Ke Zen

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint CD11b/CD18-dependent interactions of neutrophils with intestinal epithelium are mediated by fucosylated proteoglycans
    Ke Zen
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 169:5270-8. 2002
  2. pmc JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Mol Biol Cell 15:3926-37. 2004
  3. pmc Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:2694-703. 2005
  4. ncbi request reprint SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration
    Yuan Liu
    Department of Biology, Georgia State University, Atlanta, Georgia 30302, USA
    J Biol Chem 280:36132-40. 2005
  5. pmc Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47
    Yuan Liu
    Department of Biology, Georgia State University, Atlanta, GA 30302, USA
    J Mol Biol 365:680-93. 2007
  6. ncbi request reprint Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium
    Ke Zen
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    J Immunol 178:2483-90. 2007
  7. ncbi request reprint Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:44924-30. 2004
  8. ncbi request reprint Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha
    Yuan Liu
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 172:2578-85. 2004
  9. ncbi request reprint Leukocyte-epithelial interactions
    Ke Zen
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Whitehead Research Boulevard, Room 1053, 615 Michael Street, Atlanta, GA 30322, USA
    Curr Opin Cell Biol 15:557-64. 2003
  10. ncbi request reprint Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration
    Yuan Liu
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 277:10028-36. 2002

Collaborators

Detail Information

Publications18

  1. ncbi request reprint CD11b/CD18-dependent interactions of neutrophils with intestinal epithelium are mediated by fucosylated proteoglycans
    Ke Zen
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 169:5270-8. 2002
    ..These findings implicate epithelial cell surface proteoglycans decorated with sulfated fucose moieties as ligands for CD11b/CD18 during PMN migration across mucosal surfaces...
  2. pmc JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Mol Biol Cell 15:3926-37. 2004
    ....
  3. pmc Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:2694-703. 2005
    ..These findings add a new element to a multistep model of PMN transepithelial migration and may provide new targets for anti-inflammatory therapies...
  4. ncbi request reprint SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration
    Yuan Liu
    Department of Biology, Georgia State University, Atlanta, Georgia 30302, USA
    J Biol Chem 280:36132-40. 2005
    ..These results provide new insights into the structure and function of SIRPs in leukocytes and their potential role(s) in fine-tuning responses to inflammatory stimuli...
  5. pmc Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47
    Yuan Liu
    Department of Biology, Georgia State University, Atlanta, GA 30302, USA
    J Mol Biol 365:680-93. 2007
    ..Our results thus revealed the molecular basis by which SIRPalpha binds to CD47 and shed new light into the structural mechanisms of SIRP isoform mediated distinctive extracellular interactions and cellular responses...
  6. ncbi request reprint Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium
    Ke Zen
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    J Immunol 178:2483-90. 2007
    ..Thus, these results provide a novel mechanism for the regulation of PMN transepithelial migration and may suggest a new therapeutic target for intestinal inflammation...
  7. ncbi request reprint Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:44924-30. 2004
    ..Given the known sorting properties of BAP31, these findings suggest that BAP31 may play a role in regulating intracellular trafficking of CD11b/CD18 in neutrophils...
  8. ncbi request reprint Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha
    Yuan Liu
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 172:2578-85. 2004
    ..Such peptide reagents may be useful for studies on experimental models of inflammation and provide a template for the design of anti-inflammatory agents...
  9. ncbi request reprint Leukocyte-epithelial interactions
    Ke Zen
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Whitehead Research Boulevard, Room 1053, 615 Michael Street, Atlanta, GA 30322, USA
    Curr Opin Cell Biol 15:557-64. 2003
    ....
  10. ncbi request reprint Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration
    Yuan Liu
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 277:10028-36. 2002
    ..Taken together, these results demonstrate that PMN migration is regulated by CD47 through SIRPalpha-dependent and SIRPalpha-independent mechanisms...
  11. ncbi request reprint Response to genistein: assaying the activation status and chemotaxis efficacy of isolated neutrophils
    Ke Zen
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    J Immunol Methods 309:86-98. 2006
    ..g. pre-activated PMN) in their experiments...
  12. doi request reprint Role of different protein tyrosine kinases in fMLP-induced neutrophil transmigration
    Ke Zen
    Cellular and Molecular Biology and Physiology, Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Immunobiology 213:13-23. 2008
    ..In summary, our results demonstrate distinct roles of different tyrosine kinases in regulating PMN chemotaxis and suggest Src and/or Syk kinases are likely involved in CD47-mediated downstream signaling...
  13. pmc Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions
    Zhen Bian
    Program of Cellular Biology and Immunology, Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    J Immunol 188:844-53. 2012
    ..Thus, IL-17A produced at the chronic stage of colitis serves as an essential feedback signal that enhances PMN infiltration and promotes inflammation...
  14. ncbi request reprint Interaction of ICAM-1 with beta 2-integrin CD11c/CD18: characterization of a peptide ligand that mimics a putative binding site on domain D4 of ICAM-1
    Christoph Frick
    Department of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Berne, Switzerland
    Eur J Immunol 35:3610-21. 2005
    ..Using ICAM-1 deletion constructs, we showed that domain D4 is required for interaction with CD11c/CD18, suggesting that C-GRWSGWPADL-C phage binds specifically to CD11c/CD18 by structurally mimicking the interaction site on D4 of ICAM-1...
  15. ncbi request reprint Critical role of mac-1 sialyl lewis x moieties in regulating neutrophil degranulation and transmigration
    Ke Zen
    Jiangsu CDC Nanjing University Joint Institute of Virology, Nanjing University, Nanjing, Jiangsu 210093, China
    J Mol Biol 374:54-63. 2007
    ..In summary, Mac-1 sLe(x) moieties play a critical role in regulating beta(2) integrin functions during neutrophil transmigration and degranulation...
  16. doi request reprint Heparin blocks the adhesion of E. coli O157:H7 to human colonic epithelial cells
    Ling Gu
    Joint Institute of Virology, Jiangsu Center for Disease Control and Prevention, Nanjing University, Nanjing, Jiangsu 210009, China
    Biochem Biophys Res Commun 369:1061-4. 2008
    ..This study provides evidence, for the first time, that heparin and heparan sulfate can serve as novel effective blockers in preventing EHEC O157:H7 infection...
  17. ncbi request reprint PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway
    Yan Zhang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Cell Res 17:363-73. 2007
    ..Our findings indicated that PGC-1alpha was involved in the apoptotic signal transduction pathways and downregulation of PGC-1alpha may be a key point in promoting epithelial ovarian cancer growth and progression...
  18. pmc CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration
    Ke Zen
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
    PLoS ONE 3:e1826. 2008
    ..However, the counterreceptor for E-selectin and its role in mediating breast cancer cell transendothelial migration remain unknown...