institute, 333 Bostwick, Grand Rapids, Michigan 49503, USA
    Nat Methods 4:437-44. 2007
    ..Antibody arrays for glycan detection are highly effective for profiling variation in specific glycans on multiple proteins and should be useful in diverse areas of glycobiology research...