Susu Zughaier

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathway
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Infect Immun 72:371-80. 2004
  2. pmc Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins
    Susu M Zughaier
    Division of Infectious Diseases, Emory University School of Medicine, VAMC I 151, 1670 Clairmont Rd, Atlanta, GA 30033, USA
    Infect Immun 73:2940-50. 2005
  3. ncbi request reprint Hexa-acylation and KDO(2)-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid A for human monocyte derived dendritic cells
    Susu Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, VAMC 151 I, 1670 Clairmont Road, Atlanta, GA 30033, USA
    Vaccine 24:1291-7. 2006
  4. doi request reprint Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages
    Susu M Zughaier
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 9:e87688. 2014
  5. pmc Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition
    Mary E Peek
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Interdiscip Perspect Infect Dis 2012:843509. 2012
  6. ncbi request reprint Peripheral monocytes derived from patients with cystic fibrosis and healthy donors secrete NGAL in response to Pseudomonas aeruginosa infection
    Susu M Zughaier
    Emory Children s Center for Cystic Fibrosis Research, Division of Pulmonology, Allergy Immunology, Cystic Fibrosis and Sleep, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Investig Med 61:1018-25. 2013
  7. pmc Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Leukoc Biol 89:469-80. 2011
  8. pmc The human host defense peptide LL-37 interacts with Neisseria meningitidis capsular polysaccharides and inhibits inflammatory mediators release
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine and Laboratories of Microbial Pathogenesis, Atlanta, Georgia, United States of America
    PLoS ONE 5:e13627. 2010
  9. pmc Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs
    Susu Zughaier
    Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 5:e9165. 2010
  10. doi request reprint Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidis
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    J Endotoxin Res 13:343-57. 2007

Detail Information

Publications18

  1. pmc Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathway
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Infect Immun 72:371-80. 2004
    ..KDO2 linked to meningococcal lipid A was structurally required for maximal activation of the human macrophage TLR4 pathway and indicates an important role for KDO-lipid A in endotoxin biologic activity...
  2. pmc Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins
    Susu M Zughaier
    Division of Infectious Diseases, Emory University School of Medicine, VAMC I 151, 1670 Clairmont Rd, Atlanta, GA 30033, USA
    Infect Immun 73:2940-50. 2005
    ..E. coli 55:B5 and Vibrio cholerae LPS, at the same picomolar lipid A concentrations, selectively induced the MyD88-dependent pathway, while Salmonella LPS activated the MyD88-independent pathway...
  3. ncbi request reprint Hexa-acylation and KDO(2)-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid A for human monocyte derived dendritic cells
    Susu Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, VAMC 151 I, 1670 Clairmont Road, Atlanta, GA 30033, USA
    Vaccine 24:1291-7. 2006
    ....
  4. doi request reprint Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages
    Susu M Zughaier
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 9:e87688. 2014
    ..Based on these findings, we propose that N. gonorrhoeae can subvert the iron-limiting innate immune defenses to facilitate iron acquisition and intracellular survival. ..
  5. pmc Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition
    Mary E Peek
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Interdiscip Perspect Infect Dis 2012:843509. 2012
    ..The data suggest that pyoverdine is a stealth siderophore that evades NGAL recognition allowing P. aeruginosa to establish chronic infections in CF lungs...
  6. ncbi request reprint Peripheral monocytes derived from patients with cystic fibrosis and healthy donors secrete NGAL in response to Pseudomonas aeruginosa infection
    Susu M Zughaier
    Emory Children s Center for Cystic Fibrosis Research, Division of Pulmonology, Allergy Immunology, Cystic Fibrosis and Sleep, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Investig Med 61:1018-25. 2013
    ..In addition, we aimed to determine if innate immunity cells other than neutrophils act as a source of NGAL...
  7. pmc Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Leukoc Biol 89:469-80. 2011
    ..CD14 and LBP enhanced CPS bioactivity, and NF-κB was, as anticipated, the major signaling pathway. Thus, these data suggest that innate immune recognition of meningococcal CPS by macrophages can occur via TLR2- and TLR4-MD-2 pathways...
  8. pmc The human host defense peptide LL-37 interacts with Neisseria meningitidis capsular polysaccharides and inhibits inflammatory mediators release
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine and Laboratories of Microbial Pathogenesis, Atlanta, Georgia, United States of America
    PLoS ONE 5:e13627. 2010
    ..We conclude that the capacity of meningococcal CPS to activate macrophages via TLR2 and TLR4-MD-2 can be inhibited by the human cationic host defense peptide LL-37 and propose that this impacts CPS-based vaccine responses...
  9. pmc Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs
    Susu Zughaier
    Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 5:e9165. 2010
    ..This study is the first report to identify brominated noscapines as innate immune pathway anti-inflammatory molecules...
  10. doi request reprint Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidis
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    J Endotoxin Res 13:343-57. 2007
    ....
  11. pmc Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophages
    Susu M Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, and Laboratories of Microbial Pathogenesis, Atlanta, GA, USA
    Cell Microbiol 7:1251-62. 2005
    ....
  12. pmc Cationic antimicrobial peptide resistance in Neisseria meningitidis
    Yih Ling Tzeng
    Department of Veterans Affairs Medical Center, Research 151, Room 5A188, 1670 Clairmont Road, Decatur, GA 30033, USA
    J Bacteriol 187:5387-96. 2005
    ..The modification of meningococcal lipid A head groups with PEA also prevents neutralization of the biological effects of endotoxin by CAMP...
  13. pmc TLR4-dependent adjuvant activity of Neisseria meningitidis lipid A
    Susu Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, 1440 Clifton Road NE, Atlanta, GA 30322, USA
    Vaccine 25:4401-9. 2007
    ....
  14. pmc Induction of reactive oxygen species-mediated autophagy by a novel microtubule-modulating agent
    Prasanthi Karna
    Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA
    J Biol Chem 285:18737-48. 2010
    ....
  15. ncbi request reprint Incidence of macrolide resistance in Streptococcus pneumoniae after introduction of the pneumococcal conjugate vaccine: population-based assessment
    David S Stephens
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Lancet 365:855-63. 2005
    ..We assessed emergence of macrolide-resistant invasive S pneumoniae disease in Atlanta, GA, USA, before and after the licensing, in February 2000, of the heptavalent pneumococcal conjugate vaccine for young children...
  16. ncbi request reprint Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4
    Shanta M Zimmer
    Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    Glycobiology 17:847-56. 2007
    ..05). The hierarchy in the binding affinity of different lipid A structures for human rMD-2 was directly correlated with differences in TLR4 pathway activation and cytokine production by human macrophages...
  17. pmc Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 70:1724-38. 2002
    ..When present, these vaccine-induced cross-reacting antibodies conferred in vitro antibody-mediated opsonophagocytosis and killing of both GBS III and Pn14, two pathogens that cause invasive disease in young infants...
  18. pmc Transmigration across activated endothelium induces transcriptional changes, inhibits apoptosis, and decreases antimicrobial protein expression in human monocytes
    Marcie R Williams
    The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University School of Medicine, Atlanta, Georgia 30332 0535, USA
    J Leukoc Biol 86:1331-43. 2009
    ..Unexpectedly, following transmigration, monocytes displayed reduced antimicrobial protein expression...