Heidrun Engler

Summary

Country: USA

Publications

  1. ncbi request reprint Development of a formulation that enhances gene expression and efficacy following intraperitoneal administration in rabbits and mice
    Heidrun Engler
    Canji, Inc, 3525 John Hopkins Court, San Diego, CA 92121, USA
    Mol Ther 7:558-64. 2003
  2. ncbi request reprint Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha
    Heidrun Engler
    Canji, Inc, 3525 John Hopkins Court, San Diego, CA 92121, USA
    Virology 328:52-61. 2004
  3. ncbi request reprint Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responses
    Todd Machemer
    Department of Pharmacology, Canji, Inc, 3525 John Hopkins Court, San Diego, CA 92121, USA
    Mol Ther 12:254-63. 2005
  4. ncbi request reprint Pharmacologic indicators of antitumor efficacy for oncolytic virotherapy
    G William Demers
    Canji, Inc, San Diego, California 92121, USA
    Cancer Res 63:4003-8. 2003
  5. ncbi request reprint Sustained intravesical interferon protein exposure is achieved using an adenoviral-mediated gene delivery system: a study in rats evaluating dosing regimens
    Robert J Connor
    Canji, Incorporated, San Diego, California 92121, USA
    Urology 66:224-9. 2005
  6. ncbi request reprint Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation
    Jürgen Kuball
    Department of Medicine III, Johannes Gutenberg University, Mainz, Germany
    J Clin Oncol 20:957-65. 2002
  7. ncbi request reprint Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer
    Motoyuki Yamashita
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Cancer Gene Ther 9:687-91. 2002
  8. ncbi request reprint Cyclodextrin-modified polyethylenimine polymers for gene delivery
    Suzie H Pun
    Insert Therapeutics Inc, 2585 Nina Street, Pasadena, California 91107, USA
    Bioconjug Chem 15:831-40. 2004
  9. ncbi request reprint Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein
    William F Benedict
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Ther 10:525-32. 2004

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Development of a formulation that enhances gene expression and efficacy following intraperitoneal administration in rabbits and mice
    Heidrun Engler
    Canji, Inc, 3525 John Hopkins Court, San Diego, CA 92121, USA
    Mol Ther 7:558-64. 2003
    ..05). In animals, these results show that IP rAd gene therapy can be improved with the use of icodextrin, and suggest that prolonged retention and distribution in the peritoneal cavity is an important factor...
  2. ncbi request reprint Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha
    Heidrun Engler
    Canji, Inc, 3525 John Hopkins Court, San Diego, CA 92121, USA
    Virology 328:52-61. 2004
    ..The results suggest a mechanism for hepatotoxicity involving virus-induced production of local TNF-alpha release and E1a-mediated sensitization of hepatocyte killing...
  3. ncbi request reprint Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responses
    Todd Machemer
    Department of Pharmacology, Canji, Inc, 3525 John Hopkins Court, San Diego, CA 92121, USA
    Mol Ther 12:254-63. 2005
    ..Significantly, these studies may provide insight into management of acute adverse effects following rAd systemic delivery, enabling a broadening of therapeutic index...
  4. ncbi request reprint Pharmacologic indicators of antitumor efficacy for oncolytic virotherapy
    G William Demers
    Canji, Inc, San Diego, California 92121, USA
    Cancer Res 63:4003-8. 2003
    ..Oncolytic virus replication at a tumor site may not be a relevant indication of antitumor efficacy. Efficient distribution to the tumor site may be one of the most critical parameters for antitumor efficacy with oncolytic virotherapy...
  5. ncbi request reprint Sustained intravesical interferon protein exposure is achieved using an adenoviral-mediated gene delivery system: a study in rats evaluating dosing regimens
    Robert J Connor
    Canji, Incorporated, San Diego, California 92121, USA
    Urology 66:224-9. 2005
    ..We also assessed whether varying the interval between rAd-IFN/Syn3 treatments would improve the duration and levels of gene expression...
  6. ncbi request reprint Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation
    Jürgen Kuball
    Department of Medicine III, Johannes Gutenberg University, Mainz, Germany
    J Clin Oncol 20:957-65. 2002
    ..To study safety, feasibility, and biologic activity of adenovirus-mediated p53 gene transfer in patients with bladder cancer...
  7. ncbi request reprint Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer
    Motoyuki Yamashita
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Cancer Gene Ther 9:687-91. 2002
    ....
  8. ncbi request reprint Cyclodextrin-modified polyethylenimine polymers for gene delivery
    Suzie H Pun
    Insert Therapeutics Inc, 2585 Nina Street, Pasadena, California 91107, USA
    Bioconjug Chem 15:831-40. 2004
    ..Tail vein injections into mice of 120 microg of plasmid DNA formulated with CD-lPEI and AD-PEG do not reveal observable toxicities, and both nucleic acid accumulation and expression are observed in liver...
  9. ncbi request reprint Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein
    William F Benedict
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Ther 10:525-32. 2004
    ..These findings demonstrate that Ad-IFNalpha can overcome resistance to IFN-alpha protein both in vitro and in vivo and support evaluation of intravesical Ad-IFNalpha/Syn3 for the treatment of superficial bladder cancer...