Affiliation: Emory University
Zughaier S, Zimmer S, Datta A, Carlson R, Stephens D. Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins. Infect Immun. 2005;73:2940-50 pubmed
..E. coli 55:B5 and Vibrio cholerae LPS, at the same picomolar lipid A concentrations, selectively induced the MyD88-dependent pathway, while Salmonella LPS activated the MyD88-independent pathway. ..
Zughaier S, Karna P, Stephens D, Aneja R. Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs. PLoS ONE. 2010;5:e9165 pubmed publisher
..This study is the first report to identify brominated noscapines as innate immune pathway anti-inflammatory molecules. ..
Zughaier S, Shafer W, Stephens D. Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophages. Cell Microbiol. 2005;7:1251-62 pubmed
Zughaier S, Svoboda P, Pohl J, Stephens D, Shafer W. The human host defense peptide LL-37 interacts with Neisseria meningitidis capsular polysaccharides and inhibits inflammatory mediators release. PLoS ONE. 2010;5:e13627 pubmed publisher
..We conclude that the capacity of meningococcal CPS to activate macrophages via TLR2 and TLR4-MD-2 can be inhibited by the human cationic host defense peptide LL-37 and propose that this impacts CPS-based vaccine responses. ..
Zughaier S. Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2. J Leukoc Biol. 2011;89:469-80 pubmed publisher
..CD14 and LBP enhanced CPS bioactivity, and NF-?B was, as anticipated, the major signaling pathway. Thus, these data suggest that innate immune recognition of meningococcal CPS by macrophages can occur via TLR2- and TLR4-MD-2 pathways. ..
Zughaier S, Tangpricha V, Leong T, Stecenko A, McCarty N. Peripheral monocytes derived from patients with cystic fibrosis and healthy donors secrete NGAL in response to Pseudomonas aeruginosa infection. J Investig Med. 2013;61:1018-25 pubmed publisher
..In addition, we aimed to determine if innate immunity cells other than neutrophils act as a source of NGAL...
Gala R, D Souza M, Zughaier S. Evaluation of various adjuvant nanoparticulate formulations for meningococcal capsular polysaccharide-based vaccine. Vaccine. 2016;34:3260-7 pubmed publisher