Joseph L Evans

Summary

Country: USA

Publications

  1. ncbi request reprint The molecular basis for oxidative stress-induced insulin resistance
    Joseph L Evans
    Medical Research Institute, San Francisco, CA 94107, USA
    Antioxid Redox Signal 7:1040-52. 2005
  2. ncbi request reprint Antioxidants: do they have a role in the treatment of insulin resistance?
    Joseph L Evans
    Medical Research Institute, San Francisco, CA 94107, USA
    Indian J Med Res 125:355-72. 2007
  3. ncbi request reprint Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta
    Joseph L Evans
    Medical Research Institute, 444 De Haro Street, Suite 209, San Francisco, CA 94107, USA
    Curr Diabetes Rev 1:299-307. 2005
  4. ncbi request reprint Effective treatments for insulin resistance: trim the fat and douse the fire
    Joseph L Evans
    Medical Research Institute, San Francisco, CA 94107, USA
    Trends Endocrinol Metab 15:425-31. 2004
  5. ncbi request reprint Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
    Joseph L Evans
    Medical Research Institute, San Francisco, California University of California at San Francisco, San Francisco, California 94107, USA
    Diabetes 52:1-8. 2003
  6. ncbi request reprint Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    Joseph L Evans
    University of California at San Francisco, San Francisco, California 94143, USA
    Endocr Rev 23:599-622. 2002
  7. pmc Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome
    Umesh Masharani
    Department of Medicine, University of California, San Francisco, Diabetes Center, San Francisco, California 94143, USA
    J Diabetes Sci Technol 4:359-64. 2010
  8. ncbi request reprint Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators
    Ming Li
    University of California at San Francisco, Mount Zion Medical Center, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 87:4088-93. 2002
  9. ncbi request reprint Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid
    Joseph L Evans
    Northern California Diabetes Institute, Seton Medical Center, Dale City, CA 94015, USA
    Endocr Pract 8:29-35. 2002
  10. ncbi request reprint Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine St, PH501, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 85:620-8. 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The molecular basis for oxidative stress-induced insulin resistance
    Joseph L Evans
    Medical Research Institute, San Francisco, CA 94107, USA
    Antioxid Redox Signal 7:1040-52. 2005
    ....
  2. ncbi request reprint Antioxidants: do they have a role in the treatment of insulin resistance?
    Joseph L Evans
    Medical Research Institute, San Francisco, CA 94107, USA
    Indian J Med Res 125:355-72. 2007
    ..Briefly, this approach capitalizes on emerging data implicating lipid oversupply, chronic, lowgrade inflammation, and oxidative stress as root causes in the development and exacerbation of insulin resistance...
  3. ncbi request reprint Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta
    Joseph L Evans
    Medical Research Institute, 444 De Haro Street, Suite 209, San Francisco, CA 94107, USA
    Curr Diabetes Rev 1:299-307. 2005
    ..Recent studies in rodents and primates suggest that a small molecule targeting all three isoforms of PPAR would provide a significantly improved treatment option...
  4. ncbi request reprint Effective treatments for insulin resistance: trim the fat and douse the fire
    Joseph L Evans
    Medical Research Institute, San Francisco, CA 94107, USA
    Trends Endocrinol Metab 15:425-31. 2004
    ..One antioxidant that is safe and appears effective is alpha-lipoic acid. Thus, combinations of surgery, exercise training, insulin sensitizers and antioxidants will probably constitute future insulin resistance management...
  5. ncbi request reprint Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
    Joseph L Evans
    Medical Research Institute, San Francisco, California University of California at San Francisco, San Francisco, California 94107, USA
    Diabetes 52:1-8. 2003
    ....
  6. ncbi request reprint Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    Joseph L Evans
    University of California at San Francisco, San Francisco, California 94143, USA
    Endocr Rev 23:599-622. 2002
    ..Studies with antioxidants such as vitamin E, alpha-lipoic acid, and N-acetylcysteine suggest that new strategies may become available to treat these conditions...
  7. pmc Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome
    Umesh Masharani
    Department of Medicine, University of California, San Francisco, Diabetes Center, San Francisco, California 94143, USA
    J Diabetes Sci Technol 4:359-64. 2010
    ..The purpose of this study was to determine whether a preparation of controlled-release alpha lipoic acid (CRLA) influences features of the polycystic ovary syndrome (PCOS)...
  8. ncbi request reprint Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators
    Ming Li
    University of California at San Francisco, Mount Zion Medical Center, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 87:4088-93. 2002
    ..Moreover, the observation that TLK16998 and Merck L7 improved IR tyrosine phosphorylation in fibroblasts from patients with PCOS suggests that specific pharmacological therapies might be developed to treat the insulin resistance in PCOS...
  9. ncbi request reprint Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid
    Joseph L Evans
    Northern California Diabetes Institute, Seton Medical Center, Dale City, CA 94015, USA
    Endocr Pract 8:29-35. 2002
    ....
  10. ncbi request reprint Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine St, PH501, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 85:620-8. 2006
    ..Other protective mechanisms, in addition to their antioxidant properties, may underlie their differential beneficial effects on aging and physiological behaviors...
  11. ncbi request reprint Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    Cesar A Albarracin
    Alpha Therapy Center, 4626 Weber Road, Suite 100, Corpus Christi, TX 78411, USA
    Diabetes Metab Res Rev 24:41-51. 2008
    ..This randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the combination of chromium picolinate and biotin on glycaemic control...
  12. ncbi request reprint Regulation of insulin receptor function by a small molecule insulin receptor activator
    Celia Pender
    Mount Zion Medical Center, University of California, San Francisco 94143 1616, USA
    J Biol Chem 277:43565-71. 2002
    ..These studies suggest that these types of molecules could be developed to treat type 2 diabetes and other clinical conditions associated with insulin resistance...