Research Topics
Species | David L WalkerSummaryAffiliation: Emory University Country: USA Publications
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Publications
The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinctionDavid L Walker
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
Pharmacol Biochem Behav 71:379-92. 2002..A fuller understanding of the role of amygdala glutamate systems in fear and fear learning may suggest novel pharmacological approaches to the treatment of clinical anxiety disorders...- Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startleD L Walker
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Behav Neurosci 114:1019-33. 2000..e., by training rats with a lower, 0.3 mA footshock), AP5 abolished fear-potentiated startle at each timepoint. Thus, amygdala NMDA receptors appear to participate in the initial acquisition of fear memories... 
Glutamate receptor antagonist infusions into the basolateral and medial amygdala reveal differential contributions to olfactory vs. context fear conditioning and expressionDavid L Walker
Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, Georgia 30329, USA
Learn Mem 12:120-9. 2005....
Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart HeimerDavid L Walker
Yerkes National Primate Center and the Center for Behavioral Neuroscience, Emory University, 954 Gatewood Drive, Atlanta, GA 30329, USA
Brain Struct Funct 213:29-42. 2008..The generality of this idea is illustrated by selective studies looking at context conditioning, social defeat, drug withdrawal and stress induced reinstatement...- Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxietyDavid L Walker
Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
Eur J Pharmacol 463:199-216. 2003.... - Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in ratsDavid L Walker
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Behav Neurosci 116:1075-83. 2002..Thus, Group II metabotropic receptors within or very near the amygdala regulate fear and fear learning and are a potential target for anxiolytic compounds... - Quantifying fear potentiated startle using absolute versus proportional increase scoring methods: implications for the neurocircuitry of fear and anxietyDavid L Walker
Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
Psychopharmacology (Berl) 164:318-28. 2002..However, when the tested compounds also influence baseline startle, it is unclear how comparisons with control groups can best be made... - Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in ratsDavid L Walker
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 22:2343-51. 2002..These results indicate that treatments that promote NMDA receptor activity after either systemic or intra-amygdala administration promote the extinction of conditioned fear... - Light-enhanced startle: further pharmacological and behavioral characterizationDavid L Walker
Department of Psychiatry and Behavioral Sciences and the Center for Behavioral Neurosciences, Emory University School of Medicine, Woodruff Memorial Building, Suite 4000, 1639 Pierce Drive, Atlanta, GA 30322, USA
Psychopharmacology (Berl) 159:304-10. 2002..To characterize this phenomenon further, we evaluate here the sensitivity of light-enhanced startle to the anxiolytic compound chlordiazepoxide, to the noradrenergic beta-receptor antagonist propranolol, and to pre-test handling... - Differential effects of the CRF-R1 antagonist GSK876008 on fear-potentiated, light- and CRF-enhanced startle suggest preferential involvement in sustained vs phasic threat responsesDavid Walker
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Road, Yerkes Neuroscience Bldg, Rm 5214, Atlanta, GA 30329, USA
Neuropsychopharmacology 34:1533-42. 2009..Overall, these results suggest that short-duration CeA-dependent threat responses can be pharmacologically dissociated from longer duration BNST-dependent responses in terms of their sensitivity to CRF1 receptor antagonists... - Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responsesD L Walker
Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30329, USA
Prog Neuropsychopharmacol Biol Psychiatry 33:1291-308. 2009.... - Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle testDavid L Walker
Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, Georgia 30329, USA
Learn Mem 15:67-74. 2008..The results suggest that amygdala NR1/NR2B receptors play a special role in fear memory formation, whereas NR1/NR2A receptors participate more generally in synaptic transmission... - Effects of substance P in the amygdala, ventromedial hypothalamus, and periaqueductal gray on fear-potentiated startleZuowei Zhao
Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30329, USA
Neuropsychopharmacology 34:331-40. 2009.... - Calcitonin gene-related peptide in the bed nucleus of the stria terminalis produces an anxiety-like pattern of behavior and increases neural activation in anxiety-related structuresKelly S Sink
Department of Psychiatry, Yerkes National Primate Center, Emory University, Atlanta, Georgia 30329, USA
J Neurosci 31:1802-10. 2011..If so, inhibition of CGRP receptors may be a clinically useful strategy for anxiety reduction... - Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxietyMichael Davis
Department of Psychiatry, Yerkes National Primate Center, Emory University, and The Center for Behavioral Neuroscience, Atlanta, GA 30329, USA
Neuropsychopharmacology 35:105-35. 2010..In rats, sustained fear is more sensitive to anxiolytic drugs. In humans, symptoms of clinical anxiety are better detected in sustained rather than phasic fear paradigms... - Role of the amygdala in fear extinction measured with potentiated startleMichael Davis
Department of Psychiatry, Emory University, Atlanta, Georgia 30322, USA
Ann N Y Acad Sci 985:218-32. 2003.... - Are fear memories made and maintained by the same NMDA receptor-dependent mechanisms?David L Walker
Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322 USA
Neuron 41:680-2. 2004..One view is that posttraining NMDA receptor activation protects modified synapses from "synaptic drift." An alternative view is that NMDA receptors help maintain appropriate connectivity in memory-encoding networks... - Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startleK T Lu
Department of Psychiatry and Behavioral Science, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 21:RC162. 2001..These results suggest that a MAPK-dependent signaling cascade within or very near the basolateral amygdala plays an important role in the extinction of conditioned fear...
Research Grants
- Neural Substrates of Phasic versus Sustained FearDavid L Walker; Fiscal Year: 2010..Recent studies indicate that the neural substrates of short-duration fear responses may be different from those of more sustained fear responses. The experiments proposed herein are meant to further explore these differences. ..