CHANGHYON YUN

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2
    C Chris Yun
    Department of Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 277:7676-83. 2002
  2. ncbi request reprint The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1
    C Chris Yun
    Department of Medicine, Division of Digestive Disease, Emory University, Atlanta, Georgia, USA
    J Am Soc Nephrol 13:2823-30. 2002
  3. pmc Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2
    Songbai Lin
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 138:649-58. 2010
  4. pmc Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3
    Byong Kwon Yoo
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 303:G180-8. 2012
  5. ncbi request reprint LPA2 receptor mediates mitogenic signals in human colon cancer cells
    C Chris Yun
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Whitehead Bldg, Suite 201, 615 Michael St, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 289:C2-11. 2005
  6. pmc Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3
    C Chris Yun
    Division of Digestive Disease, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Physiol Biochem 13:29-40. 2003
  7. pmc Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor
    Dongsheng Wang
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 292:C396-404. 2007
  8. pmc Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1
    Dongsheng Wang
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Whitehead Bldg, Suite 201, 615 Michael St, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 289:C802-10. 2005
  9. pmc IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium
    Peijian He
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:33544-53. 2008
  10. pmc P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2
    Sami R Fam
    Department of Pharmacology, Yerkes National Primate Research Center, and Division of Digestive Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:8042-7. 2005

Research Grants

  1. Regulation of Na absorption by NHE3 in the intestine
    CHANGHYON CHRIS YUN; Fiscal Year: 2010
  2. Regulation of Na absorption by NHE3 in the intestine
    CHANGHYON YUN; Fiscal Year: 2009
  3. LPA receptor signaling in colonic epithelia
    CHANGHYON CHRIS YUN; Fiscal Year: 2010
  4. Regulation of NHE3 by glucocorticoids, SGK1 and NHERF2
    CHANGHYON YUN; Fiscal Year: 2007
  5. LPA receptor signaling in colonic epithelia
    CHANGHYON YUN; Fiscal Year: 2009

Collaborators

  • Randy Hall
  • Jerold Chun
  • Inyeong Choi
  • Florian Lang
  • Hong Sun
  • Matthew J Asay
  • Ursula Seidler
  • Georg Lamprecht
  • M Donowitz
  • E J Weinman
  • D Pearce
  • P Cohen
  • Peijian He
  • Dongsheng Wang
  • Huanchun Zhang
  • Songbai Lin
  • Byong Kwon Yoo
  • Maryse Paquet
  • Hyunsuk Shim
  • Vincent W Yang
  • Raluca Rusovici
  • Deborah S Cooper
  • Yoland Smith
  • Sami R Fam
  • Sei Jung Lee
  • Agnieszka Bialkowska
  • James X Du
  • Hye Jeong Lee
  • Amanda M Castleberry
  • Stephen F Traynelis
  • Heide Oller
  • Murali Krishna Yanda
  • Yi Ran No
  • Boris M Hogema
  • Ming Tse
  • Sunil Yeruva
  • Hugo R de Jonge
  • Anurag Kumar Singh
  • Mingmin Chen
  • Janet Klein
  • Smita Iyer
  • Amr M Ghaleb
  • Sengthong Chanchevalap
  • Amr Ghaleb
  • Jonathan P Katz
  • Han Soo Yang
  • Paul D Walden
  • Joseph Kippen
  • Hiroyuki Inuzuka
  • Masaaki Kuwajima
  • Ludmila Cebotaro
  • C Justin Lee

Detail Information

Publications23

  1. ncbi request reprint Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2
    C Chris Yun
    Department of Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 277:7676-83. 2002
    ..These data demonstrated that glucocorticoid activation of NHE3 requires the activation of SGK1 and the presence of NHERF2 acting as a scaffold protein...
  2. ncbi request reprint The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1
    C Chris Yun
    Department of Medicine, Division of Digestive Disease, Emory University, Atlanta, Georgia, USA
    J Am Soc Nephrol 13:2823-30. 2002
    ..This interaction allows the integration of genomic regulation and activation of SGK1 and NHERF2 in the control of ROMK1 activity and renal K(+) excretion...
  3. pmc Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2
    Songbai Lin
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 138:649-58. 2010
    ..We investigated the effect of lysophosphatidic acid (LPA) on Na(+)/H(+) exchanger activity and Na(+)-dependent fluid absorption in the intestine...
  4. pmc Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3
    Byong Kwon Yoo
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 303:G180-8. 2012
    ..We conclude that SK-CO15 cells with the amenity for transfection and high endogenous NHE3 expression are a new and better cell model for NHE3 regulatory investigation than widely used Caco-2 cells...
  5. ncbi request reprint LPA2 receptor mediates mitogenic signals in human colon cancer cells
    C Chris Yun
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Whitehead Bldg, Suite 201, 615 Michael St, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 289:C2-11. 2005
    ..We conclude that LPA2 is the major LPA receptor in colon cancer cells and cellular signals by LPA2 are largely mediated through its ability to interact with NHERF2...
  6. pmc Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3
    C Chris Yun
    Division of Digestive Disease, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Physiol Biochem 13:29-40. 2003
    ..In addition, SGK1 together with NHERF2 stimulates the K+ channel ROMK1, suggesting a broader role of SGK1 in regulation of ion transport...
  7. pmc Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor
    Dongsheng Wang
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 292:C396-404. 2007
    ..Together, these data show that the acute effect of glucocorticoids on NHE3 is mediated by a glucocorticoid receptor dependent mechanism that activates SGK1 in a nongenomic manner...
  8. pmc Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1
    Dongsheng Wang
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Whitehead Bldg, Suite 201, 615 Michael St, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 289:C802-10. 2005
    ..These data reveal that dexamethasone activates NHE3 activity by phosphorylating the NHE3 protein, which initiates trafficking of the protein into the plasma membrane...
  9. pmc IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium
    Peijian He
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:33544-53. 2008
    ..These results suggest that the overall effect of Ca2+ on NHE3 activity is balanced by IRBIT-dependent activation and NHERF2-dependent inhibition...
  10. pmc P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2
    Sami R Fam
    Department of Pharmacology, Yerkes National Primate Research Center, and Division of Digestive Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:8042-7. 2005
    ..These findings reveal that NHERF-2 is a key regulator of the cellular activity of P2Y(1)R and may therefore determine cell-specific differences in P2Y(1)R-mediated signaling...
  11. pmc MAGI-3 regulates LPA-induced activation of Erk and RhoA
    Huanchun Zhang
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Signal 19:261-8. 2007
    ..These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA...
  12. pmc Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5
    Huanchun Zhang
    Division of Digestive Diseases, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:15541-9. 2007
    ..These results identify KLF5 as a target of LPA-mediated signaling and suggest a role of KLF5 in promoting proliferation of intestinal epithelia in response to LPA...
  13. pmc Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad
    Raluca Rusovici
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Biochim Biophys Acta 1770:1194-203. 2007
    ..We further show that LPA treatment resulted in delayed activation of Erk. These results indicate that LPA protects Caco-2 cells from apoptotic insult by a mechanism involving Erk, Bad, and Bcl-2...
  14. pmc Astrocytic and neuronal localization of the scaffold protein Na+/H+ exchanger regulatory factor 2 (NHERF-2) in mouse brain
    Maryse Paquet
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 494:752-62. 2006
    ....
  15. pmc The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine
    Songbai Lin
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1128-38. 2010
    ..In summary, intestinal tumor initiated by Apc mutations is altered by LPA(2)-mediated signaling, which regulates tumor growth and survival by altering multiple targets...
  16. pmc Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II
    Peijian He
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30324, USA
    J Biol Chem 285:27869-78. 2010
    ..In conclusion, our current findings demonstrate that IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway...
  17. pmc Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5
    James X Du
    Division of Digestive Diseases, Department of Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:4782-93. 2007
    ..Importantly, PIAS1 increased the ability of KLF5 to enhance cell proliferation in transfected cells. These results indicate that PIAS1 is a functional partner of KLF5 and enhances the ability of KLF5 to promote proliferation...
  18. pmc Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3
    Peijian He
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Biomed Biotechnol 2010:238080. 2010
    ..The purpose of this paper is to provide a brief overview of recent progress in the regulation and functions of NHE3 present in the luminal membrane of the intestinal tract...
  19. pmc The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer
    Songbai Lin
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 136:1711-20. 2009
    ..In this study, we sought to determine whether LPA and LPA2 regulate the progression of CC in vivo...
  20. pmc The electroneutral sodium/bicarbonate cotransporter containing an amino terminal 123-amino-acid cassette is expressed predominantly in the heart
    Deborah S Cooper
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    J Biomed Sci 13:593-5. 2006
    ..These findings indicate that the variant containing cassette II is almost absent in tissues including brain, kidney, and pancreas, where NBCn1 has been extensively examined...
  21. ncbi request reprint The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity
    Maryse Paquet
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:29949-61. 2006
    ..These observations reveal that NHERF-2 can selectively modulate mGluR5 signaling, which may contribute to cell-specific regulation of mGluR5 activity...
  22. pmc Coexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3
    Dongsheng Wang
    Emory Univ School of Medicine, Div of Digestive Diseases, Whitehead Bldg, Suite 201, 615 Michael St, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 290:F428-37. 2006
    ..These findings suggest that MAST205 regulates NHE3 activity and, although the precise mechanism is yet to be determined, MAST205 appears to inhibit NHE3 activity through a phosphorylation-dependent mechanism...
  23. pmc Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells
    Byong Kwon Yoo
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 301:C1008-16. 2011
    ..Together, these results unveil a pivotal role of apical EGFR in NHE3 regulation by LPA and show that the RhoA-ROCK-Pyk2 and MEK-ERK pathways converge onto NHE3...

Research Grants14

  1. Regulation of Na absorption by NHE3 in the intestine
    CHANGHYON CHRIS YUN; Fiscal Year: 2010
    ..The outcome of the proposed studies should enhance our understanding of the regulation of NHE3 and may aid in the development of improved therapeutic modalities to neutralize diarrhea caused by Na+ malabsorption. ..
  2. Regulation of Na absorption by NHE3 in the intestine
    CHANGHYON YUN; Fiscal Year: 2009
    ..The outcome of the proposed studies should enhance our understanding of the regulation of NHE3 and may aid in the development of improved therapeutic modalities to neutralize diarrhea caused by Na+ malabsorption. ..
  3. LPA receptor signaling in colonic epithelia
    CHANGHYON CHRIS YUN; Fiscal Year: 2010
    ..Our studies will enhance our understanding of the importance and mechanism of tumorigenesis of colorectal cancer by LPA and LPA2 receptor. Our findings should help the therapeutic development against colorectal cancer. ..
  4. Regulation of NHE3 by glucocorticoids, SGK1 and NHERF2
    CHANGHYON YUN; Fiscal Year: 2007
    ..This proposal will resolve complexity in NHE3 regulation by glucocorticoids, and enhance our understanding of protein-protein interaction in regulation of membrane transport proteins. ..
  5. LPA receptor signaling in colonic epithelia
    CHANGHYON YUN; Fiscal Year: 2009
    ..Our studies will enhance our understanding of the importance and mechanism of tumorigenesis of colorectal cancer by LPA and LPA2 receptor. Our findings should help the therapeutic development against colorectal cancer. ..