Yan Y, Dalmasso G, Nguyen H, Obertone T, Sitaraman S, Merlin D. Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function. PLoS ONE. 2009;4:e5049 pubmed publisher
..Together, our data suggest that SPAK, the transcription of which is regulated by hyperosmolarity, plays an important role in epithelial barrier function. ..
Yan Y, Laroui H, Ingersoll S, Ayyadurai S, Charania M, Yang S, et al. Overexpression of Ste20-related proline/alanine-rich kinase exacerbates experimental colitis in mice. J Immunol. 2011;187:1496-505 pubmed publisher
..In conclusion, overexpression of SPAK inhibits maintenance of intestinal mucosal innate immune homeostasis, which makes regulation of SPAK important to attenuate pathological responses in inflammatory bowel disease. ..