THOMAS N WICHMANN

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Slow oscillatory discharge in the primate basal ganglia
    Thomas Wichmann
    Department of Neurology, Emory University, Suite 6000, Woodruff Memorial Research Building, 1639 Pierce Street, Atlanta, GA 30322, USA
    J Neurophysiol 87:1145-8. 2002
  2. ncbi request reprint Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonism
    Thomas Wichmann
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    J Neurophysiol 95:2120-33. 2006
  3. doi request reprint Commentary: Dopaminergic dysfunction in DYT1 dystonia
    Thomas Wichmann
    Department of Neurology School of Medicine and Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Exp Neurol 212:242-6. 2008
  4. pmc Extrastriatal dopaminergic circuits of the Basal Ganglia
    Karen S Rommelfanger
    Yerkes National Primate Research Center, Emory University Atlanta, GA, USA
    Front Neuroanat 4:139. 2010
  5. pmc Pathological basal ganglia activity in movement disorders
    T Wichmann
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Neuroscience 198:232-44. 2011
  6. ncbi request reprint Functional and pathophysiological models of the basal ganglia
    T Wichmann
    Department of Neurology, Emory University School of Medicine, Suite 6000, Woodruff Memorial Research Building, 1639 Pierce Drive, Atlanta, Georgia 30322, USA
    Curr Opin Neurobiol 6:751-8. 1996
  7. doi request reprint Milestones in research on the pathophysiology of Parkinson's disease
    Thomas Wichmann
    Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA
    Mov Disord 26:1032-41. 2011
  8. pmc A novel device to suppress electrical stimulus artifacts in electrophysiological experiments
    Thomas Wichmann
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Neurosci Methods 201:1-8. 2011
  9. ncbi request reprint Neuronal activity in the primate substantia nigra pars reticulata during the performance of simple and memory-guided elbow movements
    Thomas Wichmann
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurophysiol 91:815-27. 2004
  10. ncbi request reprint Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorder
    Thomas Wichmann
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 991:199-213. 2003

Research Grants

  1. Local field potentials in the basal ganglia
    Thomas Wichmann; Fiscal Year: 2006
  2. Local field potentials in the basal ganglia
    Thomas Wichmann; Fiscal Year: 2009
  3. Local field potentials in the basal ganglia
    Thomas Wichmann; Fiscal Year: 2007
  4. Function of dopamine in the primate substantia nigra
    Thomas Wichmann; Fiscal Year: 2007
  5. Function of dopamine in the primate substantia nigra
    Thomas Wichmann; Fiscal Year: 2006
  6. Function of dopamine in the primate substantia nigra
    Thomas Wichmann; Fiscal Year: 2005
  7. Thalamostriatal System in Parkinsonism
    THOMAS N WICHMANN; Fiscal Year: 2010
  8. Basal ganglia discharge patterns in parkinsonism
    Thomas Wichmann; Fiscal Year: 2004
  9. Influence of subthalamic nucleus on striatal dopamine
    Thomas Wichmann; Fiscal Year: 2004
  10. Local field potentials in the basal ganglia
    THOMAS N WICHMANN; Fiscal Year: 2010

Detail Information

Publications37

  1. ncbi request reprint Slow oscillatory discharge in the primate basal ganglia
    Thomas Wichmann
    Department of Neurology, Emory University, Suite 6000, Woodruff Memorial Research Building, 1639 Pierce Street, Atlanta, GA 30322, USA
    J Neurophysiol 87:1145-8. 2002
    ..The oscillations may have roles in fundamental functions of the basal ganglia-thalamocortical network, such as the regulation of the state of arousal...
  2. ncbi request reprint Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonism
    Thomas Wichmann
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    J Neurophysiol 95:2120-33. 2006
    ..Complex changes in these interactions may contribute to abnormal information processing in parkinsonism...
  3. doi request reprint Commentary: Dopaminergic dysfunction in DYT1 dystonia
    Thomas Wichmann
    Department of Neurology School of Medicine and Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Exp Neurol 212:242-6. 2008
    ....
  4. pmc Extrastriatal dopaminergic circuits of the Basal Ganglia
    Karen S Rommelfanger
    Yerkes National Primate Research Center, Emory University Atlanta, GA, USA
    Front Neuroanat 4:139. 2010
    ..Further insights into the dopaminergic modulation of basal ganglia function at extrastriatal sites may provide us with opportunities to develop new and more specific strategies for treating disorders of basal ganglia dysfunction...
  5. pmc Pathological basal ganglia activity in movement disorders
    T Wichmann
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Neuroscience 198:232-44. 2011
    ..In this review, we critically summarize our current knowledge of the pathological discharge patterns of basal ganglia neurons in Parkinson's disease, dystonia, and dyskinesias...
  6. ncbi request reprint Functional and pathophysiological models of the basal ganglia
    T Wichmann
    Department of Neurology, Emory University School of Medicine, Suite 6000, Woodruff Memorial Research Building, 1639 Pierce Drive, Atlanta, Georgia 30322, USA
    Curr Opin Neurobiol 6:751-8. 1996
    ....
  7. doi request reprint Milestones in research on the pathophysiology of Parkinson's disease
    Thomas Wichmann
    Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA
    Mov Disord 26:1032-41. 2011
    ....
  8. pmc A novel device to suppress electrical stimulus artifacts in electrophysiological experiments
    Thomas Wichmann
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Neurosci Methods 201:1-8. 2011
    ..The device is fully customizable, and can be easily adjusted to various stimulation conditions, as well as AC line noise removal...
  9. ncbi request reprint Neuronal activity in the primate substantia nigra pars reticulata during the performance of simple and memory-guided elbow movements
    Thomas Wichmann
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurophysiol 91:815-27. 2004
    ..While internal pallidal segment neurons may be preferentially concerned with controlling elemental movement parameters, neurons in the SNr may be more involved in higher motor functions or nonmotor aspects of behavior...
  10. ncbi request reprint Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorder
    Thomas Wichmann
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 991:199-213. 2003
    ..Lesions of GPi or STN are effective in treating parkinsonism, because they reduce or abolish abnormal basal ganglia output, enabling remaining circuits to function more normally...
  11. ncbi request reprint Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primates
    T Wichmann
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Brain Res 125:397-409. 1999
    ..8% to 27% of all neurons in the GPi, and from none to 10% in the SNr). The results show that neuronal discharge in the SNr is affected in parkinsonism, but that the changes in the SNr are less pronounced then those seen in the GPi...
  12. ncbi request reprint A digital averaging method for removal of stimulus artifacts in neurophysiologic experiments
    T Wichmann
    Department of Neurology, Emory University School of Medicine, Suite 6000, P O Drawer V, Woodruff Memorial Building, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Neurosci Methods 98:57-62. 2000
    ..Faster computers and optimized software may make on-line application of this technique feasible...
  13. pmc Neuronal activity in the subthalamic nucleus modulates the release of dopamine in the monkey striatum
    Yasushi Shimo
    Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA
    Eur J Neurosci 29:104-13. 2009
    ..These results suggest that activity in the primate SNc is prominently influenced by neuronal discharge in the STN, which may thus alter dopamine release in the striatum...
  14. doi request reprint Effects of stimulation of the centromedian nucleus of the thalamus on the activity of striatal cells in awake rhesus monkeys
    Bijli Nanda
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Eur J Neurosci 29:588-98. 2009
    ..Through these indirect effects, local CM stimulation may engage large portions of the striatum. These effects may be relevant in the interpretation of the therapeutic effects of CM stimulation for the treatment of neurological disorders...
  15. ncbi request reprint Role of external pallidal segment in primate parkinsonism: comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism and lesions of the external pallidal segment
    Jesus Soares
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 24:6417-26. 2004
    ..The results indicate that a mere reduction of GPe activity does not produce parkinsonism. Other changes, such as altered discharge patterns in STN and GPi, may play an important role in the generation of parkinsonism...
  16. pmc Interactions between cortical rhythms and spiking activity of single basal ganglia neurons in the normal and parkinsonian state
    Plamen Gatev
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Cereb Cortex 19:1330-44. 2009
    ..The findings indicate that basal ganglia and cortex interact in the processing of cortical rhythms that contain oscillations across a broad range of frequencies and that this interaction is severely disrupted in parkinsonism...
  17. ncbi request reprint Oscillations in the basal ganglia under normal conditions and in movement disorders
    Plamen Gatev
    Yerkes National Primate Center, Emory University, Atlanta, Georgia 30322, USA
    Mov Disord 21:1566-77. 2006
    ..Although less firmly established than the role of oscillations in movement disorders, oscillatory activities at higher frequencies may also be a component of normal basal ganglia physiology...
  18. ncbi request reprint Activation of nigral and pallidal dopamine D1-like receptors modulates basal ganglia outflow in monkeys
    Michele A Kliem
    Yerkes National Primate Center, Emory University, School of Medicine, 954 Gatewood Road, Atlanta, GA 30322, USA
    J Neurophysiol 98:1489-500. 2007
    ..Our results support the finding that D1LR activation may have powerful effects on GPi and SNr neurons and may mediate some of the effects of dopamine replacement therapies in Parkinson's disease...
  19. pmc Pathophysiology of parkinsonism
    Adriana Galvan
    Department of Neurology, School of Medicine and Division of Sensorimotor Systems, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, United States
    Clin Neurophysiol 119:1459-74. 2008
    ..Detailed knowledge of these changes will help us to develop more effective and specific symptomatic treatments for patients with Parkinson's disease...
  20. ncbi request reprint Functional neuroanatomy of the basal ganglia in Parkinson's disease
    Thomas Wichmann
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
    Adv Neurol 91:9-18. 2003
  21. ncbi request reprint A method to record changes in local neuronal discharge in response to infusion of small drug quantities in awake monkeys
    Michele Ann Kliem
    Department of Neurology, Emory University School of Medicine, Suite 6000, Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
    J Neurosci Methods 138:45-9. 2004
    ..The major advantage of this device is the ability to record with excellent quality, changes in the activity of single cells in vivo within 50-100 microm of the location of drug injections...
  22. ncbi request reprint Ultrastructural localization and function of dopamine D1-like receptors in the substantia nigra pars reticulata and the internal segment of the globus pallidus of parkinsonian monkeys
    Michele A Kliem
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Eur J Neurosci 31:836-51. 2010
    ....
  23. pmc Localization and function of GABA transporters in the globus pallidus of parkinsonian monkeys
    Adriana Galvan
    Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, GA, USA
    Exp Neurol 223:505-15. 2010
    ..These results suggest that, after dopaminergic depletion, the functions of GABA transporters are altered in GPi; without major changes in their subcellular localization...
  24. doi request reprint Update on models of basal ganglia function and dysfunction
    Mahlon Delong
    Department Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Parkinsonism Relat Disord 15:S237-40. 2009
    ..In this paper we review these fascinating changes of our appreciation of the basal ganglia circuitry, and comment on the current state of our knowledge in this field...
  25. ncbi request reprint Changing views of basal ganglia circuits and circuit disorders
    Mahlon Delong
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin EEG Neurosci 41:61-7. 2010
    ..We here discuss the changes in our current understanding of the anatomic and functional organization of BG circuits and related circuit disorders...
  26. ncbi request reprint Effects of transient focal inactivation of the basal ganglia in parkinsonian primates
    Mark S Baron
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 22:592-9. 2002
    ..Surgical outcomes might therefore be optimized by placing more discrete lesions and by restricting the extent of chronic stimulation...
  27. pmc A non-invasive technique to monitor wakefulness during electrophysiologic recording experiments in primates
    Olivier Darbin
    Division of Sensorimotor Systems, Yerkes National Primate Research Center, 954 Gatewood Road, NE Atlanta, GA 30329, USA
    J Neurosci Methods 177:448-51. 2009
    ..A comparison with frontal electroencephalographic records confirmed that such periods corresponded to wakefulness...
  28. ncbi request reprint A new probe to monitor the effects of drugs on local field potentials
    Olivier Darbin
    Department of Visual Sciences, Yerkes National Primate Center, Emory University, Neuroscience Building, Atlanta, GA 30322, USA
    J Neurosci Methods 155:291-5. 2006
    ..The device can be used to monitor LFPs with differential recording methods before, during, and after local application of drugs by reverse microdialysis, while concomitantly sampling biochemical constituents from the area of recording...
  29. ncbi request reprint Nonlinear analysis of discharge patterns in monkey basal ganglia
    Olivier Darbin
    Yerkes National Primate Research Center, School of Medicine, Emory University, Neuroscience Building, 3rd Floor, Atlanta, GA 30322, USA
    Brain Res 1118:84-93. 2006
    ..Our analyses demonstrate that the discharge of most neurons in the basal ganglia of awake monkeys has nonlinear features that may be important for information coding in the basal ganglia...
  30. ncbi request reprint Circuits and circuit disorders of the basal ganglia
    Mahlon R Delong
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Neurol 64:20-4. 2007
    ....
  31. doi request reprint Effects of striatal GABA A-receptor blockade on striatal and cortical activity in monkeys
    Olivier Darbin
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    J Neurophysiol 99:1294-305. 2008
    ..These data provide evidence that a GABAergic "tone" in the monkey striatum controls the spontaneous activity of striatal neurons, as well as the level of striatal and cortical synchrony...
  32. ncbi request reprint GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters
    Adriana Galvan
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    J Neurophysiol 94:990-1000. 2005
    ....
  33. pmc The thalamostriatal systems: anatomical and functional organization in normal and parkinsonian states
    Yoland Smith
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Brain Res Bull 78:60-8. 2009
    ..Although the available clinical evidence is encouraging, these procedures remain empirical at this stage because of the limited understanding of the thalamostriatal systems...
  34. ncbi request reprint Continuous monitoring of intracerebral glutamate levels in awake monkeys using microdialysis and enzyme fluorometric detection
    Adriana Galvan
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Neurosci Methods 126:175-85. 2003
    ..This technique effectively detects short-term changes in glutamate levels evoked by physiologic or pharmacologic manipulations in the primate brain...
  35. ncbi request reprint GABAergic circuits in the basal ganglia and movement disorders
    Adriana Galvan
    Department of Neurology, School of Medicine and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Prog Brain Res 160:287-312. 2007
    ....
  36. pmc (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism
    Gunasingh Masilamoni
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Exp Neurol 226:265-73. 2010
    ..These findings demonstrate that (18)F-FECNT is a highly sensitive PET imaging ligand to quantify both striatal dopamine denervation and midbrain dopaminergic cell loss associated with parkinsonism...
  37. ncbi request reprint Deep brain stimulation for neurologic and neuropsychiatric disorders
    Thomas Wichmann
    Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    Neuron 52:197-204. 2006
    ..This review summarizes the rationale behind DBS and the use of this technique for a variety of movement disorders and neuropsychiatric diseases...

Research Grants22

  1. Local field potentials in the basal ganglia
    Thomas Wichmann; Fiscal Year: 2006
    ..Conceivably, such criteria could be used in the next generation of DBS devices to trigger 'on-demand' stimulation. ..
  2. Local field potentials in the basal ganglia
    Thomas Wichmann; Fiscal Year: 2009
    ..Conceivably, such criteria could be used in the next generation of DBS devices to trigger 'on-demand' stimulation. ..
  3. Local field potentials in the basal ganglia
    Thomas Wichmann; Fiscal Year: 2007
    ..Conceivably, such criteria could be used in the next generation of DBS devices to trigger 'on-demand' stimulation. ..
  4. Function of dopamine in the primate substantia nigra
    Thomas Wichmann; Fiscal Year: 2007
    ..g., transplantation of ventral mesencephalic tissue) may act through local release of dopamine. ..
  5. Function of dopamine in the primate substantia nigra
    Thomas Wichmann; Fiscal Year: 2006
    ..g., transplantation of ventral mesencephalic tissue) may act through local release of dopamine. ..
  6. Function of dopamine in the primate substantia nigra
    Thomas Wichmann; Fiscal Year: 2005
    ..g., transplantation of ventral mesencephalic tissue) may act through local release of dopamine. ..
  7. Thalamostriatal System in Parkinsonism
    THOMAS N WICHMANN; Fiscal Year: 2010
    ....
  8. Basal ganglia discharge patterns in parkinsonism
    Thomas Wichmann; Fiscal Year: 2004
    ....
  9. Influence of subthalamic nucleus on striatal dopamine
    Thomas Wichmann; Fiscal Year: 2004
    ..These studies will provide insight into the role of the STN-SNc interaction under normal and parkinsonian conditions and will help to understand the mechanisms of action of neurosurgical treatments aimed at SIN in parkinsonian patients. ..
  10. Local field potentials in the basal ganglia
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..Conceivably, such criteria could be used in the next generation of DBS devices to trigger 'on-demand'stimulation. ..
  11. Influence of subthalamic nucleus on striatal dopamine
    Thomas Wichmann; Fiscal Year: 2003
    ..These studies will provide insight into the role of the STN-SNc interaction under normal and parkinsonian conditions and will help to understand the mechanisms of action of neurosurgical treatments aimed at SIN in parkinsonian patients. ..
  12. Basal ganglia discharge patterns in parkinsonism
    Thomas Wichmann; Fiscal Year: 2002
    ....
  13. Influence of subthalamic nucleus on striatal dopamine
    Thomas Wichmann; Fiscal Year: 2002
    ..These studies will provide insight into the role of the STN-SNc interaction under normal and parkinsonian conditions and will help to understand the mechanisms of action of neurosurgical treatments aimed at SIN in parkinsonian patients. ..
  14. Basal ganglia discharge patterns in parkinsonism
    Thomas Wichmann; Fiscal Year: 2001
    ....
  15. Function of dopamine in the primate substantia nigra
    Thomas Wichmann; Fiscal Year: 2009
    ..g., transplantation of ventral mesencephalic tissue) may act through local release of dopamine. ..
  16. Thalamostriatal System in Parkinsonism
    Thomas Wichmann; Fiscal Year: 2009
    ....
  17. Influence of subthalamic nucleus on striatal dopamine
    Thomas Wichmann; Fiscal Year: 2001
    ..These studies will provide insight into the role of the STN-SNc interaction under normal and parkinsonian conditions and will help to understand the mechanisms of action of neurosurgical treatments aimed at SIN in parkinsonian patients. ..
  18. Basal ganglia discharge patterns in parkinsonism
    Thomas Wichmann; Fiscal Year: 2005
    ....
  19. Basal ganglia discharge patterns in parkinsonism
    Thomas Wichmann; Fiscal Year: 2003
    ....
  20. Extrastriatal functions of dopamine
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..If significant dopaminergic effects are seen in the subthalamic nucleus, it may emerge as a new target for highly specific local dopamine replacement therapies for parkinsonian patients. ..