Stephen T Warren

Summary

Affiliation: Emory University
Country: USA

Publications

  1. Johnston H, Chopra P, Wingo T, Patel V, Epstein M, MULLE J, et al. Reply to Pl├╝ss et al.: The strength of PEMapper/PECaller lies in unbiased calling using large sample sizes. Proc Natl Acad Sci U S A. 2017;114:E8323 pubmed publisher
  2. Johnston H, Chopra P, Wingo T, Patel V, Epstein M, MULLE J, et al. PEMapper and PECaller provide a simplified approach to whole-genome sequencing. Proc Natl Acad Sci U S A. 2017;114:E1923-E1932 pubmed publisher
  3. Myrick L, Deng P, Hashimoto H, Oh Y, Cho Y, Poidevin M, et al. Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures. Proc Natl Acad Sci U S A. 2015;112:949-56 pubmed publisher
    ..These results reveal a presynaptic- and translation-independent function of FMRP that is linked to a specific subset of FXS phenotypes. ..
  4. Suhl J, Muddashetty R, Anderson B, Ifrim M, Visootsak J, Bassell G, et al. A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR. Proc Natl Acad Sci U S A. 2015;112:E6553-61 pubmed publisher
    ..These data suggest that the disrupted interaction of HuR impairs activity-dependent translation of FMRP, which may hinder synaptic plasticity in a clinically significant fashion. ..
  5. Anderson B, Chopra P, Suhl J, Warren S, Bassell G. Identification of consensus binding sites clarifies FMRP binding determinants. Nucleic Acids Res. 2016;44:6649-59 pubmed publisher
    ..Beyond probing these putative motifs, the FCBS dataset of reproducibly identified FMRP binding sites is a valuable tool for investigating FMRP targets and function. ..
  6. Chopra P, Papale L, White A, Hatch A, Brown R, Garthwaite M, et al. Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice. BMC Genomics. 2014;15:131 pubmed publisher
  7. Suhl J, Chopra P, Anderson B, Bassell G, Warren S. Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences. Hum Mol Genet. 2014;23:5479-91 pubmed publisher
    ..In addition, we generate a list of the top 40 FMRP targets associated with FXS-related phenotypes. ..
  8. Myrick L, Hashimoto H, Cheng X, Warren S. Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain. Hum Mol Genet. 2015;24:1733-40 pubmed publisher
    ..We report here the amino terminal crystal structures of wild-type FMRP, and a mutant (R138Q) that disrupts the amino terminus function, containing an integral tandem Agenet and discover a novel KH motif. ..