Lary Walker

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Mechanisms of protein seeding in neurodegenerative diseases
    Lary C Walker
    Yerkes National Primate Research Center, Department of Neurology, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    JAMA Neurol 70:304-10. 2013
  2. pmc Corruption and spread of pathogenic proteins in neurodegenerative diseases
    Lary C Walker
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30329, USA
    J Biol Chem 287:33109-15. 2012
  3. pmc Nonhuman primate models of Alzheimer-like cerebral proteopathy
    Eric Heuer
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Curr Pharm Des 18:1159-69. 2012
  4. pmc Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically
    Cansu Agca
    University of Missouri College of Veterinary Medicine, Department of Veterinary Pathobiology Columbia, MO 65211, USA
    BMC Neurosci 9:28. 2008
  5. ncbi request reprint Inducible proteopathies
    Lary C Walker
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Trends Neurosci 29:438-43. 2006
  6. ncbi request reprint Koch's postulates and infectious proteins
    Lary Walker
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA, 30322, USA
    Acta Neuropathol 112:1-4. 2006
  7. ncbi request reprint Alzheimer therapeutics-what after the cholinesterase inhibitors?
    Lary C Walker
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Age Ageing 35:332-5. 2006
  8. ncbi request reprint Emerging prospects for the disease-modifying treatment of Alzheimer's disease
    Lary C Walker
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Biochem Pharmacol 69:1001-8. 2005
  9. pmc Mosaic aging
    Lary C Walker
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Med Hypotheses 74:1048-51. 2010
  10. ncbi request reprint Diversity of Abeta deposits in the aged brain: a window on molecular heterogeneity?
    L C Walker
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Rom J Morphol Embryol 49:5-11. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Mechanisms of protein seeding in neurodegenerative diseases
    Lary C Walker
    Yerkes National Primate Research Center, Department of Neurology, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    JAMA Neurol 70:304-10. 2013
    ..This simple pathogenic principle suggests that the formation, trafficking, and metabolism of pathogenic protein seeds are promising therapeutic targets for Alzheimer disease and other neurodegenerative disorders...
  2. pmc Corruption and spread of pathogenic proteins in neurodegenerative diseases
    Lary C Walker
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30329, USA
    J Biol Chem 287:33109-15. 2012
    ..Impeding this process could represent a unified therapeutic strategy for slowing the progression of a wide range of currently intractable disorders...
  3. pmc Nonhuman primate models of Alzheimer-like cerebral proteopathy
    Eric Heuer
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Curr Pharm Des 18:1159-69. 2012
    ....
  4. pmc Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically
    Cansu Agca
    University of Missouri College of Veterinary Medicine, Department of Veterinary Pathobiology Columbia, MO 65211, USA
    BMC Neurosci 9:28. 2008
    ..Some instances of FAD have been linked to mutations in the beta-amyloid protein precursor (APP). Although there are numerous mouse AD models available, few rat AD models, which have several advantages over mice, have been generated...
  5. ncbi request reprint Inducible proteopathies
    Lary C Walker
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Trends Neurosci 29:438-43. 2006
    ....
  6. ncbi request reprint Koch's postulates and infectious proteins
    Lary Walker
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA, 30322, USA
    Acta Neuropathol 112:1-4. 2006
    ..In light of the salient differences in the mode of disease-transmission by microbes and proteins, we propose modifications of Koch's postulates that will specifically accommodate presumed infectious proteins...
  7. ncbi request reprint Alzheimer therapeutics-what after the cholinesterase inhibitors?
    Lary C Walker
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Age Ageing 35:332-5. 2006
  8. ncbi request reprint Emerging prospects for the disease-modifying treatment of Alzheimer's disease
    Lary C Walker
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Biochem Pharmacol 69:1001-8. 2005
    ..These adverse events were not anticipated from preclinical studies with rodents; hence, more biologically relevant models, such as nonhuman primates, are needed to test the safety and efficacy of novel therapies for Alzheimer's disease...
  9. pmc Mosaic aging
    Lary C Walker
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Med Hypotheses 74:1048-51. 2010
    ....
  10. ncbi request reprint Diversity of Abeta deposits in the aged brain: a window on molecular heterogeneity?
    L C Walker
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Rom J Morphol Embryol 49:5-11. 2008
    ..By illuminating the relationships between specific lesions and their molecular components, these agents can help to clarify the complex pathology of Alzheimer's disease...
  11. pmc Tauopathy with paired helical filaments in an aged chimpanzee
    Rebecca F Rosen
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 509:259-70. 2008
    ....
  12. doi request reprint Ovarian aging in squirrel monkeys (Saimiri sciureus)
    Margaret L Walker
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Reproduction 138:793-9. 2009
    ..Analysis of GCCs in older squirrel monkeys also could yield insights into the pathophysiology of granulosa cell tumors in humans...
  13. pmc Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease
    Rebecca F Rosen
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Acta Neuropathol 119:221-33. 2010
    ....
  14. pmc The grandmother effect and the uniqueness of the human aging phenotype
    James G Herndon
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Gerontology 56:217-9. 2010
    ....
  15. ncbi request reprint Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
    Melanie Meyer-Luehmann
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    Science 313:1781-4. 2006
    ..The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Abeta strains with varying biological activities reminiscent of prion strains...
  16. ncbi request reprint Proteopathy: the next therapeutic frontier?
    Lary C Walker
    CNS Pharmacology, Pfizer Ann Arbor Laboratories, MI 48105, USA
    Curr Opin Investig Drugs 3:782-7. 2002
    ..Our present knowledge suggests three broad therapeutic approaches to abrogating the proteopathic cascade: reduce the production of the offending proteins, prevent their self-assembly, or promote their removal...
  17. ncbi request reprint Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits
    Jun Yao
    Department of Psychiatry, New York University, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 90:1011-8. 2004
    ....
  18. ncbi request reprint MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier
    Diana Kuhnke
    Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
    Brain Pathol 17:347-53. 2007
    ..Our data support the concept that P-gp is important for the clearance of Abeta from brain, and thus may represent a target protein for the prevention and/or treatment of neurodegenerative disorders such as AD...
  19. ncbi request reprint Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice
    Lary C Walker
    CNS Pharmacology, Pfizer Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Peptides 23:1241-7. 2002
    ..The AD-seeding model can illuminate the emergence and spread of cerebral beta-amyloidosis and tau hyperphosphorylation, and thus could enhance our understanding of AD and its pathogenic commonalties with other cerebral proteopathies...
  20. ncbi request reprint Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    Silke Vogelgesang
    Departments of Neuropathology and Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Greifswald, Germany
    Pharmacogenetics 12:535-41. 2002
    ..Our results provide the first evidence in human brain tissue that the accumulation of Abeta may be influenced by the expression of P-gp in blood vessels, and suggest that P-gp may influence the elimination of Abeta from brain...
  21. ncbi request reprint Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta)
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mech Ageing Dev 125:149-51. 2004
    ..These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta...
  22. ncbi request reprint Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta)
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut St, Suite 467, Philadelphia, PA 19107, USA
    Alzheimer Dis Assoc Disord 18:44-6. 2004
    ..These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta...
  23. pmc Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease
    Jens Pahnke
    University of Rostock, Department of Neurology, Neurodegeneration Research Laboratory NRL, Gehlsheimer Str 20, 18147 Rostock, Germany
    Curr Alzheimer Res 5:396-405. 2008
    ..Here, we summarize findings from cell culture experiments, animal models and studies of patients with Alzheimer's disease. Furthermore, we discuss pharmacological interactions and computational methods for risk assessment...
  24. pmc The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease
    Silke Vogelgesang
    Department of Neuropathology, University of Greifswald, Germany
    Curr Alzheimer Res 1:121-5. 2004
    ..The impairment of Abeta clearance could lead to the accumulation and earlier deposition of Abeta, both in the walls of blood vessels and in the brain parenchyma, thus elevating the risk of CAA and AD...
  25. ncbi request reprint Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob disease
    Silke Vogelgesang
    Department of Neuropathology, University of Greifswald, 17487, Greifswald, Germany
    Acta Neuropathol 111:436-43. 2006
    ....
  26. ncbi request reprint Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice
    Feng Bian
    CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Comp Neurol 446:257-66. 2002
    ....