Research Topics
Genomes and GenesSpecies | Irwin D WaldmanSummaryAffiliation: Emory University Country: USA Publications
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Publications
The adrenergic receptor alpha-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHDIrwin D Waldman
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
Cogn Affect Behav Neurosci 6:18-30. 2006..Implications of the results for evaluating the validity and utility of putative endophenotype measures and for finding candidate gene effects on ADHD are discussed...
Gene x environment interactions for ADHD: synergistic effect of 5HTTLPR genotype and youth appraisals of inter-parental conflictMolly Nikolas
Department of Psychology, Michigan State University, East Lansing, Michigan, USA
Behav Brain Funct 6:23. 2010....- Antisocial behavior and alcoholism: a behavioral genetic perspective on comorbidityI D Waldman
Department of Psychology, Emory University, Atlanta, GA 30322, USA
Clin Psychol Rev 20:255-87. 2000..e., genetic and environmental influences) on comorbidity. Although not a panacea and somewhat demanding technically, behavior genetic approaches can shed new light on the comorbidity among disorders... - A logistic regression based extension of the TDT for continuous and categorical traitsI D Waldman
Department of Psychology, Emory University, Atlanta, GA 30322, USA
Ann Hum Genet 63:329-40. 1999..Given its features, we regard the logistic regression extension of the TDT as a flexible new data analytic method with extensive potential applications to problems in medical, psychiatric, and behavioral genetics... - Gene-environment interactions reexamined: does mother's marital stability interact with the dopamine receptor D2 gene in the etiology of childhood attention-deficit/hyperactivity disorder?Irwin D Waldman
Department of Psychology, Emory University, 532 North Kilgo Circle, Atlanta, GA 30322, USA
Dev Psychopathol 19:1117-28. 2007..The present findings highlight the importance of considering both the nexus of putative environmental risk factors and whether their etiology and effects are truly environmental in future Gene x Environment interaction research... 
Child and adolescent conduct disorder substantially shares genetic influences with three socioemotional dispositionsIrwin D Waldman
Department of Psychology, Emory University, Atlanta, GA30322, USA
J Abnorm Psychol 120:57-70. 2011....- The genetics of attention deficit hyperactivity disorderIrwin D Waldman
Emory University, USA
Clin Psychol Rev 26:396-432. 2006..We conclude with a consideration of some of the emerging themes that will be important in future studies of the genetics of ADHD... - Statistical approaches to complex phenotypes: evaluating neuropsychological endophenotypes for attention-deficit/hyperactivity disorderIrwin D Waldman
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
Biol Psychiatry 57:1347-56. 2005..It is demonstrated that both putative endophenotypes show association with the dopamine D4 receptor gene and meet most (but not all) of the criteria proposed for their validity and utility... - A quasi-experimental analysis of the influence of neighborhood disadvantage on child and adolescent conduct problemsJackson A Goodnight
Department of Psychology, University of Dayton, Dayton, OH 45469 1430, USA
J Abnorm Psychol 121:95-108. 2012..These findings are consistent with the hypothesis that ND has influence on conduct problems... - Evaluating the utility of sluggish cognitive tempo in discriminating among DSM-IV ADHD subtypesKelly M Harrington
Department of Psychology, Emory University, Atlanta, GA 30322, USA
J Abnorm Child Psychol 38:173-84. 2010.... - Relations between multi-informant assessments of ADHD symptoms, DAT1, and DRD4Ian R Gizer
Department of Psychology, Emory University, 532 N Kilgo Circle, Atlanta, GA 30322, USA
J Abnorm Psychol 117:869-80. 2008..e., the and, or, and averaging rules). The implications of these results for future molecular genetic studies of ADHD are discussed... - Population density and youth antisocial behaviorK Paige Harden
Department of Psychology, University of Virginia, Charlottesville, USA
J Child Psychol Psychiatry 50:999-1008. 2009..Rather, the association between population density and delinquency appears to be due to unmeasured selection variables that differ between families who live in more or less densely populated counties... - Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studiesSoo Hyun Rhee
Department of Psychology, Emory University, USA
Psychol Bull 128:490-529. 2002.... - Gene-environment interactions in attention-deficit/hyperactivity disorderCourtney A Ficks
Emory University, 317 Psychology Building, 532 Kilgo Circle, Atlanta, GA 30322, USA
Curr Psychiatry Rep 11:387-92. 2009..We discuss these findings and the future directions and limitations of current gene-environment research... - Is depression best viewed as a continuum or discrete category? A taxometric analysis of childhood and adolescent depression in a population-based sampleBenjamin L Hankin
Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA
J Abnorm Psychol 114:96-110. 2005..e., boys vs. girls and younger vs. older youth)... - Annual research review: phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathologyBenjamin B Lahey
Departments of Health Studies and Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA
J Child Psychol Psychiatry 53:536-57. 2012..We posit that any prevalent form of psychopathology, including CD, can be best understood if it is studied in the context of other correlated forms of child and adolescent psychopathology using formal models to guide inquiry... - Improved association analyses of disease subtypes in case-parent triadsMichael P Epstein
Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
Genet Epidemiol 30:209-19. 2006.... - Sex differences in the causes of self-reported adolescent delinquencyCarol A Van Hulle
Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
J Abnorm Psychol 116:236-48. 2007..Similarly, a test of the polygenic multiple threshold model suggested that girls require greater causal liability for the expression of delinquency than boys... - Smoking during pregnancy and offspring externalizing problems: an exploration of genetic and environmental confoundsBrian M D'Onofrio
Indiana University, Bloomington, IN 47405, USA
Dev Psychopathol 20:139-64. 2008..That is, the current analyses imply that important unidentified environmental factors account for the association between SDP and offspring externalizing problems, not teratogenic effects of SDP... - The structure of child and adolescent psychopathology: generating new hypothesesBenjamin B Lahey
Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
J Abnorm Psychol 113:358-85. 2004.... - Dopamine transporter genotype and methylphenidate dose response in children with ADHDMark A Stein
Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
Neuropsychopharmacology 30:1374-82. 2005..Further research is needed to determine the mechanisms related to poor response in patients with the 9/9-repeat genotype, and to determine if this group responds differentially to alternative treatments... - Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?Alysa E Doyle
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Child Psychol Psychiatry 46:774-803. 2005..Thus far, potential endophenotypes for ADHD have not been systematically studied... - Normal variation and abnormality: an empirical study of the liability distributions underlying depression and delinquencyEdwin J C G van den Oord
Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298 0126, USA
J Child Psychol Psychiatry 44:180-92. 2003..This invites an interpretation of their forming an abnormal group, one that may be qualitatively distinct... - A dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorderMark A Stein
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Pediatrics 112:e404. 2003..This study was conducted to examine dosage effects on ADHD symptoms and stimulant side effects and to explore potential moderating effects of ADHD subtype... - Etiology of sex differences in the prevalence of ADHD: an examination of inattention and hyperactivity-impulsivitySoo Hyun Rhee
Department of Psychology and Institute for Behavioral Genetics, University of Colorado, Colorado 80309, USA
Am J Med Genet B Neuropsychiatr Genet 127:60-4. 2004..This evidence for the PMT model and against the CV model was found for both inattention and hyperactivity-impulsivity, but became weaker for hyperactivity-impulsivity as symptom severity increased... - A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorderChun Hyung Kim
Molecular Neurobiology, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 103:19164-9. 2006.... - Functional gene variation in the human norepinephrine transporter: association with attention deficit hyperactivity disorderChun Hyung Kim
Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478, USA
Ann N Y Acad Sci 1129:256-60. 2008..Moreover, we observed a significant association of the -3081(T) variant with ADHD. Altered transcription of SLC6A2 may therefore represent a novel risk factor for the development of ADHD... - Specification, testing, and interpretation of gene-by-measured-environment interaction models in the presence of gene-environment correlationPaul J Rathouz
Department of Health Studies, University of Chicago, 5841 S Maryland Ave, MC 2007, Chicago, IL 60637, USA
Behav Genet 38:301-15. 2008..We propose a statistical method for deriving and interpreting variance decompositions that are true to the fitted model... - Causal inferences regarding prenatal alcohol exposure and childhood externalizing problemsBrian M D'Onofrio
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
Arch Gen Psychiatry 64:1296-304. 2007..Existing research on the neurobehavioral consequences of prenatal alcohol exposure (PAE) has not adequately accounted for genetic and environmental confounds... - Testing descriptive hypotheses regarding sex differences in the development of conduct problems and delinquencyBenjamin B Lahey
Department of Health Studies, University of Chicago, IL 60637, USA
J Abnorm Child Psychol 34:737-55. 2006..Although more males followed a childhood-onset trajectory, there were few sex differences in the early childhood risk correlates of either delinquency trajectory... - Testing structural models of DSM-IV symptoms of common forms of child and adolescent psychopathologyBenjamin B Lahey
Department of Health Studies MC 2007, University of Chicago, 5811 South Maryland Avenue, Chicago, IL 60637, USA
J Abnorm Child Psychol 36:187-206. 2008.... - Investigation of parent-of-origin effects in ADHD candidate genesJang Woo Kim
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:776-80. 2007..Thus, we conclude that a substantial parent-of-origin effect is unlikely for these leading ADHD candidate genes...
Research Grants
- MOLECULAR GENETICS OF CHILDHOOD DISRUPTIVE DISORDERSIrwin Waldman; Fiscal Year: 2004..The proposed study will increase substantially our understanding of specific genetic influences on the childhood disruptive disorders. ..