Research Topics
| Erwin Van MeirSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organizationAinsley C Nicholson
Laboratory of Molecular Neuro Oncology, Neurosurgery Department and Winship Cancer Institute, 1365 C Clifton Road, Room C5078, Emory University, Atlanta, GA 30322, USA
BMC Evol Biol 5:11. 2005....- Exciting new advances in neuro-oncology: the avenue to a cure for malignant gliomaErwin G Van Meir
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
CA Cancer J Clin 60:166-93. 2010.... 
Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factorBalveen Kaur
Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery, Hematology/Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Oncogene 24:3632-42. 2005..Modulation of this cleavage or delivery of Vasculostatin may constitute novel treatment modalities for cancer and other diseases of aberrant angiogenesis, especially in the brain...- A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapyDawn E Post
Laboratory of Molecular Neuro-Oncology, Neurosurgery Department and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Oncogene 22:2065-72. 2003..This therapeutic approach can be used to treat all solid tumors that develop hypoxia, regardless of their tissue origin or genetic alterations... - 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesisYuan Rong
Department of Pathology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
J Neuropathol Exp Neurol 65:529-39. 2006.... - Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germ-line mutation: evidence for a precursor lesionGiulia Fulci
Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, 1365B Clifton Road, Atlanta, GA 30322, USA
Cancer Res 62:2897-905. 2002..They also suggest that astrocytoma initiation in this patient resulted from monoclonal evolution driven by a sequential loss of proapoptotic and growth arrest functions of p53... - Replicative oncolytic herpes simplex viruses in combination cancer therapiesDawn E Post
Laboratory of Molecular Neuro Oncology, Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Curr Gene Ther 4:41-51. 2004..In this review, we focus on the oncolytic Herpes Simplex Virus-1 (HSV-1) vectors that have been examined in preclinical and clinical cancer models and their use in combination with chemo-, radio-, and gene therapies... - Emerging molecular therapies for brain tumorsErwin G Van Meir
Department of Neurosurgery, Winship Cancer Institute Brain Tumor Program, Emory University, Atlanta, GA 30322, USA
Semin Oncol 31:38-46. 2004..These findings are now being translated into innovative clinical trials that provide new hope for patients with these devastating diseases... - Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanismsYuan Rong
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 66:7067-74. 2006..We conclude that hypoxic up-regulation of tissue factor in glioblastoma multiforme cells depends largely on Egr-1 and is independent of HIF-1... - Noscapine crosses the blood-brain barrier and inhibits glioblastoma growthJaren W Landen
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Clin Cancer Res 10:5187-201. 2004.... - Aberrant methylation and down-regulation of TMS1/ASC in human glioblastomaAnnalisa R Stone
Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365-C Clifton Rd, NE, Atlanta, GA 30322, USA
Am J Pathol 165:1151-61. 2004..The data suggest a role for the epigenetic silencing of TMS1 in the pathogenesis of human GBM. Methylation of TMS1 may prove to be a useful prognostic marker and/or predictor of patient survival and tumor malignancy... - Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumorsDawn E Post
Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA
Clin Cancer Res 10:8603-12. 2004.... - Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulationDaniel J Brat
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Adv Anat Pathol 9:24-36. 2002..Understanding genetic events and their relation to angiogenic regulation in astrocytic neoplasms may eventually lead to therapies that are specifically directed at molecularly defined subsets of these diseases... - Cancer scene investigation: how a cold virus became a tumor killerDawn E Post
Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Emory University School of Medicine, Emory University, 1365C Clifton Rd NE, Room C5068, Atlanta, GA 30322, USA
Future Oncol 1:247-58. 2005.... - Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastomaDaniel J Brat
Department of Pathology and Laboratory Medicine, Emory University School of Medicine H 176, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Lab Invest 84:397-405. 2004..Since the hypoxic induction of angiogenesis appears to support further neoplastic growth, therapeutic targeting of the underlying vascular pathology and thrombosis could provide a new means to prolong time to progression... - Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell populationDaniel J Brat
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
Cancer Res 64:920-7. 2004.... - An integrative approach for in silico glioma researchLee A D Cooper
Center for Comprehensive Informatics, Atlanta, GA 30322, USA
IEEE Trans Biomed Eng 57:2617-21. 2010..The preliminary results demonstrate the potential of combining morphometric and molecular characterizations for in silico research... - Brain cancer propagating cells: biology, genetics and targeted therapiesCostas G Hadjipanayis
Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Emory University, School of Medicine, Atlanta, GA 30322, USA
Trends Mol Med 15:519-30. 2009..Ultimately, treatments that include specific targeting of BCPCs might potentially be more effective at treating the entire tumor mass, translating to improved patient survival and quality of life... - Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumorsDaniel J Brat
Department of Pathology and Laboratory Medicine and Laboratory of Molecular Neuro Oncology, Emory University School of Medicine, Atlanta, GA, USA
Front Biosci 8:d100-16. 2003..Thus, genetic events that occur during the progression of infiltrating astrocytomas promote angiogenesis, both by modulating hypoxia induced gene expression and by regulating of pro- and anti- angiogenic factors... - Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expressionBalveen Kaur
Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
Am J Pathol 162:19-27. 2003..The finding that expression of BAI proteins may be lost during tumor formation is of special interest as restoration of their function in tumors may be of therapeutic benefit... - Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesisBalveen Kaur
Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery and Hematology/Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuro Oncol 7:134-53. 2005..While HIF activation strongly promotes angiogenesis, the emerging vasculature is often abnormal, leading to a vicious cycle that causes further hypoxia and HIF upregulation... - Tumor initiating cells in malignant gliomas: biology and implications for therapyCostas G Hadjipanayis
Departments of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 33022, USA
J Mol Med (Berl) 87:363-74. 2009..The development of new therapeutic strategies selectively targeting TICs while sparing NSCs may provide for more effective treatment of malignant gliomas... - Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanismBalveen Kaur
Department of Neurosurgery, Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 69:1212-20. 2009..These results advance the understanding of brain-specific angiogenic regulation, and suggest that Vstat120 has therapeutic potential in the treatment of brain tumors and other intracerebral vasculopathies... - Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activityYuan Rong
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Cancer Res 69:2540-9. 2009..These mechanisms are likely at work in vivo, as EGFR expression was highly correlated with TF expression in human high-grade astrocytoma specimens... - Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor modelSeung-Hee Kang
Department of Hematology/Oncology, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 66:11991-7. 2006.... - PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastomaYuan Rong
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
Cancer Res 65:1406-13. 2005.... - Genetic and hypoxic regulation of angiogenesis in gliomasBalveen Kaur
Laboratory of Molecular Neuro-Oncology, Department of Neuro-surgery and Hematology/Oncology, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
J Neurooncol 70:229-43. 2004..This review will summarize the properties of angiogenic dysregulation that lead to the highly vascularized nature of these tumors... - Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathwayChalet Tan
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Res 65:605-12. 2005..Further studies on the mechanism of action of 103D5R will likely provide new insights into its validity/applicability for the pharmacologic targeting of HIF-1alpha for therapeutic purposes... - Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migrationFatima W Khwaja
Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Clin Cancer Res 12:6331-6. 2006..Additionally, our migration studies suggest that it may be an important mediator of tumor invasiveness, and thus, a potential target in future therapies... - Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patientsFatima W Khwaja
Laboratory of Molecular Neuro Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road NE, Atlanta, GA 30322, USA
J Proteome Res 6:559-70. 2007.... - Identification of a novel small molecule HIF-1alpha translation inhibitorTakuhito Narita
Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
Clin Cancer Res 15:6128-36. 2009..HIF-1 is overexpressed in cancer and has become an important therapeutic target in solid tumors. In this study, a novel HIF-1alpha inhibitor was identified and its molecular mechanism was investigated... - Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapy (Review)Stephen B Hunter
Department of Pathology and Laboratory Medicine, Emory University Hospital, H 173, NE, Atlanta, GA 30322, USA
Int J Oncol 23:857-69. 2003..Although at the present no molecular system for the classification of brain tumors has been generally accepted, microarray technologies offer the exciting prospect of practical molecular classification in the future... - The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesisDaniel J Brat
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuro Oncol 7:122-33. 2005..A precise definition of the mechanisms by which IL-8 exerts its proangiogenic functions requires further study for the development of effective IL-8-targeted therapies... - Replicative oncolytic adenoviruses in multimodal cancer regimensDawn E Post
Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Hum Gene Ther 14:933-46. 2003..In this review, we describe the oncolytic Ad vectors tested in preclinical and clinical models and their use in combination with chemo-, radio-, and gene therapies... - Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4Dawn E Post
Department of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road, Atlanta, GA 30322, USA
Cancer Res 67:6872-81. 2007.... - Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasionAnita C Bellail
Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Hematology/Oncology, Winship Cancer Institute and Brain Tumor Program, Emory University, Atlanta, GA 30322, USA
Int J Biochem Cell Biol 36:1046-69. 2004..This review will focus on the impact of microregional heterogeneity of the ECM on glioma invasion in the normal adult brain and its modifications in tumoral brain... - Inhibitors of hypoxia-inducible factor-1 signalingVladimir E Belozerov
Emory University, Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Winship Cancer Institute, 1365C Clifton Road, Atlanta, GA 30322, USA
Curr Opin Investig Drugs 7:1067-76. 2006..This review describes the progress toward the identification of specific inhibitors of HIF-1, and discuss the first examples of HIF-1-targeted therapeutics to enter clinical development... - BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localizationKaren H Ventii
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Res 68:6953-62. 2008..The identification of the deubiquitinating enzyme BAP1 as a tumor suppressor may lead to further understanding of how the ubiquitin proteasome system contributes to cancer and aid in the identification of new targets for cancer therapy... - Hypoxia inducible factor-1: a novel target for cancer therapyVladimir E Belozerov
Department of Neurosurgery, Hematology Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Anticancer Drugs 16:901-9. 2005..These drugs disrupt the HIF-1 signaling pathway through a variety of mechanisms, including the inhibition of HIF-1alpha protein synthesis, stabilization, nuclear translocation and HIF-1 transactivation of target genes... - Use of replicating oncolytic adenoviruses in combination therapy for cancerRoland L Chu
Laboratory of Molecular Neuro-Oncology, Departments of Neurosurgery, Hematology/Oncology, and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA
Clin Cancer Res 10:5299-312. 2004..This article focuses on oncolytic adenoviruses that have been created and tested in preclinical and clinical trials in combination with chemotherapy, radiation therapy, and gene therapy... - Proteomics of gliomas: initial biomarker discovery and evolution of technologyJuliya Kalinina
Laboratory of Molecular Neuro Oncology, Departments of Neurosurgery, Hematology and Medical Oncology, School of Medicine, and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Neuro Oncol 13:926-42. 2011.... - PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasionJee Yin Ahn
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 279:16441-51. 2004..Our results demonstrate that PIKE-A is a physiologic regulator of Akt and an oncogenic effector of cell invasion... - Natural mutagenesis of human genomes by endogenous retrotransposonsRebecca C Iskow
Genetics and Molecular Biology Graduate Program, Emory University, Atlanta, GA 30322, USA
Cell 141:1253-61. 2010..Our data indicate that transposon-mediated mutagenesis is extensive in human genomes and is likely to have a major impact on human biology and diseases... - Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markersFatima W Khwaja
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
Proteomics 6:6277-87. 2006..3-13.7 kDa peak range in non-neoplastic CSF and was most prominent in inflammatory conditions. Our approach provides a rational basis for identifying biomarkers that could be used for detection, diagnosis, and monitoring of CNS diseases... - Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cellsNicola J Mabjeesh
Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 62:2478-82. 2002..Thus, benzoquinone ansamycin drugs and their derivatives, such as 17-allyl-aminogeldanamycin, are excellent candidates as small molecule drug inhibitors of HIF-1 overexpression in cancer cells... 
Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environmentHongsung Kim
Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, Methodist Hospital, Houston, Texas 77030, USA
Mol Ther 16:599-606. 2008..Hypoxia-resistant T cells may thus be of value in the treatment of human tumors in which areas of hypoxia may otherwise account for resistance to this therapeutic strategy...- Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastomaMichael Kragh
Laboratory of Experimental Oncology, University of Copenhagen, DK-2100 Copenhagen, Denmark
Cancer Res 62:1191-5. 2002..Elucidation of the mechanisms that allow this to happen has important consequences for the understanding of tumor recurrence after antiangiogenic therapy... - Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysRoger McLendon
Nature 455:1061-8. 2008..Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer... - Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1Michele Albertoni
Laboratory of Tumor Biology and Genetics, Department of Neurosurgery, University Hosptial Lausanne, 1011 Lausanne, Switzerland
Oncogene 21:4212-9. 2002..Taken together, these data suggest that MIC-1 is an important downstream mediator of p53 function, while acting itself as an intercessor of cellular stress signaling and exerting anti-tumorigenic activities... - Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapyYueh-Chun Li
Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan
Clin Cancer Res 12:2716-29. 2006..These genetic alterations could be used to predict the responsiveness of malignant gliomas to TRAIL-based therapies in clinical treatment of the tumors... - Absence of KLF6 gene mutations in human astrocytic tumors and cell linesPasi A Koivisto
Int J Cancer 111:642-3. 2004 - Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1Ella Kim
Department of Neurosurgery, University Hospital Lubeck, Lubeck, Germany
Oncogene 22:7716-27. 2003..An important implication of our findings is that the loss of p53-mediated negative control over ets-1-dependent transcription may lead to the acquisition of an invasive phenotype in tumor cells... - Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cellsCharles S Cobbs
Surgical Service, Veterans Affairs Medical Center, University of Alabama at Birmingham Department of Surgery, Division of Neurosurgery, Birmingham, Alabama 35294, USA
Cancer Res 63:8670-3. 2003..Concentrations of peroxynitrite associated with a tumor inflammatory environment caused dysregulation of wild-type p53 transcriptional activity and downstream p21(WAF1) expression... - TRAIL triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathwaysJin H Song
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
Brain Pathol 13:539-53. 2003....
Research Grants
- THERAPEUTIC MODULATION OF ANGIOGENESIS IN HUMAN GLIOMASErwin G Van Meir; Fiscal Year: 2011..Improving the treatment of malignant gliomas, an incurable disease, is an important human health goal. ..
- Targeting Glioblastoma Using Novel Small Molecule HIF-1 Pathway InhibitorsErwin Van Meir; Fiscal Year: 2009..These preclinical studies have the potential to directly benefit human health by increasing the survival of cancer patients, a main goal of the National Cancer Institute. ..
- THERAPEUTIC MODULATION OF ANGIOGENESIS IN HUMAN GLIOMASErwin Van Meir; Fiscal Year: 2007..Improving the treatment of malignant gliomas, an incurable disease, is an important human health goal. ..
- THERAPEUTIC MODULATION OF ANGIOGENESIS IN HUMAN GLIOMASErwin Van Meir; Fiscal Year: 2004..Improving the treatment of malignant gliomas, an incurable disease, is an important human health goal. ..
- Targeting Glioblastoma Using Novel Small Molecule HIF-1 Pathway InhibitorsErwin G Van Meir; Fiscal Year: 2010..These preclinical studies have the potential to directly benefit human health by increasing the survival of cancer patients, a main goal of the National Cancer Institute. ..
- Hypoxia as a target for the treatment of brain tumorsErwin Van Meir; Fiscal Year: 2003..The translation of these preclinical studies have the potential to directly benefit human health by improving the survival of children and adults with cancer. ..
- Targeting Glioblastoma Using Novel Small Molecule HIF-1 Pathway InhibitorsErwin Van Meir; Fiscal Year: 2007..These preclinical studies have the potential to directly benefit human health by increasing the survival of cancer patients, a main goal of the National Cancer Institute. ..
- A hypoxia-dependent adenovirus for glioma therapyErwin Van Meir; Fiscal Year: 2005..The translation of these preclinical studies have the potential to directly benefit human health by improving the survival of cancer patients. ..