Haiyen Zhau

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model
    Haiyen E Zhau
    Molecular Urology and Therapeutics Program, Department of Urology, Emory University School of Medicine, 1365B Clifton Road, Suite 5107, Atlanta, GA 30322, USA
    Clin Exp Metastasis 25:601-10. 2008
  2. ncbi request reprint Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells
    Katsumi Shigemura
    Molecular Urology and Therapeutics Program, Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prostate 67:722-31. 2007
  3. pmc Soluble factors derived from stroma activated androgen receptor phosphorylation in human prostate LNCaP cells: roles of ERK/MAP kinase
    Katsumi Shigemura
    Molecular Urology and Therapeutics Program, Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prostate 69:949-55. 2009
  4. ncbi request reprint Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis
    Jianchun Xu
    Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prostate 66:1664-73. 2006
  5. pmc Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis
    Shian Ying Sung
    Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 68:9996-10003. 2008
  6. ncbi request reprint Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone
    Ruoxiang Wang
    Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Cancer Biol 15:353-64. 2005
  7. ncbi request reprint Molecular insights into prostate cancer progression: the missing link of tumor microenvironment
    Leland W K Chung
    Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Urol 173:10-20. 2005
  8. pmc Matched pairs of human prostate stromal cells display differential tropic effects on LNCaP prostate cancer cells
    Xiaojuan Sun
    Molecular Urology and Therapeutics, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, 1365B Clifton Road, NE, Suite B5103, Atlanta, GA 30322, USA
    In Vitro Cell Dev Biol Anim 46:538-46. 2010
  9. doi request reprint Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells
    Valerie A Odero-Marah
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, 1365B Clifton Road, NE, Atlanta, GA 30322, USA
    Cell Res 18:858-70. 2008
  10. doi request reprint Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells
    TISHEEKA R GRAHAM
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Cancer Res 68:2479-88. 2008

Detail Information

Publications42

  1. pmc Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model
    Haiyen E Zhau
    Molecular Urology and Therapeutics Program, Department of Urology, Emory University School of Medicine, 1365B Clifton Road, Suite 5107, Atlanta, GA 30322, USA
    Clin Exp Metastasis 25:601-10. 2008
    ..The ARCaP EMT model is highly attractive for developing new therapeutic agents to treat prostate cancer bone metastasis...
  2. ncbi request reprint Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells
    Katsumi Shigemura
    Molecular Urology and Therapeutics Program, Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prostate 67:722-31. 2007
    ..This study determined a common mediator responsible for ADAM9 protein regulation which supports human prostate cancer (PCa) cell growth and survival...
  3. pmc Soluble factors derived from stroma activated androgen receptor phosphorylation in human prostate LNCaP cells: roles of ERK/MAP kinase
    Katsumi Shigemura
    Molecular Urology and Therapeutics Program, Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prostate 69:949-55. 2009
    ..In this study, we characterized AR phosphorylation in LNCaP cells co-cultured with the conditioned medium (CM) from human prostate stromal fibroblasts...
  4. ncbi request reprint Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis
    Jianchun Xu
    Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prostate 66:1664-73. 2006
    ..This study characterized the host microenvironmental role in cancer progression, epithelial to mesenchymal transition (EMT), and bone and adrenal metastasis in parental ARCaP and its derived cell subclones...
  5. pmc Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis
    Shian Ying Sung
    Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 68:9996-10003. 2008
    ..These observations collectively suggest coevolution of cancer and stromal cells occurred under three-dimensional growth condition, which ultimately accelerates cancer growth and metastasis...
  6. ncbi request reprint Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone
    Ruoxiang Wang
    Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Cancer Biol 15:353-64. 2005
    ..Continued exploration of cancer growth under 3D conditions will rapidly lead to new discoveries and ultimately to improvements in the treatment of men with hormonal refractory prostate cancer...
  7. ncbi request reprint Molecular insights into prostate cancer progression: the missing link of tumor microenvironment
    Leland W K Chung
    Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Urol 173:10-20. 2005
    ....
  8. pmc Matched pairs of human prostate stromal cells display differential tropic effects on LNCaP prostate cancer cells
    Xiaojuan Sun
    Molecular Urology and Therapeutics, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, 1365B Clifton Road, NE, Suite B5103, Atlanta, GA 30322, USA
    In Vitro Cell Dev Biol Anim 46:538-46. 2010
    ..This work thus established a panel of valuable human prostate stromal cell lines, which could be used in co-culture to study the interaction between prostate cancer and prostate stromal cells...
  9. doi request reprint Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells
    Valerie A Odero-Marah
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, 1365B Clifton Road, NE, Atlanta, GA 30322, USA
    Cell Res 18:858-70. 2008
    ..Our results indicate that RANKL is a novel marker for EMT during prostate cancer progression. RANKL may function as a link between EMT, bone turnover, and prostate cancer skeletal metastasis...
  10. doi request reprint Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells
    TISHEEKA R GRAHAM
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Cancer Res 68:2479-88. 2008
    ..These results identify ZEB1 as a key transcriptional regulator of EMT in prostate cancer and suggest that the aberrant expression of ZEB1 in prostate cancer cells occurs in part in response to IGF-I stimulation...
  11. ncbi request reprint Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis
    Takeo Nomura
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 12:7294-305. 2006
    ..Because aberrant expression of beta2M has been reported in human renal cell carcinoma, we investigated the effects of beta2M overexpression on cancer cell growth and analyzed its molecular signaling pathway...
  12. ncbi request reprint Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells
    Katsumi Shigemura
    Molecular Urology and Therapeutics Program, Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer 109:1279-89. 2007
    ..has been shown to induce apoptosis in malignant cells. The effect of honokiol and the combined therapy with docetaxel on prostate cancer (PCa) growth and bone metastasis was investigated in experimental models...
  13. ncbi request reprint beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis
    Wen Chin Huang
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Microchemical and Proteomics Facility, and Divison of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:9108-16. 2006
    ..These results suggest that beta2M signaling is an attractive new therapeutic target for the treatment of lethal prostate cancer bone metastasis...
  14. ncbi request reprint Oxidative stress induces ADAM9 protein expression in human prostate cancer cells
    Shian Ying Sung
    Molecular Urology and Therapeutics Program, Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 66:9519-26. 2006
    ..ADAM9 could be responsible for supporting prostate cancer cell survival and progression. By decreasing ADAM9 expression, we observed apoptotic cell death in prostate cancer cells...
  15. ncbi request reprint Stromal-epithelial interaction in prostate cancer progression
    Leland W K Chung
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin Genitourin Cancer 5:162-70. 2006
    ..By understanding the salient features of cancer-host interaction, novel therapeutics might be developed to target the cancer and its host in the treatment of lethal prostate cancer metastases...
  16. ncbi request reprint New targets for therapy in prostate cancer: modulation of stromal-epithelial interactions
    Leland W K Chung
    Molecular Urology and Therapeutics Program, Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Urology 62:44-54. 2003
    ..Co-targeting tumor cells and stroma using systemic Ad vector is a viable and promising option for treatment of both localized and metastatic prostate cancer...
  17. pmc Beta2-microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells
    Wen Chin Huang
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, GA 30322, USA
    Clin Cancer Res 14:5341-7. 2008
    ..The objective of this study is to determine the mechanism by which targeting beta2M using anti-beta2M antibody inhibited growth and induced apoptosis in prostate cancer cells...
  18. ncbi request reprint A novel targeting modality to enhance adenoviral replication by vitamin D(3) in androgen-independent human prostate cancer cells and tumors
    Chia Ling Hsieh
    Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 62:3084-92. 2002
    ..Viral replication is highly enhanced by i.p. administration of vitamin D(3). Ultimately, enhancing Ad-hOC-E1 viral replication by vitamin D(3) may be used clinically to treat localized and osseous metastatic prostate cancer in men...
  19. ncbi request reprint Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer
    Hiroyuki Kubo
    Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Gene Ther 14:227-41. 2003
    ..Further studies including the development of viral delivery will enhance the efficacy of Ad-OC-hsv-TK...
  20. ncbi request reprint Functional androgen receptor confers sensitization of androgen-independent prostate cancer cells to anticancer therapy via caspase activation
    Rodney Davis
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Biochem Biophys Res Commun 309:937-45. 2003
    ....
  21. pmc Visualizing human prostate cancer cells in mouse skeleton using bioconjugated near-infrared fluorescent quantum dots
    Chunmeng Shi
    Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Urology 74:446-51. 2009
    ..To visualize human prostate cancer cells in mouse bone with bioconjugated near-infrared quantum dot (QD) probes. Near-infrared fluorescent probes using QDs can visualize tumors in deep tissues in vivo...
  22. ncbi request reprint PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer
    Ruoxiang Wang
    Molecular Urology and Therapeutics, Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 64:1589-94. 2004
    ..As the only prostate-specific gene identified in the most frequently amplified genomic region in prostate cancer, PrLZ may be the link between chromosome 8q amplification and malignant transformation of the prostate epithelia...
  23. pmc Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells
    Shumin Zhang
    Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Mol Cancer 9:9. 2010
    ..Mcl-1 overexpression has been associated with progression in leukemia and some solid tumors including prostate cancer (PCa). However, the regulatory mechanism for Mcl-1 expression in PCa cells remains elusive...
  24. doi request reprint BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis
    Seong Il Seo
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, 1365 B C ifton Road, Atlanta, GA 30322, USA
    Clin Cancer Res 14:6198-206. 2008
    ....
  25. ncbi request reprint PrLZ is expressed in normal prostate development and in human prostate cancer progression
    Ruoxiang Wang
    Department of Urology and Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 13:6040-8. 2007
    ..1. PrLZ is the only known gene in this locus with prostate specificity. Expression level of PrLZ was elevated specifically in cancer cells, suggesting its association with malignancy...
  26. pmc A novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells
    Ritu Aneja
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Eur J Cancer 46:1668-78. 2010
    ..EM011 did not exert any detectable toxicity in normal tissues with frequently dividing cells such as the gut and bone marrow. Thus, these data warrant further evaluation of EM011 for the management of prostate cancer...
  27. ncbi request reprint Targeting beta2-microglobulin mediated signaling as a novel therapeutic approach for human renal cell carcinoma
    Takeo Nomura
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Urol 178:292-300. 2007
    ....
  28. ncbi request reprint Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway
    Wen Chin Huang
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 65:2303-13. 2005
    ....
  29. pmc Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins
    Ruoxiang Wang
    Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 389:455-60. 2009
    ..This information is a valuable addition to the investigation of the oncogenic properties of the PrLZ gene...
  30. doi request reprint Quantum dots: emerging applications in urologic oncology
    Chunmeng Shi
    Molecular Urology and Therapeutics Program, Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Urol Oncol 26:86-92. 2008
    ..In this article, we describe the development of multifunctional QDs and their potential applications in oncology, with a particular emphasis on the diagnosis, prognosis, and treatment of urologic cancers...
  31. pmc Near IR heptamethine cyanine dye-mediated cancer imaging
    Xiaojian Yang
    Molecular Urology and Therapeutics, Department of Urology, Winship Cancer Institute, Atlanta, GA, USA
    Clin Cancer Res 16:2833-44. 2010
    ..Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging of tumors. In this study, we show the preferential uptake and retention of two hepatamethine cyanine dyes, IR-783 and MHI-148, in tumor cells and tissues...
  32. ncbi request reprint Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry
    Yun Xing
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 1001, Atlanta, Georgia 30322, USA
    Nat Protoc 2:1152-65. 2007
    ..In general, QD bioconjugation is completed within 1 day, and multiplexed molecular profiling takes 1-3 days depending on the number of biomarkers and QD probes used...
  33. pmc Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells
    Bekir Cinar
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Biochem J 379:421-31. 2004
    ..Collectively, these data indicate that cross-modulation between AR and NF-kappaB p65 transcription factors may occur by a novel mechanism involving binding to a common cis -DNA element...
  34. ncbi request reprint Ethnic differences in distribution of serum prostate-specific antigen: a study in a healthy Chinese male population
    Dalin He
    Department of Urology, First Hospital of Xi an Jiaotong University, Xi an, Shaanxi, China
    Urology 63:722-6. 2004
    ..To evaluate the normal distribution of serum prostate-specific antigen (PSA) levels in healthy Chinese men, because, until recently, studies conducted to establish normal serum PSA values have not involved a Chinese population...
  35. ncbi request reprint Over-expression of hypoxia-inducible factor-1alpha increases the invasive potency of LNCaP cells in vitro
    Yong Luo
    Department of Urology, First Hospital of Xi an Jiaotong University, Xi an Jiaotong University, Ministry of Education, Xi an, People s Republic of China
    BJU Int 98:1315-9. 2006
    ....
  36. ncbi request reprint Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 277:16189-201. 2002
    ..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression...
  37. ncbi request reprint A potential for tissue restrictive gene therapy in renal cell carcinoma using MN/CA IX promoter
    Yen Chuan Ou
    Division of Urology, Department of Surgery, Taichung Veterans General Hospital, National Yang Ming University School of Medicine, Taiwan
    Anticancer Res 25:881-6. 2005
    ..The expression of the MN/carbonic anhydrase IX (CA IX) protein is detected in renal cell carcinoma (RCC). A tumor-specific MN promoter was designed and evaluated...
  38. ncbi request reprint Amplification and overexpression of prosaposin in prostate cancer
    Shahriar Koochekpour
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Genes Chromosomes Cancer 44:351-64. 2005
    ....
  39. ncbi request reprint Perlecan knockdown in metastatic prostate cancer cells reduces heparin-binding growth factor responses in vitro and tumor growth in vivo
    Cristiana Savorè
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Clin Exp Metastasis 22:377-90. 2005
    ..We conclude that Pln is an essential ECM component involved in growth responses of metastatic prostate cancer cells to HBGFs deposited in local and metastatic microenvironment...
  40. ncbi request reprint Sonic and desert hedgehog signaling in human fetal prostate development
    Guodong Zhu
    Department of Urology, The First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, China
    Prostate 67:674-84. 2007
    ..Hedgehog signaling is thought to play an important role in rodent prostate organogenesis and morphogenesis. However, the role of this signaling pathway in human fetal prostate development has not been investigated...
  41. ncbi request reprint PC-1/PrLZ contributes to malignant progression in prostate cancer
    Hui Zhang
    Laboratory of Molecular Oncology, Institute of Biotechnology, Beijing, P R China
    Cancer Res 67:8906-13. 2007
    ..Inhibiting PC-1 expression may represent a novel therapeutic strategy to delay prostate cancer progression...
  42. ncbi request reprint Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4390, USA
    J Biol Chem 278:15056-64. 2003
    ..Moreover, MMP-26 and MMP-9 proteins were both expressed in the same human prostate carcinoma tissue samples examined. These results indicate that MMP-26 may be a physiological and pathological activator of pro-MMP-9...

Research Grants4

  1. CHARACTERIZATION OF AN INVASIVE HUMAN PROSTATE CANCER
    Haiyen Zhau; Fiscal Year: 2001
    ..The ARCaP model may allow definition of the molecular basis of prostate cancer progression to androgen independence and expression of invasive and bone-homing phenotypes. ..
  2. CHARACTERIZATION OF AN INVASIVE HUMAN PROSTATE CANCER
    Haiyen Zhau; Fiscal Year: 2002
    ..The ARCaP model may allow definition of the molecular basis of prostate cancer progression to androgen independence and expression of invasive and bone-homing phenotypes. ..
  3. CHARACTERIZATION OF AN INVASIVE HUMAN PROSTATE CANCER
    Haiyen Zhau; Fiscal Year: 2003
    ..The ARCaP model may allow definition of the molecular basis of prostate cancer progression to androgen independence and expression of invasive and bone-homing phenotypes. ..
  4. CHARACTERIZATION OF AN INVASIVE HUMAN PROSTATE CANCER
    Haiyen Zhau; Fiscal Year: 2004
    ..The ARCaP model may allow definition of the molecular basis of prostate cancer progression to androgen independence and expression of invasive and bone-homing phenotypes. ..