David L Walker

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction
    David L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 71:379-92. 2002
  2. ncbi request reprint Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle
    D L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Behav Neurosci 114:1019-33. 2000
  3. pmc Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test
    David L Walker
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, Georgia 30329, USA
    Learn Mem 15:67-74. 2008
  4. pmc Glutamate receptor antagonist infusions into the basolateral and medial amygdala reveal differential contributions to olfactory vs. context fear conditioning and expression
    David L Walker
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, Georgia 30329, USA
    Learn Mem 12:120-9. 2005
  5. ncbi request reprint Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart Heimer
    David L Walker
    Yerkes National Primate Center and the Center for Behavioral Neuroscience, Emory University, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Brain Struct Funct 213:29-42. 2008
  6. pmc Differential effects of the CRF-R1 antagonist GSK876008 on fear-potentiated, light- and CRF-enhanced startle suggest preferential involvement in sustained vs phasic threat responses
    David Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Road, Yerkes Neuroscience Bldg, Rm 5214, Atlanta, GA 30329, USA
    Neuropsychopharmacology 34:1533-42. 2009
  7. ncbi request reprint Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
    David L Walker
    Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Eur J Pharmacol 463:199-216. 2003
  8. ncbi request reprint Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats
    David L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Behav Neurosci 116:1075-83. 2002
  9. ncbi request reprint Quantifying fear potentiated startle using absolute versus proportional increase scoring methods: implications for the neurocircuitry of fear and anxiety
    David L Walker
    Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 164:318-28. 2002
  10. ncbi request reprint Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats
    David L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 22:2343-51. 2002

Research Grants

  1. Neural Substrates of Phasic versus Sustained Fear
    David L Walker; Fiscal Year: 2010

Detail Information

Publications19

  1. ncbi request reprint The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction
    David L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 71:379-92. 2002
    ..A fuller understanding of the role of amygdala glutamate systems in fear and fear learning may suggest novel pharmacological approaches to the treatment of clinical anxiety disorders...
  2. ncbi request reprint Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle
    D L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Behav Neurosci 114:1019-33. 2000
    ..e., by training rats with a lower, 0.3 mA footshock), AP5 abolished fear-potentiated startle at each timepoint. Thus, amygdala NMDA receptors appear to participate in the initial acquisition of fear memories...
  3. pmc Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test
    David L Walker
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, Georgia 30329, USA
    Learn Mem 15:67-74. 2008
    ..The results suggest that amygdala NR1/NR2B receptors play a special role in fear memory formation, whereas NR1/NR2A receptors participate more generally in synaptic transmission...
  4. pmc Glutamate receptor antagonist infusions into the basolateral and medial amygdala reveal differential contributions to olfactory vs. context fear conditioning and expression
    David L Walker
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, Georgia 30329, USA
    Learn Mem 12:120-9. 2005
    ....
  5. ncbi request reprint Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart Heimer
    David L Walker
    Yerkes National Primate Center and the Center for Behavioral Neuroscience, Emory University, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Brain Struct Funct 213:29-42. 2008
    ..The generality of this idea is illustrated by selective studies looking at context conditioning, social defeat, drug withdrawal and stress induced reinstatement...
  6. pmc Differential effects of the CRF-R1 antagonist GSK876008 on fear-potentiated, light- and CRF-enhanced startle suggest preferential involvement in sustained vs phasic threat responses
    David Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Road, Yerkes Neuroscience Bldg, Rm 5214, Atlanta, GA 30329, USA
    Neuropsychopharmacology 34:1533-42. 2009
    ..Overall, these results suggest that short-duration CeA-dependent threat responses can be pharmacologically dissociated from longer duration BNST-dependent responses in terms of their sensitivity to CRF1 receptor antagonists...
  7. ncbi request reprint Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
    David L Walker
    Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Eur J Pharmacol 463:199-216. 2003
    ....
  8. ncbi request reprint Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats
    David L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Behav Neurosci 116:1075-83. 2002
    ..Thus, Group II metabotropic receptors within or very near the amygdala regulate fear and fear learning and are a potential target for anxiolytic compounds...
  9. ncbi request reprint Quantifying fear potentiated startle using absolute versus proportional increase scoring methods: implications for the neurocircuitry of fear and anxiety
    David L Walker
    Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 164:318-28. 2002
    ..However, when the tested compounds also influence baseline startle, it is unclear how comparisons with control groups can best be made...
  10. ncbi request reprint Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats
    David L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 22:2343-51. 2002
    ..These results indicate that treatments that promote NMDA receptor activity after either systemic or intra-amygdala administration promote the extinction of conditioned fear...
  11. ncbi request reprint Light-enhanced startle: further pharmacological and behavioral characterization
    David L Walker
    Department of Psychiatry and Behavioral Sciences and the Center for Behavioral Neurosciences, Emory University School of Medicine, Woodruff Memorial Building, Suite 4000, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 159:304-10. 2002
    ..To characterize this phenomenon further, we evaluate here the sensitivity of light-enhanced startle to the anxiolytic compound chlordiazepoxide, to the noradrenergic beta-receptor antagonist propranolol, and to pre-test handling...
  12. pmc Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses
    D L Walker
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30329, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:1291-308. 2009
    ....
  13. pmc Calcitonin gene-related peptide in the bed nucleus of the stria terminalis produces an anxiety-like pattern of behavior and increases neural activation in anxiety-related structures
    Kelly S Sink
    Department of Psychiatry, Yerkes National Primate Center, Emory University, Atlanta, Georgia 30329, USA
    J Neurosci 31:1802-10. 2011
    ..If so, inhibition of CGRP receptors may be a clinically useful strategy for anxiety reduction...
  14. pmc Effects of substance P in the amygdala, ventromedial hypothalamus, and periaqueductal gray on fear-potentiated startle
    Zuowei Zhao
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30329, USA
    Neuropsychopharmacology 34:331-40. 2009
    ....
  15. pmc CGRP antagonist infused into the bed nucleus of the stria terminalis impairs the acquisition and expression of context but not discretely cued fear
    Kelly S Sink
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Learn Mem 20:730-9. 2013
    ..More generally, the results add to a growing body of evidence indicating behaviorally, possibly clinically, relevant modulation of BNST function by neuroactive peptides...
  16. pmc Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety
    Michael Davis
    Department of Psychiatry, Yerkes National Primate Center, Emory University, and The Center for Behavioral Neuroscience, Atlanta, GA 30329, USA
    Neuropsychopharmacology 35:105-35. 2010
    ..In rats, sustained fear is more sensitive to anxiolytic drugs. In humans, symptoms of clinical anxiety are better detected in sustained rather than phasic fear paradigms...
  17. ncbi request reprint Role of the amygdala in fear extinction measured with potentiated startle
    Michael Davis
    Department of Psychiatry, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 985:218-32. 2003
    ....
  18. ncbi request reprint Are fear memories made and maintained by the same NMDA receptor-dependent mechanisms?
    David L Walker
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322 USA
    Neuron 41:680-2. 2004
    ..One view is that posttraining NMDA receptor activation protects modified synapses from "synaptic drift." An alternative view is that NMDA receptors help maintain appropriate connectivity in memory-encoding networks...
  19. ncbi request reprint Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle
    K T Lu
    Department of Psychiatry and Behavioral Science, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 21:RC162. 2001
    ..These results suggest that a MAPK-dependent signaling cascade within or very near the basolateral amygdala plays an important role in the extinction of conditioned fear...

Research Grants1

  1. Neural Substrates of Phasic versus Sustained Fear
    David L Walker; Fiscal Year: 2010
    ..Recent studies indicate that the neural substrates of short-duration fear responses may be different from those of more sustained fear responses. The experiments proposed herein are meant to further explore these differences. ..