PAULA VERTINO

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint DNMT1 is a component of a multiprotein DNA replication complex
    Paula M Vertino
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia, USA
    Cell Cycle 1:416-23. 2002
  2. pmc Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma
    Annalisa R Stone
    Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Rd, NE, Atlanta, GA 30322, USA
    Am J Pathol 165:1151-61. 2004
  3. ncbi request reprint R loops: lassoing DNA methylation at CpGi
    Paula M Vertino
    Department of Radiation Oncology and the Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30307, USA
    Mol Cell 45:708-9. 2012
  4. ncbi request reprint Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture
    Krista M Stimson
    Department of Radiation Oncology and the Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 277:4951-8. 2002
  5. ncbi request reprint Epigenetic regulation of MDR1 gene in breast cancer: CpG methylation status dominates the stable maintenance of a silent gene
    Dipali Sharma
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30332, USA
    Cancer Biol Ther 3:549-50. 2004
  6. ncbi request reprint Effects of methylation on expression of TMS1/ASC in human breast cancer cells
    Jeoffrey J Levine
    Program in Genetics and Molecular Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 22:3475-88. 2003
  7. pmc Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes
    Dipali Sharma
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:6370-8. 2006
  8. pmc Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy
    Jacob D Kagey
    Graduate Program in Genetics and Molecular Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Cancer Res 8:1048-59. 2010
  9. doi request reprint Age/race differences in HER2 testing and in incidence rates for breast cancer triple subtypes: a population-based study and first report
    Mary Jo Lund
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Cancer 116:2549-59. 2010
  10. pmc Cancer DNA methylation: molecular mechanisms and clinical implications
    Michael T McCabe
    Department of Radiation Oncology and Hematology, Emory University School of Medicine and the Emory Winship Cancer Institute, Atlanta, Georgia 30322, USA
    Clin Cancer Res 15:3927-37. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint DNMT1 is a component of a multiprotein DNA replication complex
    Paula M Vertino
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia, USA
    Cell Cycle 1:416-23. 2002
    ....
  2. pmc Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma
    Annalisa R Stone
    Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Rd, NE, Atlanta, GA 30322, USA
    Am J Pathol 165:1151-61. 2004
    ..The data suggest a role for the epigenetic silencing of TMS1 in the pathogenesis of human GBM. Methylation of TMS1 may prove to be a useful prognostic marker and/or predictor of patient survival and tumor malignancy...
  3. ncbi request reprint R loops: lassoing DNA methylation at CpGi
    Paula M Vertino
    Department of Radiation Oncology and the Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30307, USA
    Mol Cell 45:708-9. 2012
    ..In this issue of Molecular Cell, Ginno et al. (2012) describe unusual sequence features at promoter CpG islands that can lead to formation of persistent RNA-DNA hybrids (R loops), which are proposed to prevent genomic DNA methylation...
  4. ncbi request reprint Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture
    Krista M Stimson
    Department of Radiation Oncology and the Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 277:4951-8. 2002
    ....
  5. ncbi request reprint Epigenetic regulation of MDR1 gene in breast cancer: CpG methylation status dominates the stable maintenance of a silent gene
    Dipali Sharma
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30332, USA
    Cancer Biol Ther 3:549-50. 2004
  6. ncbi request reprint Effects of methylation on expression of TMS1/ASC in human breast cancer cells
    Jeoffrey J Levine
    Program in Genetics and Molecular Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 22:3475-88. 2003
    ..The transition to this stably repressed state may be facilitated by spreading of methylation into the proximal promoter and direct effects of methylation on TMS1 transcription...
  7. pmc Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes
    Dipali Sharma
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:6370-8. 2006
    ..The mechanistic insight provided by this study might help in designing therapeutic strategies directed toward epigenetic mechanisms in the prevention or treatment of breast cancer...
  8. pmc Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy
    Jacob D Kagey
    Graduate Program in Genetics and Molecular Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Cancer Res 8:1048-59. 2010
    ..Our data suggest that the ability to maintain Pol II occupancy is a critical factor in the long-term stability of drug-induced CpG island demethylation...
  9. doi request reprint Age/race differences in HER2 testing and in incidence rates for breast cancer triple subtypes: a population-based study and first report
    Mary Jo Lund
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Cancer 116:2549-59. 2010
    ..We document the population-based prevalence of HER2 testing / status, triple subtypes and present the first report of subtype incidence rates...
  10. pmc Cancer DNA methylation: molecular mechanisms and clinical implications
    Michael T McCabe
    Department of Radiation Oncology and Hematology, Emory University School of Medicine and the Emory Winship Cancer Institute, Atlanta, Georgia 30322, USA
    Clin Cancer Res 15:3927-37. 2009
    ..Finally, we discuss the clinical implications of aberrant DNA methylation and the utility of methylated biomarkers in cancer diagnosis and management...
  11. pmc Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity
    Priya Kapoor-Vazirani
    Department of Radiation Oncology and the Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Cancer Res 68:6810-21. 2008
    ....
  12. pmc A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation
    Michael T McCabe
    Department of Radiation Oncology, Emory University School of Medicine, 1365C Clifton Road, Atlanta, GA 30322, USA
    Cancer Res 69:282-91. 2009
    ..These findings show that hypermethylation of certain gene loci is controlled in part by an underlying susceptibility influenced by both local sequence context and trans-acting factors...
  13. pmc Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha
    Mary E Lucas
    Graduate Program in Genetics and Molecular Biology, The Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 284:14698-709. 2009
    ..These data indicate that the intronic HS2 element acts in cis to maintain transcriptional competency at the TMS1 locus and that this activity is mediated by the ets transcription factor, GABPalpha...
  14. ncbi request reprint DNA motifs associated with aberrant CpG island methylation
    F Alex Feltus
    Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
    Genomics 87:572-9. 2006
    ..The motifs identified here are candidate methylation-targeting or methylation-protection DNA sequences...
  15. pmc Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells
    Michael T McCabe
    Department of Radiation Oncology, Emory University School of Medicine, 1365C Clifton Road, Atlanta, GA 30322 The Winship Cancer Institute of Emory University, 1365C Clifton Road, Atlanta, GA 30322
    Cancer Genet Cytogenet 197:130-41. 2010
    ..Thus, homozygous deletions affecting LKB1 in cervical cancers may generate multiple fusion transcripts involving LKB1, SBNO2, and c19orf26...
  16. pmc Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells
    MELISSA J PARSONS
    Graduate Program in Genetics and Molecular Biology, Emory University, Atlanta, Georgia, USA
    Cancer Res 69:1706-11. 2009
    ..This conclusion is supported by in vivo data showing that TMS1 is selectively down-regulated in the aberrant epithelial cells filling the lumen of the breast duct in a subset of primary DCIS lesions...
  17. pmc leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3
    Neeraj K Saxena
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:13316-25. 2007
    ..Our data suggest that CYCLIN D1 may be a target gene for leptin mediated growth stimulation of breast cancer cells and molecular mechanisms involve activated Stat3-mediated recruitment of distinct coactivator complexes...
  18. pmc Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase
    Krithika Subramanian
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 30:336-47. 2008
    ..These findings raise the possibility that generation, recognition, and removal of modifications within the ER hinge region generate "ER modification cassettes" that yield distinct patterns for signaling downstream events...
  19. ncbi request reprint LKB1 mutation in large cell carcinoma of the lung
    Diansheng Zhong
    The Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 32322, USA
    Lung Cancer 53:285-94. 2006
    ..These results suggest that, in addition to adenocarcinomas, acquired loss of function mutations in LKB1 may also be frequently involved in the pathogenesis of large cell lung carcinomas...
  20. ncbi request reprint Infrequent mutation of ATBF1 in human breast cancer
    Xiaodong Sun
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cancer Res Clin Oncol 133:103-5. 2007
    ..These findings suggest that ATBF1 plays a role in breast cancer through transcriptional downregulation rather than mutations...
  21. pmc SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation
    Priya Kapoor-Vazirani
    Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Cell Biol 31:1594-609. 2011
    ..These data indicate that H4K20me3 invokes gene repression by antagonizing hMOF-mediated H4K16Ac and suggest that overcoming Pol II pausing might be a rate-limiting step in achieving tumor suppressor gene reactivation in cancer therapy...
  22. pmc Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells
    Lizheng Guo
    Department of Hematology and Oncology, The Winship Cancer Institute, Atlanta VA Medical Center, Atlanta, George, USA
    Mol Cancer Res 6:1421-30. 2008
    ..Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors...
  23. doi request reprint Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses
    Chheng Orn Evans
    Department of Neurosurgery and Laboratory of Molecular Neurosurgery and Biotechnology, Emory University School of Medicine, 1365 B Clifton Rd, NE, Suite 6200, Atlanta, GA, 30322, USA
    Pituitary 11:231-45. 2008
    ..In the current era of molecular medicine, these findings greatly enhance our understanding and supercede immunohistochemical diagnosis...
  24. doi request reprint The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
    Shumin Zhang
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30043, USA
    Cancer Res 68:740-8. 2008
    ..Taken together, these results show that LKB1 is a critical mediator of the NSCLC polarity program in lung cancer cells through a novel LKB1-cdc42-PAK pathway...
  25. pmc LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins
    Diansheng Zhong
    The Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 68:7270-7. 2008
    ..This observation may explain the lack of LKB1 somatic mutations in brain, breast, and colon cancers, where Akt is frequently activated due to mutations in phosphatidylinositol 3-kinase, PTEN, or Akt itself...
  26. ncbi request reprint Methylation matters: a new spin on maspin
    Joseph F Costello
    Nat Genet 31:123-4. 2002

Research Grants12

  1. Defining Genomic Signatures for Aberrant DNA Methylation in Human Cancers
    Paula M Vertino; Fiscal Year: 2010
    ..Moreover, the ability to identify those genes at risk of epigenetic silencing will provide novel molecular targets for further study as potential biomarkers for improved cancer diagnosis and treatment planning. ..
  2. GENESIS AND CONSEQUENCES OF ABERRANT DNA METHYLATION
    PAULA VERTINO; Fiscal Year: 2007
    ....
  3. GENESIS AND CONSEQUENCES OF ABERRANT DNA METHYLATION
    PAULA VERTINO; Fiscal Year: 2002
    ....