Guilermo E Umpierez

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, GA, USA
    Crit Care Med 40:1792-8. 2012
  2. ncbi Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis
    Guillermo E Umpierrez
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Am J Med 117:291-6. 2004
  3. ncbi Treatment of diabetic ketoacidosis with subcutaneous insulin aspart
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Diabetes Care 27:1873-8. 2004
  4. ncbi Insulin analogs versus human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 32:1164-9. 2009
  5. ncbi Comparison of inpatient insulin regimens with detemir plus aspart versus neutral protamine hagedorn plus regular in medical patients with type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia 30303, USA
    J Clin Endocrinol Metab 94:564-9. 2009
  6. ncbi Intravenous intralipid-induced blood pressure elevation and endothelial dysfunction in obese African-Americans with type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, General Clinical Research Center, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, Georgia 30303, USA
    J Clin Endocrinol Metab 94:609-14. 2009
  7. ncbi Narrative review: ketosis-prone type 2 diabetes mellitus
    Guillermo E Umpierrez
    Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Ann Intern Med 144:350-7. 2006
  8. ncbi Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)
    Guillermo E Umpierrez
    General Clinical Research Center, Emory University School of Medicine, Grady Health System, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Diabetes Care 30:2181-6. 2007
  9. ncbi Inpatient management of diabetes: an increasing challenge to the hospitalist physician
    Guillermo E Umpierrez
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    J Hosp Med 2:33-5. 2007
  10. ncbi Primary aldosteronism in diabetic subjects with resistant hypertension
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Diabetes Care 30:1699-703. 2007

Research Grants

  1. Markers of normoglycemic remission in obese diabetics
    Guillermo Umpierrez; Fiscal Year: 2006

Collaborators

Detail Information

Publications50

  1. ncbi A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, GA, USA
    Crit Care Med 40:1792-8. 2012
    ....
  2. ncbi Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis
    Guillermo E Umpierrez
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Am J Med 117:291-6. 2004
    ..To compare the efficacy and safety of subcutaneous insulin lispro with that of a standard low-dose intravenous infusion protocol of regular insulin in patients with uncomplicated diabetic ketoacidosis...
  3. ncbi Treatment of diabetic ketoacidosis with subcutaneous insulin aspart
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Diabetes Care 27:1873-8. 2004
    ....
  4. ncbi Insulin analogs versus human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 32:1164-9. 2009
    ..To compare the safety and efficacy of insulin analogs and human insulins both during acute intravenous treatment and during the transition to subcutaneous insulin in patients with diabetic ketoacidosis (DKA)...
  5. ncbi Comparison of inpatient insulin regimens with detemir plus aspart versus neutral protamine hagedorn plus regular in medical patients with type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia 30303, USA
    J Clin Endocrinol Metab 94:564-9. 2009
    ..Studies comparing the use of basal bolus with insulin analogs vs. split-mixed regimens with human insulins in hospitalized patients with type 2 diabetes are lacking...
  6. ncbi Intravenous intralipid-induced blood pressure elevation and endothelial dysfunction in obese African-Americans with type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, General Clinical Research Center, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, Georgia 30303, USA
    J Clin Endocrinol Metab 94:609-14. 2009
    ..We evaluated the effect of sustained elevations of FFA on blood pressure, endothelial function, insulin secretion, inflammatory markers, and renin-angiotensin system...
  7. ncbi Narrative review: ketosis-prone type 2 diabetes mellitus
    Guillermo E Umpierrez
    Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Ann Intern Med 144:350-7. 2006
    ..The underlying mechanisms for beta-cell dysfunction in ketosis-prone type 2 diabetes are not known; however, preliminary evidence suggests an increased susceptibility to glucose desensitization...
  8. ncbi Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)
    Guillermo E Umpierrez
    General Clinical Research Center, Emory University School of Medicine, Grady Health System, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Diabetes Care 30:2181-6. 2007
    ..We sought to study the optimal management of hyperglycemia in non-intensive care unit patients with type 2 diabetes, as few studies thus far have focused on the subject...
  9. ncbi Inpatient management of diabetes: an increasing challenge to the hospitalist physician
    Guillermo E Umpierrez
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    J Hosp Med 2:33-5. 2007
  10. ncbi Primary aldosteronism in diabetic subjects with resistant hypertension
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Diabetes Care 30:1699-703. 2007
    ..Despite the high prevalence of hypertension in patients with type 2 diabetes, the prevalence of primary aldosteronism in this population has not been determined...
  11. ncbi Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery)
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 34:256-61. 2011
    ..The optimal treatment of hyperglycemia in general surgical patients with type 2 diabetes mellitus is not known...
  12. ncbi Lack of lipotoxicity effect on {beta}-cell dysfunction in ketosis-prone type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:626-31. 2010
    ..A high FFA level by intralipid infusion for 48 h was not associated with beta-cell decompensation (lipotoxicity) in KPDM patients...
  13. ncbi Diabetes mellitus in the Hispanic/Latino population: an increasing health care challenge in the United States
    Guillermo E Umpierrez
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30303, USA
    Am J Med Sci 334:274-82. 2007
    ..In this manuscript, we review recent epidemiologic information on the prevalence, pathophysiology, and complications of diabetes, as well as the recommendations for the management of Hispanics with type 2 diabetes...
  14. ncbi How to manage type 2 diabetes in medical and surgical patients in the hospital
    Guilermo E Umpierez
    Emory University School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, Atlanta, GA 30303, USA
    Cleve Clin J Med 78:379-84. 2011
    ..This paper discusses the prevalence, outcomes, and evidence for best management of hyperglycemia and diabetes in hospitalized patients outside the critical care setting...
  15. ncbi The effects of LY2189265, a long-acting glucagon-like peptide-1 analogue, in a randomized, placebo-controlled, double-blind study of overweight/obese patients with type 2 diabetes: the EGO study
    G E Umpierrez
    Emory School of Medicine, Emory University, Atlanta, GA 30303, USA
    Diabetes Obes Metab 13:418-25. 2011
    ..To evaluate the efficacy and tolerability of once-weekly LY2189265 (LY), a novel glucagon-like peptide-1 (GLP-1) IgG4-Fc fusion protein, in patients with type 2 diabetes failing oral antihyperglycaemic medications (OAMs)...
  16. ncbi Effects of oral and intravenous fat load on blood pressure, endothelial function, sympathetic activity, and oxidative stress in obese healthy subjects
    Aidar R Gosmanov
    Emory University School of Medicine, Atlanta, GA 30303, USA
    Am J Physiol Endocrinol Metab 299:E953-8. 2010
    ..Thus, fat load, independent of its source, has deleterious hemodynamic effects in obese subjects...
  17. ncbi Ketosis-prone type 2 diabetes: effect of hyperglycemia on beta-cell function and skeletal muscle insulin signaling
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
    Endocr Pract 13:283-90. 2007
    ..To determine the underlying mechanism for the severe and transient beta-cell dysfunction and impaired insulin action in obese African American patients with ketosis-prone diabetes...
  18. ncbi Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises
    Frankie B Stentz
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Diabetes 53:2079-86. 2004
    ..Return of these values to normal levels with insulin therapy demonstrates a robust anti-inflammatory effect of insulin...
  19. ncbi Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes
    Guillermo E Umpierrez
    Division of Endocrinology and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Clin Endocrinol Metab 87:978-82. 2002
    ..Patients with newly diagnosed hyperglycemia had a significantly higher mortality rate and a lower functional outcome than patients with a known history of diabetes or normoglycemia...
  20. ncbi Effects of intravenous glucose load on insulin secretion in patients with ketosis-prone diabetes during near-normoglycemia remission
    Aidar R Gosmanov
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:854-60. 2010
    ..The aim of this study was to determine the effect of glucotoxicity on beta-cell function during remission in obese patients with KPD...
  21. ncbi Nebivolol in high-risk, obese African Americans with stage 1 hypertension: effects on blood pressure, vascular compliance, and endothelial function
    Nadya Merchant
    Department of Cardiology, Emory University, 69 Jesse Hill Drive SE, Atlanta, GA30303, USA
    J Clin Hypertens (Greenwich) 11:720-5. 2009
    ..005). Monotherapy with nebivolol in obese, hypertensive African Americans results in significant systolic and diastolic BP reduction by mechanisms that include improved vascular function and compliance...
  22. ncbi Perioperative glucose control in the diabetic or nondiabetic patient
    Dawn D Smiley
    Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30303, USA
    South Med J 99:580-9; quiz 590-1. 2006
    ..This paper reviews the pathophysiology of hyperglycemia during trauma and surgical stress and will provide practical recommendations for the preoperative, intraoperative, and postoperative care of diabetic patients...
  23. ncbi Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes
    Aidar R Gosmanov
    Dept of Physiology, College of Medicine, Univ of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Endocrinol Metab 287:E8-E15. 2004
    ....
  24. ncbi Diabetic ketoacidosis: risk factors and management strategies
    Guillermo E Umpierrez
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Treat Endocrinol 2:95-108. 2003
    ..Novel approaches to patient education incorporating a variety of healthcare beliefs and socioeconomic issues are critical to an effective prevention program...
  25. ncbi Diabetes and fractures: an overshadowed association
    Natasha B Khazai
    Division of Endocrinology, Diabetes and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Curr Opin Endocrinol Diabetes Obes 16:435-45. 2009
    ..To review recent literature on fracture risk in patients with type 1 and type 2 diabetes...
  26. ncbi Safety and efficacy of continuous insulin infusion in noncritical care settings
    Dawn Smiley
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    J Hosp Med 5:212-7. 2010
    ..Continuous insulin infusion (CII) to manage hyperglycemia is the accepted standard of care in the intensive care unit (ICU); however, the safety and efficacy of CII in the non-ICU setting has not been determined...
  27. ncbi Management of hyperglycemia in hospitalized patients
    Dawn Smiley
    Department of Medicine, Emory University School of Medicine, 49 Jesse Hill Jr Dr SE, Atlanta, GA 30303, USA
    Ann N Y Acad Sci 1212:1-11. 2010
    ....
  28. ncbi Sliding scale insulin use: myth or insanity?
    Guillermo E Umpierrez
    Department of Medicine Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30303, USA
    Am J Med 120:563-7. 2007
    ..To understand its wide use and acceptance, we reviewed the origin, advantages, and disadvantages of sliding scale insulin in the inpatient setting...
  29. ncbi Changes in serum leptin in lean and obese subjects with acute hyperglycemic crises
    Abbas E Kitabchi
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Clin Endocrinol Metab 88:2593-6. 2003
    ..The low serum leptin level on admission in subjects with hyperglycemic crises may be the result of impaired adipocyte glucose utilization due to insulin deficiency and/or to increased catecholamine levels...
  30. ncbi Predictors of intensive care unit and hospital length of stay in diabetic ketoacidosis
    Amado X Freire
    Department of Medicine, The University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    J Crit Care 17:207-11. 2002
    ....
  31. ncbi Prevalence and clinical outcome of inpatient hyperglycemia in a community pediatric hospital
    Andres Palacio
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Hosp Med 3:212-7. 2008
    ..No previous studies, however, have examined the association of hyperglycemia and clinical outcome in children admitted to a community pediatric hospital...
  32. ncbi Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population
    Amado X Freire
    Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, Memphis, 38163, USA
    Chest 128:3109-16. 2005
    ..Tight glycemic control is recommended for patients in the ICU, as hyperglycemia is associated with increased morbidity and mortality...
  33. ncbi Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, 956 Court Ave, Suite D334, Memphis, Tennessee 38163, USA
    Diabetes Care 29:2739-48. 2006
  34. ncbi Hyperglycemia during total parenteral nutrition: an important marker of poor outcome and mortality in hospitalized patients
    Francisco J Pasquel
    Department ofMedicine, Emory University School ofMedicine, Atlanta, Georgia, USA
    Diabetes Care 33:739-41. 2010
    ..To determine the effect of total parenteral nutrition (TPN)-induced hyperglycemia on hospital outcome...
  35. ncbi Thirty years of personal experience in hyperglycemic crises: diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes, and Metabolism, University of Tennessee Health Science Center, 920 Madison Avenue 909, Memphis, TN 38163, USA
    J Clin Endocrinol Metab 93:1541-52. 2008
    ..This paper summarizes the results of these prospective studies on the management and pathophysiology of DKA...
  36. ncbi Evidence for strict inpatient blood glucose control: time to revise glycemic goals in hospitalized patients
    Abbas E Kitabchi
    University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Metabolism 57:116-20. 2008
    ..We propose a more conservative approach of glycemic control than current American Association of Clinical Endocrinology recommendations until results of prospective, multicenter, randomized studies become available...
  37. ncbi Diabetes management in urban African Americans: review of a public hospital experience
    David C Ziemer
    Department of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    Ethn Dis 18:336-41. 2008
    ..To review characteristics of an urban (primarily African American) diabetes patient population and discuss experience with treatment strategies, we summarize key retrospective and prospective analyses conducted during 15 years...
  38. ncbi Diabetic ketoacidosis induces in vivo activation of human T-lymphocytes
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem Biophys Res Commun 315:404-7. 2004
    ..We propose DKA changes the T-lymphocytes to insulin sensitive tissues as a compensatory mechanism...
  39. ncbi Substitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: comparison of vascular, metabolic, and inflammatory effects
    Joselita Siqueira
    Department of Medicine, Emory University, Atlanta, Georgia 30303, USA
    J Clin Endocrinol Metab 96:3207-16. 2011
    ..Recently concerns with its use have been raised due to the proinflammatory effects that may lead to increased complications because they are rich in ω-6 polyunsaturated fatty acids...
  40. ncbi Recurrent diabetic ketoacidosis in inner-city minority patients: behavioral, socioeconomic, and psychosocial factors
    Lori Randall
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Diabetes Care 34:1891-6. 2011
    ..To conduct a bedside study to determine the factors driving insulin noncompliance in inner-city patients with recurrent diabetic ketoacidosis (DKA)...
  41. ncbi Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study
    Guillermo E Umpierrez
    Division of Endocrinology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Diabetes Care 26:1181-5. 2003
    ..However, longitudinal studies to determine the natural history of thyroid dysfunction in patients with type 1 diabetes are lacking...
  42. ncbi Impact of diabetes mellitus on perioperative outcomes after resection for pancreatic adenocarcinoma
    Carrie K Chu
    Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA
    J Am Coll Surg 210:463-73. 2010
    ..Associations between diabetes mellitus (DM) and pancreatic ductal adenocarcinoma (PDAC) are well established; however, the impact of DM on perioperative morbidity and mortality after PDAC resection is unclear...
  43. ncbi Management of intractable hypoglycemia with Yttirum-90 radioembolization in a patient with malignant insulinoma
    Prakash Chandra
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Am J Med Sci 340:414-7. 2010
    ..However, the effect of Y-90 administration seems to be transient and without evidence of tumor shrinkage in imaging studies...
  44. ncbi Hyperglycemic crises in diabetes
    Abbas E Kitabchi
    Diabetes Care 27:S94-102. 2004
  45. ncbi Hyperglycemic crises in patients with diabetes mellitus
    Abbas E Kitabchi
    Diabetes Care 26:S109-17. 2003
  46. ncbi The use of alkali therapy in severe diabetic ketoacidosis
    Kashif A Latif
    Diabetes Care 25:2113-4. 2002
  47. ncbi Diabetic ketoacidosis in type 2 diabetes mellitus--pathophysiology and clinical presentation
    Stephen N Davis
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232-6303, USA
    Nat Clin Pract Endocrinol Metab 3:730-1. 2007
  48. ncbi Pregnancy complicated by diabetic ketoacidosis: maternal and fetal outcomes
    Michael B Schneider
    Diabetes Care 26:958-9. 2003
  49. ncbi Insulin resistance and pubertal changes
    Peter W F Wilson
    J Clin Endocrinol Metab 93:2472-3. 2008
  50. ncbi Ketosis-prone type 2 diabetes: time to revise the classification of diabetes
    Guillermo E Umpierrez
    Diabetes Care 29:2755-7. 2006

Research Grants1

  1. Markers of normoglycemic remission in obese diabetics
    Guillermo Umpierrez; Fiscal Year: 2006
    ..Identifying such markers will facilitate and guide future therapeutic interventions and may identify patients at risk to develop chronic complications of diabetes ..