Research Topics
| THOMAS N WICHMANNSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Slow oscillatory discharge in the primate basal gangliaThomas Wichmann
Department of Neurology, Emory University, Suite 6000, Woodruff Memorial Research Building, 1639 Pierce Street, Atlanta, GA 30322, USA
J Neurophysiol 87:1145-8. 2002..The oscillations may have roles in fundamental functions of the basal ganglia-thalamocortical network, such as the regulation of the state of arousal...- Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonismThomas Wichmann
Department of Neurology, Emory University, Atlanta, GA 30322, USA
J Neurophysiol 95:2120-33. 2006..Complex changes in these interactions may contribute to abnormal information processing in parkinsonism... 
Commentary: Dopaminergic dysfunction in DYT1 dystoniaThomas Wichmann
Department of Neurology School of Medicine and Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
Exp Neurol 212:242-6. 2008....
Pathological basal ganglia activity in movement disordersT Wichmann
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Neuroscience 198:232-44. 2011..In this review, we critically summarize our current knowledge of the pathological discharge patterns of basal ganglia neurons in Parkinson's disease, dystonia, and dyskinesias...- Functional and pathophysiological models of the basal gangliaT Wichmann
Department of Neurology, Emory University School of Medicine, Suite 6000, Woodruff Memorial Research Building, 1639 Pierce Drive, Atlanta, Georgia 30322, USA
Curr Opin Neurobiol 6:751-8. 1996.... - Milestones in research on the pathophysiology of Parkinson's diseaseThomas Wichmann
Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA
Mov Disord 26:1032-41. 2011.... - A novel device to suppress electrical stimulus artifacts in electrophysiological experimentsThomas Wichmann
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
J Neurosci Methods 201:1-8. 2011..The device is fully customizable, and can be easily adjusted to various stimulation conditions, as well as AC line noise removal... - Neuronal activity in the primate substantia nigra pars reticulata during the performance of simple and memory-guided elbow movementsThomas Wichmann
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurophysiol 91:815-27. 2004..While internal pallidal segment neurons may be preferentially concerned with controlling elemental movement parameters, neurons in the SNr may be more involved in higher motor functions or nonmotor aspects of behavior... - Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorderThomas Wichmann
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Ann N Y Acad Sci 991:199-213. 2003..Lesions of GPi or STN are effective in treating parkinsonism, because they reduce or abolish abnormal basal ganglia output, enabling remaining circuits to function more normally... - Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primatesT Wichmann
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Exp Brain Res 125:397-409. 1999..8% to 27% of all neurons in the GPi, and from none to 10% in the SNr). The results show that neuronal discharge in the SNr is affected in parkinsonism, but that the changes in the SNr are less pronounced then those seen in the GPi... - A digital averaging method for removal of stimulus artifacts in neurophysiologic experimentsT Wichmann
Department of Neurology, Emory University School of Medicine, Suite 6000, P O Drawer V, Woodruff Memorial Building, 1639 Pierce Drive, Atlanta, GA 30322, USA
J Neurosci Methods 98:57-62. 2000..Faster computers and optimized software may make on-line application of this technique feasible... - Neuronal activity in the subthalamic nucleus modulates the release of dopamine in the monkey striatumYasushi Shimo
Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA
Eur J Neurosci 29:104-13. 2009..These results suggest that activity in the primate SNc is prominently influenced by neuronal discharge in the STN, which may thus alter dopamine release in the striatum... - Effects of stimulation of the centromedian nucleus of the thalamus on the activity of striatal cells in awake rhesus monkeysBijli Nanda
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Eur J Neurosci 29:588-98. 2009..Through these indirect effects, local CM stimulation may engage large portions of the striatum. These effects may be relevant in the interpretation of the therapeutic effects of CM stimulation for the treatment of neurological disorders... - Role of external pallidal segment in primate parkinsonism: comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism and lesions of the external pallidal segmentJesus Soares
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 24:6417-26. 2004..The results indicate that a mere reduction of GPe activity does not produce parkinsonism. Other changes, such as altered discharge patterns in STN and GPi, may play an important role in the generation of parkinsonism... - Interactions between cortical rhythms and spiking activity of single basal ganglia neurons in the normal and parkinsonian statePlamen Gatev
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Cereb Cortex 19:1330-44. 2009..The findings indicate that basal ganglia and cortex interact in the processing of cortical rhythms that contain oscillations across a broad range of frequencies and that this interaction is severely disrupted in parkinsonism... - Oscillations in the basal ganglia under normal conditions and in movement disordersPlamen Gatev
Yerkes National Primate Center, Emory University, Atlanta, Georgia 30322, USA
Mov Disord 21:1566-77. 2006..Although less firmly established than the role of oscillations in movement disorders, oscillatory activities at higher frequencies may also be a component of normal basal ganglia physiology... - Pathophysiology of parkinsonismAdriana Galvan
Department of Neurology, School of Medicine and Division of Sensorimotor Systems, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, United States
Clin Neurophysiol 119:1459-74. 2008..Detailed knowledge of these changes will help us to develop more effective and specific symptomatic treatments for patients with Parkinson's disease... - Functional neuroanatomy of the basal ganglia in Parkinson's diseaseThomas Wichmann
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
Adv Neurol 91:9-18. 2003 - Activation of nigral and pallidal dopamine D1-like receptors modulates basal ganglia outflow in monkeysMichele A Kliem
Yerkes National Primate Center, Emory University, School of Medicine, 954 Gatewood Road, Atlanta, GA 30322, USA
J Neurophysiol 98:1489-500. 2007..Our results support the finding that D1LR activation may have powerful effects on GPi and SNr neurons and may mediate some of the effects of dopamine replacement therapies in Parkinson's disease... - A non-invasive technique to monitor wakefulness during electrophysiologic recording experiments in primatesOlivier Darbin
Division of Sensorimotor Systems, Yerkes National Primate Research Center, 954 Gatewood Road, NE Atlanta, GA 30329, USA
J Neurosci Methods 177:448-51. 2009..A comparison with frontal electroencephalographic records confirmed that such periods corresponded to wakefulness... - Update on models of basal ganglia function and dysfunctionMahlon Delong
Department Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Parkinsonism Relat Disord 15:S237-40. 2009..In this paper we review these fascinating changes of our appreciation of the basal ganglia circuitry, and comment on the current state of our knowledge in this field... - Localization and function of GABA transporters in the globus pallidus of parkinsonian monkeysAdriana Galvan
Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, GA, USA
Exp Neurol 223:505-15. 2010..These results suggest that, after dopaminergic depletion, the functions of GABA transporters are altered in GPi; without major changes in their subcellular localization... - Ultrastructural localization and function of dopamine D1-like receptors in the substantia nigra pars reticulata and the internal segment of the globus pallidus of parkinsonian monkeysMichele A Kliem
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
Eur J Neurosci 31:836-51. 2010.... - Changing views of basal ganglia circuits and circuit disordersMahlon Delong
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Clin EEG Neurosci 41:61-7. 2010..quot; We here discuss the changes in our current understanding of the anatomic and functional organization of BG circuits and related circuit disorders... - Continuous monitoring of intracerebral glutamate levels in awake monkeys using microdialysis and enzyme fluorometric detectionAdriana Galvan
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
J Neurosci Methods 126:175-85. 2003..This technique effectively detects short-term changes in glutamate levels evoked by physiologic or pharmacologic manipulations in the primate brain... - The thalamostriatal systems: anatomical and functional organization in normal and parkinsonian statesYoland Smith
Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
Brain Res Bull 78:60-8. 2009..Although the available clinical evidence is encouraging, these procedures remain empirical at this stage because of the limited understanding of the thalamostriatal systems... - A method to record changes in local neuronal discharge in response to infusion of small drug quantities in awake monkeysMichele Ann Kliem
Department of Neurology, Emory University School of Medicine, Suite 6000, Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
J Neurosci Methods 138:45-9. 2004..The major advantage of this device is the ability to record with excellent quality, changes in the activity of single cells in vivo within 50-100 microm of the location of drug injections... - GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transportersAdriana Galvan
Department of Neurology, Emory University, Atlanta, GA 30322, USA
J Neurophysiol 94:990-1000. 2005.... - A new probe to monitor the effects of drugs on local field potentialsOlivier Darbin
Department of Visual Sciences, Yerkes National Primate Center, Emory University, Neuroscience Building, Atlanta, GA 30322, USA
J Neurosci Methods 155:291-5. 2006..The device can be used to monitor LFPs with differential recording methods before, during, and after local application of drugs by reverse microdialysis, while concomitantly sampling biochemical constituents from the area of recording... - Nonlinear analysis of discharge patterns in monkey basal gangliaOlivier Darbin
Yerkes National Primate Research Center, School of Medicine, Emory University, Neuroscience Building, 3rd Floor, Atlanta, GA 30322, USA
Brain Res 1118:84-93. 2006..Our analyses demonstrate that the discharge of most neurons in the basal ganglia of awake monkeys has nonlinear features that may be important for information coding in the basal ganglia... - Circuits and circuit disorders of the basal gangliaMahlon R Delong
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Arch Neurol 64:20-4. 2007.... - Effects of striatal GABA A-receptor blockade on striatal and cortical activity in monkeysOlivier Darbin
Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
J Neurophysiol 99:1294-305. 2008..These data provide evidence that a GABAergic "tone" in the monkey striatum controls the spontaneous activity of striatal neurons, as well as the level of striatal and cortical synchrony... - Effects of transient focal inactivation of the basal ganglia in parkinsonian primatesMark S Baron
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 22:592-9. 2002..Surgical outcomes might therefore be optimized by placing more discrete lesions and by restricting the extent of chronic stimulation... - GABAergic circuits in the basal ganglia and movement disordersAdriana Galvan
Department of Neurology, School of Medicine and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Prog Brain Res 160:287-312. 2007.... - (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonismGunasingh Masilamoni
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Exp Neurol 226:265-73. 2010..These findings demonstrate that (18)F-FECNT is a highly sensitive PET imaging ligand to quantify both striatal dopamine denervation and midbrain dopaminergic cell loss associated with parkinsonism... - Deep brain stimulation for neurologic and neuropsychiatric disordersThomas Wichmann
Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
Neuron 52:197-204. 2006..This review summarizes the rationale behind DBS and the use of this technique for a variety of movement disorders and neuropsychiatric diseases...
Research Grants
- Local field potentials in the basal gangliaThomas Wichmann; Fiscal Year: 2007..Conceivably, such criteria could be used in the next generation of DBS devices to trigger 'on-demand' stimulation. ..
- Function of dopamine in the primate substantia nigraThomas Wichmann; Fiscal Year: 2009..g., transplantation of ventral mesencephalic tissue) may act through local release of dopamine. ..
- Local field potentials in the basal gangliaThomas Wichmann; Fiscal Year: 2009..Conceivably, such criteria could be used in the next generation of DBS devices to trigger 'on-demand' stimulation. ..
- Thalamostriatal System in ParkinsonismTHOMAS N WICHMANN; Fiscal Year: 2010....
- Local field potentials in the basal gangliaTHOMAS N WICHMANN; Fiscal Year: 2010..Conceivably, such criteria could be used in the next generation of DBS devices to trigger 'on-demand'stimulation. ..
- Influence of subthalamic nucleus on striatal dopamineThomas Wichmann; Fiscal Year: 2004..These studies will provide insight into the role of the STN-SNc interaction under normal and parkinsonian conditions and will help to understand the mechanisms of action of neurosurgical treatments aimed at SIN in parkinsonian patients. ..
- Basal ganglia discharge patterns in parkinsonismThomas Wichmann; Fiscal Year: 2005....
- Extrastriatal functions of dopamineTHOMAS N WICHMANN; Fiscal Year: 2010..If significant dopaminergic effects are seen in the subthalamic nucleus, it may emerge as a new target for highly specific local dopamine replacement therapies for parkinsonian patients. ..