Yutao Yan

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e5049. 2009
  2. ncbi Overexpression of Ste20-related proline/alanine-rich kinase exacerbates experimental colitis in mice
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 187:1496-505. 2011
  3. ncbi Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e6073. 2009
  4. ncbi Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 173:1013-28. 2008
  5. ncbi Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response
    Hang Thi Thu Nguyen
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 137:1435-47.e1-2. 2009
  6. ncbi PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells
    Guillaume Dalmasso
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 299:G687-96. 2010
  7. ncbi MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation
    Hang Thi Thu Nguyen
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:1479-89. 2010
  8. ncbi Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model
    Hamed Laroui
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 138:843-53.e1-2. 2010
  9. ncbi The PepT1-NOD2 signaling pathway aggravates induced colitis in mice
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 141:1334-45. 2011
  10. ncbi Ecto-phosphorylation of CD98 regulates cell-cell interactions
    Hang Thi Thu Nguyen
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 3:e3895. 2008

Detail Information

Publications33

  1. ncbi Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e5049. 2009
    ..Together, our data suggest that SPAK, the transcription of which is regulated by hyperosmolarity, plays an important role in epithelial barrier function...
  2. ncbi Overexpression of Ste20-related proline/alanine-rich kinase exacerbates experimental colitis in mice
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 187:1496-505. 2011
    ..In conclusion, overexpression of SPAK inhibits maintenance of intestinal mucosal innate immune homeostasis, which makes regulation of SPAK important to attenuate pathological responses in inflammatory bowel disease...
  3. ncbi Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e6073. 2009
    ..In this study we systematically analyzed clinical parameters, histological changes, intestinal barrier properties and cytokine profile during the colitic and recovery phase...
  4. ncbi Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 173:1013-28. 2008
    ..The development of compounds that can either modulate or disrupt the activity of SPAK-mediated pathways is therefore important for the control and attenuation of downstream pathological responses, particularly in IBD...
  5. ncbi Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response
    Hang Thi Thu Nguyen
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 137:1435-47.e1-2. 2009
    ..Here, we address the effects of pathogenic bacteria on colonic PepT1 expression together with its functional consequences...
  6. ncbi PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells
    Guillaume Dalmasso
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 299:G687-96. 2010
    ..Given that PepT1 is highly expressed in the colon during inflammation, PepT1-mediated Tri-DAP transport may occur more effectively during such conditions, further contributing to intestinal inflammation...
  7. ncbi MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation
    Hang Thi Thu Nguyen
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:1479-89. 2010
    ..This study raises microRNAs as a promising target for therapeutic modulations of CD98 expression in intestinal inflammatory disorders...
  8. ncbi Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model
    Hamed Laroui
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 138:843-53.e1-2. 2010
    ..We engineered nanoparticles (NPs) to deliver an anti-inflammatory tripeptide Lys-Pro-Val (KPV) to the colon and assessed its therapeutic efficacy in a mouse model of colitis...
  9. ncbi The PepT1-NOD2 signaling pathway aggravates induced colitis in mice
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 141:1334-45. 2011
    ....
  10. ncbi Ecto-phosphorylation of CD98 regulates cell-cell interactions
    Hang Thi Thu Nguyen
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 3:e3895. 2008
    ..Our findings reveal a novel mechanism involved in regulating the multiple functions of CD98 and raise CD98 as a promising target for therapeutic modulations of cell-cell interactions...
  11. ncbi Intestinal epithelial CD98 synthesis specifically modulates expression of colonic microRNAs during colitis
    Moiz A Charania
    Department of Biology, Center Diagnostics and Therapeutics, Georgia State University, Atlanta, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1282-91. 2012
    ..This is new evidence that protein expression modulates miRNA expression and suggests the existence of regulatory crosstalk between proteins and miRNAs in diseases such as colitis...
  12. ncbi Adenosine 2B receptor expression is post-transcriptionally regulated by microRNA
    Vasantha L Kolachala
    Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:18184-90. 2010
    ..Collectively, these data demonstrate that TNF-alpha-induced A(2B)AR expression in colonic epithelial cells is post-transcriptionally regulated by miR27b and miR128a and show that miR27b influences A(2B)AR expression in murine colitis...
  13. ncbi MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 300:G52-9. 2011
    ..Altogether, our study provides for the first time evidence for the regulation of PepT1 expression at a posttranscriptional level by miRNAs in intestinal epithelial cells during pathophysiological states...
  14. ncbi Butyrate transcriptionally enhances peptide transporter PepT1 expression and activity
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2476. 2008
    ..This study aimed at investigating PepT1 regulation by butyrate, a short-chain fatty acid produced by commensal bacteria and accumulated inside inflamed colonocyte...
  15. ncbi Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice
    Hang Thi Thu Nguyen
    Department of Biology, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA
    Lab Invest 92:1203-12. 2012
    ..In conclusion, we show that CD98 exerts an oncogenic activity in terms of intestinal tumorigenesis, via an ability to regulate tumor growth and survival...
  16. ncbi Leptin transcriptionally enhances peptide transporter (hPepT1) expression and activity via the cAMP-response element-binding protein and Cdx2 transcription factors
    Vivienne Nduati
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:1359-73. 2007
    ..These findings provide important new insights into the mechanisms of intestinal inflammation and may suggest new therapeutic modalities in the future...
  17. ncbi L-Ala-γ-D-Glu-meso-diaminopimelic acid (DAP) interacts directly with leucine-rich region domain of nucleotide-binding oligomerization domain 1, increasing phosphorylation activity of receptor-interacting serine/threonine-protein kinase 2 and its interacti
    Hamed Laroui
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 286:31003-13. 2011
    ..In conclusion, we have shown that Tri-DAP interacts directly with the LRR domain of NOD1 and consequently increases RICK/NOD1 association and RICK phosphorylation activity...
  18. ncbi Characterization of the human intestinal CD98 promoter and its regulation by interferon-gamma
    Yutao Yan
    Div of Digestive Diseases, Dept of Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 292:G535-45. 2007
    ....
  19. ncbi ADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells
    Laetitia Charrier
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:16948-58. 2007
    ..Altogether these findings point to ADAM-15 as a possible therapeutic target for prevention of inappropriate T cell activation involved in some pathologies...
  20. ncbi Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation
    Vasantha L Kolachala
    Division of Digestive Diseases, Department of Medicine, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    J Biol Chem 282:32965-73. 2007
    ....
  21. ncbi Microbiota modulate host gene expression via microRNAs
    Guillaume Dalmasso
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 6:e19293. 2011
    ..In conclusion, our study demonstrates that microbiota modulate host microRNA expression, which could in turn regulate host gene expression...
  22. ncbi CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice
    Hang Thi Thu Nguyen
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    J Clin Invest 121:1733-47. 2011
    ..Modulation of CD98 expression in IECs therefore represents a promising therapeutic strategy for the treatment and prevention of inflammatory intestinal diseases, such as IBD and colitis-associated cancer...
  23. ncbi MicroRNAs determine human intestinal epithelial cell fate
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Differentiation 80:147-54. 2010
    ..19A cell phenotype. In conclusion, our study shows that miRNAs might play a role in determining the unique physiological characteristics of IECs...
  24. ncbi PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, USA
    Gastroenterology 134:166-78. 2008
    ..The aim of this study was to 1) investigate whether the KPV anti-inflammatory effect is PepT1-mediated in intestinal epithelian and immune cells, and 2) examine the anti-inflammatory effects in two models of mice colitis...
  25. ncbi The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease
    Sarah A Ingersoll
    Center for Diagnostics and Therapeutics, Department of Biology, Georgia State University, Atlanta, 30302 5090, USA
    Am J Physiol Gastrointest Liver Physiol 302:G484-92. 2012
    ..It is important to understand the mechanisms of PepT1 action during chronic intestinal inflammation to develop future therapies addressing inappropriate immune activation in the colon...
  26. ncbi Functional TNFα gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon
    Hamed Laroui
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA, United States
    Biomaterials 32:1218-28. 2011
    ..Our results collectively indicate that polyethyleneimine/TNFα siRNA nanocomplexes represent an efficient therapeutic option for diseases such as IBD...
  27. ncbi Intestinal epithelial CD98: an oligomeric and multifunctional protein
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1780:1087-92. 2008
    ..A role for CD98 in intestinal inflammation, such as Intestinal Bowel Disease (IBD), is also proposed...
  28. ncbi Extracellular interaction between hCD98 and the PDZ class II domain of hCASK in intestinal epithelia
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    J Membr Biol 215:15-26. 2007
    ..These novel results, which provide the first evidence for a PDZ domain-dependent interaction between a membrane protein and an extracellular protein, open a new field of investigation related to extracellular signaling in cell biology...
  29. ncbi hPepT1 mediates bacterial tripeptide fMLP uptake in human monocytes
    Laetitia Charrier
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Lab Invest 86:490-503. 2006
    ..2. Furthermore, we provide evidence for hPepT1-mediated fMLP transport, which might constitute a novel immune cell activation pathway during intestinal inflammation...
  30. ncbi Dystroglycan receptor is involved in integrin activation in intestinal epithelia
    Adel Driss
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, Atlanta, 30322, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1228-42. 2006
    ..Collectively, these novel results indicate that dystroglycans play important roles in the regulation of interactions between intestinal epithelial cells and the extracellular matrix...
  31. ncbi Ste20-related proline/alanine-rich kinase: a novel regulator of intestinal inflammation
    Yutao Yan
    Emory University, Department of Medicine, Division of Digestive Diseases, 615 Michael Street, Atlanta, GA 30322, United States
    World J Gastroenterol 14:6115-21. 2008
    ....
  32. ncbi ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers
    Laetitia Charrier
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 288:G346-53. 2005
    ..Together, these results suggest that ADAM-15 may have important pathophysiological roles in intestinal cells...
  33. ncbi Characterization of a novel vaccine candidate and serine proteinase inhibitor from Schistosoma japonicum (Sj serpin)
    Yutao Yan
    Emory University, 615 Michael St, Atlanta, GA 30322, USA
    Vet Parasitol 131:53-60. 2005
    ..japonicum as demonstrated by a 36 and 39% reduction in the recovery of adult worms and eggs, respectively. These data suggested a role for Sj serpin as a vaccine candidate or as a novel target for anti-schistosome drugs...