Larry Young

Summary

Affiliation: Emory University
Country: USA

Publications

  1. Horie K, Inoue K, Suzuki S, Adachi S, Yada S, Hirayama T, et al. Oxytocin receptor knockout prairie voles generated by CRISPR/Cas9 editing show reduced preference for social novelty and exaggerated repetitive behaviors. Horm Behav. 2018;: pubmed publisher
  2. Walum H, Young L. The neural mechanisms and circuitry of the pair bond. Nat Rev Neurosci. 2018;19:643-654 pubmed publisher
    ..Here, we discuss current viewpoints on the biology underlying pair bond formation, its maintenance and associated behaviours from neural and evolutionary perspectives. ..
  3. Dobolyi A, Cservenák M, Young L. Thalamic integration of social stimuli regulating parental behavior and the oxytocin system. Front Neuroendocrinol. 2018;51:102-115 pubmed publisher
  4. Johnson Z, Walum H, Jamal Y, Xiao Y, Keebaugh A, Inoue K, et al. Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles. Horm Behav. 2016;79:8-17 pubmed publisher
    ..These results are consistent with the hypothesis that central OTR signaling facilitates social bond formation by coordinating activity across a pair bonding neural network. ..
  5. Bosch O, Dabrowska J, Modi M, Johnson Z, Keebaugh A, Barrett C, et al. Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles. Psychoneuroendocrinology. 2016;64:66-78 pubmed publisher
    ..Additionally, therapeutic strategies targeting these systems should be considered for treatment of social loss-mediated depression. ..
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    Young L, Murphy Young A, Hammock E. Anatomy and neurochemistry of the pair bond. J Comp Neurol. 2005;493:51-7 pubmed
    ..Here we present an integrated description of the interaction of these circuits in a model of pair bond formation in rodents with a discussion of the implications of these findings for evolution, individual variation, and human bonding. ..
  7. King L, Walum H, Inoue K, Eyrich N, Young L. Variation in the Oxytocin Receptor Gene Predicts Brain Region-Specific Expression and Social Attachment. Biol Psychiatry. 2016;80:160-169 pubmed publisher
  8. Smith A, Freeman S, Barnhart T, Abbott D, Ahlers E, Kukis D, et al. Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys. Bioorg Med Chem Lett. 2016;26:3370-3375 pubmed publisher
    ..Follow-up investigations will focus on next generation biomarkers bearing improved binding characteristics and brain penetrability as well as investigating tissue in regions where biomarker uptake was observed. ..
  9. Johnson Z, Walum H, Xiao Y, Riefkohl P, Young L. Oxytocin receptors modulate a social salience neural network in male prairie voles. Horm Behav. 2017;87:16-24 pubmed publisher

More Information

Publications16

  1. Johnson Z, Young L. Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience. Neurosci Biobehav Rev. 2017;76:87-98 pubmed publisher
  2. Bosch O, Pohl T, Neumann I, Young L. Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system. Behav Brain Res. 2018;341:114-121 pubmed publisher
    ..This animal model has potential for mechanistic studies of behavioral and physiological consequences of partner loss in single mothers. ..
  3. Pohl T, Young L, Bosch O. Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships. Int J Psychophysiol. 2019;136:54-63 pubmed publisher
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    Young L, Nilsen R, Waymire K, MacGregor G, Insel T. Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole. Nature. 1999;400:766-8 pubmed
    ..These data indicate that the pattern of V1a-receptor gene expression in the brain may be functionally associated with species-typical social behaviours in male vertebrates. ..
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    Young L, Pitkow L, Ferguson J. Neuropeptides and social behavior: animal models relevant to autism. Mol Psychiatry. 2002;7 Suppl 2:S38-9 pubmed
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    Young L. Regulating the social brain: a new role for CD38. Neuron. 2007;54:353-6 pubmed
    ..A recent paper by Jin et al. published in Nature demonstrates that the transmembrane receptor CD38 plays a critical role in regulating social behaviors by regulating the release of OT from hypothalamic neurons. ..
  7. Bosch O, Young L. Oxytocin and Social Relationships: From Attachment to Bond Disruption. Curr Top Behav Neurosci. 2018;35:97-117 pubmed publisher
    ..This work has important translational implications relevant to the disruptions of social bonds in childhood and in adults. ..