Christopher P Vellano

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:38659-69. 2011
  2. pmc RGS14 at the interface of hippocampal signaling and synaptic plasticity
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, GA 30322, USA
    Trends Pharmacol Sci 32:666-74. 2011
  3. pmc Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States
    Biochemistry 50:752-62. 2011
  4. pmc Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 288:3620-31. 2013
  5. pmc RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory
    Sarah Emerson Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:16994-8. 2010
  6. pmc Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop
    Kelly L McCoy
    Department of Pharmacology, O Wayne Rollins Research Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Signal 24:1351-60. 2012

Collaborators

  • Yoland Smith
  • Kelly L McCoy
  • John R Hepler
  • Sarah Emerson Lee
  • Stephen F Traynelis
  • Stefka Gyoneva
  • Alan V Smrcka
  • Stephen B Simons
  • Suneela Ramineni
  • Cindee K Yates
  • Meilan Zhao
  • Jason P Schroeder
  • D Patrick Cowan
  • Kerry J Ressler
  • Serena M Dudek
  • David Weinshenker
  • Scott A Heldt
  • J David Sweatt
  • Yue Feng

Detail Information

Publications6

  1. pmc G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:38659-69. 2011
    ..Together, these findings indicate that RGS14 can form complexes with GPCRs in cells that are dependent on Gα(i/o) and that these RGS14·Gα(i1)·GPCR complexes may be substrates for other signaling partners such as Ric-8A...
  2. pmc RGS14 at the interface of hippocampal signaling and synaptic plasticity
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, GA 30322, USA
    Trends Pharmacol Sci 32:666-74. 2011
    ....
  3. pmc Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States
    Biochemistry 50:752-62. 2011
    ..These findings demonstrate that RGS14 is a newly appreciated integrator of unconventional Ric-8A and Gαi1 signaling...
  4. pmc Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 288:3620-31. 2013
    ..Together, these findings indicate that inactive Gα(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by GPCRs...
  5. pmc RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory
    Sarah Emerson Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:16994-8. 2010
    ..These results demonstrate that RGS14 is a key regulator of signaling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory but distinct from the canonical DG-CA3-CA1 circuit...
  6. pmc Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop
    Kelly L McCoy
    Department of Pharmacology, O Wayne Rollins Research Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Signal 24:1351-60. 2012
    ..In summary, we have identified key molecular determinants for PAR1 interactions with G(q/11), and our findings support a model where G(q/11), G(i/o) or G(12/13) each bind to distinct sites within the cytoplasmic regions of PAR1...