Muxiang Zhou

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia
    Lubing Gu
    Division of Pediatric Hematology Oncology BMT, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 99:3367-75. 2002
  2. pmc MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells
    L Gu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    Oncogene 31:1342-53. 2012
  3. pmc Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer
    Sheng Zhou
    Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    BMC Cancer 6:231. 2006
  4. ncbi request reprint DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells
    Muxiang Zhou
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 303:124-31. 2002
  5. ncbi request reprint PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells
    Muxiang Zhou
    Division of Pediatric Hematology Oncology Bone Marrow Transplantation, Emory University School of Medicine, 2040 Ridgewood Drive N E, Atlanta, GA 30322, USA
    Cancer Res 63:6357-62. 2003
  6. ncbi request reprint Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53
    Muxiang Zhou
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 22:8137-44. 2003
  7. pmc MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia
    Sheng Zhou
    Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Cell Biol 31:4928-37. 2011
  8. ncbi request reprint Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively
    Lubing Gu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 279:52141-9. 2004
  9. pmc Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma
    Jing He
    Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, GA, USA
    Cell Cycle 10:2994-3002. 2011
  10. ncbi request reprint An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy
    Ningxi Zhu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 23:7545-51. 2004

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia
    Lubing Gu
    Division of Pediatric Hematology Oncology BMT, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 99:3367-75. 2002
    ..Our findings suggest that by inducing p65 expression, MDM2 has a p53-independent role in tumorigenesis, which may further elucidate the association between MDM2 overexpression and resistant disease in childhood ALL...
  2. pmc MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells
    L Gu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    Oncogene 31:1342-53. 2012
    ....
  3. pmc Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer
    Sheng Zhou
    Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    BMC Cancer 6:231. 2006
    ..This study investigates the relationship between eIF4E and angiogenesis, as well as their prognostic impact in patients with human breast cancer...
  4. ncbi request reprint DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells
    Muxiang Zhou
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 303:124-31. 2002
    ..Furthermore, our data indicate that loss of wt-p53 function in tumor cells may contribute to up-regulation of survivin and resistance to DNA-damaging agents...
  5. ncbi request reprint PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells
    Muxiang Zhou
    Division of Pediatric Hematology Oncology Bone Marrow Transplantation, Emory University School of Medicine, 2040 Ridgewood Drive N E, Atlanta, GA 30322, USA
    Cancer Res 63:6357-62. 2003
    ..Furthermore, loss of PTEN can result in resistance to apoptosis by activating MDM2-mediated antiapoptotic mechanism...
  6. ncbi request reprint Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53
    Muxiang Zhou
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 22:8137-44. 2003
    ..Our data suggest that IkBm simultaneously downregulates NF-kB activation and sequesters p53 in the cytoplasm, thus enhancing NF-kB-regulated apoptosis but blocking p53-dependent apoptosis...
  7. pmc MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia
    Sheng Zhou
    Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Cell Biol 31:4928-37. 2011
    ..Our results suggest that MDM2 plays a p53-independent role in the regulation of VEGF, which may promote tumor growth and metastasis...
  8. ncbi request reprint Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively
    Lubing Gu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 279:52141-9. 2004
    ..Furthermore, loss of p53-mediated control over ETS-1-dependent transactivation of IKKalpha may represent a novel pathway for the constitutive activation of NF-kB-mediated gene expression and therapy resistance in cancer...
  9. pmc Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma
    Jing He
    Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, GA, USA
    Cell Cycle 10:2994-3002. 2011
    ....
  10. ncbi request reprint An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy
    Ningxi Zhu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 23:7545-51. 2004
    ..These results suggest that survivin-2B variant is a proapoptotic factor and its expression is upregulated by p53...
  11. ncbi request reprint KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia
    Ningxi Zhu
    The Division of Pediatric Hematology Oncology, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    J Biol Chem 281:14711-8. 2006
    ..These findings identify a novel regulatory pathway for the expression of survivin under the control of KLF5 and p53. Deregulation of this pathway may result in overexpression of survivin in cancer, thus contributing to drug resistance...
  12. doi request reprint Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells
    Ningxi Zhu
    Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Mol Cancer Ther 7:1101-9. 2008
    ....
  13. pmc Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells
    Jun Fang
    Division of Hematology Oncology, Department of Pediatrics, Emory University School of Medicine, Atlanta, USA
    BMC Cancer 8:69. 2008
    ..Our present study investigates the possible mechanism by which the interaction between TF and FVIIa regulates chemotherapy resistance in neuroblastoma cell lines...
  14. ncbi request reprint Contribution of STAT3 to the activation of survivin by GM-CSF in CD34+ cell lines
    Lubing Gu
    Division of Pediatric Hematology Oncology, Aflac Cancer Center and Blood Disorders Service, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Hematol 35:957-66. 2007
    ..Because survivin regulates cell proliferation and survival via its antiapoptotic function, we studied the link between STAT3 signaling and survivin expression in CD34(+) cells...
  15. pmc Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
    Xiang Hong Peng
    Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:25903-14. 2006
    ..Understanding key molecular events in EGFR signaling-induced apoptosis resistance should provide new information for the development of novel therapeutic agents targeting EGFR, HIF-1alpha, and/or survivin...
  16. pmc Methylation of RASSF1A gene promoter is regulated by p53 and DAXX
    Hailong Zhang
    Division of Hematology Oncology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    FASEB J 27:232-42. 2013
    ..Discovery of this mechanism provides new insight into the interactions among the tumor-related factors p53, RASSF1A, DAXX, and MDM2 in cancer pathogenesis...
  17. ncbi request reprint Expression of inhibitor-of-apoptosis protein (IAP) livin by neuroblastoma cells: correlation with prognostic factors and outcome
    Dae Kwang Kim
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Pediatr Dev Pathol 8:621-9. 2005
    ....
  18. pmc Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells
    Xiaoling Zhang
    Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 70:9895-904. 2010
    ..Given that MDM2-overexpressing cancer cells are commonly chemoresistant, our findings suggest that this naturally derived agent may have a highly useful role in the treatment of cancer patients with refractory disease...
  19. pmc Regulation of XIAP translation and induction by MDM2 following irradiation
    Lubing Gu
    Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Cell 15:363-75. 2009
    ..Upregulation of XIAP in MDM2-overexpressing cancer cells in response to irradiation resulted in resistance of these cells to radiation-induced apoptosis...
  20. ncbi request reprint Transcriptional repression of the eukaryotic initiation factor 4E gene by wild type p53
    Ningxi Zhu
    Division of Pediatric Hematology Oncology BMT, Emory University School of Medicine, Atlanta, GA, USA
    Biochem Biophys Res Commun 335:1272-9. 2005
    ....
  21. pmc Translation of TRAF1 is regulated by IRES-dependent mechanism and stimulated by vincristine
    Lin Yang
    Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nucleic Acids Res 38:4503-13. 2010
    ....
  22. pmc Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia
    Hailong Zhang
    Department of Pediatrics and Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 9:e100960. 2014
    ..These results suggested that nilotinib can inhibit MDM2 and induce a p53-independent apoptosis pathway by downregulating XIAP; thus, nilotinib can treat not only Ph+, but also Ph- ALL patients whose cancer cells overexpress MDM2. ..
  23. pmc Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway
    Mei Huang
    Department of Pediatrics, AFLAC Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Cancer Ther 12:184-94. 2013
    ..These results suggest that increased inhibition of XIAP due to downregulation of MDM2 may play a critical role in triptolide-induced apoptosis in MDM2-overexpressing cancers...
  24. pmc Differential expression of survivin-2B and survivin-DeltaEx3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC)
    Xiang Ling
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Lung Cancer 49:353-61. 2005
    ..Thus, controlling the differential expression of survivin-2B and survivin-DeltaEx3 may represent novel approaches for cancer therapeutics in NSCLC...
  25. pmc Transmembrane TNF-alpha mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt lymphoma cells
    Hailong Zhang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, Hubei, 430030, PR China
    J Leukoc Biol 84:789-97. 2008
    ..On the contrary, tmTNF-alpha, when acting as a ligand, inhibits NF-kappaB activity through forward signaling, which is inclined to induce tumor cell death...
  26. ncbi request reprint Inhibition of nuclear factor-kappaB activation is essential for membrane-associated TNF-alpha-induced apoptosis in HL-60 cells
    Wenfang Shi
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Immunol Cell Biol 84:366-73. 2006
    ....
  27. ncbi request reprint Mechanism of action differences in the antitumor effects of transmembrane and secretory tumor necrosis factor-alpha in vitro and in vivo
    Qingfen Li
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China
    Cancer Immunol Immunother 55:1470-9. 2006
    ..We conclude that the non-secreted form of TNFalpha may be an ideal candidate for cancer gene therapy due to its therapeutic potential and lowered side effect profile...
  28. doi request reprint Down-regulation of tissue factor by siRNA increased doxorubicin-induced apoptosis in human neuroblastoma
    Jun Fang
    Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Molecular Targeting Laboratory of Hubei Province, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 28:42-5. 2008
    ..Over-expression of TF might contribute to chemotherapy resistance in human neuroblastoma and its progression, at lest in part, by regulating doxorubicin-induced apoptosis...

Research Grants10

  1. MUTUAL REGULATION OF P53, MDM2 AND NFKB:
    Muxiang Zhou; Fiscal Year: 2000
    ....
  2. Berberine downregulates MDM2 by interaction with DAXX in cancer cells
    Muxiang Zhou; Fiscal Year: 2010
    ..Importantly, we will investigate whether the natural product BBR could be used as an effective therapeutic reagent in the treatment of pediatric and refractory cancer patient populations. ..
  3. MDM2 regulates XIAP gene expression in cancer treatment
    Muxiang Zhou; Fiscal Year: 2010
    ..Our research should help pave a new path towards some of these much needed treatments for patients with refractory cancers. ..
  4. MDM2 regulates XIAP gene expression in cancer treatment
    Muxiang Zhou; Fiscal Year: 2009
    ..Our research should help pave a new path towards some of these much needed treatments for patients with refractory cancers. ..
  5. MUTUAL REGULATION OF P53, MDM2 AND NFKB:
    Muxiang Zhou; Fiscal Year: 2004
    ....
  6. MUTUAL REGULATION OF P53, MDM2 AND NFKB:
    Muxiang Zhou; Fiscal Year: 2003
    ....
  7. MUTUAL REGULATION OF P53, MDM2 AND NFKB:
    Muxiang Zhou; Fiscal Year: 2002
    ....
  8. MUTUAL REGULATION OF P53, MDM2 AND NFKB:
    Muxiang Zhou; Fiscal Year: 2001
    ....
  9. MDM2 regulates XIAP gene expression in cancer treatment
    Muxiang Zhou; Fiscal Year: 2011
    ..Our research should help pave a new path towards some of these much needed treatments for patients with refractory cancers. ..